5-Hydroxytryptamine M-receptor antagonism in the hypothalamus facilitates gastric emptying in the guinea-pig

Neuropharmacology

Volumn 25, Issue 11, 1986, Pages 1293-1296

  Costall, B ^a   Kelly, M E ^a   Naylor, R J ^a   Tan, C C W ^a   Tattersall, F D ^a  

^a UNIVERSITY OF BRADFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYLSEROTONIN; METHYSERGIDE; RITANSERIN; SEROTONIN; SEROTONIN RECEPTOR; TROPISETRON;

ANIMAL EXPERIMENT; CENTRAL NERVOUS SYSTEM; DRUG ANTAGONISM; DRUG EFFICACY; GUINEA PIG; HYPOTHALAMUS; INTRACEREBRAL DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; STOMACH; STOMACH EMPTYING; STOMACH MOTILITY; THERAPY;

ANIMALS; GASTRIC EMPTYING; GUINEA PIGS; HYPOTHALAMUS; INDOLES; MALE; METHYSERGIDE; PIPERIDINES; RECEPTORS, SEROTONIN; RITANSERIN; SEROTONIN;

EID: 0023032192     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/0028-3908(86)90151-6     Document Type: Article

References (9)

1. Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine
2. 5-hydroxytryptamine receptor antagonism by metoclopramide and ICS 205–930 in the guinea-pig leads to enhancement of contractions of stomach muscle strips induced by electrical field stimulation and facilitation of gastric emptying ‘in vivo’
3. An analysis of the hypothalamic sites at which substituted benzamide drugs act to facilitate gastric emptying in the guinea-pig
4. Apomorphine and gastric emptying in the guinea-pig
5. Selective inhibition of the Bezold-Jarisch effect of 5-HT in the rat by antagonists at neuronal 5-HT receptors
6. Serotonin can antagonise the actions of metoclopramide and SCH 23390 to enhance field stimulation contractions of smooth muscle from guinea-pig stomach
7. Drugs increasing gastrointestinal motility
8. Indentification of serotonin M-receptor subtypes and their specific blockade by a new class of drugs
9. The pharmacological basis of the therapeutic activity of clebopride and related substituted benzamides