Nisoldipine and pressure-natriuresis curves in transgenic (mRen2)27 rats

Journal of Hypertension

Volumn 14, Issue 4, 1996, Pages 529-535

  Gross, Volkmar ^a,b   Luft, Friedrich C ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

Calcium antagonists; Nisoldipine; Pressure natriuresis; Renal blood flow; Renal function curves; Transgenic rats

Indexed keywords

4 AMINOHIPPURIC ACID; ANTIHYPERTENSIVE AGENT; CALCIUM CHANNEL BLOCKING AGENT; INULIN; NISOLDIPINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLAMP; CONTROLLED STUDY; DIURESIS; GLOMERULUS FILTRATION RATE; HYPERTENSION; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY BLOOD FLOW; KIDNEY PERFUSION; KIDNEY PLASMA FLOW; MALE; NATRIURESIS; NONHUMAN; PERFUSION PRESSURE; PRIORITY JOURNAL; RAT; SODIUM EXCRETION; TRANSGENIC ANIMAL; WATER ABSORPTION;

EID: 0030010664     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-199604000-00018     Document Type: Article

References (25)

1. Mullins JJ, Peter J, Ganten D: Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene. Nature 1990, 344:541-544.
2. Peters J, Ganten D, Mullins JJ: The development of hypertension in transgenic rats, transgenic (mRen2)27. Prog Hypertens 1995, 3:in press.
3. Gross V, Roman RJ, Cowley AW Jr. Abnormal pressure-natriuresis In transgenic renin gene rats. J Hypertens 1994; 12:1029-1034.
4. 1 receptor blockade on pressure natriuresis and diuresis in (mRen2)27 transgenic rats. Hypertension 1995, 26:471-479.
5. Cowley AW Jr, Mattson DL, Lu S, Roman RJ: The renal medulla and hypertension. Hypertension 1995, 25 (part 2):663-673.
6. Hirth-Dietrich C, Stasch JP, Ganten D, Luft FC: Renal effects of captopril and nitrendipine in transgenic rats with an extra renin gene. Hypertension 1994, 23:626-631.
7. Roman RJ, Cowley JR Jr: Characterization of a new model for the study of pressure-natriuresis in the rat. Am J Physiol 1985, 248:F190-F198.
8. B Führ J, Kaczmarczyk J, Krüttgen CD. Eine einfache colorimetrische Methode zur Inulinbestimmung für Nieren-Clearanceuntersuchungen bei Stoffwechselgesunden und Diabetikern. Klin Wachenschr 1955, 33:729-730.
9. Führ J: Cleararvce-Methoden zur Nierenfunktionsprüfung unter besonderer Berücksichtigung des Total-Clearance-Verfahrens. Ärzt Labor 1958, 4:79-95.
10. Selkurt EE, Womack I, Dailey WN: Mechanism of natriuresis and diuresis during elevated renal arterial pressure. Am J Physiol 1965, 209:95-99.
11. Guyton AC, Manning RD, Lohmeier TE, Hall JE: The kidney and hypertension. In Dopamine receptor agonists. Edited by Poste G, Crooke ST. New York: Plenum Publishing Corporation, 1964: 237-258.
12. Guyton AC: Renal function curve - a key to understanding the pathogenesis of hypertension. Hypertension 1987, 10:1-6.
13. Guyton AC, Hall JE, Colemann TG, Manning RD Jr: The dominant role of the kidney in the long-term regulation of arterial pressure in normal and hypertensive states. In Hypertension: Pathophysiology, diagnosis, and management Edited by Laragh JH, Brenner BM, New York: Raven Press; 1990: 1029-1052.
14. Romero JC, Raij L, Granger JP, Ruilope LM, Rodico JL: Multiple effects of calcium entry blockers on renal function in hypertension. Hypertension 1987, 10:140-151.
15. Epstein M, De Micheli AG, Forster H: Natriuretic effects of calcium antagonists in humans: a review of experimental evidence and clinical data. Cardiovasc Drug Reviews 1991, 9: 398-412.
16. DiBona GF: Effects of vasodilator antihypertensive agents on renal function. J Cardiovasc Pharm 1987, 9 (suppl 1):S14-S16
17. Fenoy FJ, Kauker ML, Milicic I, Roman RI: Normalization of pressure-natriuresis by nisoldipine in spontaneously hypertensive rats. Hypertension 1992, 19:49-55.
18. Garthoff B, Hirth C, Federmann A, Kazda S, Stasch JP: Renal effects of 1,4-dihydropyridines in animal models of hypertension and renal failure. J Cardiovasc Pharmacol 1987, 9 (suppl 1):S8-S13
19. Navar LG, Champion WJ, Thomas CE: Effects of calcium channel blockade on renal vascular resistance response to changes in perfusion pressure and angiotensin-converting enzyme inhibition in dogs. Circ Res 1986, 58:874-881.
20. Dibona GF, Sawin LL: Renal tubular site of action of felodipine. J Pharm Exp Ther 1984, 228:420-424.
21. Lin H, Young DB: The antihypertensive mechanism of verapamil. Alteration of glomerular filtration rate regulation. Hypertension 1988, 11:639-644.
22. Fenoy FJ, Milicic I, Mistry M, Mecca TE, Roman RJ: Effect of clentiazem on arterial pressure and renal function in normotensive and hypertensive rats. J Pharm Exp Therap 1992, 261:470-475.
23. Kauker ML, Zeigker DW, Zawada ET: Renal tubular effect of nisoldipine, a calcium channel blocker, in rats. J Cardiovasc Pharm 1967, 9 (suppl 1):S32-S38.
24. Loutzenhiser R, Epstein M, Horton C: Modification by dihydropyridine-type calcium antagonists of the renal hemodynamic response to vasoconstrictors. J Cardiovasc Pharmacol 1987, 9 (suppl 1):S70-S75.
25. Steinhausen M, Fleming JT, Holz FG, Parekh N, Dussel R: Nitrendipine and the pressure-dependent vasodilation of vessels in the hydronephrotic kidney. J Cardiovasc Pharm 1987, 9 (suppl 1):S39-S43.