The renin-angiotensin system and renal function in transgenic (mRen2)27 rats

Experimental Nephrology

Volumn 4, Issue SUPPL. 1, 1996, Pages 20-26

  Gross, Volkmar ^a,b   Lippoldt, Andrea ^a,b   Bohlender, Jürgen ^a,b   Ganten, Detlev ^b,c   Ganten, Ursula ^b   Luft, Friedrich C ^a,b,d  

^a HUMBOLDT UNIVERSITY   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d FRANZ VOLHARD CLINIC   (Germany)

Author keywords

ACE inhibition; AT1 receptor blockade; Hypertension; Pressure natriuresis; Rats; Renin angiotensin system; Transgenic

Indexed keywords

ANGIOTENSIN 1 RECEPTOR;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; KIDNEY FUNCTION; NONHUMAN; PRIORITY JOURNAL; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SPONTANEOUSLY HYPERTENSIVE RAT; TRANSGENIC ANIMAL;

ANGIOTENSIN II; ANIMALS; ANIMALS, GENETICALLY MODIFIED; DISEASE MODELS, ANIMAL; HYPERTENSION, RENAL; KIDNEY; MICE; NATRIURESIS; PRESSURE; RATS; RATS, SPRAGUE-DAWLEY; RENIN; RENIN-ANGIOTENSIN SYSTEM;

EID: 0029750324     PISSN: 10187782     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Mullins JJ, Peter J, Ganten D: Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene. Nature 1990;344:541-544.
2. Paul M, Wagner J, Hoffmann S, Urata H, Ganten D: Transgenic rats: A new experimental model for the study of candidate genes in hypertension. Annu Rev Physiol 1994;50:811-829.
3. Djavidani B, Sander M, Kreutz R, Zeh K, Bader M, Mellon SH, Vecsei P, Peters J, Ganten D: Chronic dexamethasone treatment suppresses hypertension development in the transgenic rat TGR(mRen2)27. J Hypertens 1995; 13:637-645.
4. Guyton AC, Manning RD, Lohmeier TE, Hall JE: The kidney and hypertension; in Poste G, Crooke ST (eds): Dopamine Receptor Agonists. New York, Plenum Publishing, 1984, pp 237-258.
5. Roman RJ: Pressure diuresis mechanism in the control of renal function and arterial pressure. Fed Proc 1986;45:2878-2884.
6. Guyton AC: Abnormal renal function and autoregulation in essential hypertension. Hypertension 1991;18(suppl III):III-9-III-53.
7. Guyton AC: Renal function curve - A key to understanding the pathogenesis of hypertension. Hypertension 1987;10:1-6.
8. Cowley AW Jr, Roman RJ: The pressure-diuresis-natriuresis mechanism in normal and hypertensive states; in Zanchetti A, Tarazi RC (eds): Handbook of Hypertension. Elsevier Science Publishers, 1986, vol 8: Pathophysiology of Hypertension - Regulatory Mechanisms, pp 295-314.
9. Guyton AC, Hall JE, Coleman TG, Manning RD Jr: The dominant role of the kidneys in the long-term regulation of arterial pressure in normal and hypertensive states; in Laragh JH, Brenner BM (eds): Hypertension: Pathophysiology, Diagnosis, and Management. New York, Raven Press, 1990, pp 1029-1052.
10. Navar LG, Paul RV, Carmines PK, Chou C-L, Marsh DJ: Intrarenal mechanisms mediating pressure natriuresis: Role of angiotensin and prostaglandins. Fed Proc 1986;45:2885-2891.
11. Romero JC, Knox FG: Mechanisms underlying pressure-related natriuresis: The role of the renin-angiotensin and prostaglandin system. State of the art lecture. Hypertension 1988;11: 724-738.
12. Roman RJ, Cowley AW Jr: Abnormal pressure-natriuresis response in spontaneously hypertensive rats. Am J Physiol 1985;248:F199-F205.
13. Roman RJ: Altered pressure-natriuresis relationship in young spontaneously hypertensive rats. Hypertension 1987;9(suppl 3):III-130-III-136.
14. Roman RJ: Abnormal renal hemodynamics and pressure-natriuresis relationship in Dahl salt-sensitive rats. Am J Physiol 1986;251: F57-F65.
15. Gross V, Lippoldt A, Schneider W, Yagil Ch, Yagil Y, Luft FC: Pressure natriuresis in salt sensitive and salt resistant Sabra rats. Hypertension, submitted.
16. 2 and renal function in the Lyon hypertensive rat. Am J Physiol 1994;266: R1530-R1536.
17. Kline RL, McLennan GP: Chronic hydralazine treatment alters the acute pressure-natriuresis curve in young spontaneously hypertensive rats. Can J Physiol Pharmacol 1991;69:164-169.
18. Takenaka T, Suzuki H, Furukawa T, Ogata Y, Saruta T: Role of intrarenal renin-angiotensin system on pressure-natriuresis in spontaneously hypertensive rats. Clin Exp Hypertens A 1990;12:1377-1394.
19. Harris PJ, Navar LG: Tubular transport responses to angiotensin. Am J Physiol 1985;248: F621-F630.
20. Hollenberg NK: The renin-angiotensin system and sodium homeostasis. J Cardiovasc Pharmacol 1984;6:S-176-S-183.
21. Navar LG, Rosivall L: Contribution of the renin-angiotensin system to the control of intrarenal hemodynamics. Kidney Int 1984;25: 857-868.
22. Rosenfeld JB, Zabludowski J: The renin-angiotensin system, the kidney, and hypertension. J Cardiovasc Pharmacol 1989;13(suppl 3):S-22-S-26.
23. Levens NR, Peach MJ, Carey RM: Role of the intrarenal renin-angiotensin system in the control of renal function. Circ Res 1981;48:157-167.
24. Mitchel KD, Braam B, Navar LG: Hypertensinogenic mechanisms mediated by renal actions of renin-angiotensin system. Hypertension 1992;19(suppl 1):I-18-I-27.
25. Van der Mark J, Kline RL: Altered pressure natriuresis in chronic angiotensin II hypertension in rats. Am J Physiol 1994;266:R739-R748.
26. Gross V, Roman RJ, Cowley AW Jr: Abnormal pressure-natriuresis in transgenic renin gene rats. J Hypertens 1994;12:1029-1034.
27. Gross V, Luft FC: Nisoldipine and pressure-natriuresis curves in transgenic (mRen2)27 rats. J Hypertens 1996;14:529-535.
28. Gross V, Lippoldt A, Schneider W, Luft FC: Effect of captopril and AT1 receptor blockade on pressure natriuresis and diuresis in (mRen2)27 rats. Hypertension 1995;26:471-479.
29. Lippoldt A, Gross V, Bohlender J, Ganten U, Luft FC: Life-long angiotensin converting enzyme inhibition, pressure natriuresis, and renin angiotensin system gene expression in transgenic (mRen-2)27 rats. J Am Soc Nephrol, in press.
30. Min LO, Medeiros IA, Mullins JJ, Ganten D, Barres C, Cerutti C, Vincent M, Sassard J: High blood pressure maintenance in transgenic mRen-2 vs. Lyon genetically hypertensive rats. Am J Physiol 1993;265:R180-R186.
31. Tobian L, Lange J, Azar S, Iwai J, Koop D, Coffee K, Johnson MA: Reduction of natriuretic capacity and renin release in isolated, blood-perfused kidneys of Dahl hypertension-prone rats. Circ Res 1978;43(suppl I):I-192-I-197.
32. Tobian L, Johnson MA, Lange J, Magraw S: Effect of varying perfusion pressure on the output of sodium and renin and the vascular resistance in kidneys of rats with 'post-salt' hypertension and Kyoto spontaneous hypertension. Circ Res 1975;36(suppl I):162-170.
33. Mitchell KD, Mullins JJ: Ang II dependence of tubuloglomerular feedback responsiveness in hypertensive ren-2 transgenic rats. Am J Physiol 1995;268:F821-F828.
34. Hirth-Dietrich C, Stasch JP, Ganten D, Luft FC: Renal effects of captopril and nitrendipine in transgenic rats with an extra renin gene. Hypertension 1994;23:626-631.
35. Bachmann S, Peters J, Engler E, Ganten D, Mullins J: Transgenic rats carrying the mouse renin gene - Morphological characterization of a low-renin hypertension model. Kidney Int 1992;41:24-36.
36. Lee MA, Böhm M, Kim S, Bachmann S, Bachmann J, Bader M, Ganten D: Differential gene expression of renin and angiotensinogen in the TGR(mREN-2)27 transgenic rat. Hypertension 1995;25:570-580.
37. Tokita Y, Franco-Saenz R, Mulrow PJ: Reversal of suppressed kidney renin level in the hypertensive transgenic rat TGR (mRen-2)27 by ACE inhibition. Am J Hypertens 1995;8: 1031-1039.
38. Tokita Y, Franco-Saenz R, Mulrow PJ, Ganten D: Effects of nephrectomy and adrenalectomy on the renin-angiotensin system of transgenic rats TGR(mRen2)27. Endocrinology 1994; 134:253-257.
39. Tokita Y, Franc-Saenz R, Reimann EM, Mulrow PJ: Hypertension in transgenic rat TGR (mRen-2)27 may be due to enhanced kinetics of the reaction betwen mouse renin and rat angiotensinogen. Hypertension 1994;23:422-427.
40. Veniant M, Whitworth CE, Menard J, Sharp MGF, Gonzales MF, Bruneval P, Mullins JJ: Developmental studies demonstrate age-dependent elevation of renin activity in TGR (mRen2)27 rats. Am J Hypertens 1995;8: 1167-1176.
41. Bohlender J, Menard J, Wagner J, Luft FC, Ganten D: Human renin-dependent hypertension in rats transgenic for human angiotensinogen. Hypertension 1996;27(pt 2):535-540.
42. Tokita Y, Yamaguchi T, Franco-Saenz R, Mulrow PJ, Ganten D: Adrenal renin is released into the circulation of the hypertensive transgenic rat TGR(mRen-2)27. Trans Assoc Am Physicians 1992;105:123-129.
43. Navar LG, Lewis L, Hymel A, Braam B, Mitchel KD: Tubular fluid concentrations and kidney content of angiotensin I and II in anesthetized rats. J Am Soc Nephrol 1994;5:1153-1158.