5-Hydroxytryptamine 3 receptor and regulation of gastric emptying in rats

Archives Internationales de Pharmacodynamie et de Therapie

Volumn 331, Issue 2, 1996, Pages 203-218

  Ito, C ^a   Isobe, Y ^a   Tsuchida, K ^a   Hlguchi, S ^a  

^a Department of Pharmacology Research Center   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 METHYL 3 INDOLECARBOXYLIC ACID [1 [2 (METHYLSULFONYLAMINO)ETHYL] 4 PIPERIDINYLMETHYL] ESTER; 2 [(2 METHYL 1 IMIDAZOLYL)METHYL]BENZO[F]THIOCHROMEN 1 ONE; 3 (5 METHYL 1H IMIDAZOL 4 YL) 1 (1 METHYL 1H INDOL 3 YL) 1 PROPANONE; 5,7 DIHYDROXYTRYPTAMINE; AZASETRON; BENZAMIDE DERIVATIVE; CISAPRIDE; CISPLATIN; GRANISETRON; METOCLOPRAMIDE; NEUROTOXIN; NEW DRUG; ONDANSETRON; RADIOLIGAND; RAMOSETRON; RENZAPRIDE; SEROTONIN 3 AGONIST; SEROTONIN 3 ANTAGONIST; SEROTONIN 3 RECEPTOR; TROPISETRON; UNCLASSIFIED DRUG; ZACOPRIDE; 1 (3 CHLOROPHENYL)BIGUANIDE; 1-(3-CHLOROPHENYL)BIGUANIDE; ANTINEOPLASTIC AGENT; BIGUANIDE DERIVATIVE; CHROMONE DERIVATIVE; IMIDAZOLE DERIVATIVE; INDOLE DERIVATIVE; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR; SULFONAMIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN CORTEX; CONTROLLED STUDY; CORPUS STRIATUM; DRUG MECHANISM; DRUG POTENCY; GUINEA PIG; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; RAT; RECEPTOR BINDING; REGULATORY MECHANISM; SEROTONINERGIC SYSTEM; STOMACH EMPTYING; SUBCUTANEOUS DRUG ADMINISTRATION; ANIMAL; BINDING COMPETITION; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; ENTEROCHROMAFFIN CELL; METABOLISM; RADIOASSAY; SMALL INTESTINE; STRUCTURE ACTIVITY RELATION; WISTAR RAT;

ANIMALS; ANTINEOPLASTIC AGENTS; BIGUANIDES; BINDING, COMPETITIVE; CEREBRAL CORTEX; CHROMONES; CISPLATIN; CORPUS STRIATUM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENTEROCHROMAFFIN CELLS; GASTRIC EMPTYING; IMIDAZOLES; INDOLES; INJECTIONS, SUBCUTANEOUS; INTESTINE, SMALL; MALE; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT3; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 0029658428     PISSN: 00039780     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. BACIIY, A., HéAULME, M., GIUUICE, A., MICIIAUU, J. C., LEFEVRE, I. A., SOUILHAC, J., MANARA, L., EMERIT, M. B., GOZLAN, H., HAMON, M., KLANE, P. E., SOUBRIé, P. and LE FUR, G. L. SR57227A: a potent and selective agonist at central and peripheral 5-HT, receptors in vitro and in vivo. Europ. J. Pharinacol. 237, 299-309 (1993).
2. BANNER, S. E. and SäNGER, G. J. Differences between 5-HT, receptor antagonists in modulation of visceral hypersensitivity. Brit. J. Pharinacol. 114, 558-562 (1995).
3. BJORKI.UND, A., BAUMGARTEN, H. G. and RENSCII, A. 5,7-Dihydroxytryptamine: Improvement of its selectivity for serotonin neurons in the CNS by pretreatment with desipramine. J. Neurochem. 2-1, 833-835 (1975).
4. BON-HAUS, D. W., WING, E. H. F., STEFANICII, E., KUNYSZ, E. A. and EGI.CN, R. M. Pharmacological characterization of 5-hydroxytryptamine, receptors in murine brain and ileum using the novel radioligand [3H]RS-42358-197: Evidence for receptor heterogeneity. J. Ncurochem. 61, 1927-1932 (1993).
5. BUCIIIIOT, K. U., COSTAI.I., B., ENGEL, G., GUNNING, S. J., NAYI.OR, R. J. and RICHARDSON, B. P. 5-Hydroxytryptamine receptor antagonism by metoclopramide and ICS 205-930 in the guinea-pig leads to enhancement of contractions of stomach muscle strips induced by electrical field stimulation and facilitation of gastric emptying in vivo. J. Pluirni. Pharmacol 37, 664-667 (19S5).
6. BUTI.ER, A., EI.SWOOD, C. J., BURRIOGE, J., IRELAND, S. J., BUN, K. T., KILPATRICK, G. J. and TYERS, M. B. The pharmacological characterization of 5-HT, receptors in three isolated preparations derived from guinea-pig tissues. Brit. J. Phannacol. 101, 591-598 (1990).
7. COIIF.N, M. L., BLOOMQUIST, W., GIDDA, J. S. and LACEFIELD, W. LY277359 maleate: a potent and selective 5-HT, receptor antagonist without gastroprokinetic activity. J. Pharmacol. c.\;>. Ther. 254, 350-355 (1990).
8. COSTAI.I., B., GUNNING, S. J. and NAYI.OR, R. J. An analysis of the hypothalamic sites at which substituted benzamide drugs act to facilitate gastric emptying in the guinea-pig. Neuropharmacology 24, 869-875 (1985).
9. COSTALL, B., Kri.t.Y, M. E., NAYLOR, R. J., TAN, C. C. W. and TATTFRSALL, K. D. 5-Hydroxytryptamine M-receptor antagonism in the hypothalamus facilitates gastric emptying in the guinea-pig. Neuropharmacology 25, 1293-1296 (1986).
10. COSTAI.I., B., GUNNING, S. J., NAYI.OR, R. J. and TYERS, M. B. The effect of GR38032F, a novel 5-HT, receptor antagonist on gastric emptying in the guinea-pig. Brit. J. Pharmacol. 91, 263-264 (1987).
11. CUBEDDU, L. X. and Hon.MANN, I. S. Participation of serotonin on early and delayed emesis induced by initial and subsequent cycles of cisplatinum-based chemotherapy: Effects of antiemetics. J. din. Phannacol. 33, 691-697 (1993).
12. CUBEDDU, L. X., HOITMANN, I. S., FUENMAYOR, N. T. and MAI.AVI:, J. J. Changes in serotonin metabolism in cancer patients: Its relationship to nausea and vomiting induced by chemothcrapcutic drugs. Brit. J. Cancer 66, 198-203 (1992).
13. DUNNETT, C. W. A multiple comparison procedure for comparing several treatments with a control. Amer. Suit. Ass. J. 50, 1096-1121 (1955).
14. FOZAR, J. R. The development of 5-HT, receptor antagonists. In: Mylccharanc, E. J., Angus, J. A., De La Lande, I. S. and Humphrey, P. P. A. (Eds.). Serotonin, Actions, Receptors, Pathophysiology, pp. 204-221. Macmillan Press, Basingstoke (1989).
15. FOZARD, J. R. and HOST, M. Selective inhibition of Bezold-Jarisch effect of 5-HT in the rat by antagonists of neuronal 5-HT receptors. Brit. J. Pharmacol. 77, 520P (1984).
16. FUKUI, H., YAMAMOTO, M., ANUO, T., SASAKI, S. and SATO, S. Increase in serotonin levels in the dog ileum and blood by cisplatin as measured by microdialysis. Neuropharmacology 32, 959-968 (1993).
17. GEUAUER, A., MERGER, M. and KII.HINGER, H. Modulation by 5-HT, and 5-HT4 receptors of the release of 5-hydroxytryptamine from guinea-pig small intestine. NaunynSchmieilcbcrgs Arch. Pharmacol. 347, 137-140 (1993).
18. GULLIKSON, G. W., VlRINA, M. A., LOEFFt.ER, R. F., YANG, D-C., GOI.DSTIN, B., WANG, S.-X., MOUMMI, C., FI.YNN, D. L. and ZABROWSKI, D. L. SC-49518 enhances gastric emptying of solid and liquid meals and stimulates gastrointestinal motility in dogs by a 5-hydroxytryptamine4 receptor mechanism. J. Pharmacol. exp. Thcr. 264, 240-248 (1992).
19. HEGDE, S. S., WONG, A. G., PERRY, M. R., Ku, P., MOY, T. M., LOEB, M. and EGLEN, R. M. 5-HT4 receptor mediated stimulation of gastric emptying in rats. Nmmyn-Schieileberg's Arch. Pharmacol. 351, 589-595 (1995).
20. HOVER, D., CLARKE, D. E., FOJ.ARD, J. R., HARTIG, P. R., MARTIN, G. R., MVLECHARANE, E. J., SAXENA, P. R. and HUMPHREY, P. P. A. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol. Rev. 46, 157-203 (1994).
21. ITO, C, ISOBE, Y., KIJIMA, H., KIUCIII, H., OIITSUKI, H., KAWAMURA, R., MURAMATSU, M. and OroMO, S. Anti-emetic effect of GK-128, a novel 5-HT, receptor antagonist. Jap. J. Pharmacol 61, 198 P (1993).
22. ITO, C, ISOBE, Y., KIJIMA, H., KIUCIII, H., OIITSUKI, H., KAWAMURA, R., TSUCIIIDA, K. and HIGUCIII, S. The anti-emetic activity of GK-128 in Stincns nuirimis. Europ. J. Pharmacol. 285, 37-43 (1995).
23. ITO, C, ISOBE, Y., KAWAMURA, R., TSUCIIIDA, K. and HIGUCIII, S. Characterization of 5-HT, receptors mediating contractions and relaxations in the guinea-pig distal colon. Gastrocnterology 110, A685 (1996a).
24. ITO, C, KAWAMURA, R., KIUCIII, Y., ISOBE, Y., TSUCIIIUA, K. and HIGUCIII. S. Effect of GK128 (2-[(2-mcthylimidazol-l-yl) methyl] benzo [f] tliiochromen-1-one monohydrochloride hemihydrate), a selective 5-HT, receptor antagonist, on colonie function in rats. J. Pharmacol. exp. T/icr. (in press) (1996b).
25. JONSSON, G., POI.LARE, T., IlAi.i.MAN, H. and SACHS, C. Developmental plasticity of central serotoncrgic neurons after 5,7-dihydroxytryptamine treatment. Ann. A'. }'. Acml. Sei. 305, 328-345 (1978).
26. KILPATRICK, G. J., JONES, B. J. and TYLRS, M. B. l-(m-Chloro-phenyl)-biguanide, a potent high affinity 5-HT., receptor agonist. Europ. J. Pharmacol. 182, 193-197 (1990).
27. KisiiiBAYAsm, N., MIWA, Y., HAYASIII, H., Isiin, A., ICIIIKAWA, S., NONAKA, H., YOKOYAMA, T. and SUZUKI, F. 5-HT, receptor antagonists. 3. Quinoline derivatives which may be effective in the therapy of irritable bowel syndrome. J. mal. Chum. 36, 3286-3292 (1993).
28. Loxoo, D. L., WESLEY, M., HOWSI:R, D., HUBBARD, S. M., ANULRSON, T. and YOUNG, R. C. Results of a randomised double-blind trial of scopolamine versus placebo administration by transdermal patch for the control of cisplatin-induced emesis. Cancer Trctitm. Rep. 66, 1975-1976(1982).
29. MIYATA, K., KAMATO, T., NISIIIDA, A., ITO, H., KATSUYAMA, Y., IWAI, A., YUKI, H., YAMANO, M., TSUTSUMI, R., OIITA, M., TAKEDA, M. and HONUA, K. Pharmacologie profile of (R)-5-[l-methyl-3-indolyl)carbonyI]-4, 5, 6, 7,-tetrahydro-l//-benzimidazol hydrochloricle (YM060), a potent and selective 5-hydroxytryptamine, receptor antagonist, and its enantiomer in the isolated tissue. J. Pharmacol. exp. Tim: 259, 15-21 ( 1991 ).
30. SANGER, G. J. and WARUM-, K. A. Constipation evoked by 5-HT, receptor-antagonism: Evidence for heterogenous efficacy among different antagonists in guinea-pigs. J. Pluirm. Pharmacol. 46, 666-670 (1994).
31. SATO, N., SAKAMORI, M., HAGA, K., TAKEHARA, S. and SKTOGUCIII, M. Antagonistic activity of Y-25130 on 5-HT, receptors. Jap. J. Pharmacol. 59, 443-448 (1992).
32. SCHEUE, H. Tlie Analysis of Variance. John Wiley and Sons Inc., New York (1959).
33. SCIIIAVONE, A., VOLONTE, M. and MICHELLTTI, R. The gastrointestinal motor effect of bcnzamidc derivatives is unrelated to 5-HT, receptor blockade. Europ. J. Pharmacol. 187, 323-329 (1990).
34. SCHWORER, H., RACKé, K. and KK.BINGER, H. Cisplatin increases the release of 5-hydroxytryptamine from the isolated vascularly perfused small intestine of the guinea-pig: Involvement of 5-HT, receptors. ffaitiiyn-Sclimii'ilcberg's Arch. Pharmacol. 344, 143-149 (1991).
35. TYERS, M. B. 5-HT, receptors. Ann. N. Y. AcaJ. Sei. 600, 194-205 (1990).
36. VICTOR, M., CARRERO, P., CLENCH, M. H., DAVIS, R. H., ANDRES, J. M., KRAN/INI, D. A. and MATHIAS, J. R. Intestinal motility changes in rats after enteric serotonergic neuron destruction. Amer. J. Physiol. 260, G232-G239 (1991).
37. WONO, E. H. F., BONHAUS, D. W., Wu, I., STEFANISCII, E. and EGLEN, R. M. Labelling of 5-hydroxytryptaminej receptors with a novel 5-HT3 receptor ligand, [JH]RS-42358-197. J. Neiirocliem. 60, 921-930 (1993a).
38. WONG, E. H. F., BONIIAUS, D. W., LEE, J. A., Wu, I., LOURY, D. N. and EGI.EN, R. M. Different densities of 5-HT, receptors are labeled by [3H]quipazine, [JH]GR65630 and ['HJgranisetron. Neuropharmacology 32, 869-875 (1993b).