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Volumn 11, Issue 4, 1990, Pages 578-610

Endocrine pharmacology of antiestrogens as antitumor agents

Author keywords

[No Author keywords available]

Indexed keywords

ANTIESTROGEN; DROLOXIFENE; N BUTYL 11 (3,17BETA DIHYDROXYESTRA 1,3,5(10) TRIEN 7ALPHA YL) N METHYLUNDECANAMIDE; RALOXIFENE; TAMOXIFEN; TOREMIFENE; TRIOXIFENE; ZINDOXIFENE;

EID: 0025242415     PISSN: 0163769X     EISSN: 0163769X     Source Type: Journal    
DOI: 10.1210/edrv-11-4-578     Document Type: Article
Times cited : (402)

References (453)
  • 1
    • 70449221678 scopus 로고
    • A nonsteroidal estrogen antagonist l-(P-2-diethylaminoethoxyphenyl)-l-phenyl-2-p-methoxyphenylethanol
    • Lerner LJ, Holthaus Jr FJ, Thompson CR 1958 A nonsteroidal estrogen antagonist l-(p-2-diethylaminoethoxyphenyl)-l-phenyl-2-p-methoxyphenylethanol. Endocrinology 63:295
    • (1958) Endocrinology , vol.63 , pp. 295
    • Lerner, L.J.1    Holthaus, F.J.2    Thompson, C.R.3
  • 2
  • 3
    • 0025338591 scopus 로고
    • Development of antiestrogens and their use in breast cancer: Eighth cain memorial award lecture
    • Lerner LJ, Jordan VC 1990 Development of antiestrogens and their use in breast cancer: eighth Cain Memorial Award Lecture. Cancer Res 50:4177
    • (1990) Cancer Res , vol.50 , pp. 4177
    • Lerner, L.J.1    Jordan, V.C.2
  • 6
    • 0018429114 scopus 로고
    • Induction of ovulation with clomiphene citrate
    • Huppert LC 1979 Induction of ovulation with clomiphene citrate. Fertil Steril 31:1
    • (1979) Fertil Steril , vol.31 , pp. 1
    • Huppert, L.C.1
  • 7
    • 0014710806 scopus 로고
    • Postcoital contraception
    • Emmens CW 1970 Postcoital contraception. Br Med Bull 26:45
    • (1970) Br Med Bull , vol.26 , pp. 45
    • Emmens, C.W.1
  • 9
    • 0001733527 scopus 로고
    • On oophorectomy in cancer of the breast
    • Boyd S 1900 On oophorectomy in cancer of the breast. Br Med J ii:1161
    • (1900) Br Med J Ii , pp. 1161
    • Boyd, S.1
  • 10
    • 84965250913 scopus 로고
    • Influence of synthetic oestrogens upon advanced malignant disease
    • Haddow A, Watkinson JM, Paterson E 1944 Influence of synthetic oestrogens upon advanced malignant disease. Br Med J ii:393
    • (1944) Br Med J Ii , pp. 393
    • Haddow, A.1    Watkinson, J.M.2    Paterson, E.3
  • 11
    • 0001528477 scopus 로고
    • Synthetic oestrogens in mammary cancer
    • Walpole AL, Paterson E 1949 Synthetic oestrogens in mammary cancer. Lancet 2:783
    • (1949) Lancet , vol.2 , pp. 783
    • Walpole, A.L.1    Paterson, E.2
  • 15
    • 0015294754 scopus 로고
    • Effect of some triphenylethylenes on oestradiol binding
    • Skidmore JR, Walpole AL, Woodburn J 1972 Effect of some triphenylethylenes on oestradiol binding in vitro to macromolecules from uterus and anterior pituitary. J Endocrinol 52:289
    • (1972) J Endocrinol , vol.52 , pp. 289
    • Skidmore, J.R.1    Walpole, A.L.2    Woodburn, J.3
  • 16
    • 0017044241 scopus 로고
    • Antiestrogens in the treatment of breast cancer
    • Legha SS, Carter SK 1976 Antiestrogens in the treatment of breast cancer. Cancer Treat Rev 3:205
    • (1976) Cancer Treat Rev , vol.3 , pp. 205
    • Legha, S.S.1    Carter, S.K.2
  • 17
    • 0015069359 scopus 로고
    • A new antioestrogenic agent in late breast cancer. An early clinical appraisal of ici46.474
    • Cole MP, Jones CTA, Todd IDH 1971 A new antioestrogenic agent in late breast cancer. An early clinical appraisal of ICI46.474. Br J Cancer 25:270
    • (1971) Br J Cancer , vol.25 , pp. 270
    • Cole, M.P.1    Jones, C.2    Todd, I.3
  • 18
    • 0015915672 scopus 로고
    • Antioestrogen therapy for breast cancer: A trial of tamoxifen at two dose levels
    • Ward HWC 1973 Antioestrogen therapy for breast cancer: a trial of tamoxifen at two dose levels. Br Med J i:13
    • (1973) Br Med J I , pp. 13
    • Ward, H.1
  • 20
    • 0017046748 scopus 로고    scopus 로고
    • (Key Biscayne, Florida, April 28, 1976)
    • Proceedings of the Annual Spring Meeting of the Primary Breast Cancer Therapy Group: Tamoxifen workshop. (Key Biscayne, Florida, April 28, 1976). Cancer Treat Rep 60:1409
    • Cancer Treat Rep , vol.60 , pp. 1409
  • 21
    • 0023773272 scopus 로고
    • Development of tamoxifen for breast cancer therapy: A tribute to the late arthur l. walpole
    • Jordan VC 1988 Development of tamoxifen for breast cancer therapy: a tribute to the late Arthur L. Walpole. Breast Cancer Res Treat 11:197
    • (1988) Breast Cancer Res Treat , vol.11 , pp. 197
    • Jordan, V.C.1
  • 24
    • 0024269590 scopus 로고
    • Effect of adjuvant tamoxifen and of cytotoxic therapy on mortality in early breast cancer
    • Early Breast Cancer Trialists’ Collaborative Group 1988 Effect of adjuvant tamoxifen and of cytotoxic therapy on mortality in early breast cancer. N Engl J Med 319:1681
    • (1988) N Engl J Med , vol.319 , pp. 1681
  • 28
    • 0020050189 scopus 로고
    • Mechanisms of oestrogen antagonism by nonsteroidal antioestrogens
    • Sutherland RL, Murphy LC 1982 Mechanisms of oestrogen antagonism by nonsteroidal antioestrogens. Mol Cell Endocrinol 25:5
    • (1982) Mol Cell Endocrinol , vol.25 , pp. 5
    • Sutherland, R.L.1    Murphy, L.C.2
  • 29
    • 0021618186 scopus 로고
    • The pharmacology and clinical uses of tamoxifen
    • Furr BJA, Jordan VC 1984 The pharmacology and clinical uses of tamoxifen. Pharmacol Ther 25:127
    • (1984) Pharmacol Ther , vol.25 , pp. 127
    • Furr, B.1    Jordan, V.C.2
  • 30
    • 0021709492 scopus 로고
    • Biochemical pharmacology of antiestrogen action
    • Jordan VC 1984 Biochemical pharmacology of antiestrogen action. Pharmacol Rev 36:245
    • (1984) Pharmacol Rev , vol.36 , pp. 245
    • Jordan, V.C.1
  • 32
    • 0023700011 scopus 로고
    • Pharmacodynamic and biological effects of anti-estrogens in different models
    • Pasqualini JR, Sumida C, Glambiagi N 1988 Pharmacodynamic and biological effects of anti-estrogens in different models. J Steroid Biochem 31:613
    • (1988) J Steroid Biochem , vol.31 , pp. 613
    • Pasqualini, J.R.1    Sumida, C.2    Glambiagi, N.3
  • 33
    • 0023694062 scopus 로고    scopus 로고
    • Tamoxifen in the treatment of breast cancer
    • Legha SS Tamoxifen in the treatment of breast cancer. Ann Intern Med 109:219
    • Ann Intern Med , vol.109 , pp. 219
    • Legha, S.S.1
  • 34
    • 0024654213 scopus 로고
    • Tamoxifen. A reappraisal of its pharmacodynamic and pharmacokinetic properties and therapeutic use
    • Buckley MMT, Goa KL 1989 Tamoxifen. A reappraisal of its pharmacodynamic and pharmacokinetic properties and therapeutic use. Drugs 37:451
    • (1989) Drugs , vol.37 , pp. 451
    • Buckley, M.1    Goa, K.L.2
  • 36
    • 0020585962 scopus 로고
    • Direct and reversible inhibition of estradiol-stimulated prolactin synthesis by antiestrogens
    • Lieberman ME, Jordan VC, Fritsch M, Santos MA, Gorski J 1983 Direct and reversible inhibition of estradiol-stimulated prolactin synthesis by antiestrogens in vitro. J Biol Chem 258:4734
    • (1983) J Biol Chem , vol.258 , pp. 4734
    • Lieberman, M.E.1    Jordan, V.C.2    Fritsch, M.3    Santos, M.A.4    Gorski, J.5
  • 37
    • 0020587401 scopus 로고
    • An estrogen receptor model to describe the regulation of prolactin synthesis by antiestrogens
    • Lieberman ME, Gorski J, Jordan VC 1983 An estrogen receptor model to describe the regulation of prolactin synthesis by antiestrogens in vitro. J Biol Chem 258:4741
    • (1983) J Biol Chem , vol.258 , pp. 4741
    • Lieberman, M.E.1    Gorski, J.2    Jordan, V.C.3
  • 39
    • 0021671343 scopus 로고
    • Estrogen-stimulated prolactin synthesis
    • Jordan VC, Lieberman ME 1984 Estrogen-stimulated prolactin synthesis in vitro: Classification of agonist, partial agonist and antagonist actions based on structure. Mol Pharmacol 26:279
    • (1984) Mol Pharmacol , vol.26 , pp. 279
    • Jordan, V.C.1    Lieberman, M.E.2
  • 40
    • 0022632650 scopus 로고
    • Oestrogenic and antioestrogenic actions in a series of triphenylbut-l-enes: Modulation of prolactin synthesis
    • Jordan VC, Koch R, Mittal S, Schneider MR 1986 Oestrogenic and antioestrogenic actions in a series of triphenylbut-l-enes: modulation of prolactin synthesis in vitro. Br J Pharmacol 87:217
    • (1986) Br J Pharmacol , vol.87 , pp. 217
    • Jordan, V.C.1    Koch, R.2    Mittal, S.3    Schneider, M.R.4
  • 41
    • 0023903560 scopus 로고
    • Estrogenic actions in vitro of hydroxylated derivatives of D16726 (Zindoxifene) an agent with known antimammary cancer activity in vivo
    • Robinson SP, Koch R, Jordan VC 1988 Estrogenic actions in vitro of hydroxylated derivatives of D16726 (Zindoxifene) an agent with known antimammary cancer activity in vivo. Cancer Res 48:784
    • (1988) Cancer Res , vol.48 , pp. 784
    • Robinson, S.P.1    Koch, R.2    Jordan, V.C.3
  • 42
    • 0023880304 scopus 로고
    • Ligand interaction at the estrogen receptor to program antiestrogen action: A study with non-steroidal compounds
    • Jordan VC, Koch R, Langan S, McCague R 1988 Ligand interaction at the estrogen receptor to program antiestrogen action: a study with non-steroidal compounds in vitro. Endocrinology 122:1449
    • (1988) Endocrinology , vol.122 , pp. 1449
    • Jordan, V.C.1    Koch, R.2    Langan, S.3    McCague, R.4
  • 43
    • 0024600318 scopus 로고
    • Regulation of prolactin synthesis
    • Jordan VC, Koch R 1989 Regulation of prolactin synthesis in vitro by estrogenic and antiestrogenic derivatives of estradiol and estrone. Endocrinology 124:77
    • (1989) Endocrinology , vol.124 , pp. 77
    • Jordan, V.C.1    Koch, R.2
  • 44
    • 0023110431 scopus 로고
    • Laboratory models of breast cancer to aid the elucidation of antiestrogen action
    • Jordan VC 1987 Laboratory models of breast cancer to aid the elucidation of antiestrogen action. J Lab Clin Med 109:267
    • (1987) J Lab Clin Med , vol.109 , pp. 267
    • Jordan, V.C.1
  • 45
    • 0022004418 scopus 로고
    • Host factors affecting the growth of carcinogen-induced rat mammary carcinomas: A review and tribute to charles brenton huggins
    • Welsch CW 1985 Host factors affecting the growth of carcinogen-induced rat mammary carcinomas: a review and tribute to Charles Brenton Huggins. Cancer Res 45:3415
    • (1985) Cancer Res , vol.45 , pp. 3415
    • Welsch, C.W.1
  • 46
    • 0018182801 scopus 로고
    • Human breast carcinoma cells in continuous culture: A review
    • Engel LW, Young WA 1978 Human breast carcinoma cells in continuous culture: a review. Cancer Res 38:4339
    • (1978) Cancer Res , vol.38 , pp. 4339
    • Engel, L.W.1    Young, W.A.2
  • 48
    • 0017371484 scopus 로고
    • Effects of estrone, estradiol and estriol on hormone responsive breast cancer in long term tissue culture
    • Lippman ME, Monaco ME, Bolan G 1977 Effects of estrone, estradiol and estriol on hormone responsive breast cancer in long term tissue culture. Cancer Res 37:1901
    • (1977) Cancer Res , vol.37 , pp. 1901
    • Lippman, M.E.1    Monaco, M.E.2    Bolan, G.3
  • 49
    • 0018940905 scopus 로고
    • The effect of 17β estradiol and tamoxifen on the zr-75-1 human breast cancer cell line in defined medium
    • Allegra JC, Lippman ME 1980 The effect of 17β estradiol and tamoxifen on the ZR-75-1 human breast cancer cell line in defined medium. Eur J Cancer Clin Oncol 16:1007
    • (1980) Eur J Cancer Clin Oncol , vol.16 , pp. 1007
    • Allegra, J.C.1    Lippman, M.E.2
  • 50
    • 0019197688 scopus 로고
    • Estrogen and the growth of breast cancer: New evidence suggests indirect action
    • Shafie SM 1980 Estrogen and the growth of breast cancer: new evidence suggests indirect action. Science 209:701
    • (1980) Science , vol.209 , pp. 701
    • Shafie, S.M.1
  • 51
    • 0016740410 scopus 로고
    • Oestrogen-responsive human breast cancer in long term tissue culture
    • Lippman ME, Bolan G 1975 Oestrogen-responsive human breast cancer in long term tissue culture. Nature 256:592
    • (1975) Nature , vol.256 , pp. 592
    • Lippman, M.E.1    Bolan, G.2
  • 52
    • 2542464918 scopus 로고
    • Phenol red in tissue culture media is a weak estrogen: Implications concerning the study of estrogen-responsive cells in culture
    • Berthois Y, Katzenellenbogen JA, Katzenellenbogen BS 1986 Phenol red in tissue culture media is a weak estrogen: implications concerning the study of estrogen-responsive cells in culture. Proc Natl Acad Sci USA 83:2496
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 2496
    • Berthois, Y.1    Katzenellenbogen, J.A.2    Katzenellenbogen, B.S.3
  • 53
    • 0023807142 scopus 로고
    • The control of hormone-dependent breast cancer growth—are we talking about estrogen alone?
    • Jordan VC 1988 The control of hormone-dependent breast cancer growth—are we talking about estrogen alone? Eur J Cancer Clin Oncol 24:1245
    • (1988) Eur J Cancer Clin Oncol , vol.24 , pp. 1245
    • Jordan, V.C.1
  • 55
    • 0023732493 scopus 로고
    • Lipophyllic impurities, not phenolsulfophthalein, account for the estrogenic activity in commercial preparations of phenol red
    • Bindal RD, Carlson KE, Katzenellenbogen BS, Katzenellenbogen JA 1988 Lipophyllic impurities, not phenolsulfophthalein, account for the estrogenic activity in commercial preparations of phenol red. J Steroid Biochem 31:287
    • (1988) J Steroid Biochem , vol.31 , pp. 287
    • Bindal, R.D.1    Carlson, K.E.2    Katzenellenbogen, B.S.3    Katzenellenbogen, J.A.4
  • 56
    • 51149188436 scopus 로고
    • Synthetic oestrogenic agents without the phenanthrene nucleus
    • Dodds EC, Lawson W 1936 Synthetic oestrogenic agents without the phenanthrene nucleus. Nature 137:996
    • (1936) Nature , vol.137 , pp. 996
    • Dodds, E.C.1    Lawson, W.2
  • 57
    • 0023752961 scopus 로고
    • Bis (4-hydroxyphenyl)2-phenoxysulphenyl)phenylmethane: Isolation and structure elucidation of a novel estrogen from commercial preparations of phenol red (phenolsulfophthalein)
    • Bindall RD, Katzenellenbogen JA 1988 Bis (4-hydroxyphenyl)2-phenoxysulphenyl)phenylmethane: isolation and structure elucidation of a novel estrogen from commercial preparations of phenol red (phenolsulfophthalein). J Med Chem 31:1978
    • (1988) J Med Chem , vol.31 , pp. 1978
    • Bindall, R.D.1    Katzenellenbogen, J.A.2
  • 58
    • 0001186777 scopus 로고
    • A simple aromatic oestrogenic agent with an activity of the same order as that of oestrone
    • Dodds EC, Lawson W 1937 A simple aromatic oestrogenic agent with an activity of the same order as that of oestrone. Nature 139:627
    • (1937) Nature , vol.139 , pp. 627
    • Dodds, E.C.1    Lawson, W.2
  • 59
    • 0011159453 scopus 로고
    • Phenol methyl ethers as oestrogenic agents
    • Zondek B, Bergmann M 1938 Phenol methyl ethers as oestrogenic agents. Biochem J 32:641
    • (1938) Biochem J , vol.32 , pp. 641
    • Zondek, B.1    Bergmann, M.2
  • 60
    • 0001211358 scopus 로고
    • Oestrogenic activity of p-hydroxy-propenyl benzene (Anol)
    • Dodds EC, Lawson W 1937 Oestrogenic activity of p-hydroxy-propenyl benzene (Anol). Nature 139:1068
    • (1937) Nature , vol.139 , pp. 1068
    • Dodds, E.C.1    Lawson, W.2
  • 61
    • 7144246247 scopus 로고
    • Oestrogenic activity of dianol, a dimeride of p-propenyl-phenol
    • Campbell NR, Dodds EC, Lawson W 1938 Oestrogenic activity of dianol, a dimeride of p-propenyl-phenol. Nature 141:78
    • (1938) Nature , vol.141 , pp. 78
    • Campbell, N.R.1    Dodds, E.C.2    Lawson, W.3
  • 62
    • 0013580758 scopus 로고
    • Oestrogenic activity of anol: A highly active phenol isolated from the byproducts
    • Campbell NR, Dodds EC, Lawson W 1938 Oestrogenic activity of anol: a highly active phenol isolated from the byproducts. Nature 142:1121
    • (1938) Nature , vol.142 , pp. 1121
    • Campbell, N.R.1    Dodds, E.C.2    Lawson, W.3
  • 63
    • 33749017015 scopus 로고
    • Oestrogenic activity of certain synthetic compounds
    • Dodds EC, Golberg L, Lawson W, Robinson R 1938 Oestrogenic activity of certain synthetic compounds. Nature 141:247
    • (1938) Nature , vol.141 , pp. 247
    • Dodds, E.C.1    Golberg, L.2    Lawson, W.3    Robinson, R.4
  • 64
    • 50349133151 scopus 로고
    • Biological effects of the synthetic oestrogenic substance 4:4’-dihydroxy-a:β diethylstil-bene
    • Dodds EC, Lawson W, Noble RL 1938 Biological effects of the synthetic oestrogenic substance 4:4’-dihydroxy-a:β diethylstil-bene. Lancet 1:1389
    • (1938) Lancet , vol.1 , pp. 1389
    • Dodds, E.C.1    Lawson, W.2    Noble, R.L.3
  • 65
    • 0017665570 scopus 로고
    • A mono-hydroxylated metabolite of tamoxifen with potent antioestrogenic activity
    • Jordan VC, Collins MM, Rowsby L, Prestwich G 1977 A mono-hydroxylated metabolite of tamoxifen with potent antioestrogenic activity. J Endocrinol 75:305
    • (1977) J Endocrinol , vol.75 , pp. 305
    • Jordan, V.C.1    Collins, M.M.2    Rowsby, L.3    Prestwich, G.4
  • 66
    • 0019941226 scopus 로고
    • Importance of the alkylaminoethyoxy side chain for the estrogenic and antiestrogenic actions of tamoxifen and trioxifene in the immature rat uterus
    • Jordan VC, Gosden B 1982 Importance of the alkylaminoethyoxy side chain for the estrogenic and antiestrogenic actions of tamoxifen and trioxifene in the immature rat uterus. Mol Cell Endocrinol 27:291
    • (1982) Mol Cell Endocrinol , vol.27 , pp. 291
    • Jordan, V.C.1    Gosden, B.2
  • 68
    • 0020067155 scopus 로고
    • Antiestrogen basicity-activity relationships: A comparison of the estrogen receptor binding and anti-uterotrophic potencies of several analogues of (z)-l,2 diphenyl-l-[4-[2-(di-methylamino)ethoxy]phenyl]-l-butene (tamoxifen, nolvadex) having altered basicity
    • Robertson DW, Katzenellenbogen JA, Hayes JR, Katzenellenbogen BS 1982 Antiestrogen basicity-activity relationships: a comparison of the estrogen receptor binding and anti-uterotrophic potencies of several analogues of (Z)-l,2 diphenyl-l-[4-[2-(di-methylamino)ethoxy]phenyl]-l-butene (tamoxifen, Nolvadex) having altered basicity. J Med Chem 25:167
    • (1982) J Med Chem , vol.25 , pp. 167
    • Robertson, D.W.1    Katzenellenbogen, J.A.2    Hayes, J.R.3    Katzenellenbogen, B.S.4
  • 69
    • 0022973829 scopus 로고
    • Analogues of tamoxifen: The role of the basic side chain. application of a whole cell oestrogen-receptor binding assay to n-oxides and quaternery salts
    • Jarman M, Leung O-T, LeClercq G, Devleeschouwer N, Stoessel S, Coombes RC, Skilton RA 1986 Analogues of tamoxifen: the role of the basic side chain. Application of a whole cell oestrogen-receptor binding assay to N-oxides and quaternery salts. AntiCancer Drug Design 1:259
    • (1986) Anticancer Drug Design , vol.1 , pp. 259
    • Jarman, M.1    Leung, O.-T.2    LeClercq, G.3    Devleeschouwer, N.4    Stoessel, S.5    Coombes, R.C.6    Skilton, R.A.7
  • 70
    • 0024842049 scopus 로고
    • Structural components necessary for the antiestrogenic activity of tamoxifen
    • Murphy CS, Jordan VC 1989 Structural components necessary for the antiestrogenic activity of tamoxifen. J Steroid Biochem 34:407
    • (1989) J Steroid Biochem , vol.34 , pp. 407
    • Murphy, C.S.1    Jordan, V.C.2
  • 71
    • 36949059277 scopus 로고
    • Contrasting endocrine activities of
    • Harper MJK, Walpole AL 1966 Contrasting endocrine activities of cis and trans isomers in a series of substituted triphenylethy-lenes. Nature 212:87
    • (1966) Nature , vol.212 , pp. 87
    • Harper, M.1    Walpole, A.L.2
  • 72
    • 0019443284 scopus 로고
    • Geometric isomers of substituted triphenylethylenes and antiestrogen action
    • Jordan VC, Haldeman B, Allen KE 1981 Geometric isomers of substituted triphenylethylenes and antiestrogen action. Endocrinology 108:1353
    • (1981) Endocrinology , vol.108 , pp. 1353
    • Jordan, V.C.1    Haldeman, B.2    Allen, K.E.3
  • 73
    • 0021348096 scopus 로고
    • Bioactivities, estrogen receptor interactions and plasminogen activator-inducing activities of tamoxifen and hydroxy-tamoxifen isomers in mcf-7 human breast cancer cells
    • Katzenellenbogen BS, Norman MJ, Eckert RL, Peltz SW, Mangel WF 1984 Bioactivities, estrogen receptor interactions and plasminogen activator-inducing activities of tamoxifen and hydroxy-tamoxifen isomers in MCF-7 human breast cancer cells. Cancer Res 44:112
    • (1984) Cancer Res , vol.44 , pp. 112
    • Katzenellenbogen, B.S.1    Norman, M.J.2    Eckert, R.L.3    Peltz, S.W.4    Mangel, W.F.5
  • 74
    • 0021872966 scopus 로고
    • Facile geometric isomerization of phenolic nonsteroidal estrogens and antiestrogens: Limitations to the interpretation of experiments characterizing the activity of individual isomers
    • Katzenellenbogen JA, Carlson KE, Katzenellenbogen BS 1985 Facile geometric isomerization of phenolic nonsteroidal estrogens and antiestrogens: limitations to the interpretation of experiments characterizing the activity of individual isomers. J Steroid Biochem 22:589
    • (1985) J Steroid Biochem , vol.22 , pp. 589
    • Katzenellenbogen, J.A.1    Carlson, K.E.2    Katzenellenbogen, B.S.3
  • 75
    • 0021910118 scopus 로고
    • Structure-activity relationships of estrogens: Receptor affinity and estrogen antagonist activity of certain (e)-and (z)-l,2,3-triaryl-2-propen-l-ones
    • Mittal S, Durani S, Kapil RS 1985 Structure-activity relationships of estrogens: receptor affinity and estrogen antagonist activity of certain (E)-and (Z)-l,2,3-triaryl-2-propen-l-ones. J Med Chem 28:492
    • (1985) J Med Chem , vol.28 , pp. 492
    • Mittal, S.1    Durani, S.2    Kapil, R.S.3
  • 76
    • 0024163040 scopus 로고
    • Analogies and differences in the modulation of progesterone receptor induction and cell proliferation by estrogens and antiestrogens in mcf-7 human breast cancer cells: Study with 24 triphenylacrylonitrile derivatives
    • Bignon E, Pons M, Gilbert J, Crastes de Paulet A 1988 Analogies and differences in the modulation of progesterone receptor induction and cell proliferation by estrogens and antiestrogens in MCF-7 human breast cancer cells: study with 24 triphenylacrylonitrile derivatives. J Steroid Chem 26:877
    • (1988) J Steroid Chem , vol.26 , pp. 877
    • Bignon, E.1    Pons, M.2    Gilbert, J.3    Crastes De Paulet, A.4
  • 77
    • 0022922221 scopus 로고
    • Synthesis and estrogen receptor binding of 6,7-dihydro-8-phenyl-9-[4-[2-(Dimethylamino)ethoxy]phenyl] 5h-benzocyclo-heptene, a non-isomerizabile analogue of tamoxifen. x-ray crystallographic studies
    • McCague R, Kuroda R, LeClercq G, Stoessel S 1986 Synthesis and estrogen receptor binding of 6,7-dihydro-8-phenyl-9-[4-[2-(dimethylamino)ethoxy]phenyl] 5H-benzocyclo-heptene, a non-isomerizabile analogue of tamoxifen. X-ray crystallographic studies. J Med Chem 29:2053
    • (1986) J Med Chem , vol.29 , pp. 2053
    • McCague, R.1    Kuroda, R.2    LeClercq, G.3    Stoessel, S.4
  • 78
    • 0023726546 scopus 로고
    • Non-isomerizable analogues of (Z)-and (e)-4 hydroxytamoxifen. synthesis and endocrinological properties of substituted diphenylbenzocyclohep-tenes
    • McCague R, LeClercq G, Jordan VC 1988 Non-isomerizable analogues of (Z)-and (E)-4 hydroxytamoxifen. Synthesis and endocrinological properties of substituted diphenylbenzocyclohep-tenes. J Med Chem 31:1285
    • (1988) J Med Chem , vol.31 , pp. 1285
    • McCague, R.1    LeClercq, G.2    Jordan, V.C.3
  • 80
    • 0025200665 scopus 로고
    • Structure-function relationships of hydroxylated metabolites of tamoxifen that control the proliferation of estrogen-responsive t47d breast cancer cells
    • Murphy CS, Langan-Fahey S, McCague R, Jordan VC 1990 Structure-function relationships of hydroxylated metabolites of tamoxifen that control the proliferation of estrogen-responsive T47D breast cancer cells in vitro. Mol Pharmacol, in press
    • (1990) Mol Pharmacol, in Press
    • Murphy, C.S.1    Langan-Fahey, S.2    McCague, R.3    Jordan, V.C.4
  • 82
    • 0020621727 scopus 로고
    • Tricyclic triarylethylene antiestrogens: Dibenz[b,f] oxepins, dibenzo[b,f] thiepins, dibenzo[a,e] cyclo octenes and dibenzo[b,f] thiocins
    • Acton D, Hill G, Tait BS 1983 Tricyclic triarylethylene antiestrogens: dibenz[b,f] oxepins, dibenzo[b,f] thiepins, dibenzo[a,e] cyclo octenes and dibenzo[b,f] thiocins. J Med Chem 26:1131
    • (1983) J Med Chem , vol.26 , pp. 1131
    • Acton, D.1    Hill, G.2    Tait, B.S.3
  • 83
    • 0018721780 scopus 로고
    • Synthesis and antiestrogenic activity of [3,4-dihydro-2-(4-meth-oxyphenyl)-l-naphthalenyl] [4-[2-(l-pyrrolidinyl)ethoxy]-phenyl]methanone, methanesulfane acid salt
    • Jones CD, Suarez T, Massey EH, Black LJ, Tinsley FC 1979 Synthesis and antiestrogenic activity of [3,4-dihydro-2-(4-meth-oxyphenyl)-l-naphthalenyl] [4-[2-(l-pyrrolidinyl)ethoxy]-phenyl]methanone, methanesulfane acid salt. J Med Chem 22:962
    • (1979) J Med Chem , vol.22 , pp. 962
    • Jones, C.D.1    Suarez, T.2    Massey, E.H.3    Black, L.J.4    Tinsley, F.C.5
  • 84
    • 0019416798 scopus 로고
    • Activity of the antioestrogen trioxifene against at-nitrosomethylurea-induced rat mammary carcinomas
    • Rose DP, Fisher AH, Jordan VC 1981 Activity of the antioestrogen trioxifene against AT-nitrosomethylurea-induced rat mammary carcinomas. Eur J Cancer Clin Oncol 17:893
    • (1981) Eur J Cancer Clin Oncol , vol.17 , pp. 893
    • Rose, D.P.1    Fisher, A.H.2    Jordan, V.C.3
  • 86
    • 0022655909 scopus 로고
    • Trioxifene mesylate in the treatment of advanced breast cancer
    • Lee RW, Rubdar AU, Blumenschein GR, Hortobagyi GN 1986 Trioxifene mesylate in the treatment of advanced breast cancer. Cancer 57:40
    • (1986) Cancer , vol.57 , pp. 40
    • Lee, R.1    Rubdar, W.2    Blumenschein, A.3    Hortobagyi, G.N.4
  • 87
    • 0020694796 scopus 로고
    • Antagonism of estrogen action with a new benzothiopene-derived antiestrogen
    • Black LJ, Jones CD, Falcone JF 1983 Antagonism of estrogen action with a new benzothiopene-derived antiestrogen. Life Sei 32:1031
    • (1983) Life Sei , vol.32 , pp. 1031
    • Black, L.J.1    Jones, C.D.2    Falcone, J.F.3
  • 88
    • 0021201213 scopus 로고
    • Antiestrogens 2 structure-activity studies in a series of 3-aroyl-2-(4-hydroxy phenyl) benzo[b]thien-3-yl] [4-[2-(l-piperidinyl)ethoxy] phenyl] meth-anone hydrochloride (ly 156758), a remarkably effective estrogen antagonist with only minimal intrinsic estrogenicity
    • Jones CD, Jevnikor MG, Pike AJ, Peters MK, Black LJ, Thompson AR, Falcone JF, Clemens JA 1984 Antiestrogens 2 structure-activity studies in a series of 3-aroyl-2-(4-hydroxy phenyl) benzo[b]thien-3-yl] [4-[2-(l-piperidinyl)ethoxy] phenyl] meth-anone hydrochloride (LY 156758), a remarkably effective estrogen antagonist with only minimal intrinsic estrogenicity. J Med Chem 27:1057
    • (1984) J Med Chem , vol.27 , pp. 1057
    • Jones, C.D.1    Jevnikor, M.G.2    Pike, A.J.3    Peters, M.K.4    Black, L.J.5    Thompson, A.R.6    Falcone, J.F.7    Clemens, J.A.8
  • 89
    • 0021926339 scopus 로고
    • Keoxifene shows pure antiestrogenic activity in pituitary gonadotrophs
    • Simard J, Labrie F 1985 Keoxifene shows pure antiestrogenic activity in pituitary gonadotrophs. Mol Cell Endocrinol 39:141
    • (1985) Mol Cell Endocrinol , vol.39 , pp. 141
    • Simard, J.1    Labrie, F.2
  • 90
    • 0020582094 scopus 로고
    • Effects of a new antiestrogen, keoxifene (Ly 156758) on growth of carcinogen-induced mammary tumors and on lh and prolactin levels
    • Clemens JA, Bennet DR, Black LJ, Jones CD 1983 Effects of a new antiestrogen, keoxifene (LY 156758) on growth of carcinogen-induced mammary tumors and on LH and prolactin levels. Life Sei 32:2869
    • (1983) Life Sei , vol.32 , pp. 2869
    • Clemens, J.A.1    Bennet, D.R.2    Black, L.J.3    Jones, C.D.4
  • 91
    • 0023229345 scopus 로고
    • Antitumor actions of keoxifene and tamoxifen in the at-nitrosomethylurea-induced rat mammary carcinoma model
    • Gottardis MM, Jordan VC 1987 Antitumor actions of keoxifene and tamoxifen in the AT-nitrosomethylurea-induced rat mammary carcinoma model. Cancer Res 47:4020
    • (1987) Cancer Res , vol.47 , pp. 4020
    • Gottardis, M.M.1    Jordan, V.C.2
  • 92
    • 0020589843 scopus 로고
    • Disposition and metabolism of a new antiestrogen ly156758 in rats, dogs and monkeys
    • Gallick NG, Lindstrom TD 1983 Disposition and metabolism of a new antiestrogen LY156758 in rats, dogs and monkeys. Fed Proc 42:376
    • (1983) Fed Proc , vol.42 , pp. 376
    • Gallick, N.G.1    Lindstrom, T.D.2
  • 93
    • 0021361279 scopus 로고
    • Ring substituted 1,2 dialkyated 1,2-bis (Hydroxyphenyl) ethanes 2. synthesis and estrogen receptor binding affinity of 4,4,-5 5’-and 6,6-disubstituted metahexestrols
    • Hartman RW, Buchborn H, Kranzfelder G, Schönenberger H 1984 Ring substituted 1,2 dialkyated 1,2-bis (hydroxyphenyl) ethanes 2. Synthesis and estrogen receptor binding affinity of 4,4,-5 5’-and 6,6-disubstituted metahexestrols. J Med Chem 27:577
    • (1984) J Med Chem , vol.27 , pp. 577
    • Hartman, R.W.1    Buchborn, H.2    Kranzfelder, G.3    Schönenberger, H.4
  • 94
    • 0018825761 scopus 로고
    • Antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of l,l,2,2-tetralkyl-l,2 diphenylethanes
    • Hartmann RW, Kranzfelder G, von Angerer E, Schönenberger H 1980 Antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of l,l,2,2-tetralkyl-l,2 diphenylethanes. J Med Chem 23:841
    • (1980) J Med Chem , vol.23 , pp. 841
    • Hartmann, R.W.1    Kranzfelder, G.2    Von Angerer, E.3    Schönenberger, H.4
  • 95
    • 0021881611 scopus 로고
    • Antiproliferative effects of 1,2-diphenylethane oestrogens and antioestrogens on human breast cancer cells
    • Hartman RW, Sinchai T, Krenzfelder G 1985 Antiproliferative effects of 1,2-diphenylethane oestrogens and antioestrogens on human breast cancer cells. J Cancer Res Clin Oncol 110:17
    • (1985) J Cancer Res Clin Oncol , vol.110 , pp. 17
    • Hartman, R.W.1    Sinchai, T.2    Krenzfelder, G.3
  • 96
    • 0022214794 scopus 로고
    • Ring-substituted 1,1,2,2-tetra alkylated 1,2-bis (Hydroxy phenyl) ethanes 4. synthesis, estrogen receptor binding affinity and evaluation of antiestrogenic and mammary tumor inhibiting activity of symmetrically disubstituted l,l,2,2-tetramethyl-l,2-bis (hydroxy phenyl) ethanes
    • Hartman RW, Schwarz W, Heindl A, Schönenberger H 1985 Ring-substituted 1,1,2,2-tetra alkylated 1,2-bis (hydroxy phenyl) ethanes 4. Synthesis, estrogen receptor binding affinity and evaluation of antiestrogenic and mammary tumor inhibiting activity of symmetrically disubstituted l,l,2,2-tetramethyl-l,2-bis (hydroxy phenyl) ethanes. J Med Chem 28:1295
    • (1985) J Med Chem , vol.28 , pp. 1295
    • Hartman, R.W.1    Schwarz, W.2    Heindl, A.3    Schönenberger, H.4
  • 97
    • 0022922585 scopus 로고
    • Influence of alkyl chain ramification on estradiol receptor binding affinity and intrinsic activity of 1,2-dialky-lated 1,2-bis (4-or 3-hydroxyphenyl) ethane estrogens and antiestrogens
    • Hartman RW 1986 Influence of alkyl chain ramification on estradiol receptor binding affinity and intrinsic activity of 1,2-dialky-lated 1,2-bis (4-or 3-hydroxyphenyl) ethane estrogens and antiestrogens. J Med Chem 29:1668
    • (1986) J Med Chem , vol.29 , pp. 1668
    • Hartman, R.W.1
  • 98
    • 0022450912 scopus 로고
    • Acetoxy substituted 1,1,2-triphenylbut-l-enes: Estrogenic, antiestrogenic and mammary tumor inhibiting activity
    • Schneider MR 1986 Acetoxy substituted 1,1,2-triphenylbut-l-enes: estrogenic, antiestrogenic and mammary tumor inhibiting activity. J Cancer Res Clin Oncol 112:119
    • (1986) J Cancer Res Clin Oncol , vol.112 , pp. 119
    • Schneider, M.R.1
  • 99
    • 0022494478 scopus 로고
    • Catechol estrogens of the 1,1,2-triphenylbut-l-ene type: Relationship between structure, estrogen receptor affinity, estrogenic and antiestrogenic properties and mammary tumor inhibiting activities
    • Schneider MR, Ball H, Schiller CD 1986 Catechol estrogens of the 1,1,2-triphenylbut-l-ene type: relationship between structure, estrogen receptor affinity, estrogenic and antiestrogenic properties and mammary tumor inhibiting activities. J Med Chem 29:1355
    • (1986) J Med Chem , vol.29 , pp. 1355
    • Schneider, M.R.1    Ball, H.2    Schiller, C.D.3
  • 101
    • 0022607083 scopus 로고    scopus 로고
    • Ball h 1986 2-phenylindenes: Development of a new mammary tumor inhibiting antiestrogen by combination of estrogenic side effect lowering structural elements
    • Schneider MR, Ball H 1986 2-phenylindenes: development of a new mammary tumor inhibiting antiestrogen by combination of estrogenic side effect lowering structural elements. J Med Chem 29:75
    • J Med Chem , vol.29 , pp. 75
    • Schneider, M.R.1
  • 102
    • 0021543591 scopus 로고
    • Development of new drugs for endocrine tumour chemotherapy
    • Von Angerer E 1984 Development of new drugs for endocrine tumour chemotherapy. Cancer Treat Rev II [Suppl] A: 147
    • (1984) Cancer Treat Rev II [Suppl] A , pp. 147
    • Von Angerer, E.1
  • 103
    • 0021874708 scopus 로고
    • The inhibitory effect of 5-acetoxy-2-(4-acetoxyphenyl)-l-ethyl-3-methylindole (d16726) on estrogen-dependent mammary tumors
    • Von Angerer E, Prekajoe J, Berger M 1985 The inhibitory effect of 5-acetoxy-2-(4-acetoxyphenyl)-l-ethyl-3-methylindole (D16726) on estrogen-dependent mammary tumors. Eur J Cancer Clin Oncol 21:531
    • (1985) Eur J Cancer Clin Oncol , vol.21 , pp. 531
    • Von Angerer, E.1    Prekajoe, J.2    Berger, M.3
  • 104
    • 0023078836 scopus 로고
    • 2-phenylindoles. Effect of
    • Von Angerer E, Strohmeier J 1987 2-phenylindoles. Effect of N-benzylation on estrogen receptor affinity, estrogenic properties and mammary tumor inhibiting activity. J Med Chem 30:131
    • (1987) J Med Chem , vol.30 , pp. 131
    • Von Angerer, E.1    Strohmeier, J.2
  • 107
    • 0025264960 scopus 로고
    • Phase i/ii study of the anti-oestrogen zindoxifene (D16726) in the treatment of advanced breast cancer
    • A Cancer Research Campaign Phase I/II Clinical Trials Committee study
    • Stein RC, Dowsett M, Cunningham DC, Davenport J, Ford HT, Gazet J-C, Von Angerer E, Coombes RC 1990 Phase I/II study of the anti-oestrogen zindoxifene (D16726) in the treatment of advanced breast cancer. A Cancer Research Campaign Phase I/II Clinical Trials Committee study. Br J Cancer 61:431
    • (1990) Br J Cancer , vol.61 , pp. 431
    • Stein, R.C.1    Dowsett, M.2    Cunningham, D.C.3    Davenport, J.4    Ford, H.T.5    Gazet, J.-C.6    Von Angerer, E.7    Coombes, R.C.8
  • 108
    • 0023098499 scopus 로고
    • Chromatographic analysis of the new antiestrogen zindoxifene and its metabolites in biological material
    • Birnbock H, Ringshandl R, Von Angerer E 1987 Chromatographic analysis of the new antiestrogen zindoxifene and its metabolites in biological material. J Chromatogr 414:235
    • (1987) J Chromatogr , vol.414 , pp. 235
    • Birnbock, H.1    Ringshandl, R.2    Von Angerer, E.3
  • 111
    • 0024241588 scopus 로고
    • Antitumor actions of toremifene in the 7,12 dimethylbenzanthracene (Dmba)-induced rat mammary tumor model
    • Robinson SP, Mauel DA, Jordan VC 1988 Antitumor actions of toremifene in the 7,12 dimethylbenzanthracene (DMBA)-induced rat mammary tumor model. Eur J Cancer Clin Oncol 24:1817
    • (1988) Eur J Cancer Clin Oncol , vol.24 , pp. 1817
    • Robinson, S.P.1    Mauel, D.A.2    Jordan, V.C.3
  • 113
    • 0024205961 scopus 로고
    • Expression of the c-ha-ras and neu oncogenes in dmba-induced antiestrogen treated rat mammary tumors
    • Vuorio T, Warri A, Sandberg M, Alitalo K, Vuorio E 1988 Expression of the C-Ha-ras and neu oncogenes in DMBA-induced antiestrogen treated rat mammary tumors. Int J Cancer 42:774
    • (1988) Int J Cancer , vol.42 , pp. 774
    • Vuorio, T.1    Warri, A.2    Sandberg, M.3    Alitalo, K.4    Vuorio, E.5
  • 115
    • 0024509832 scopus 로고
    • Antiestrogenic action of toremifene on hormone-dependent,-independent and heterogeneous breast tumor growth in the athymic mouse
    • Robinson SP, Jordan VC 1989 Antiestrogenic action of toremifene on hormone-dependent,-independent and heterogeneous breast tumor growth in the athymic mouse. Cancer Res 49:1758
    • (1989) Cancer Res , vol.49 , pp. 1758
    • Robinson, S.P.1    Jordan, V.C.2
  • 116
    • 0025264436 scopus 로고
    • Inhibition of hormone-dependent and independent breast cancer cell growth
    • Robinson SP, Goldstein D, Witt PL, Borden EC, Jordan VC 1990 Inhibition of hormone-dependent and independent breast cancer cell growth in vivo and in vitro with the antiestrogen toremifene and recombinant human interferon a2. Breast Cancer Res Treat 15:95
    • (1990) Breast Cancer Res Treat , vol.15 , pp. 95
    • Robinson, S.P.1    Goldstein, D.2    Witt, P.L.3    Borden, E.C.4    Jordan, V.C.5
  • 117
    • 0025301010 scopus 로고
    • In vitro and in vivo binding of toremifene and its metabolites in rat uterus
    • Simberg NH, Murai JT, Siiteri PK 1990 In vitro and in vivo binding of toremifene and its metabolites in rat uterus. J Steroid Biochem 36:197
    • (1990) J Steroid Biochem , vol.36 , pp. 197
    • Simberg, N.H.1    Murai, J.T.2    Siiteri, P.K.3
  • 119
    • 0023269337 scopus 로고
    • Quantitation of toremifene and its major metabolites in human plasma by
    • Holleran WM, Gharbo SA, DeGregorio MW 1987 Quantitation of toremifene and its major metabolites in human plasma by highperformance liquid chromatography following fluorescent activation. Anal Letters 20:871
    • (1987) Anal Letters , vol.20 , pp. 871
    • Holleran, W.M.1    Gharbo, S.A.2    DeGregorio, M.W.3
  • 120
    • 0024459880 scopus 로고
    • Toremifene: Pharmacologic and pharmacokinetic basis of reversing multidrug resistance
    • DeGregorio MW, Ford JM, Benz CC, Wiebe VJ 1989 Toremifene: pharmacologic and pharmacokinetic basis of reversing multidrug resistance. J Clin Oncol 7:1359
    • (1989) J Clin Oncol , vol.7 , pp. 1359
    • DeGregorio, M.W.1    Ford, J.M.2    Benz, C.C.3    Wiebe, V.J.4
  • 124
    • 0024832067 scopus 로고
    • Liquid chromatographic-atmospheric pressure ionizastion mass spectrometric analysis of toremifene metabolites in human urine
    • Watanabe N, Erie T, Koyama M 1989 Liquid chromatographic-atmospheric pressure ionizastion mass spectrometric analysis of toremifene metabolites in human urine. J Chromatog 497:169
    • (1989) J Chromatog , vol.497 , pp. 169
    • Watanabe, N.1    Erie, T.2    Koyama, M.3
  • 125
    • 0025301011 scopus 로고
    • Antiestrogenic and antitumor properties of the new triphenylethylene derivative toremifene in the rat
    • DiSalle E, Zaccheo T, Ornati G 1990 Antiestrogenic and antitumor properties of the new triphenylethylene derivative toremifene in the rat. J Steroid Biochem 36:203
    • (1990) J Steroid Biochem , vol.36 , pp. 203
    • DiSalle, E.1    Zaccheo, T.2    Ornati, G.3
  • 127
    • 0020375149 scopus 로고
    • Estrogenic and antiestrogenic activity of monophenolic analogs of tamoxifen (Z)-2-[p(l,2-diphenyl-l-butenyl-phenoxy]-n,7v dimethylethylamine
    • Ruenitz PC, Bagley JR, Molker CM 1983 Estrogenic and antiestrogenic activity of monophenolic analogs of tamoxifen (Z)-2-[P(l,2-diphenyl-l-butenyl-phenoxy]-N,7V dimethylethylamine. J Med Chem 25:1056
    • (1983) J Med Chem , vol.25 , pp. 1056
    • Ruenitz, P.C.1    Bagley, J.R.2    Molker, C.M.3
  • 128
    • 0020506431 scopus 로고
    • Antiestrogenic action of 3-hydroxytamoxifen in the human breast cancer cell line mcf-7
    • Roos W, Oeze L, Loser R, Eppenburger U 1983 Antiestrogenic action of 3-hydroxytamoxifen in the human breast cancer cell line MCF-7. J Natl Cancer Inst 71:55
    • (1983) J Natl Cancer Inst , vol.71 , pp. 55
    • Roos, W.1    Oeze, L.2    Loser, R.3    Eppenburger, U.4
  • 129
    • 0021829829 scopus 로고
    • In vivo and in vitro antiestrogenic action of 3-hydroxy-tamoxifen, tamoxifen and 4-hydroxytamoxifen
    • Loser R, Siebel K, Roos W, Eppenburger U 1985 In vivo and in vitro antiestrogenic action of 3-hydroxy-tamoxifen, tamoxifen and 4-hydroxytamoxifen. Eur J Cancer Clin Oncol 21:985
    • (1985) Eur J Cancer Clin Oncol , vol.21 , pp. 985
    • Loser, R.1    Siebel, K.2    Roos, W.3    Eppenburger, U.4
  • 130
    • 0024594298 scopus 로고
    • Effect of continuous vs. intermittent application of 3-hydroxytamoxifen or tamoxifen on the proliferation of the human breast cancer cell line MCF-7
    • Dietel M, Loser R, Rohlke P, Jonat W, Niendorf A, Gerding D, Kohr A, Holzel F, Arps H 1989 Effect of continuous vs. intermittent application of 3-hydroxytamoxifen or tamoxifen on the proliferation of the human breast cancer cell line MCF-7. J Cancer Res Clin Oncol 115:36
    • (1989) J Cancer Res Clin Oncol , vol.115 , pp. 36
    • Dietel, M.1    Loser, R.2    Rohlke, P.3    Jonat, W.4    Niendorf, A.5    Gerding, D.6    Kohr, A.7    Holzel, F.8    Arps, H.9
  • 131
    • 0023747407 scopus 로고
    • Biology and mode of action of pure antiestrogens
    • Wakeling AE, Bowler J 1988 Biology and mode of action of pure antiestrogens. J Steroid Biochem 30:141
    • (1988) J Steroid Biochem , vol.30 , pp. 141
    • Wakeling, A.E.1    Bowler, J.2
  • 133
    • 0023093455 scopus 로고
    • Steroidal pure antioestrogens
    • Wakeling AE, Bowler J 1987 Steroidal pure antioestrogens. J Endocrinol 112:R7-R10
    • (1987) J Endocrinol , vol.112 , pp. R7-R10
    • Wakeling, A.E.1    Bowler, J.2
  • 134
    • 0023701360 scopus 로고
    • Novel antioestrogens without partial agonist activity
    • Wakeling AE, Bowler J 1988 Novel antioestrogens without partial agonist activity. J Steroid Biochem 31:645
    • (1988) J Steroid Biochem , vol.31 , pp. 645
    • Wakeling, A.E.1    Bowler, J.2
  • 135
    • 0024790884 scopus 로고
    • The potential for a novel pure antioestrogen
    • Wakeling AE 1989 The potential for a novel pure antioestrogen. Horm Res 32 [Suppl 1]:257
    • (1989) Horm Res , vol.32 , pp. 257
    • Wakeling, A.E.1
  • 136
    • 0024586152 scopus 로고
    • Contrasting ability of antiestrogens to inhibit mcf-7 growth stimulated by estradiol or epidermal growth factor
    • Cormier EM, Jordan VC 1989 Contrasting ability of antiestrogens to inhibit MCF-7 growth stimulated by estradiol or epidermal growth factor. Eur J Cancer Clin Oncol 25:57
    • (1989) Eur J Cancer Clin Oncol , vol.25 , pp. 57
    • Cormier, E.M.1    Jordan, V.C.2
  • 138
    • 0024850428 scopus 로고
    • Short-and long-term estrogen deprivation of t47d human breast cancer cells in culture
    • Murphy CS, Meisner LF, Wu SQ, Jordan VC 1989 Short-and long-term estrogen deprivation of T47D human breast cancer cells in culture. Eur J Cancer Clin Oncol 25:1777
    • (1989) Eur J Cancer Clin Oncol , vol.25 , pp. 1777
    • Murphy, C.S.1    Meisner, L.F.2    Wu, S.Q.3    Jordan, V.C.4
  • 139
    • 0025371743 scopus 로고
    • Biological response of the antiestrogen ici-164,384 in human hormone-dependent and hormone-independent mammary cancer cell lines
    • Pasqualini JR, Geliy C 1990 Biological response of the antiestrogen ICI-164,384 in human hormone-dependent and hormone-independent mammary cancer cell lines. Cancer Lett 50:133
    • (1990) Cancer Lett , vol.50 , pp. 133
    • Pasqualini, J.R.1    Geliy, C.2
  • 140
    • 0024505761 scopus 로고
    • Points of action of estrogen antagonists and a calmodulin antagonist within the mcf-7 human breast cancer cell cycle
    • Musgrove EA, Wakeling AE, Sutherland RL 1989 Points of action of estrogen antagonists and a calmodulin antagonist within the MCF-7 human breast cancer cell cycle. Cancer Res 49:2398
    • (1989) Cancer Res , vol.49 , pp. 2398
    • Musgrove, E.A.1    Wakeling, A.E.2    Sutherland, R.L.3
  • 141
    • 0021734042 scopus 로고
    • Tamoxifen stimulation of human breast cancer cell proliferation
    • Reddel RR, Sutherland RL 1984 Tamoxifen stimulation of human breast cancer cell proliferation in vitro: a possible model for tamoxifen tumour flare. Eur J Cancer Clin Oncol 20:1419
    • (1984) Eur J Cancer Clin Oncol , vol.20 , pp. 1419
    • Reddel, R.R.1    Sutherland, R.L.2
  • 142
    • 0025239673 scopus 로고
    • Tamoxifen for breast cancer: Associated endometrial cancer
    • Gusberg SB 1990 Tamoxifen for breast cancer: associated endometrial cancer. Cancer 65:1463
    • (1990) Cancer , vol.65 , pp. 1463
    • Gusberg, S.B.1
  • 143
    • 0024847508 scopus 로고
    • Comparative studies on the effect of steroidal and nonsteroidal oestrogen antagonists on the proliferation of human breast cancer cells
    • Wakeling AE 1989 Comparative studies on the effect of steroidal and nonsteroidal oestrogen antagonists on the proliferation of human breast cancer cells. J Steroid Biochem 34:183
    • (1989) J Steroid Biochem , vol.34 , pp. 183
    • Wakeling, A.E.1
  • 144
    • 0023718363 scopus 로고
    • Action of oestrogens and antioestrogens on rat mammary gland development: Relevance to breast cancer prevention
    • Nicholson RI, Gotting KE, Gee J, Walker KJ 1988 Action of oestrogens and antioestrogens on rat mammary gland development: relevance to breast cancer prevention. J Steroid Biochem 30:95
    • (1988) J Steroid Biochem , vol.30 , pp. 95
    • Nicholson, R.I.1    Gotting, K.E.2    Gee, J.3    Walker, K.J.4
  • 145
    • 0024319781 scopus 로고
    • Inhibition of tamoxifen-stimulated growth of an mcf-7 tumor variant in athymic mice by novel steroidal antiestrogens
    • Gottardis MM, Jiang SY, Jeng MH, Jordan VC 1989 Inhibition of tamoxifen-stimulated growth of an MCF-7 tumor variant in athymic mice by novel steroidal antiestrogens. Cancer Res 49:4090
    • (1989) Cancer Res , vol.49 , pp. 4090
    • Gottardis, M.M.1    Jiang, S.Y.2    Jeng, M.H.3    Jordan, V.C.4
  • 146
    • 0025300620 scopus 로고
    • Effect of steroidal and nonsteroidal antiestrogens on the growth of a tamoxifen-stimulated human endometrial carcinoma (Enca 101) in athymic mice
    • Gottardis MM, Ricchio M, Satyaswaroop PG, Jordan VC 1990 Effect of steroidal and nonsteroidal antiestrogens on the growth of a tamoxifen-stimulated human endometrial carcinoma (EnCa 101) in athymic mice. Cancer Res 50:3189
    • (1990) Cancer Res , vol.50 , pp. 3189
    • Gottardis, M.M.1    Ricchio, M.2    Satyaswaroop, P.G.3    Jordan, V.C.4
  • 148
    • 0023284318 scopus 로고
    • Estrogenic regulation of growth and polypeptide growth factor secretion in human breast carcinoma
    • Dickson RB, Lippman ME 1987 Estrogenic regulation of growth and polypeptide growth factor secretion in human breast carcinoma. Endocr Rev 8:29
    • (1987) Endocr Rev , vol.8 , pp. 29
    • Dickson, R.B.1    Lippman, M.E.2
  • 149
    • 0022485353 scopus 로고
    • Estrogen-induced factors of breast cancer cells partially replace estrogen to promote tumor growth
    • Dickson RB, McManaway ME, Lippman ME 1986 Estrogen-induced factors of breast cancer cells partially replace estrogen to promote tumor growth. Science 232:1540
    • (1986) Science , vol.232 , pp. 1540
    • Dickson, R.B.1    McManaway, M.E.2    Lippman, M.E.3
  • 150
    • 0023526097 scopus 로고
    • Effect of v-rash oncogene transfection on estrogen-independent tumorigenicity of estrogen-dependent human breast cancer cells
    • H oncogene transfection on estrogen-independent tumorigenicity of estrogen-dependent human breast cancer cells. Cancer Res 47:5733
    • (1987) Cancer Res , vol.47 , pp. 5733
    • Kasid, A.1    Knabbe, C.2    Lippman, M.E.3
  • 151
  • 152
    • 0000201238 scopus 로고
    • Growth factors from murine sarcoma virus transformed cells
    • DeLarco JE, Todero GJ 1978 Growth factors from murine sarcoma virus transformed cells. Proc Natl Acad Sci USA 75:4001
    • (1978) Proc Natl Acad Sci USA , vol.75 , pp. 4001
    • DeLarco, J.E.1    Todero, G.J.2
  • 153
    • 0009518290 scopus 로고
    • Sarcoma growth factor from conditioned medium of virally transformed cells is composed of both type
    • Anzano MS, Roberts AB, Smith JM, Sporn MB, DeLares JE 1983 Sarcoma growth factor from conditioned medium of virally transformed cells is composed of both type a and type transforming growth factors. Proc Natl Acad Sci USA 80:6264
    • (1983) Proc Natl Acad Sci USA , vol.80 , pp. 6264
    • Anzano, M.S.1    Roberts, A.B.2    Smith, J.M.3    Sporn, M.B.4    DeLares, J.E.5
  • 157
    • 0023693197 scopus 로고    scopus 로고
    • Complementary deoxyribonucleic acid cloning of a novel transforming growth factor-β messenger ribonucleic acid from chick embryo chondrocytes
    • Jakowlew SB, Dillard PJ, Kondaiah P, Sporn MB, Roberts AB Complementary deoxyribonucleic acid cloning of a novel transforming growth factor-β messenger ribonucleic acid from chick embryo chondrocytes. Mol Endocrinol 2:747
    • Mol Endocrinol , vol.2 , pp. 747
    • Jakowlew, S.B.1    Dillard, P.J.2    Kondaiah, P.3    Sporn, M.B.4    Roberts, A.B.5
  • 158
    • 0023693197 scopus 로고    scopus 로고
    • Complementary deoxyribonucleic acid cloning of a messenger ribonucleic acid from chick embryo chondrocytes
    • Jakowlew SB, Dillard PJ, Sporn MB, Roberts AB 1988 Complementary deoxyribonucleic acid cloning of a messenger ribonucleic acid from chick embryo chondrocytes. Mol Endocrinol 2:747
    • (1988) Mol Endocrinol , vol.2 , pp. 747
    • Jakowlew, S.B.1    Dillard, P.J.2    Sporn, M.B.3    Roberts, A.B.4
  • 160
  • 162
    • 0023676353 scopus 로고
    • Transforming growth factor β: Potential autocrine growth inhibitor of estrogen receptor negative human breast cells
    • Arteaga CL, Tandon AK, VonHoff DD, Osborne CK 1988 Transforming growth factor β: potential autocrine growth inhibitor of estrogen receptor negative human breast cells. Cancer Res 48:3898
    • (1988) Cancer Res , vol.48 , pp. 3898
    • Arteaga, C.L.1    Tandon, A.K.2    VonHoff, D.D.3    Osborne, C.K.4
  • 163
    • 0024516846 scopus 로고
    • Regulation of transforming growth factor
    • Murphy LC, Dotzlaw H 1989 Regulation of transforming growth factor a and transforming growth factor /S messenger ribonucleic acid abundance in T47D human breast cancer cells. Mol Endocrinol 3:611
    • (1989) Mol Endocrinol , vol.3 , pp. 611
    • Murphy, L.C.1    Dotzlaw, H.2
  • 164
    • 0023625418 scopus 로고
    • Evidence that transforming growth factor β is a hormonally regulated negative growth factor in human breast cancer cells
    • Knabbe C, Lippman ME, Wakefield LM, Flanders KC, Kasid A, Derynick R, Dickson RB 1987 Evidence that transforming growth factor β is a hormonally regulated negative growth factor in human breast cancer cells. Cell 48:417
    • (1987) Cell , vol.48 , pp. 417
    • Knabbe, C.1    Lippman, M.E.2    Wakefield, L.M.3    Flanders, K.C.4    Kasid, A.5    Derynick, R.6    Dickson, R.B.7
  • 165
    • 0025101596 scopus 로고
    • Differential regulation of expression of three transforming growth factor β species in human breast cancer cell lines by estradiol
    • Arrick BA, Korc M, Derynck R 1990 Differential regulation of expression of three transforming growth factor β species in human breast cancer cell lines by estradiol. Cancer Res 50:299
    • (1990) Cancer Res , vol.50 , pp. 299
    • Arrick, B.A.1    Korc, M.2    Derynck, R.3
  • 167
    • 85003165454 scopus 로고    scopus 로고
    • Characterization of a receptor-negative, hormone nonresponsive clone derived from a t47d human breast cancer cell line kept under estrogen free conditions
    • Murphy CS, Pink JJ, Jordan VC, Characterization of a receptor-negative, hormone nonresponsive clone derived from a T47D human breast cancer cell line kept under estrogen free conditions. Cancer Res, in press
    • Cancer Res, in Press
    • Murphy, C.S.1    Pink, J.J.2    Jordan, V.C.3
  • 168
    • 0019723660 scopus 로고    scopus 로고
    • Difference between oestrogen receptor activation by oestrogen and antioestrogen
    • Rochefort H, Borgna JL 1981 Difference between oestrogen receptor activation by oestrogen and antioestrogen. Nature 292:257
    • Nature , vol.292 , pp. 257
    • Rochefort, H.1    Borgna, J.L.2
  • 169
    • 0020395816 scopus 로고
    • The inhibition of the estrogen receptor’s positive cooperative [3h] estradiol binding by the antagonist clomiphene
    • 3H] estradiol binding by the antagonist clomiphene. J Biol Chem 257:11540
    • (1982) J Biol Chem , vol.257 , pp. 11540
    • Sasson, S.1    Notides, A.C.2
  • 172
    • 0022871619 scopus 로고
    • Different interaction of estradiol and antiestrogens with the estrogen receptor of rat uterus
    • Faye JC, Fargin A, Bayard F 1986 Different interaction of estradiol and antiestrogens with the estrogen receptor of rat uterus. Mol Cell Endocrinology 47:119
    • (1986) Mol Cell Endocrinology , vol.47 , pp. 119
    • Faye, J.C.1    Fargin, A.2    Bayard, F.3
  • 173
    • 0023035514 scopus 로고
    • Conformational transitions of the estrogen receptor monomer. Effect of estrogens, antiestrogen and temperature
    • Hansen JC, Gorski J 1986 Conformational transitions of the estrogen receptor monomer. Effect of estrogens, antiestrogen and temperature. J Biol Chem 261:13990
    • (1986) J Biol Chem , vol.261 , pp. 13990
    • Hansen, J.C.1    Gorski, J.2
  • 174
    • 0020117389 scopus 로고
    • Effect of antibodies to estrogen receptor on the binding of [3h] labeled antiestrogens and androstanediol in the uterus
    • 3H] labeled antiestrogens and androstanediol in the uterus. Endocrinology 110:1355
    • (1982) Endocrinology , vol.110 , pp. 1355
    • Garcia, M.1    Greene, G.L.2    Rochefort, H.3    Jensen, E.V.4
  • 175
    • 0021346046 scopus 로고
    • The inhibition of prolactin synthesis in gh3 rat pituitary tumor cells by monohy-droxytamoxifen is associated with changes in the properties of the estrogen receptor
    • Tate AC, Lieberman ME, Jordan VC 1984 The inhibition of prolactin synthesis in GH3 rat pituitary tumor cells by monohy-droxytamoxifen is associated with changes in the properties of the estrogen receptor. J Steroid Biochem 20:391
    • (1984) J Steroid Biochem , vol.20 , pp. 391
    • Tate, A.C.1    Lieberman, M.E.2    Jordan, V.C.3
  • 176
    • 0021365432 scopus 로고
    • Differences between estrogen and antiestrogen-estrogen receptor complexes from human breast tumors identified with an antibody raised against the estrogen receptor
    • Tate AC, Greene GL, DeSombre ER, Jensen EV, Jordan VC 1984 Differences between estrogen and antiestrogen-estrogen receptor complexes from human breast tumors identified with an antibody raised against the estrogen receptor. Cancer Res 44:1012
    • (1984) Cancer Res , vol.44 , pp. 1012
    • Tate, A.C.1    Greene, G.L.2    DeSombre, E.R.3    Jensen, E.V.4    Jordan, V.C.5
  • 177
    • 0010734092 scopus 로고
    • Binding of antiestrogens exposes an occult antigenic determinant in the human estrogen receptor
    • Martin PM, Berthois Y, Jensen EV 1988 Binding of antiestrogens exposes an occult antigenic determinant in the human estrogen receptor. Proc Natl Acad Sci USA 85:2533
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 2533
    • Martin, P.M.1    Berthois, Y.2    Jensen, E.V.3
  • 178
    • 0020315152 scopus 로고
    • Physical properties of estrogen receptors complexes in mcf-7 human breast cancer cells
    • Eckert RL, Katzenellenbogen BS 1982 Physical properties of estrogen receptors complexes in MCF-7 human breast cancer cells. J Biol Chem 257:8840
    • (1982) J Biol Chem , vol.257 , pp. 8840
    • Eckert, R.L.1    Katzenellenbogen, B.S.2
  • 180
    • 0022507916 scopus 로고
    • Comparison of the physicochemical properties of uterine nuclear estrogen receptors bound to estradiol or 4-hydroxytamoxifen
    • Attardi B, Happe HK 1986 Comparison of the physicochemical properties of uterine nuclear estrogen receptors bound to estradiol or 4-hydroxytamoxifen. Endocrinology 119:904
    • (1986) Endocrinology , vol.119 , pp. 904
    • Attardi, B.1    Happe, H.K.2
  • 181
    • 0023896574 scopus 로고
    • Comparative analysis of estrogen receptors covalently labeled with an estrogen and an antiestrogen in several estrogen target cells as studied by limited proteolysis
    • Elliston JF, Katzenellenbogen BS 1988 Comparative analysis of estrogen receptors covalently labeled with an estrogen and an antiestrogen in several estrogen target cells as studied by limited proteolysis. J Steroid Biochem 29:559
    • (1988) J Steroid Biochem , vol.29 , pp. 559
    • Elliston, J.F.1    Katzenellenbogen, B.S.2
  • 182
    • 0024330337 scopus 로고
    • Identification of cystine-530 as the covalent attachment site of an affinity labeling estrogen (Ketononestrola-ziridine) and antiestrogen (tamoxifenaziridine) on the human estrogen receptor
    • Harlow KW, Smith DN, Katzenellenbogen JA, Green GL, Katzenellenbogen BS 1989 Identification of cystine-530 as the covalent attachment site of an affinity labeling estrogen (ketononestrola-ziridine) and antiestrogen (tamoxifenaziridine) on the human estrogen receptor. J Biol Chem 264:17476
    • (1989) J Biol Chem , vol.264 , pp. 17476
    • Harlow, K.W.1    Smith, D.N.2    Katzenellenbogen, J.A.3    Green, G.L.4    Katzenellenbogen, B.S.5
  • 184
    • 0025343668 scopus 로고
    • Unique molecular properties of a urea-and salt-stable dna-binding estrogen receptor dimer covalently labeled with the antiestrogen [3h] desmethylnafoxidine aziridine. A comparison with the estrogen receptor complex
    • 3H] desmethylnafoxidine aziridine. A comparison with the estrogen receptor complex. Mol Endocrinol 4:255
    • (1990) Mol Endocrinol , vol.4 , pp. 255
    • Hutchens, T.W.1    McNaught, R.W.2    Yip, T.T.3    Suzuki, T.4    Li, C.M.5    Besch, P.K.6
  • 185
    • 0023224201 scopus 로고
    • Desmethylnafoxidine aziridine: An electrophilic affinity label for the estrogen receptor with high specificity and selectivity
    • Simpson DM, Elliston JF, Katzenellenbogen JA 1987 Desmethylnafoxidine aziridine: an electrophilic affinity label for the estrogen receptor with high specificity and selectivity. J Steroid Biochem 28:233
    • (1987) J Steroid Biochem , vol.28 , pp. 233
    • Simpson, D.M.1    Elliston, J.F.2    Katzenellenbogen, J.A.3
  • 186
    • 0020365665 scopus 로고
    • Estrogen receptor dna interaction. Differences between activation by estrogen and antiestrogen
    • Evans E, Baskevitch PP, Rochefort H 1982 Estrogen receptor DNA interaction. Differences between activation by estrogen and antiestrogen. Eur J Biochem 128:185
    • (1982) Eur J Biochem , vol.128 , pp. 185
    • Evans, E.1    Baskevitch, P.P.2    Rochefort, H.3
  • 187
    • 0022529219 scopus 로고
    • Acceptor sites on chromatin for receptor bound by estrogen
    • Singh RK, Ruh MF, Butler WB, Ruh TS 1986 Acceptor sites on chromatin for receptor bound by estrogen versus antiestrogen in antiestrogen-sensitive and-resistant MCF-7 cells. Endocrinology 118:1087
    • (1986) Endocrinology , vol.118 , pp. 1087
    • Singh, R.K.1    Ruh, M.F.2    Butler, W.B.3    Ruh, T.S.4
  • 188
    • 0023895442 scopus 로고
    • The human oestrogen receptor functions in yeast
    • Metzer D, White JH, Chambon P 1988 The human oestrogen receptor functions in yeast. Nature 334:31
    • (1988) Nature , vol.334 , pp. 31
    • Metzer, D.1    White, J.H.2    Chambon, P.3
  • 189
    • 0023712331 scopus 로고
    • The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function
    • Webster NJCT, Green S, Jin SR, Chambon P 1988 The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function. Cell 54:199
    • (1988) Cell , vol.54 , pp. 199
    • Webster, N.1    Green, S.2    Jin, S.R.3    Chambon, P.4
  • 190
    • 0023808861 scopus 로고
    • The estrogen receptor binds tightly to its response element as a ligand-induced homodimer
    • Kumar V, Chambon P 1988 The estrogen receptor binds tightly to its response element as a ligand-induced homodimer. Cell 55:145
    • (1988) Cell , vol.55 , pp. 145
    • Kumar, V.1    Chambon, P.2
  • 191
    • 0025267297 scopus 로고
    • Uterine estrogen receptor interaction with estrogen responsive dna sequence
    • Curtis SW, Korach KS 1990 Uterine estrogen receptor interaction with estrogen responsive DNA sequence in utero: effect of ligand binding on receptor-DNA-complexes. Mol Endocrinol 4:276
    • (1990) Mol Endocrinol , vol.4 , pp. 276
    • Curtis, S.W.1    Korach, K.S.2
  • 193
    • 0024318808 scopus 로고
    • Identification of two transactivation domains in the mouse oestrogen receptor
    • Lees JA, Fawell SE, Parker MG 1989 Identification of two transactivation domains in the mouse oestrogen receptor. Nucleic Acids Res 17:5477
    • (1989) Nucleic Acids Res , vol.17 , pp. 5477
    • Lees, J.A.1    Fawell, S.E.2    Parker, M.G.3
  • 194
    • 0025084510 scopus 로고
    • Inhibition of estrogen receptor-dna binding by the “pure” antiestrogen ici 164,384 appears to be mediated by impaired receptor dimerization
    • Fawell SE, White R, Howe S, Syndenham M, Page M, Parker MG 1990 Inhibition of estrogen receptor-DNA binding by the “pure” antiestrogen ICI 164,384 appears to be mediated by impaired receptor dimerization. Proc Natl Acad Sci USA 87:6883
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 6883
    • Fawell, S.E.1    White, R.2    Howe, S.3    Syndenham, M.4    Page, M.5    Parker, M.G.6
  • 195
    • 0019122379 scopus 로고
    • The pharmacology of tamoxifen in laboratory animals
    • Jordan VC, Allen KE, Dix CJ 1980 The pharmacology of tamoxifen in laboratory animals. Cancer Treat Rep 64:745
    • (1980) Cancer Treat Rep , vol.64 , pp. 745
    • Jordan, V.C.1    Allen, K.E.2    Dix, C.J.3
  • 196
    • 0017354838 scopus 로고
    • Recurrent breast cancer treated with the antioestrogen tamoxifen: Correlation between hormonal changes and clinical course
    • Willis KJ, London DR, Wardtt WC, Butt WR, Lynch SS, Rudd BT 1977 Recurrent breast cancer treated with the antioestrogen tamoxifen: correlation between hormonal changes and clinical course. Br Med J i:425
    • (1977) Br Med J I , pp. 425
    • Willis, K.J.1    London, D.R.2    Wardtt, W.C.3    Butt, W.R.4    Lynch, S.S.5    Rudd, B.T.6
  • 197
    • 0017190910 scopus 로고
    • Effect of the antioestrogen tamoxifen on plasma levels of luteinizing hormone, follicle stimulating hormone prolactin, oestradiol and progesterone in hormal premenopausal women
    • Groom CV, Griffiths K 1976 Effect of the antioestrogen tamoxifen on plasma levels of luteinizing hormone, follicle stimulating hormone prolactin, oestradiol and progesterone in hormal premenopausal women. J Endocrinol 70:421
    • (1976) J Endocrinol , vol.70 , pp. 421
    • Groom, C.V.1    Griffiths, K.2
  • 198
    • 0022227647 scopus 로고
    • Prolactin-inducible proteins in human breast cancer cells
    • Shui RPC, Iwasiow BM 1985 Prolactin-inducible proteins in human breast cancer cells. J Biol Chem 260:11307
    • (1985) J Biol Chem , vol.260 , pp. 11307
    • Shui, R.1    Iwasiow, B.M.2
  • 199
    • 0023191190 scopus 로고
    • Role of serum in the prolactin responsiveness of mcf-7 human breast cancer cells in long term tissue culture
    • Biswas R, Vonderhaar BK 1987 Role of serum in the prolactin responsiveness of MCF-7 human breast cancer cells in long term tissue culture. Cancer Res 47:3509
    • (1987) Cancer Res , vol.47 , pp. 3509
    • Biswas, R.1    Vonderhaar, B.K.2
  • 200
    • 0024539364 scopus 로고
    • Effect of tamoxifen on plasma insulin-like growth factor i in patients with breast cancer
    • Colletti RB, Roberts JD, Devlin JT, Copeland KC 1989 Effect of tamoxifen on plasma insulin-like growth factor I in patients with breast cancer. Cancer Res 49:1882
    • (1989) Cancer Res , vol.49 , pp. 1882
    • Colletti, R.B.1    Roberts, J.D.2    Devlin, J.T.3    Copeland, K.C.4
  • 201
    • 0024550730 scopus 로고
    • Analysis of insulin-like growth factor i gene expression in malignancy: Evidence for a paracrine role in human breast cancer
    • Yee D, Paik S, Lebovic GS, Marcus RR, Favoni RE, Cullen KJ, Lippman ME, Rosen N 1989 Analysis of insulin-like growth factor I gene expression in malignancy: evidence for a paracrine role in human breast cancer. Mol Endocrinol 3:509
    • (1989) Mol Endocrinol , vol.3 , pp. 509
    • Yee, D.1    Paik, S.2    Lebovic, G.S.3    Marcus, R.R.4    Favoni, R.E.5    Cullen, K.J.6    Lippman, M.E.7    Rosen, N.8
  • 202
    • 0017796895 scopus 로고
    • Increases in steroid binding globulins induced by tamoxifen in patients with carcinoma of the breast
    • Sakai F, Cheix F, Clavel M, Colon J, Mayer M, Ponnata E, Saez S 1978 Increases in steroid binding globulins induced by tamoxifen in patients with carcinoma of the breast. J Endocrinol 76:219
    • (1978) J Endocrinol , vol.76 , pp. 219
    • Sakai, F.1    Cheix, F.2    Clavel, M.3    Colon, J.4    Mayer, M.5    Ponnata, E.6    Saez, S.7
  • 203
    • 0022631810 scopus 로고
    • Hormonal changes during a prolonged tamoxifen treatment in patients with advanced breast cancer
    • Szamel I, Vincze B, Hindy I, Herman I, Borvendog J, Eckhardt S 1986 Hormonal changes during a prolonged tamoxifen treatment in patients with advanced breast cancer. Oncology 43:7
    • (1986) Oncology , vol.43 , pp. 7
    • Szamel, I.1    Vincze, B.2    Hindy, I.3    Herman, I.4    Borvendog, J.5    Eckhardt, S.6
  • 204
    • 0023278380 scopus 로고
    • Long-term adjuvant therapy with tamoxifen: Effects on sex hormone binding globulin and antithrombin iii
    • Jordan VC, Fritz NF, Tormey DC 1987 Long-term adjuvant therapy with tamoxifen: effects on sex hormone binding globulin and antithrombin III. Cancer Res 47:4517
    • (1987) Cancer Res , vol.47 , pp. 4517
    • Jordan, V.C.1    Fritz, N.F.2    Tormey, D.C.3
  • 205
    • 0023610186 scopus 로고
    • The mechanism of hormone-sensitive breast cancer progression on antiestrogen therapy
    • Pommier RF, Woltering EA, Keenan ET, Fletcher WS 1987 The mechanism of hormone-sensitive breast cancer progression on antiestrogen therapy. Arch Surg 122:1311
    • (1987) Arch Surg , vol.122 , pp. 1311
    • Pommier, R.F.1    Woltering, E.A.2    Keenan, E.T.3    Fletcher, W.S.4
  • 206
    • 0018619521 scopus 로고
    • Differential binding of antiestrogens by rat uterine and chick oviduct cytosol
    • Sutherland RL, Foo MS 1979 Differential binding of antiestrogens by rat uterine and chick oviduct cytosol. Biochem Biophys Res Commun 91:183
    • (1979) Biochem Biophys Res Commun , vol.91 , pp. 183
    • Sutherland, R.L.1    Foo, M.S.2
  • 207
    • 0018952796 scopus 로고
    • The binding of tamoxifen to human mammary carcinoma cytosol
    • Sutherland RL, Murphy LC 1980 The binding of tamoxifen to human mammary carcinoma cytosol. Eur J Cancer Clin Oncol 16:1141
    • (1980) Eur J Cancer Clin Oncol , vol.16 , pp. 1141
    • Sutherland, R.L.1    Murphy, L.C.2
  • 209
    • 0020080803 scopus 로고
    • Heterogeneity of binding sites for tamoxifen and tamoxifen derivatives in estrogen target and nontarget fetal organs of guinea pigs
    • Gulino A, Pasqualini JR 1982 Heterogeneity of binding sites for tamoxifen and tamoxifen derivatives in estrogen target and nontarget fetal organs of guinea pigs. Cancer Res 42:1913
    • (1982) Cancer Res , vol.42 , pp. 1913
    • Gulino, A.1    Pasqualini, J.R.2
  • 210
    • 0020530005 scopus 로고
    • An antiestrogen binding protein in human tissues
    • Kon OL 1983 An antiestrogen binding protein in human tissues. J Biol Chem 258:3173
    • (1983) J Biol Chem , vol.258 , pp. 3173
    • Kon, O.L.1
  • 211
    • 0020569987 scopus 로고
    • Characterization and quantitation of antiestrogen binding sites in estrogen receptor-positive and-negative human breast cancer cell lines
    • Miller MA, Katzenellenbogen BS 1983 Characterization and quantitation of antiestrogen binding sites in estrogen receptor-positive and-negative human breast cancer cell lines. Cancer Res 43:3094
    • (1983) Cancer Res , vol.43 , pp. 3094
    • Miller, M.A.1    Katzenellenbogen, B.S.2
  • 212
    • 0020713776 scopus 로고
    • Antiestrogen-binding sites distinct from the estrogen receptor: Subcellular localization, ligand specificity and distribution in tissues of the rat
    • Sudo K, Monsma FJ, Katzenellenbogen BS 1983 Antiestrogen-binding sites distinct from the estrogen receptor: subcellular localization, ligand specificity and distribution in tissues of the rat. Endocrinology 112:425
    • (1983) Endocrinology , vol.112 , pp. 425
    • Sudo, K.1    Monsma, F.J.2    Katzenellenbogen, B.S.3
  • 213
    • 0021320348 scopus 로고
    • High affinity specific antiestrogen binding sites are concentrated in rough microsomal membranes of rat liver
    • Watts CKW, Sutherland RL 1984 High affinity specific antiestrogen binding sites are concentrated in rough microsomal membranes of rat liver. Biochem Biophys Res Commun 120:109
    • (1984) Biochem Biophys Res Commun , vol.120 , pp. 109
    • Watts, C.1    Sutherland, R.L.2
  • 214
    • 0022448329 scopus 로고
    • Microsomal binding sites for antioestrogens in rat liver: Properties and detergent solubilization
    • Watts CKW, Sutherland RL 1986 Microsomal binding sites for antioestrogens in rat liver: properties and detergent solubilization. Biochem J 236:903
    • (1986) Biochem J , vol.236 , pp. 903
    • Watts, C.1    Sutherland, R.L.2
  • 215
    • 0021345346 scopus 로고
    • Microsomal binding sites for nonsteroidal antiestrogens in mcf-7 human mammary carcinoma cells. Demonstration of high affinity and narrow specificity for basic ether derivatives of triphenylethylene
    • Watts CKW, Murphy LC, Sutherland RL 1984 Microsomal binding sites for nonsteroidal antiestrogens in MCF-7 human mammary carcinoma cells. Demonstration of high affinity and narrow specificity for basic ether derivatives of triphenylethylene. J Biol Chem 259:4223
    • (1984) J Biol Chem , vol.259 , pp. 4223
    • Watts, C.1    Murphy, L.C.2    Sutherland, R.L.3
  • 216
    • 0020616733 scopus 로고
    • Antitumor activity of clomi-phene analogs
    • Murphy LC, Sutherland RL 1983 Antitumor activity of clomi-phene analogs in vitro: relationship to affinity for the estrogen receptor and another high affinity antiestrogen-binding site. J Clin Endocrinol Metab 57:373
    • (1983) J Clin Endocrinol Metab , vol.57 , pp. 373
    • Murphy, L.C.1    Sutherland, R.L.2
  • 217
    • 0021811501 scopus 로고
    • Affinity of ligands other than triar-ylethylenes for liver microsomal antiestrogen binding sites
    • Ruenitz PC, Bagley JR 1985 Affinity of ligands other than triar-ylethylenes for liver microsomal antiestrogen binding sites. Biochem Pharmacol 34:2807
    • (1985) Biochem Pharmacol , vol.34 , pp. 2807
    • Ruenitz, P.C.1    Bagley, J.R.2
  • 218
    • 0021847689 scopus 로고
    • Possible mechanisms for the agonist actions of tamoxifen and the antagonist actions of mer-25 (Etha-moxytriphetol) in the mouse uterus
    • Lyman SD, Jordan VC 1985 Possible mechanisms for the agonist actions of tamoxifen and the antagonist actions of MER-25 (etha-moxytriphetol) in the mouse uterus. Biochem Pharmacol 34:2795
    • (1985) Biochem Pharmacol , vol.34 , pp. 2795
    • Lyman, S.D.1    Jordan, V.C.2
  • 219
    • 0023228065 scopus 로고
    • Studies on the ligand specificity and potential identity of microsomal antiestrogen-binding sites
    • Watts CKW, Sutherland RL 1987 Studies on the ligand specificity and potential identity of microsomal antiestrogen-binding sites. Mol Pharmacol 31:541
    • (1987) Mol Pharmacol , vol.31 , pp. 541
    • Watts, C.1    Sutherland, R.L.2
  • 220
    • 0021321610 scopus 로고
    • Tamoxifen is a calmodulin antagonist in the activation of camp phosphodiesterase
    • Lam HYP 1984 Tamoxifen is a calmodulin antagonist in the activation of cAMP phosphodiesterase. Biochem Biophys Res Commun 118:27
    • (1984) Biochem Biophys Res Commun , vol.118 , pp. 27
    • Lam, H.1
  • 221
    • 0022828736 scopus 로고
    • Calmodulin antagonism and growth-inhibiting activity of triphenylethylene antiestrogens in mcf-7 human breast cancer cells
    • Gulino A, Barrera G, Varea A, Farina A, Ferretti C, Screpanti I, Dianzoni MU, Frati L 1986 Calmodulin antagonism and growth-inhibiting activity of triphenylethylene antiestrogens in MCF-7 human breast cancer cells. Cancer Res 46:6274
    • (1986) Cancer Res , vol.46 , pp. 6274
    • Gulino, A.1    Barrera, G.2    Varea, A.3    Farina, A.4    Ferretti, C.5    Screpanti, I.6    Dianzoni, M.U.7    Frati, L.8
  • 222
    • 0023129529 scopus 로고
    • Calcium channel antagonist properties of the antineoplastic antiestrogen tamoxifen in the pc12 neurosecretory cell line
    • Greenberg DA, Carpenter CL, Messing RO 1987 Calcium channel antagonist properties of the antineoplastic antiestrogen tamoxifen in the PC12 neurosecretory cell line. Cancer Res 47:70
    • (1987) Cancer Res , vol.47 , pp. 70
    • Greenberg, D.A.1    Carpenter, C.L.2    Messing, R.O.3
  • 223
    • 0022251461 scopus 로고
    • Effect of tamoxifen, a nonsteroidal antiestrogen, on phospholipid/calcium-dependent protein kinase and phosphorylation of its endogenous substrate proteins from the rat brain and ovary
    • Su HD, Mazzei GJ, Vogler WR, Kuo JF 1985 Effect of tamoxifen, a nonsteroidal antiestrogen, on phospholipid/calcium-dependent protein kinase and phosphorylation of its endogenous substrate proteins from the rat brain and ovary. Biochem Pharmacol 34:3649
    • (1985) Biochem Pharmacol , vol.34 , pp. 3649
    • Su, H.D.1    Mazzei, G.J.2    Vogler, W.R.3    Kuo, J.F.4
  • 226
    • 0023764676 scopus 로고
    • Specific and direct binding of protein kinase c to an immobilized tamoxifen analogue
    • O’Brian CA, Housey GM, Weinstein IB 1988 Specific and direct binding of protein kinase C to an immobilized tamoxifen analogue. Cancer Res 48:3626
    • (1988) Cancer Res , vol.48 , pp. 3626
    • O’Brian, C.A.1    Housey, G.M.2    Weinstein, I.B.3
  • 227
    • 0021273172 scopus 로고
    • Some chemical and biochemical aspects of liver microsomal metabolism of tamoxifen
    • Ruenitz PC, Bagley JR, Pape CW 1984 Some chemical and biochemical aspects of liver microsomal metabolism of tamoxifen. Drug Metab Dispos 12:478
    • (1984) Drug Metab Dispos , vol.12 , pp. 478
    • Ruenitz, P.C.1    Bagley, J.R.2    Pape, C.W.3
  • 228
    • 0020050103 scopus 로고
    • Cooperativity patterns in the interaction of the antiestrogen drug clomiphene with the muscarinic receptors
    • Ben-Baruch G, Schrieber G, Sokolovsky M 1982 Cooperativity patterns in the interaction of the antiestrogen drug clomiphene with the muscarinic receptors. Mol Pharmacol 21:287
    • (1982) Mol Pharmacol , vol.21 , pp. 287
    • Ben-Baruch, G.1    Schrieber, G.2    Sokolovsky, M.3
  • 229
    • 0021745797 scopus 로고
    • Interaction of nonsteroidal antiestrogens with dopamine-receptor binding
    • Hiemke C, Ghraaf R 1984 Interaction of nonsteroidal antiestrogens with dopamine-receptor binding. J Steroid Biochem 21:663
    • (1984) J Steroid Biochem , vol.21 , pp. 663
    • Hiemke, C.1    Ghraaf, R.2
  • 230
    • 0023219861 scopus 로고
    • An evaluation of the interactions of antiestrogen with pituitary and striatal dopamine receptors
    • Toney TW, Katzenellenbogen BS 1987 An evaluation of the interactions of antiestrogen with pituitary and striatal dopamine receptors. J Receptor Res 7:695
    • (1987) J Receptor Res , vol.7 , pp. 695
    • Toney, T.W.1    Katzenellenbogen, B.S.2
  • 231
    • 0021988504 scopus 로고
    • Evidence that the antiestrogen binding site is a histamine or histamine-like receptor
    • Brandes LJ, Macdonald LM, Bogdonovic RP 1985 Evidence that the antiestrogen binding site is a histamine or histamine-like receptor. Biochem Biophys Res Commun 126:905
    • (1985) Biochem Biophys Res Commun , vol.126 , pp. 905
    • Brandes, L.J.1    Macdonald, L.M.2    Bogdonovic, R.P.3
  • 233
    • 0022966298 scopus 로고
    • The antiproliferative properties of tamoxifen and phenothiazines may be mediated by a unique histamine receptor (?h3) distinct from the calmodulin-binding site
    • Brandes LJ, Bogdonovic RP, Cawker MD, Bose R 1986 The antiproliferative properties of tamoxifen and phenothiazines may be mediated by a unique histamine receptor (?H3) distinct from the calmodulin-binding site. Cancer Chemother Pharmacol 18:21
    • (1986) Cancer Chemother Pharmacol , vol.18 , pp. 21
    • Brandes, L.J.1    Bogdonovic, R.P.2    Cawker, M.D.3    Bose, R.4
  • 234
    • 0022499491 scopus 로고
    • New evidence that the antiestrogen binding site is a novel growth promoting histamine receptor (?h3) which mediates the antiestrogenic and antiproliferative effects of tamoxifen
    • Brandes LJ, Bogdonovic RP 1986 New evidence that the antiestrogen binding site is a novel growth promoting histamine receptor (?H3) which mediates the antiestrogenic and antiproliferative effects of tamoxifen. Biochem Biophys Res Commun 134:601
    • (1986) Biochem Biophys Res Commun , vol.134 , pp. 601
    • Brandes, L.J.1    Bogdonovic, R.P.2
  • 235
    • 0022415521 scopus 로고
    • An evaluation of the role of antiestrogen-binding sites in mediating the growth modulating effects of antiestrogens: Studies using t-butyl-phenoxyethyl diethylamine, a compound lacking affinity for the estrogen receptor
    • Sheen YY, Simpson DM, Katzenellenbogen BS 1985 An evaluation of the role of antiestrogen-binding sites in mediating the growth modulating effects of antiestrogens: studies using t-butyl-phenoxyethyl diethylamine, a compound lacking affinity for the estrogen receptor. Endocrinology 117:561
    • (1985) Endocrinology , vol.117 , pp. 561
    • Sheen, Y.Y.1    Simpson, D.M.2    Katzenellenbogen, B.S.3
  • 236
    • 0021219010 scopus 로고
    • A diphenylmethane derivative specific for the antiestrogen binding site found in rat liver micro-somes
    • Brandes LJ, Hermonant MW 1984 A diphenylmethane derivative specific for the antiestrogen binding site found in rat liver micro-somes. Biochem Biophys Res Commun 123:724
    • (1984) Biochem Biophys Res Commun , vol.123 , pp. 724
    • Brandes, L.J.1    Hermonant, M.W.2
  • 237
    • 0021736302 scopus 로고
    • A diphenylmethane derivative selective for the antiestrogen binding site may help define its biological role
    • Brandes LJ 1984 A diphenylmethane derivative selective for the antiestrogen binding site may help define its biological role. Biochem Biophys Res Commun 124:244
    • (1984) Biochem Biophys Res Commun , vol.124 , pp. 244
    • Brandes, L.J.1
  • 238
    • 0023906156 scopus 로고
    • Further evidence for a biological role of antiestrogen binding sites in mediating the growth inhibitory action of diphenylmethane derivatives
    • Fargin A, Bayard F, Faye JC, Traore M, Poirot M, Klaebe A, Perie JJ 1988 Further evidence for a biological role of antiestrogen binding sites in mediating the growth inhibitory action of diphenylmethane derivatives. Chem Biol Interact 66:101
    • (1988) Chem Biol Interact , vol.66 , pp. 101
    • Fargin, A.1    Bayard, F.2    Faye, J.C.3    Traore, M.4    Poirot, M.5    Klaebe, A.6    Perie, J.J.7
  • 239
    • 0023268953 scopus 로고
    • Tamoxifen-induced modification of serum lipoprotein phospholipids in the cockerel
    • Breckenridge WC, Lazier CB 1987 Tamoxifen-induced modification of serum lipoprotein phospholipids in the cockerel. Lipids 22:505
    • (1987) Lipids , vol.22 , pp. 505
    • Breckenridge, W.C.1    Lazier, C.B.2
  • 241
    • 0021245887 scopus 로고
    • Triphenylethylene antiestrogen binding sites in cockerel liver nuclei: Evidence for an endogenous ligand
    • Murphy PR, Butts C, Lazier CB 1984 Triphenylethylene antiestrogen binding sites in cockerel liver nuclei: evidence for an endogenous ligand. Endocrinology 15:420
    • (1984) Endocrinology , vol.15 , pp. 420
    • Murphy, P.R.1    Butts, C.2    Lazier, C.B.3
  • 242
    • 0020555754 scopus 로고
    • Characterization of a triphenylethylene-antiestrogen binding site on rat serum low density lipoprotein
    • Winneker RC, Guthrie SC, Clark JH 1983 Characterization of a triphenylethylene-antiestrogen binding site on rat serum low density lipoprotein. Endocrinology 112:1823
    • (1983) Endocrinology , vol.112 , pp. 1823
    • Winneker, R.C.1    Guthrie, S.C.2    Clark, J.H.3
  • 243
    • 0021839478 scopus 로고
    • Binding of oxygenated cholesterol metabolites to antiestrogen binding sites from chicken liver
    • Murphy PR, Breckenridge WC, Lazier CB 1985 Binding of oxygenated cholesterol metabolites to antiestrogen binding sites from chicken liver. Biochem Biophys Res Commun 127:786
    • (1985) Biochem Biophys Res Commun , vol.127 , pp. 786
    • Murphy, P.R.1    Breckenridge, W.C.2    Lazier, C.B.3
  • 244
  • 245
    • 0020655358 scopus 로고
    • Tamoxifen treatment failures in hormonally responsive breast cancer
    • Bloom ND, Fishman JH 1983 Tamoxifen treatment failures in hormonally responsive breast cancer. Cancer 51:1190
    • (1983) Cancer , vol.51 , pp. 1190
    • Bloom, N.D.1    Fishman, J.H.2
  • 246
    • 85003100294 scopus 로고    scopus 로고
    • Dels of hormone dependent breast cancer. In: Harris jr, heilman s, henderson ic, kinne dw (eds) breast diseases
    • Jordan VC, Animal models of hormone dependent breast cancer. In: Harris JR, Heilman S, Henderson IC, Kinne DW (eds) Breast Diseases. JB Lippincott, Philadelphia, in press
    • JB Lippincott, Philadelphia, in Press
    • Jordan, V.C.1    Animal, M.2
  • 247
    • 0017046748 scopus 로고    scopus 로고
    • Antiestrogenic and antitumor properties of tamoxifen in laboratory animals
    • Jordan VC 1976 Antiestrogenic and antitumor properties of tamoxifen in laboratory animals. Cancer Treat Rep 60:1409
    • (1976) Cancer Treat Rep , vol.60 , pp. 1409
    • Jordan, V.C.1
  • 248
    • 84912434840 scopus 로고
    • The biochemistry of tamoxifen therapy of breast cancer. In: Agarwal mk (ed) antihormones
    • Elsevier/North Holland, Amsterdam
    • Nicholson RI, Daniel P, Gaskell SJ, Syne JS, Davis P, Griffiths K 1979 The biochemistry of tamoxifen therapy of breast cancer. In: Agarwal MK (ed) Antihormones. Elsevier/North Holland, Amsterdam, pp 253-267
    • (1979) Antihormones , pp. 253-267
    • Nicholson, R.I.1    Daniel, P.2    Gaskell, S.J.3    Syne, J.S.4    Davis, P.5    Griffiths, K.6
  • 249
    • 0019349516 scopus 로고
    • Antitumor effect of the antiestrogen tamoxifen on a pregnancy dependent mouse mammary tumor (Tpdmt-4)
    • Matsuzawa A, Mizuno Y, Yamamoto T 1981 Antitumor effect of the antiestrogen tamoxifen on a pregnancy dependent mouse mammary tumor (TPDMT-4). Cancer Res 41:316
    • (1981) Cancer Res , vol.41 , pp. 316
    • Matsuzawa, A.1    Mizuno, Y.2    Yamamoto, T.3
  • 251
    • 0014649888 scopus 로고
    • Heterotransplantation of a human malignant tumor to “nude” mice
    • Rygaard J, Paulson CO 1969 Heterotransplantation of a human malignant tumor to “nude” mice. Acta Path Microbiol Suppl 77:758
    • (1969) Acta Path Microbiol Suppl , vol.77 , pp. 758
    • Rygaard, J.1    Paulson, C.O.2
  • 252
    • 0016184996 scopus 로고
    • Heterotransplantation of human malignant tumors in “nude” thymusless mice ii. Malignant tumors induced by injection of cell cultures derived from human solid tumors
    • Giovanella BC, Stehlin JS, Williams LJ 1974 Heterotransplantation of human malignant tumors in “nude” thymusless mice II. Malignant tumors induced by injection of cell cultures derived from human solid tumors. J Natl Cancer Inst 52:921
    • (1974) J Natl Cancer Inst , vol.52 , pp. 921
    • Giovanella, B.C.1    Stehlin, J.S.2    Williams, L.J.3
  • 254
    • 0020658509 scopus 로고
    • Human endometrial adenocarcinoma transplanted into nude mice: Growth regulation by estradiol
    • Satyaswaroop PG, Zaino RJ, Mortel R 1983 Human endometrial adenocarcinoma transplanted into nude mice: growth regulation by estradiol. Science 219:58
    • (1983) Science , vol.219 , pp. 58
    • Satyaswaroop, P.G.1    Zaino, R.J.2    Mortel, R.3
  • 255
    • 0021129120 scopus 로고
    • Estrogen-like effects of tamoxifen on human endometrial carcinoma transplanted into nude mice
    • Satyaswaroop PG, Zaino RJ, Mortel R 1984 Estrogen-like effects of tamoxifen on human endometrial carcinoma transplanted into nude mice. Cancer Res 44:4006
    • (1984) Cancer Res , vol.44 , pp. 4006
    • Satyaswaroop, P.G.1    Zaino, R.J.2    Mortel, R.3
  • 256
    • 0022406658 scopus 로고
    • Photoaffinity labeling of the progesterone receptor from human endometrial carcinoma
    • Clark LL, Satyaswaroop PG 1985 Photoaffinity labeling of the progesterone receptor from human endometrial carcinoma. Cancer Res 45:5417
    • (1985) Cancer Res , vol.45 , pp. 5417
    • Clark, L.L.1    Satyaswaroop, P.G.2
  • 257
    • 0019309560 scopus 로고
    • Estrogen proliferation of clonal human breast carcinoma cells in athymic mice
    • Soule HD, McGrath CM 1980 Estrogen proliferation of clonal human breast carcinoma cells in athymic mice. Cancer Lett 10:177
    • (1980) Cancer Lett , vol.10 , pp. 177
    • Soule, H.D.1    McGrath, C.M.2
  • 258
    • 0019185003 scopus 로고
    • Formation of metastasis by human breast carcinoma cells (Mcf-7) in nude mice
    • Shafie SM, Liotta LA 1980 Formation of metastasis by human breast carcinoma cells (MCF-7) in nude mice. Cancer Lett 11:81
    • (1980) Cancer Lett , vol.11 , pp. 81
    • Shafie, S.M.1    Liotta, L.A.2
  • 260
    • 0023693189 scopus 로고
    • Secreted growth factors from estrogen receptor-negative human breast cancer do not support growth of estrogen receptor positive breast cancer in the nude mouse model
    • Osborne CK, Rose CR, Coronado EB, Fugua SAW, Kitten LJ 1988 Secreted growth factors from estrogen receptor-negative human breast cancer do not support growth of estrogen receptor positive breast cancer in the nude mouse model. Breast Cancer Res Treat 11:211
    • (1988) Breast Cancer Res Treat , vol.11 , pp. 211
    • Osborne, C.K.1    Rose, C.R.2    Coronado, E.B.3    Fugua, S.4    Kitten, L.J.5
  • 261
    • 0024817495 scopus 로고
    • Immune-deficient animals to study “hormone-dependent” breast and endometrial cancer
    • Jordan VC, Gottardis MM, Robinson SP, Friedl A 1989 Immune-deficient animals to study “hormone-dependent” breast and endometrial cancer. J Steroid Biochem 34:169
    • (1989) J Steroid Biochem , vol.34 , pp. 169
    • Jordan, V.C.1    Gottardis, M.M.2    Robinson, S.P.3    Friedl, A.4
  • 262
    • 0021958425 scopus 로고
    • Effect of estrogens and antiestrogens on growth of human breast cancer cells in athymic mice
    • Osborne CK, Hobbs K, Clark GM 1985 Effect of estrogens and antiestrogens on growth of human breast cancer cells in athymic mice. Cancer Res 45:584
    • (1985) Cancer Res , vol.45 , pp. 584
    • Osborne, C.K.1    Hobbs, K.2    Clark, G.M.3
  • 263
    • 0023683768 scopus 로고
    • Estradiol-stimulated growth of mcf-7 tumors implanted in athymic mice: A model to study the tumoristatic action of tamoxifen
    • Gottardis MM, Robinson SP, Jordan VC 1988 Estradiol-stimulated growth of MCF-7 tumors implanted in athymic mice: a model to study the tumoristatic action of tamoxifen. J Steroid Biochem 30:311
    • (1988) J Steroid Biochem , vol.30 , pp. 311
    • Gottardis, M.M.1    Robinson, S.P.2    Jordan, V.C.3
  • 265
    • 0024509832 scopus 로고
    • Antiestrogen action of toremifene on hormone-dependent,-independent and heterogeneous breast tumor growth in the athymic mouse
    • Robinson SP, Jordan VC 1989 Antiestrogen action of toremifene on hormone-dependent,-independent and heterogeneous breast tumor growth in the athymic mouse. Cancer Res 49:1758
    • (1989) Cancer Res , vol.49 , pp. 1758
    • Robinson, S.P.1    Jordan, V.C.2
  • 266
    • 0014793252 scopus 로고
    • Two modes of interaction between oestrogen and antioestrogen
    • Terenius L 1970 Two modes of interaction between oestrogen and antioestrogen. Acta Endocrinol Suppl 64:47
    • (1970) Acta Endocrinol Suppl , vol.64 , pp. 47
    • Terenius, L.1
  • 267
    • 0015027149 scopus 로고
    • Structure-activity relationships of antiestrogens with regard to interaction with 17/3-oestradiol in the mouse uterus and vagina
    • Terenius L 1971 Structure-activity relationships of antiestrogens with regard to interaction with 17/3-oestradiol in the mouse uterus and vagina. Acta Endocrinol [Suppl] (Copenh) 66:431
    • (1971) Acta Endocrinol [Suppl] (Copenh) , vol.66 , pp. 431
    • Terenius, L.1
  • 268
    • 0018190261 scopus 로고
    • Dose-related effect of nonsteroidal antioestrogens and non-steroidal oestrogens on the measurement of cytoplasmic oestrogen receptors in the rat and mouse uterus
    • Jordan VC, Rowsby L, Dix CJ, Prestwich G 1978 Dose-related effect of nonsteroidal antioestrogens and non-steroidal oestrogens on the measurement of cytoplasmic oestrogen receptors in the rat and mouse uterus. J Endocrinol 78:71
    • (1978) J Endocrinol , vol.78 , pp. 71
    • Jordan, V.C.1    Rowsby, L.2    Dix, C.J.3    Prestwich, G.4
  • 269
    • 0023760993 scopus 로고
    • Development of tamoxifen-stimulated growth of mcf-7 tumors in athymic mice after long-term antiestrogen administration
    • Gottardis MM, Jordan VC 1988 Development of tamoxifen-stimulated growth of MCF-7 tumors in athymic mice after long-term antiestrogen administration. Cancer Res 48:5183
    • (1988) Cancer Res , vol.48 , pp. 5183
    • Gottardis, M.M.1    Jordan, V.C.2
  • 270
    • 0023235522 scopus 로고
    • Human breast cancer in the athymic nude mouse: Cytostatic effects of long-term antiestrogen therapy
    • Osborne CK, Coronado EB, Robinson JP 1987 Human breast cancer in the athymic nude mouse: cytostatic effects of long-term antiestrogen therapy. Eur J Cancer Clin Oncol 23:1189
    • (1987) Eur J Cancer Clin Oncol , vol.23 , pp. 1189
    • Osborne, C.K.1    Coronado, E.B.2    Robinson, J.P.3
  • 271
    • 0022619994 scopus 로고
    • Mammary tumorigensis and tumor morphology in four c3h sublines with or without exogenous mammary tumor virus
    • Vaage J, Smith GH, Asch BB, Teramoto Y 1986 Mammary tumorigensis and tumor morphology in four C3H sublines with or without exogenous mammary tumor virus. Cancer Res 46:2096
    • (1986) Cancer Res , vol.46 , pp. 2096
    • Vaage, J.1    Smith, G.H.2    Asch, B.B.3    Teramoto, Y.4
  • 272
    • 0000299781 scopus 로고
    • Some possible effects of nursing on the mammary gland tumor incidence in mice
    • Bittner JJ 1936 Some possible effects of nursing on the mammary gland tumor incidence in mice. Science 84:162
    • (1936) Science , vol.84 , pp. 162
    • Bittner, J.J.1
  • 273
    • 27244448314 scopus 로고
    • Mammary tumors in mice in relation to nursing
    • Bittner JJ 1937 Mammary tumors in mice in relation to nursing. Am J Cancer 30:530
    • (1937) Am J Cancer , vol.30 , pp. 530
    • Bittner, J.J.1
  • 274
    • 85044705292 scopus 로고
    • Further investigations on the origins of tumors in mice iii on the part played by internal secretions in the spontaneous development of tumors
    • Lathrop AE, Loeb L 1916 Further investigations on the origins of tumors in mice III on the part played by internal secretions in the spontaneous development of tumors. J Cancer Res 1:1
    • (1916) J Cancer Res , vol.1 , pp. 1
    • Lathrop, A.E.1    Loeb, L.2
  • 275
    • 0001055370 scopus 로고
    • Apperition de cancer de la mamelle chez le souris male, sourmise a desinjection de folliculine
    • Lacassagne A 1932 Apperition de cancer de la mamelle chez le souris male, sourmise a des injection de folliculine. C R Acad Sci [D] (Paris) 195:630
    • (1932) C R Acad Sci [D] (Paris) , vol.195 , pp. 630
    • Lacassagne, A.1
  • 276
    • 0025325981 scopus 로고
    • Progesterone receptor stimulates transcription of mouse mammary tumor virus in a cell free system
    • Kalff M, Gross B, Beato M 1990 Progesterone receptor stimulates transcription of mouse mammary tumor virus in a cell free system. Nature 344:360
    • (1990) Nature , vol.344 , pp. 360
    • Kalff, M.1    Gross, B.2    Beato, M.3
  • 277
    • 0016837109 scopus 로고
    • Response of a pregnancy-dependent mouse mammary tumor to hormones
    • Matsuzawa A, Yamamoto T 1975 Response of a pregnancy-dependent mouse mammary tumor to hormones. J Natl Cancer Inst 55:447
    • (1975) J Natl Cancer Inst , vol.55 , pp. 447
    • Matsuzawa, A.1    Yamamoto, T.2
  • 278
    • 0014853985 scopus 로고
    • Mammary tumor development in br6 mice: Hormonal stimulation
    • Lee AE 1970 Mammary tumor development in BR6 mice: hormonal stimulation. Br J Cancer 24:568
    • (1970) Br J Cancer , vol.24 , pp. 568
    • Lee, A.E.1
  • 279
    • 0013782672 scopus 로고
    • Responsiveness of mouse mammary tumors to pregnancy
    • Van Nie R, Thung PJ 1965 Responsiveness of mouse mammary tumors to pregnancy. Eur J Cancer 1:41
    • (1965) Eur J Cancer , vol.1 , pp. 41
    • van Nie, R.1    Thung, P.J.2
  • 280
    • 0017193199 scopus 로고
    • Sex hormone receptors in mammary tumors of gr mice
    • Shuyser M, Evers SG, Degeoij CCJ 1976 Sex hormone receptors in mammary tumors of GR mice. Nature 263:386
    • (1976) Nature , vol.263 , pp. 386
    • Shuyser, M.1    Evers, S.G.2    Degeoij, C.3
  • 281
    • 0024989452 scopus 로고
    • The antioestrogenic and antitumour properties of prolonged tamoxifen therapy in c3h/ouj mice
    • Jordan VC, Lababidi MK, Mirecki DM 1990 The antioestrogenic and antitumour properties of prolonged tamoxifen therapy in C3H/OUJ mice. Eur J Cancer 26:718
    • (1990) Eur J Cancer , vol.26 , pp. 718
    • Jordan, V.C.1    Lababidi, M.K.2    Mirecki, D.M.3
  • 282
    • 0001626384 scopus 로고
    • Antitumour activity of the antioestrogen ici46.474 (tamoxifen) in the dimethylbenzanthracene (dmba)-induced rat mammary carcinoma model
    • Jordan VC 1974 Antitumour activity of the antioestrogen ICI46.474 (tamoxifen) in the dimethylbenzanthracene (DMBA)-induced rat mammary carcinoma model. J Steroid Biochem 5:354
    • (1974) J Steroid Biochem , vol.5 , pp. 354
    • Jordan, V.C.1
  • 283
    • 0017078344 scopus 로고
    • Effect of tamoxifen (Ici 46,474) on initiation and growth of dmba-induced rat mammary carcinomata
    • Jordan VC 1976 Effect of tamoxifen (ICI 46,474) on initiation and growth of DMBA-induced rat mammary carcinomata. Eur J Cancer 12:419
    • (1976) Eur J Cancer , vol.12 , pp. 419
    • Jordan, V.C.1
  • 284
    • 0017685863 scopus 로고
    • Antagonism of development and growth of 7,12 dimethylbenz(A)anthracene-induced rat mammary tumors by the antiestrogen u23,469 and effects on estrogen and progesterone receptors
    • Tsai TLS, Katzenellenbogen BS 1977 Antagonism of development and growth of 7,12 dimethylbenz(a)anthracene-induced rat mammary tumors by the antiestrogen U23,469 and effects on estrogen and progesterone receptors. Cancer Res 37:1537
    • (1977) Cancer Res , vol.37 , pp. 1537
    • Tsai, T.1    Katzenellenbogen, B.S.2
  • 285
    • 0018955540 scopus 로고
    • Characterization of estradiol, progesterone and prolactin receptors in nitrosomethylurea-in-duced mammary tumors and effect of antiestrogen treatment on the development and growth of these tumors
    • Turcot-Lemay L, Kelly PA 1980 Characterization of estradiol, progesterone and prolactin receptors in nitrosomethylurea-in-duced mammary tumors and effect of antiestrogen treatment on the development and growth of these tumors. Cancer Res 40:3232
    • (1980) Cancer Res , vol.40 , pp. 3232
    • Turcot-Lemay, L.1    Kelly, P.A.2
  • 286
    • 0018906517 scopus 로고
    • Evaluation of the antitumour activity of the nonsteroidal antioestrogen monohydroxytamoxifen in the dmba-induced rat mammary carcinoma model
    • Jordan VC, Allen KE 1980 Evaluation of the antitumour activity of the nonsteroidal antioestrogen monohydroxytamoxifen in the DMBA-induced rat mammary carcinoma model. Eur J Cancer 16:239
    • (1980) Eur J Cancer , vol.16 , pp. 239
    • Jordan, V.C.1    Allen, K.E.2
  • 287
    • 0020067287 scopus 로고
    • Adjuvant tamoxifen therapy for early breast cancer: An experimental study with reference to oestrogen and progesterone receptors
    • Wilson AJ, Tehrani F, Baum M 1982 Adjuvant tamoxifen therapy for early breast cancer: an experimental study with reference to oestrogen and progesterone receptors. Br J Surg 69:121
    • (1982) Br J Surg , vol.69 , pp. 121
    • Wilson, A.J.1    Tehrani, F.2    Baum, M.3
  • 288
    • 0002420533 scopus 로고
    • Use of the dmba-induced rat mammary carcinoma system for the evaluation of tamoxifen treatment as a potential adjuvant therapy
    • October Supplement, Macclesfield, ICI pharmaceuticals division
    • Jordan VC 1978 Use of the DMBA-induced rat mammary carcinoma system for the evaluation of tamoxifen treatment as a potential adjuvant therapy. Reviews on endocrine-related cancer, October Supplement 49-55, Macclesfield, ICI pharmaceuticals division
    • (1978) Reviews on Endocrine-Related Cancer , pp. 49-55
    • Jordan, V.C.1
  • 289
    • 0002487846 scopus 로고
    • The effectiveness of long-term tamoxifen treatment in a laboratory model for adjuvant hormone therapy of breast cancer
    • In: Salmon SE, Jones SE, New York, Grune and Stratton
    • Jordan VC, Dix CJ, Allen KE 1979 The effectiveness of long-term tamoxifen treatment in a laboratory model for adjuvant hormone therapy of breast cancer. In: Salmon SE, Jones SE (eds) Adjuvant Therapy of Cancer II. New York, Grune and Stratton, pp 19-26
    • (1979) Adjuvant Therapy of Cancer II , pp. 19-26
    • Jordan, V.C.1    Dix, C.J.2    Allen, K.E.3
  • 290
    • 0023193251 scopus 로고
    • Reversal of the antitumor effects of tamoxifen by progesterone in the 7,12 dimethylbenzanthracene-induced rat mammary carcinoma model
    • Robinson SP, Jordan VC 1987 Reversal of the antitumor effects of tamoxifen by progesterone in the 7,12 dimethylbenzanthracene-induced rat mammary carcinoma model. Cancer Res 47:5386
    • (1987) Cancer Res , vol.47 , pp. 5386
    • Robinson, S.P.1    Jordan, V.C.2
  • 291
    • 0024214940 scopus 로고
    • Chemosuppression of breast cancer with tamoxifen: Laboratory evidence and future clinical investigations
    • Jordan VC 1988 Chemosuppression of breast cancer with tamoxifen: laboratory evidence and future clinical investigations. Cancer Invest 6:5-11
    • (1988) Cancer Invest , vol.6 , pp. 5-11
    • Jordan, V.C.1
  • 292
    • 85003196655 scopus 로고
    • Osuppression of breast cancer with long-term tamoxifen therapy. Preventive medicine, in press
    • Jordan VC, Chemosuppression of breast cancer with long-term tamoxifen therapy. Preventive Medicine, in press
    • (1986) J Biol Chem
    • Jordan, V.C.1
  • 293
    • 0347450835 scopus 로고    scopus 로고
    • Tamoxifen and contra-lateral breast cancer
    • Cuzick J, Baum M 1985 Tamoxifen and contra-lateral breast cancer. Lancet 2:282
    • Lancet , vol.2 , pp. 282
    • Cuzick, J.1    Baum, M.2
  • 294
    • 0024506261 scopus 로고
    • A randomized clinical trial evaluating tamoxifen in the treatment of patients with node-negative breast cancer who have estrogen receptor positive tumors
    • and the NSABP
    • Fisher B, Constantino J, Redmond C, and the NSABP 1989 A randomized clinical trial evaluating tamoxifen in the treatment of patients with node-negative breast cancer who have estrogen receptor positive tumors. N Engl J Med 32:479
    • (1989) N Engl J Med , vol.32 , pp. 479
    • Fisher, B.1    Constantino, J.2    Redmond, C.3
  • 296
    • 0004496862 scopus 로고
    • Adjuvant tamoxifen in the management of operable breast cancer: The scottish trial
    • Breast Cancer Trials Committee, Scottish Cancer Trials Office (MRC) 1987 Adjuvant tamoxifen in the management of operable breast cancer: the Scottish Trial. Lancet 2:171
    • (1987) Lancet , vol.2 , pp. 171
  • 298
    • 0020658348 scopus 로고
    • Adjuvant tamoxifen for operable carcinoma of the breast: Report of a clinical trial by the christie hospital and holt radium institute
    • Ribeiro G, Palmer MK 1983 Adjuvant tamoxifen for operable carcinoma of the breast: report of a clinical trial by the Christie Hospital and Holt Radium Institute. Br Med J 286:827
    • (1983) Br Med J , vol.286 , pp. 827
    • Ribeiro, G.1    Palmer, M.K.2
  • 299
    • 0021859316 scopus 로고
    • The christie hospital tamoxifen (Nolvadex) adjuvant trial for operable breast carcinoma—seven year results
    • Ribeiro G, Swindell R 1985 The Christie Hospital tamoxifen (Nolvadex) adjuvant trial for operable breast carcinoma—seven year results. Eur J Cancer Clin Oncol 21:897
    • (1985) Eur J Cancer Clin Oncol , vol.21 , pp. 897
    • Ribeiro, G.1    Swindell, R.2
  • 300
    • 77956028902 scopus 로고
    • Controlled trial of tamoxifen as single adjuvant agent in management of early breast cancer
    • Baum M, and the Nolvadex Adjuvant Trial Organization 1983 Controlled trial of tamoxifen as single adjuvant agent in management of early breast cancer. Lancet 1:257
    • (1983) Lancet , vol.1 , pp. 257
    • Baum, M.1
  • 301
    • 0021918182 scopus 로고
    • Controlled trial of tamoxifen as single adjuvant agent in management of early breast cancer
    • Baum M, and the Nolvadex Adjuvant Trial Organization. 1985. Controlled trial of tamoxifen as single adjuvant agent in management of early breast cancer. Lancet 1:836.
    • (1985) Lancet , vol.1 , pp. 836
    • Baum, M.1
  • 302
    • 0023888245 scopus 로고
    • Controlled trial of tamoxifen as a single adjuvant agent in management of early breast cancer
    • Baum M. and the Nolvadex Adjuvant Trial Organization. 1988. Controlled trial of tamoxifen as a single adjuvant agent in management of early breast cancer. Br J Cancer 57:608
    • (1988) Br J Cancer , vol.57 , pp. 608
    • Baum, M.1
  • 303
    • 0023918505 scopus 로고
    • Cyclophosphamide and tamoxifen as adjuvant therapies in the management of breast cancer. Preliminary analysis by the crc adjuvant trial working party
    • Abram WP, Baum M, Berstock DA 1988 Cyclophosphamide and tamoxifen as adjuvant therapies in the management of breast cancer. Preliminary analysis by the CRC adjuvant trial working party. Br J Cancer 57:604
    • (1988) Br J Cancer , vol.57 , pp. 604
    • Abram, W.P.1    Baum, M.2    Berstock, D.A.3
  • 305
    • 0021259498 scopus 로고
    • Randomized trial of chemoen-docrine therapy, endocrine therapy and mastectomy alone in postmenopausal patients with operable breast cancer and axillary node metastases
    • Ludwig Breast Cancer Group 1984 Randomized trial of chemoen-docrine therapy, endocrine therapy and mastectomy alone in postmenopausal patients with operable breast cancer and axillary node metastases. Lancet 1:1256
    • (1984) Lancet , vol.1 , pp. 1256
  • 308
    • 0020963216 scopus 로고
    • Laboratory studies to develop general principles for the adjuvant treatment of breast cancer with antiestrogens: Problems and potential for future clinical applications
    • Jordan VC 1983 Laboratory studies to develop general principles for the adjuvant treatment of breast cancer with antiestrogens: problems and potential for future clinical applications. Breast Cancer Res Treat 3 [Suppl 1]:73
    • (1983) Breast Cancer Res Treat , vol.3 , pp. 73
    • Jordan, V.C.1
  • 309
    • 0023280302 scopus 로고
    • Long-term adjuvant therapy with tamoxifen in breast cancer: How long is long?
    • Tormey DC 1987 Long-term adjuvant therapy with tamoxifen in breast cancer: how long is long? Ann Intern Med 106:762
    • (1987) Ann Intern Med , vol.106 , pp. 762
    • Tormey, D.C.1
  • 310
    • 0021681961 scopus 로고
    • Long-term adjuvant tamoxifen therapy in node positive breast cancer: A metabolic and pilot clinical study
    • Tormey DC, Jordan VC 1984 Long-term adjuvant tamoxifen therapy in node positive breast cancer: a metabolic and pilot clinical study. Breast Cancer Res Treat 4:297
    • (1984) Breast Cancer Res Treat , vol.4 , pp. 297
    • Tormey, D.C.1    Jordan, V.C.2
  • 312
    • 0019122379 scopus 로고
    • The pharmacology of tamoxifen in laboratory animals
    • Jordan VC, Allen KE, Dix CJ 1980 The pharmacology of tamoxifen in laboratory animals. Cancer Treat Rep 64:745
    • (1980) Cancer Treat Rep , vol.64 , pp. 745
    • Jordan, V.C.1    Allen, K.E.2    Dix, C.J.3
  • 313
    • 0025194009 scopus 로고
    • Adjuvant trial of 12 cycles of cmfpt followed by observation or continuous tamoxifen versus four cycles of cmfpt in postmenopausal women with breast cancer: An ecog phase iii study
    • Falkson HC, Gray R, Wolberg WH, Gilchrist KW, Harris JE, Tormey DC, Falkson G 1990 Adjuvant trial of 12 cycles of CMFPT followed by observation or continuous tamoxifen versus four cycles of CMFPT in postmenopausal women with breast cancer: an ECOG Phase III study. J Clin Oncol 8:599
    • (1990) J Clin Oncol , vol.8 , pp. 599
    • Falkson, H.C.1    Gray, R.2    Wolberg, W.H.3    Gilchrist, K.W.4    Harris, J.E.5    Tormey, D.C.6    Falkson, G.7
  • 314
    • 0023199112 scopus 로고
    • Prolonging tamoxifen for primary breast cancer. Findings from the national surgical adjuvant breast and bowel project clinical trial
    • Fisher B and National Surgical Breast and Bowel Project Investigators 1987 Prolonging tamoxifen for primary breast cancer. Findings from the National Surgical Adjuvant Breast and Bowel Project Clinical Trial. Ann Intern Med 106:649
    • (1987) Ann Intern Med , vol.106 , pp. 649
    • Fisher, B.1
  • 316
    • 0022623005 scopus 로고
    • Adjuvant chemotherapy with and without tamoxifen in the treatment of primary breast cancer: 5 year results from the national surgical adjuvant breast and bowel project
    • NSABP investigators
    • Fisher B, Redmond C, Brown A, Fisher ER, Wolmark N, Bowman D, Plotkin D, Wolter J, Bornstein R, Legault-Poisson S, Saffer EA and NSABP investigators 1986 Adjuvant chemotherapy with and without tamoxifen in the treatment of primary breast cancer: 5 year results from the National Surgical Adjuvant Breast and Bowel Project. J Clin Oncol 4:459
    • (1986) J Clin Oncol , vol.4 , pp. 459
    • Fisher, B.1    Redmond, C.2    Brown, A.3    Fisher, E.R.4    Wolmark, N.5    Bowman, D.6    Plotkin, D.7    Wolter, J.8    Bornstein, R.9    Legault-Poisson, S.10    Saffer, E.A.11
  • 319
    • 0025334752 scopus 로고    scopus 로고
    • Margolese rg and other members of the nsabp 1990 postoperative chemotherapy and tamoxifen compared with tamoxifen alone in the treatment of positive-node breast cancer patients aged 50 years and older with tumors responsive to tamoxifen: Results from the national surgical adjuvant breast and bowel project b-16
    • Fisher B, Redmond C, Legault-Poisson S, Dimitrov NV, Brown AM, Wickerham DL, Wolmark N, Margolese RG and other members of the NSABP 1990 Postoperative chemotherapy and tamoxifen compared with tamoxifen alone in the treatment of positive-node breast cancer patients aged 50 years and older with tumors responsive to tamoxifen: results from the National Surgical Adjuvant Breast and Bowel Project B-16. J Clin Oncol 8:1005
    • J Clin Oncol , vol.1005 , pp. 8
    • Fisher, B.1    Redmond, C.2    Legault-Poisson, S.3    Dimitrov, N.V.4    Brown, A.M.5    Wickerham, D.L.6    Wolmark, N.7
  • 320
    • 0015893137 scopus 로고
    • Active outward transport of daurorubicin in resistant ehrlich ascites tumour cells
    • Dano K 1973 Active outward transport of daurorubicin in resistant Ehrlich ascites tumour cells. Biochim Biophys Acta 232:466
    • (1973) Biochim Biophys Acta , vol.232 , pp. 466
    • Dano, K.1
  • 321
    • 85003082402 scopus 로고
    • Active efflux of daunorubicin and adriamycin
    • Inaba M, Koboyashi H, Sakwai Y, Johnson RK 1979 Active efflux of daunorubicin and Adriamycin® in sensitive and resistant sublines of P388 leukemia. Cancer Res 39:2220
    • (1979) Cancer Res , vol.39 , pp. 2220
    • Inaba, M.1    Koboyashi, H.2    Sakwai, Y.3    Johnson, R.K.4
  • 322
    • 0021856764 scopus 로고    scopus 로고
    • Pastan 11985 reduced drug accumulation in multiple drug resistant human kb carcinoma cell line
    • Fojo A, Akiyama SI, Gottesman MM, Pastan 11985 Reduced drug accumulation in multiple drug resistant human KB carcinoma cell line. Cancer Res 45:3002
    • Cancer Res , vol.45 , pp. 3002
    • Fojo, A.1    Akiyama, S.I.2    Gottesman, M.M.3
  • 323
    • 0021797892 scopus 로고
    • Amplification of p-glycoprotein genes in multidrug resistant mammalian cell lines
    • Riordan RJ, Deuchars K, Kartner W, Alan M, Trent J, Ling V 1985 Amplification of p-glycoprotein genes in multidrug resistant mammalian cell lines. Nature 316:817
    • (1985) Nature , vol.316 , pp. 817
    • Riordan, R.J.1    Deuchars, K.2    Kartner, W.3    Alan, M.4    Trent, J.5    Ling, V.6
  • 324
    • 0021852930 scopus 로고
    • Detection of p-glycoprotein in multidrug resistant cell lines by monoclonal antibodies
    • Kartner N, Evernder-Parelle D, Bradley G, Ling V 1985 Detection of P-glycoprotein in multidrug resistant cell lines by monoclonal antibodies. Nature 316:820
    • (1985) Nature , vol.316 , pp. 820
    • Kartner, N.1    Evernder-Parelle, D.2    Bradley, G.3    Ling, V.4
  • 325
    • 0021162802 scopus 로고
    • Reversal of acquired resistance to doxorubicin in p388 murine leukemia cells by tamoxifen and triparanol analogues
    • Ramu A, Gläubiger A, Kuks Z 1984 Reversal of acquired resistance to doxorubicin in P388 murine leukemia cells by tamoxifen and triparanol analogues. Cancer Res 44:4392
    • (1984) Cancer Res , vol.44 , pp. 4392
    • Ramu, A.1    Gläubiger, A.2    Kuks, Z.3
  • 326
    • 0022491180 scopus 로고
    • Interaction among membrane transport systems: Anthracyclines, calcium antagonists and anti-oestrogens
    • Kessel D 1986 Interaction among membrane transport systems: anthracyclines, calcium antagonists and anti-oestrogens. Biochem Pharmacol 35:2825
    • (1986) Biochem Pharmacol , vol.35 , pp. 2825
    • Kessel, D.1
  • 327
    • 0025196231 scopus 로고
    • Enhancement of adriamycin
    • Chatterjee M, Harris AL 1990 Enhancement of Adriamycin® cytotoxicity in a multidrug resistant Chinese Hamster ovary (CHO) subline, CHO-Adr®, by toremifene and its modulation by alpha! acid glycoprotein. Eur J Cancer 26:432
    • (1990) Eur J Cancer , vol.26 , pp. 432
    • Chatterjee, M.1    Harris, A.L.2
  • 328
    • 0021027147 scopus 로고
    • Tamoxifen and 5-fluorouracil in breast cancer: Cytotoxic synergism
    • Benz C, Cadman E, Gwin J 1983 Tamoxifen and 5-fluorouracil in breast cancer: cytotoxic synergism in vitro. Cancer Res 43:5298
    • (1983) Cancer Res , vol.43 , pp. 5298
    • Benz, C.1    Cadman, E.2    Gwin, J.3
  • 329
    • 0021028641 scopus 로고
    • Tamoxifen and 5-fluorouracil in breast cancer: Modulation of cellular rna
    • Benz C, Santos G, Cadman E 1983 Tamoxifen and 5-fluorouracil in breast cancer: modulation of cellular RNA. Cancer Res 43:5304
    • (1983) Cancer Res , vol.43 , pp. 5304
    • Benz, C.1    Santos, G.2    Cadman, E.3
  • 330
    • 0021907156 scopus 로고
    • Antagonism of the cytocidal activity and uptake of melphalan by tamoxifen in human breast cancer cells
    • Goldenberg GJ, Froese EK 1985 Antagonism of the cytocidal activity and uptake of melphalan by tamoxifen in human breast cancer cells in vitro. Biochem Pharmacol 34:763
    • (1985) Biochem Pharmacol , vol.34 , pp. 763
    • Goldenberg, C.1    Froese, G.2
  • 331
    • 0022348002 scopus 로고
    • Tamoxifen citrate counteracts the antitumor effects of cytotoxic drugs
    • Hug V, Hortobagyi GN, Drewinko B 1985 Tamoxifen citrate counteracts the antitumor effects of cytotoxic drugs in vitro. J Clin Oncol 3:1672
    • (1985) J Clin Oncol , vol.3 , pp. 1672
    • Hug, V.1    Hortobagyi, G.N.2    Drewinko, B.3
  • 332
    • 0024393056 scopus 로고
    • Antagonism of chemotherapy-induced cytotoxicity for human breast cancer cells by antiestrogens
    • Osborne CK, Kitten L, Arteaga CL 1989 Antagonism of chemotherapy-induced cytotoxicity for human breast cancer cells by antiestrogens. J Clin Oncol 7:710
    • (1989) J Clin Oncol , vol.7 , pp. 710
    • Osborne, C.K.1    Kitten, L.2    Arteaga, C.L.3
  • 333
    • 0019870622 scopus 로고
    • Estradiol independent growth of a subline of mcf-7 human breast cancer cells in culture
    • Nawata H, Chang MJ, Bronzert D, Lippman ME 1981 Estradiol independent growth of a subline of MCF-7 human breast cancer cells in culture. J Biol Chem 256:6895
    • (1981) J Biol Chem , vol.256 , pp. 6895
    • Nawata, H.1    Chang, M.J.2    Bronzert, D.3    Lippman, M.E.4
  • 334
    • 0019797751 scopus 로고
    • Isolation and characterization of a tamoxifen resistant line derived from mcf-7 human breast cancer cells
    • Nawata H, Bronzert D, Lippman ME 1981 Isolation and characterization of a tamoxifen resistant line derived from MCF-7 human breast cancer cells. J Biol Chem 256:5016
    • (1981) J Biol Chem , vol.256 , pp. 5016
    • Nawata, H.1    Bronzert, D.2    Lippman, M.E.3
  • 335
    • 0021747651 scopus 로고
    • Antiestrogen binding in antiestrogen growth resistant estrogen-responsive clonal variants of mcf-7 human breast cancer cells
    • Miller MA, Lippman ME, Katzenellengogen BS 1984 Antiestrogen binding in antiestrogen growth resistant estrogen-responsive clonal variants of MCF-7 human breast cancer cells. Cancer Res 44:5038
    • (1984) Cancer Res , vol.44 , pp. 5038
    • Miller, M.A.1    Lippman, M.E.2    Katzenellengogen, B.S.3
  • 337
    • 0020516248 scopus 로고
    • Antiestrogenic effects of ly117018 in mcf-7 cells
    • Scholl SM, Huff KK, Lippman ME 1983 Antiestrogenic effects of LY117018 in MCF-7 cells. Endocrinology 113:611
    • (1983) Endocrinology , vol.113 , pp. 611
    • Scholl, S.M.1    Huff, K.K.2    Lippman, M.E.3
  • 338
    • 0021927466 scopus 로고
    • Selection and characterization of a breast cancer cell line resistant to the antiestrogen ly117018
    • Bronzert DA, Greene GL, Lippman ME 1985 Selection and characterization of a breast cancer cell line resistant to the antiestrogen LY117018. Endocrinology 117:1409
    • (1985) Endocrinology , vol.117 , pp. 1409
    • Bronzert, D.A.1    Greene, G.L.2    Lippman, M.E.3
  • 339
    • 0022641791 scopus 로고
    • Use of two mcf-7 variants to evaluate the growth regulating potential of estrogen-induced products
    • Davidson NE, Bronzert DA, Chambon P, Gelman EP, Lippman ME 1986 Use of two MCF-7 variants to evaluate the growth regulating potential of estrogen-induced products. Cancer Res 46:1904
    • (1986) Cancer Res , vol.46 , pp. 1904
    • Davidson, N.E.1    Bronzert, D.A.2    Chambon, P.3    Gelman, E.P.4    Lippman, M.E.5
  • 342
    • 0024336285 scopus 로고
    • Oestrogenic activity of tamoxifen and its metabolites on gene regulation and cell proliferation in mcf-7 breast cancer cells
    • Johnson MD, Westley BR, May FEB 1989 Oestrogenic activity of tamoxifen and its metabolites on gene regulation and cell proliferation in MCF-7 breast cancer cells. Br J Cancer 59:727
    • (1989) Br J Cancer , vol.59 , pp. 727
    • Johnson, M.D.1    Westley, B.R.2    May, F.3
  • 343
    • 0025191263 scopus 로고
    • Characterization of the estrogen receptor in two antiestrogen-resistant cell lines ly2 and t47d
    • Mullick A, Chambon P 1990 Characterization of the estrogen receptor in two antiestrogen-resistant cell lines LY2 and T47D. Cancer Res 50:333
    • (1990) Cancer Res , vol.50 , pp. 333
    • Mullick, A.1    Chambon, P.2
  • 344
    • 0024514882 scopus 로고
    • Characterization of a tamoxifen-resistant variant of the zr-75-1 human breast cancer cell line (Zr-75-9al) and stability of the resistant phenotype
    • van der Berg HW, Lynch M, Martin J, Nelson J, Dickson GR, Crockard AD 1989 Characterization of a tamoxifen-resistant variant of the ZR-75-1 human breast cancer cell line (ZR-75-9al) and stability of the resistant phenotype. Br J Cancer 59:522
    • (1989) Br J Cancer , vol.59 , pp. 522
    • van Der Berg, H.W.1    Lynch, M.2    Martin, J.3    Nelson, J.4    Dickson, G.R.5    Crockard, A.D.6
  • 345
    • 0023199060 scopus 로고
    • Proliferation, hormonal responsiveness and estrogen receptor content of mcf-7 human breast cancer cells grown in the shortterm and long-term absence of estrogens
    • Katzenellenbogen BS, Kendra KL, Norman MJ, Berthois Y 1987 Proliferation, hormonal responsiveness and estrogen receptor content of MCF-7 human breast cancer cells grown in the shortterm and long-term absence of estrogens. Cancer Res 47:4355
    • (1987) Cancer Res , vol.47 , pp. 4355
    • Katzenellenbogen, B.S.1    Kendra, K.L.2    Norman, M.J.3    Berthois, Y.4
  • 346
    • 0023606475 scopus 로고
    • Adaptation of estrogen-dependent mcf-7 cells to low estrogen (Phenol red-free) culture
    • Welshons WV, Jordan VC 1987 Adaptation of estrogen-dependent MCF-7 cells to low estrogen (phenol red-free) culture. Eur J Cancer Clin Oncol 23:1935
    • (1987) Eur J Cancer Clin Oncol , vol.23 , pp. 1935
    • Welshons, W.V.1    Jordan, V.C.2
  • 348
    • 0024329938 scopus 로고
    • Enhanced growth of an estrogen receptor negative endometrial adenocarcinoma by estradiol in athymic mice
    • Friedl A, Gottardis MM, Pink J, Buchler DA, Jordan VC 1989 Enhanced growth of an estrogen receptor negative endometrial adenocarcinoma by estradiol in athymic mice. Cancer Res 49:4758
    • (1989) Cancer Res , vol.49 , pp. 4758
    • Friedl, A.1    Gottardis, M.M.2    Pink, J.3    Buchler, D.A.4    Jordan, V.C.5
  • 349
    • 0023679753 scopus 로고
    • Interaction of phenol red with estrogenic and antiestrogenic action on growth of human breast cancer cells zr-75-1 and t47d
    • Glover JF, Irwin JT, Darbre PD 1988 Interaction of phenol red with estrogenic and antiestrogenic action on growth of human breast cancer cells ZR-75-1 and T47D. Cancer Res 48:3693
    • (1988) Cancer Res , vol.48 , pp. 3693
    • Glover, J.F.1    Irwin, J.T.2    Darbre, P.D.3
  • 350
    • 0023805317 scopus 로고
    • Oestrogen regulates oestrogen receptor mrna levels in an oestrogen responsive human breast cancer cell line
    • Westley BR, May FEB 1988 Oestrogen regulates oestrogen receptor mRNA levels in an oestrogen responsive human breast cancer cell line. Biochem Biophys Res Commun 155:1113
    • (1988) Biochem Biophys Res Commun , vol.155 , pp. 1113
    • Westley, B.R.1    May, F.2
  • 351
    • 0023176345 scopus 로고
    • Epidermal growth factor partially reverses the growth inhibitory effects of antioestrogens on t47d human breast cancer cell growth
    • Koga M, Sutherland RL 1987 Epidermal growth factor partially reverses the growth inhibitory effects of antioestrogens on T47D human breast cancer cell growth. Biochem Biophys Res Commun 146:739
    • (1987) Biochem Biophys Res Commun , vol.146 , pp. 739
    • Koga, M.1    Sutherland, R.L.2
  • 352
    • 0024597190 scopus 로고
    • Modulation of the growth inhibitory effects of progestins and the antiestrogen hy-droxyclomiphene on human breast cancer cells by epidermal growth factor and insulin
    • Koga M, Musgrove EA, Sutherland RL 1989 Modulation of the growth inhibitory effects of progestins and the antiestrogen hy-droxyclomiphene on human breast cancer cells by epidermal growth factor and insulin. Cancer Res 49:112
    • (1989) Cancer Res , vol.49 , pp. 112
    • Koga, M.1    Musgrove, E.A.2    Sutherland, R.L.3
  • 353
    • 0024582602 scopus 로고
    • The paracrine stimulation of mcf-7 cells by mda-mb-231 cells: Possible role in antiestrogen failure
    • Robinson SP, Jordan VC 1989 The paracrine stimulation of MCF-7 cells by MDA-MB-231 cells: possible role in antiestrogen failure. Eur J Cancer Clin Oncol 25:493
    • (1989) Eur J Cancer Clin Oncol , vol.25 , pp. 493
    • Robinson, S.P.1    Jordan, V.C.2
  • 354
    • 0007444568 scopus 로고
    • Palliation by castration or by hormone administration
    • Stoll BA (ed) W. Heinemann Medical Books, London
    • Stoll BA 1977 Palliation by castration or by hormone administration. In: Breast Cancer Management Early and Late. Stoll BA (ed) W. Heinemann Medical Books, London, pp 133-146
    • (1977) Breast Cancer Management Early and Late , pp. 133-146
    • Stoll, B.A.1
  • 355
    • 0019237077 scopus 로고
    • Serum concentrations of tamoxifen and major metabolites during longterm nolvadex therapy, correlated with clinical response
    • In Mouridsen HT, Palshoff T (eds) Breast Cancer—Experimental and Clinical Aspects, Pergamon Press, Oxford
    • Patterson JS, Settatree RS, Adam AK, Kemp JV 1980 Serum concentrations of tamoxifen and major metabolites during longterm Nolvadex therapy, correlated with clinical response. In Mouridsen HT, Palshoff T (eds) Breast Cancer—Experimental and Clinical Aspects, Pergamon Press, Oxford, pp 89-92
    • (1980) Breast Cancer—Experimental and Clinical Aspects , pp. 89-92
    • Patterson, J.S.1    Settatree, R.S.2    Adam, A.K.3    Kemp, J.V.4
  • 356
    • 0020402019 scopus 로고
    • Metabolites of tamoxifen in animals and man: Identification, pharmacology and significance
    • Jordan VC 1982 Metabolites of tamoxifen in animals and man: identification, pharmacology and significance. Breast Cancer Res Treat 2:123
    • (1982) Breast Cancer Res Treat , vol.2 , pp. 123
    • Jordan, V.C.1
  • 357
    • 0024316533 scopus 로고
    • Differential ability of antiestrogens to stimulate breast cancer cell (Mcf-7) growth
    • Gottardis MM, Wagner RJ, Borden EC, Jordan VC 1989 Differential ability of antiestrogens to stimulate breast cancer cell (MCF-7) growth in vivo and in vitro. Cancer Res 49:4765
    • (1989) Cancer Res , vol.49 , pp. 4765
    • Gottardis, M.M.1    Wagner, R.J.2    Borden, E.C.3    Jordan, V.C.4
  • 358
    • 0020566189 scopus 로고
    • Identification and biological activity of tamoxifen metabolites in human serum
    • Kemp JV, Adam HK, Wakeling AE, Slater R 1983 Identification and biological activity of tamoxifen metabolites in human serum. Biochem Pharmacol 32:2045
    • (1983) Biochem Pharmacol , vol.32 , pp. 2045
    • Kemp, J.V.1    Adam, H.K.2    Wakeling, A.E.3    Slater, R.4
  • 359
    • 0020691322 scopus 로고
    • Determination and pharmacology of a new hydroxylated metabolite of tamoxifen observed in patient sera during therapy for advanced breast cancer
    • Jordan VC, Bain RR, Brown RR, Gosden B, Santos MA 1983 Determination and pharmacology of a new hydroxylated metabolite of tamoxifen observed in patient sera during therapy for advanced breast cancer. Cancer Res 43:1446
    • (1983) Cancer Res , vol.43 , pp. 1446
    • Jordan, V.C.1    Bain, R.R.2    Brown, R.R.3    Gosden, B.4    Santos, M.A.5
  • 361
    • 0023922814 scopus 로고
    • Identification of 4-hydroxy iv-desmethyltamoxifen as a metabolite in human bile
    • Lien EA, Solheim E, Kvinnsland S, Veland PM 1988 Identification of 4-hydroxy IV-desmethyltamoxifen as a metabolite in human bile. Cancer Res 48:2304
    • (1988) Cancer Res , vol.48 , pp. 2304
    • Lien, E.A.1    Solheim, E.2    Kvinnsland, S.3    Veland, P.M.4
  • 362
    • 0024584001 scopus 로고
    • Distribution of 4-hydroxy-iv-desmethyl tamoxifen and other tamoxifen metabolites in human biological fluids during tamoxifen treatment
    • Lien EA, Solheim E, Lea OA, Lundgren S, Krinnsland S, Ueland PM 1989 Distribution of 4-hydroxy-IV-desmethyl tamoxifen and other tamoxifen metabolites in human biological fluids during tamoxifen treatment. Cancer Res 49:2175
    • (1989) Cancer Res , vol.49 , pp. 2175
    • Lien, E.A.1    Solheim, E.2    Lea, O.A.3    Lundgren, S.4    Krinnsland, S.5    Ueland, P.M.6
  • 363
    • 0024836272 scopus 로고
    • Implications of tamoxifen metabolism in the athymic mouse for the study of antitumor effects upon human breast cancer xenografts
    • Robinson SP, Langan-Fahey SM, Jordan VC 1989 Implications of tamoxifen metabolism in the athymic mouse for the study of antitumor effects upon human breast cancer xenografts. Eur J Cancer Clin Oncol 25:1769
    • (1989) Eur J Cancer Clin Oncol , vol.25 , pp. 1769
    • Robinson, S.P.1    Langan-Fahey, S.M.2    Jordan, V.C.3
  • 364
    • 0015763703 scopus 로고
    • The metabolism of tamoxifen (Ici 46,474) part i in laboratory animals
    • Fromson JM, Pearson S, Bramah S 1973 The metabolism of tamoxifen (ICI 46,474) Part I in laboratory animals. Xenobiotica 3:693
    • (1973) Xenobiotica , vol.3 , pp. 693
    • Fromson, J.M.1    Pearson, S.2    Bramah, S.3
  • 365
    • 0023259551 scopus 로고
    • Analysis of tamoxifen and its metabolites in human plasma by gas chromatography-mass spectrometry (Gc-ms) using selected ion monitoring (sim)
    • Murphy C, Fotsis T, Pantzar P, Aldercreutz H, Martin F 1987 Analysis of tamoxifen and its metabolites in human plasma by gas chromatography-mass spectrometry (GC-MS) using selected ion monitoring (SIM). J Steroid Biochem 26:547
    • (1987) J Steroid Biochem , vol.26 , pp. 547
    • Murphy, C.1    Fotsis, T.2    Pantzar, P.3    Aldercreutz, H.4    Martin, F.5
  • 366
    • 0023263237 scopus 로고
    • Species specific pharmacology of antiestrogens: Role of metabolism
    • Jordan VC, Robinson SP 1987 Species specific pharmacology of antiestrogens: role of metabolism. Fed Proc 46:1870
    • (1987) Fed Proc , vol.46 , pp. 1870
    • Jordan, V.C.1    Robinson, S.P.2
  • 367
    • 0021889085 scopus 로고
    • Metabolism of tamoxifen and its uterotrophic activity
    • Lyman SD, Jordan VC 1985 Metabolism of tamoxifen and its uterotrophic activity. Biochem Pharmacol 34:2787
    • (1985) Biochem Pharmacol , vol.34 , pp. 2787
    • Lyman, S.D.1    Jordan, V.C.2
  • 369
    • 0018662275 scopus 로고
    • Determination of tamoxifen and an hydroxylated metabolite in plasma from patients with advanced breast cancer
    • Daniel CP, Gaskell SJ, Bishop H, Nicholson RI 1979 Determination of tamoxifen and an hydroxylated metabolite in plasma from patients with advanced breast cancer. J Endocrinol 83:401
    • (1979) J Endocrinol , vol.83 , pp. 401
    • Daniel, C.P.1    Gaskell, S.J.2    Bishop, H.3    Nicholson, R.I.4
  • 370
    • 0018905434 scopus 로고
    • Measurement of tamoxifen in serum by thin layer densitometry
    • Adam HK, Gay MA, Moore RH 1980 Measurement of tamoxifen in serum by thin layer densitometry. J Endocrinol 84:35
    • (1980) J Endocrinol , vol.84 , pp. 35
    • Adam, H.K.1    Gay, M.A.2    Moore, R.H.3
  • 371
    • 0020960714 scopus 로고
    • High performance liquid chromatographic analysis of tamoxifen and major metabolites in human plasma
    • Camaggi CM, Strocchi E, Canova N 1983 High performance liquid chromatographic analysis of tamoxifen and major metabolites in human plasma. J Chromatogr 275:436
    • (1983) J Chromatogr , vol.275 , pp. 436
    • Camaggi, C.M.1    Strocchi, E.2    Canova, N.3
  • 372
    • 0022355562 scopus 로고
    • Quantitation of tamoxifen, 4-hydroxytamoxifen and iv-desmethyltamoxifen in human plasma by high performance liquid chromatography
    • Wilbur BJ, Benz CC, DeGregorio MW 1985 Quantitation of tamoxifen, 4-hydroxytamoxifen and IV-desmethyltamoxifen in human plasma by high performance liquid chromatography. Anal Lett 18:1915
    • (1985) Anal Lett , vol.18 , pp. 1915
    • Wilbur, B.J.1    Benz, C.C.2    DeGregorio, M.W.3
  • 374
    • 0023662670 scopus 로고
    • Quantitation of tamoxifen and iv-desmethyltamoxifen in human plasma by high-performance liquid chromatography, photochemical reaction and fluorescence detection and its application to biopharmaceutic investigations
    • Nieder M, Jaeger H 1987 Quantitation of tamoxifen and IV-desmethyltamoxifen in human plasma by high-performance liquid chromatography, photochemical reaction and fluorescence detection and its application to biopharmaceutic investigations. J Chromatogr 413:207
    • (1987) J Chromatogr , vol.413 , pp. 207
    • Nieder, M.1    Jaeger, H.2
  • 375
    • 0023608330 scopus 로고
    • Determination of tamoxifen and four metabolites in serum by low-disper-sion liquid chromatography
    • Lein EA, Ueland PM, Solheim E, Kvinnsland S 1987 Determination of tamoxifen and four metabolites in serum by low-disper-sion liquid chromatography. Clin Chem 33:1608
    • (1987) Clin Chem , vol.33 , pp. 1608
    • Lein, E.A.1    Ueland, P.M.2    Solheim, E.3    Kvinnsland, S.4
  • 376
    • 85003065693 scopus 로고
    • Metabolites in patients on long term adjuvant therapy for breast cancer
    • in press
    • Langan-Fahey SM, Tormey DC, Jordan VC, Tamoxifen metabolites in patients on long term adjuvant therapy for breast cancer. Eur J Cancer, in press
    • (1986) Eur j cancer
    • Langan-Fahey, S.M.1    Tormey, D.C.2    Jordan, V.C.3
  • 377
    • 0020676409 scopus 로고
    • Determination of tamoxifen and metabolites in human serum by high performance liquid chromatography with post column fluorescence activation
    • Brown RR, Bain RR, Jordan VC 1983 Determination of tamoxifen and metabolites in human serum by high performance liquid chromatography with post column fluorescence activation. J Chromatogr 272:351
    • (1983) J Chromatogr , vol.272 , pp. 351
    • Brown, R.R.1    Bain, R.R.2    Jordan, V.C.3
  • 378
    • 0024493595 scopus 로고
    • Long-term adjuvant tamoxifen therapy
    • In: DeVita VT, Heilman S, Rosenberg SA(eds), LB Lippincott, Philadelphia
    • Jordan VC 1989 Long-term adjuvant tamoxifen therapy. In: DeVita VT, Heilman S, Rosenberg SA (eds) Important Advances in Oncology, LB Lippincott, Philadelphia, pp 179-192
    • (1989) Important Advances in Oncology , pp. 179-192
    • Jordan, V.C.1
  • 379
    • 0025043542 scopus 로고
    • Long-term adjuvant tamoxifen therapy for breast cancer
    • Jordan VC 1990 Long-term adjuvant tamoxifen therapy for breast cancer. Breast Cancer Res Treat 15:125
    • (1990) Breast Cancer Res Treat , vol.15 , pp. 125
    • Jordan, V.C.1
  • 380
    • 0018140486 scopus 로고
    • A comparison of the effects of clomiphene and tamoxifen treatment on the concentration of oestradiol and progesterone in the peripheral plasma of infertile women
    • Senior BE, Cawood ML, Oakey RE, McKiddie M, Siddle DR 1978 A comparison of the effects of clomiphene and tamoxifen treatment on the concentration of oestradiol and progesterone in the peripheral plasma of infertile women. Clin Endocrinol 8:381
    • (1978) Clin Endocrinol , vol.8 , pp. 381
    • Senior, B.E.1    Cawood, M.L.2    Oakey, R.E.3    McKiddie, M.4    Siddle, D.R.5
  • 381
    • 0018759577 scopus 로고
    • Endocrine consequences of continuous antiestrogen therapy with tamoxifen in premenopausal women
    • Sherman BM, Chapler FK, Crickard K, Wycoff D 1979 Endocrine consequences of continuous antiestrogen therapy with tamoxifen in premenopausal women. J Clin Invest 64:398
    • (1979) J Clin Invest , vol.64 , pp. 398
    • Sherman, B.M.1    Chapler, F.K.2    Crickard, K.3    Wycoff, D.4
  • 382
    • 0018957499 scopus 로고
    • Effects of adjuvant chemohormonal therapy on the ovarian and adrenal function of breast cancer patients
    • Rose DP, Davis TE 1980 Effects of adjuvant chemohormonal therapy on the ovarian and adrenal function of breast cancer patients. Cancer Res 40:4043
    • (1980) Cancer Res , vol.40 , pp. 4043
    • Rose, D.P.1    Davis, T.E.2
  • 383
    • 0019170370 scopus 로고
    • Antiestrogen-induced remission in premenopausal women with stage iv breast cancer: Effects on ovarian function
    • Manni A, Pearson OH 1980 Antiestrogen-induced remission in premenopausal women with stage IV breast cancer: effects on ovarian function. Cancer Treat Rep 64:779
    • (1980) Cancer Treat Rep , vol.64 , pp. 779
    • Manni, A.1    Pearson, O.H.2
  • 384
    • 0020607846 scopus 로고
    • Endocrine profiles in tamoxifen-induced ovulatory cycles
    • Tajima C, Fukushima T 1983 Endocrine profiles in tamoxifen-induced ovulatory cycles. Fertil Steril 40:23
    • (1983) Fertil Steril , vol.40 , pp. 23
    • Tajima, C.1    Fukushima, T.2
  • 387
    • 0023146033 scopus 로고
    • Endocrine effects of adjuvant chemotherapy and long-term tamoxifen administration on node positive patients with breast cancer
    • Jordan VC, Fritz NF, Tormey DC 1987 Endocrine effects of adjuvant chemotherapy and long-term tamoxifen administration on node positive patients with breast cancer. Cancer Res 47:624
    • (1987) Cancer Res , vol.47 , pp. 624
    • Jordan, V.C.1    Fritz, N.F.2    Tormey, D.C.3
  • 388
    • 0023949587 scopus 로고
    • Endocrine status of premenopausal node positive breast cancer patients following adjuvant chemotherapy and long-term tamoxifen
    • Ravdin PM, Fritz NF, Tormey DC, Jordan VC 1988 Endocrine status of premenopausal node positive breast cancer patients following adjuvant chemotherapy and long-term tamoxifen. Cancer Res 48:1026
    • (1988) Cancer Res , vol.48 , pp. 1026
    • Ravdin, P.M.1    Fritz, N.F.2    Tormey, D.C.3    Jordan, V.C.4
  • 389
    • 0015228433 scopus 로고
    • New synthetic agent for the induction of ovulation: Preliminary trial in women
    • Klopper A, Hall M 1971 New synthetic agent for the induction of ovulation: preliminary trial in women. Br Med J i:152
    • (1971) Br Med J I , pp. 152
    • Klopper, A.1    Hall, M.2
  • 393
    • 0024819780 scopus 로고
    • Combined endocrine effects of lh-rh agonist (Zoladex®) and tamoxifen (nolvadex
    • Robertson JFR, Walker KJ, Nicholson RI, Blarney RW 1989 Combined endocrine effects of LH-RH agonist (Zoladex®) and tamoxifen (Nolvadex®) therapy in premenopausal women with breast cancer. Br J Surg 76:1262
    • (1989) Br J Surg , vol.76 , pp. 1262
    • Robertson, J.1    Walker, K.J.2    Nicholson, R.I.3    Blarney, R.W.4
  • 394
    • 0014053604 scopus 로고
    • A new derivative of triphenylethylene: Effect on implantation and mode of action in rats
    • Harper MJK, Walpole AL 1967 A new derivative of triphenylethylene: effect on implantation and mode of action in rats. J Reprod Fertil 13:101
    • (1967) J Reprod Fertil , vol.13 , pp. 101
    • Harper, M.1    Walpole, A.L.2
  • 395
    • 0014039539 scopus 로고
    • Mode of action of ici 46,474 in preventing implantation in rats
    • Harper MJK, Walpole AL 1967 Mode of action of ICI 46,474 in preventing implantation in rats. J Endocrinol 37:83
    • (1967) J Endocrinol , vol.37 , pp. 83
    • Harper, M.1    Walpole, A.L.2
  • 396
    • 0014847041 scopus 로고
    • Role of estrogen in ovulation. A study using the estrogen antagonist ici 46,474
    • Labhsetwar AP 1970 Role of estrogen in ovulation. A study using the estrogen antagonist ICI 46,474. Endocrinology 87:542
    • (1970) Endocrinology , vol.87 , pp. 542
    • Labhsetwar, A.P.1
  • 397
    • 0015136407 scopus 로고
    • Antiestrogenic and antifertility compounds 4:L,l,2-triarylalkan-l-ols and 1,1,2-triar-ylalk-l-enes containing basic ether group
    • Collins DJ, Hobbs JJ, Emmens CW 1971 Antiestrogenic and antifertility compounds 4:l,l,2-triarylalkan-l-ols and 1,1,2-triar-ylalk-l-enes containing basic ether group. J Med Chem 14:952
    • (1971) J Med Chem , vol.14 , pp. 952
    • Collins, D.J.1    Hobbs, J.J.2    Emmens, C.W.3
  • 398
    • 0024834980 scopus 로고
    • A controlled study of the ocular effects of tamoxifen in conventional dosage in the treatment of breast carcinoma
    • Longstaff S, Sigurdson H, O’Keefe M, Ogston S, Preece P 1989 A controlled study of the ocular effects of tamoxifen in conventional dosage in the treatment of breast carcinoma. Eur J Cancer Clin Oncol 25:1805
    • (1989) Eur J Cancer Clin Oncol , vol.25 , pp. 1805
    • Longstaff, S.1    Sigurdson, H.2    O’Keefe, M.3    Ogston, S.4    Preece, P.5
  • 400
    • 0023430358 scopus 로고
    • Tamoxifen prevents the skeletal effects of ovarian hormone deficiency in rats
    • Turner RT, Wakley GK, Hannon KS, Bell NA 1987 Tamoxifen prevents the skeletal effects of ovarian hormone deficiency in rats. J Bone Min Res 2:449
    • (1987) J Bone Min Res , vol.2 , pp. 449
    • Turner, R.T.1    Wakley, G.K.2    Hannon, K.S.3    Bell, N.A.4
  • 401
    • 0023547257 scopus 로고
    • Effect of antiestrogens on bone in castrated and intact female rats
    • Jordan VC, Phelps E, Lingren JU 1987 Effect of antiestrogens on bone in castrated and intact female rats. Breast Cancer Res Treat 10:31
    • (1987) Breast Cancer Res Treat , vol.10 , pp. 31
    • Jordan, V.C.1    Phelps, E.2    Lingren, J.U.3
  • 402
    • 0023930991 scopus 로고
    • Tamoxifen inhibits osteoclast mediated resorption of trabecular bone in ovarian hormone deficient rats
    • Turner RT, Wakley GK, Hannon KS, Bell NA 1988 Tamoxifen inhibits osteoclast mediated resorption of trabecular bone in ovarian hormone deficient rats. Endocrinology 122:1146
    • (1988) Endocrinology , vol.122 , pp. 1146
    • Turner, R.T.1    Wakley, G.K.2    Hannon, K.S.3    Bell, N.A.4
  • 403
    • 0024263371 scopus 로고
    • The effects of tamoxifen on the osteopenia induced by sciatce neurotomy in the rat: A histomorphometric study
    • Wakley GK, Hannon KS, Bell NA, Turner RT 1988 The effects of tamoxifen on the osteopenia induced by sciatce neurotomy in the rat: a histomorphometric study. Calcif Tissue Int 43:883
    • (1988) Calcif Tissue Int , vol.43 , pp. 883
    • Wakley, G.K.1    Hannon, K.S.2    Bell, N.A.3    Turner, R.T.4
  • 405
    • 0017152984 scopus 로고
    • Tamoxifen as an antitumour agent: Effect on oestrogen binding
    • Jordan VC, Dowse LJ 1976 Tamoxifen as an antitumour agent: effect on oestrogen binding. J Endocrinol 68:297
    • (1976) J Endocrinol , vol.68 , pp. 297
    • Jordan, V.C.1    Dowse, L.J.2
  • 406
    • 0017068218 scopus 로고
    • Tamoxifen as an antitumour agent: Role of oestradiol and prolactin
    • Jordan VC, Koerner S 1976 Tamoxifen as an antitumour agent: role of oestradiol and prolactin. J Endocrinol 68:305
    • (1976) J Endocrinol , vol.68 , pp. 305
    • Jordan, V.C.1    Koerner, S.2
  • 407
    • 0017098034 scopus 로고
    • Tamoxifen as an antitumour agent: Oestrogen binding as a predictive test for tumour response
    • Jordan VC, Jaspan T 1976 Tamoxifen as an antitumour agent: oestrogen binding as a predictive test for tumour response. J Endocrinol 68:453
    • (1976) J Endocrinol , vol.68 , pp. 453
    • Jordan, V.C.1    Jaspan, T.2
  • 410
    • 0024374726 scopus 로고
    • Bone mineral content of women receiving tamoxifen for mastalgia
    • Fentiman IS, Caleffi M, Rodin A 1989 Bone mineral content of women receiving tamoxifen for mastalgia. Br J Cancer 60:262
    • (1989) Br J Cancer , vol.60 , pp. 262
    • Fentiman, I.S.1    Caleffi, M.2    Rodin, A.3
  • 412
    • 0025291890 scopus 로고
    • Long-term adjuvant tamoxifen in early breast cancer: Effect on bone mineral density in postmenopausal women
    • Fornander T, Rutqvist LE, Sjöberg HE, Blomqvist L, Mattsson A, Glas U 1990 Long-term adjuvant tamoxifen in early breast cancer: effect on bone mineral density in postmenopausal women. J Clin Oncol 8:1019
    • (1990) J Clin Oncol , vol.8 , pp. 1019
    • Fornander, T.1    Rutqvist, L.E.2    Sjöberg, H.E.3    Blomqvist, L.4    Mattsson, A.5    Glas, U.6
  • 413
    • 0021238933 scopus 로고
    • Serum lipoproteins after breast cancer surgery and effects of tamoxifen
    • Rossner S, Wallgren A 1984 Serum lipoproteins after breast cancer surgery and effects of tamoxifen. Atherosclerosis 53:339
    • (1984) Atherosclerosis , vol.53 , pp. 339
    • Rossner, S.1    Wallgren, A.2
  • 416
    • 0023803515 scopus 로고
    • Effect of tamoxifen on oestrogen binding, lipid and lipoprotein concentrations and blood clotting parameters in premenopausal women with breast pain
    • Caleffi M, Fentiman IS, Clark GM, Wang DY, Needham J, Clark K, LaVille A, Lewis B 1988 Effect of tamoxifen on oestrogen binding, lipid and lipoprotein concentrations and blood clotting parameters in premenopausal women with breast pain. J Endocrinol 119:335
    • (1988) J Endocrinol , vol.119 , pp. 335
    • Caleffi, M.1    Fentiman, I.S.2    Clark, G.M.3    Wang, D.Y.4    Needham, J.5    Clark, K.6    LaVille, A.7    Lewis, B.8
  • 417
    • 0025343030 scopus 로고
    • Effect of tamoxifen treatment on plasma lipids and lipoproteins lipid composition
    • Bagdade JD, Wolter J, Subbaiah PV, Ryan W 1990 Effect of tamoxifen treatment on plasma lipids and lipoproteins lipid composition. J Clin Endocrinol Metab 70:1132
    • (1990) J Clin Endocrinol Metab , vol.70 , pp. 1132
    • Bagdade, J.D.1    Wolter, J.2    Subbaiah, P.3    Ryan, W.4
  • 418
    • 0025324359 scopus 로고
    • Lipid and lipoprotein effects of tamoxifen therapy in postmenopausal patients with node negative breast cancer
    • Love RR, Newcomb PA, Wiebe DA, Surawicz TS, Jordan VC, Carbone PP, DeMets DL 1990 Lipid and lipoprotein effects of tamoxifen therapy in postmenopausal patients with node negative breast cancer. JNCI 82:1327
    • (1990) JNCI , vol.82 , pp. 1327
    • Love, R.R.1    Newcomb, P.A.2    Wiebe, D.A.3    Surawicz, T.S.4    Jordan, V.C.5    Carbone, P.P.6    DeMets, D.L.7
  • 420
    • 0019319147 scopus 로고
    • Tamoxifen and thromboembolism
    • Hendrick A, Subraminian V 1980 Tamoxifen and thromboembolism. JAMA 243:514
    • (1980) JAMA , vol.243 , pp. 514
    • Hendrick, A.1    Subraminian, V.2
  • 421
    • 0021269031 scopus 로고
    • Venous thrombosis as a side effect of tamoxifen treatment
    • Lipton A, Harvey HA, Hamilton RW 1984 Venous thrombosis as a side effect of tamoxifen treatment. Cancer Treat Rep 68:887
    • (1984) Cancer Treat Rep , vol.68 , pp. 887
    • Lipton, A.1    Harvey, H.A.2    Hamilton, R.W.3
  • 422
    • 0021255302 scopus 로고
    • Tamoxifen treatment of metastatic breast cancer and antithrombin iii levels
    • Enck RE, Rios CN 1984 Tamoxifen treatment of metastatic breast cancer and antithrombin III levels. Cancer 53:2607
    • (1984) Cancer , vol.53 , pp. 2607
    • Enck, R.E.1    Rios, C.N.2
  • 423
    • 0019413049 scopus 로고
    • Oestrogen-like effects of tamoxifen on the concentration of proteins in plasma
    • Fex G, Adielson G, Mattson W 1981 Oestrogen-like effects of tamoxifen on the concentration of proteins in plasma. Acta Endocrinol (Copenh) 97:109
    • (1981) Acta Endocrinol (Copenh) , vol.97 , pp. 109
    • Fex, G.1    Adielson, G.2    Mattson, W.3
  • 424
    • 0019852254 scopus 로고
    • Oestrogen-like action of tamoxifen on vaginal epithelium in breast cancer patients
    • Boccardo F, Buzzi L, Ruboyotti A, Nicolo G, Rosso R 1981 Oestrogen-like action of tamoxifen on vaginal epithelium in breast cancer patients. Oncology 38:281
    • (1981) Oncology , vol.38 , pp. 281
    • Boccardo, F.1    Buzzi, L.2    Ruboyotti, A.3    Nicolo, G.4    Rosso, R.5
  • 425
    • 0016424339 scopus 로고
    • Prolonged antioestrogen activity of ici 46,474 in the ovariectomy mouse
    • Jordan VC 1975 Prolonged antioestrogen activity of ICI 46,474 in the ovariectomy mouse. J Reprod Fertil 52:251
    • (1975) J Reprod Fertil , vol.52 , pp. 251
    • Jordan, V.C.1
  • 427
    • 0024561852 scopus 로고
    • Tamoxifen and the uterus and endometrium
    • Stewart HJ, Knight GM 1989 Tamoxifen and the uterus and endometrium. Lancet 1:375
    • (1989) Lancet , vol.1 , pp. 375
    • Stewart, H.J.1    Knight, G.M.2
  • 428
    • 0019205022 scopus 로고
    • Treatment of advanced endometrial adenocarcinoma with tamoxifen
    • Swenerton KD 1980 Treatment of advanced endometrial adenocarcinoma with tamoxifen. Cancer Treat Rep 64:805
    • (1980) Cancer Treat Rep , vol.64 , pp. 805
    • Swenerton, K.D.1
  • 429
    • 0023915865 scopus 로고
    • Contrasting actions of tamoxifen on endometrial and breast tumor growth in the athymic mouse
    • Gottardis MM, Robinson SP, Satyaswaroop PG, Jordan VC 1988 Contrasting actions of tamoxifen on endometrial and breast tumor growth in the athymic mouse. Cancer Res 48:812
    • (1988) Cancer Res , vol.48 , pp. 812
    • Gottardis, M.M.1    Robinson, S.P.2    Satyaswaroop, P.G.3    Jordan, V.C.4
  • 430
    • 0021960977 scopus 로고
    • Endometrial adenocarcinoma in breast cancer patients receiving tamoxifen
    • Killackey MA, Hakes TB, Pierce VK 1985 Endometrial adenocarcinoma in breast cancer patients receiving tamoxifen. Cancer Treat Rep 69:237
    • (1985) Cancer Treat Rep , vol.69 , pp. 237
    • Killackey, M.A.1    Hakes, T.B.2    Pierce, V.K.3
  • 431
    • 0024259680 scopus 로고
    • Pelvic irradiation and tamoxifen as risk factors for carcinoma of corpus uteri
    • Hardell L 1988 Pelvic irradiation and tamoxifen as risk factors for carcinoma of corpus uteri. Lancet 2:1432
    • (1988) Lancet , vol.2 , pp. 1432
    • Hardell, L.1
  • 432
    • 0023719255 scopus 로고
    • Tamoxifen as risk factor for carcinoma of corpus uteri
    • Hardell L 1988 Tamoxifen as risk factor for carcinoma of corpus uteri. Lancet 2:563
    • (1988) Lancet , vol.2 , pp. 563
    • Hardell, L.1
  • 433
    • 0020601449 scopus 로고
    • Breast cancer in young women and use of oral contraceptives: Possible modifying effect of formulation and age at use
    • Pike MC, Henderson BE, Krailo MD, Duke A, Roy S 1983 Breast cancer in young women and use of oral contraceptives: possible modifying effect of formulation and age at use. Lancet 1:926
    • (1983) Lancet , vol.1 , pp. 926
    • Pike, M.C.1    Henderson, B.E.2    Krailo, M.D.3    Duke, A.4    Roy, S.5
  • 434
    • 0024358792 scopus 로고
    • The risk of breast cancer after estrogen and estrogen-progestin replacement
    • Bergkvist L, Adami H, Persson I, Hoover R, Schairer C 1989 The risk of breast cancer after estrogen and estrogen-progestin replacement. N Engl J Med 321:293
    • (1989) N Engl J Med , vol.321 , pp. 293
    • Bergkvist, L.1    Adami, H.2    Persson, I.3    Hoover, R.4    Schairer, C.5
  • 435
    • 0023132778 scopus 로고
    • Oral contraceptives and breast cancer
    • Longman SM, Buehring GC 1987 Oral contraceptives and breast cancer, in vitro effect of contraceptive steroids on human mammary cell growth. Cancer 59:281
    • (1987) Cancer , vol.59 , pp. 281
    • Longman, S.M.1    Buehring, G.C.2
  • 436
    • 0023212905 scopus 로고
    • Progestin effects on growth in the human breast cancer cell line t47d. Possible therapeutic implications
    • Hissom JR, Moore MR 1987 Progestin effects on growth in the human breast cancer cell line T47D. Possible therapeutic implications. Biochem Biophys Res Commun 45:706
    • (1987) Biochem Biophys Res Commun , vol.45 , pp. 706
    • Hissom, J.R.1    Moore, M.R.2
  • 437
    • 0018741430 scopus 로고
    • Therapeutic effect of tamoxifen versus tamoxifen combined with medroxy progesterone acetate in advanced breast cancer in postmenopausal women
    • Mouridsen HT, Elleman K, Mattsson W 1979 Therapeutic effect of tamoxifen versus tamoxifen combined with medroxy progesterone acetate in advanced breast cancer in postmenopausal women. Cancer Treat Rep 63:171
    • (1979) Cancer Treat Rep , vol.63 , pp. 171
    • Mouridsen, H.T.1    Elleman, K.2    Mattsson, W.3
  • 438
    • 0018941624 scopus 로고
    • Oral contraceptive steroids as promoters of hepatocarcinogenesis in female sprague dawley rats
    • Yager JD, Yager R 1980 Oral contraceptive steroids as promoters of hepatocarcinogenesis in female Sprague Dawley rats. Cancer Res 40:3680
    • (1980) Cancer Res , vol.40 , pp. 3680
    • Yager, J.D.1    Yager, R.2
  • 439
    • 0025334463 scopus 로고
    • A phase ii trial of tamoxifen in hepatocellular carcinoma
    • Engstrom PF, Levin B, Moertel CG, Schutt A 1990 A phase II trial of tamoxifen in hepatocellular carcinoma. Cancer 65:2641
    • (1990) Cancer , vol.65 , pp. 2641
    • Engstrom, P.F.1    Levin, B.2    Moertel, C.G.3    Schutt, A.4
  • 441
    • 0023640816 scopus 로고
    • Tamoxifen and benign breast problems
    • Fentiman IS, Powles TJ 1987 Tamoxifen and benign breast problems. Lancet 2:1070
    • (1987) Lancet , vol.2 , pp. 1070
    • Fentiman, I.S.1    Powles, T.J.2
  • 442
    • 0025133996 scopus 로고
    • Prospect for antiestrogen chemoprevention of breast cancer
    • Love RR 1990 Prospect for antiestrogen chemoprevention of breast cancer. J Natl Cancer Inst 90:18
    • (1990) J Natl Cancer Inst , vol.90 , pp. 18
    • Love, R.R.1
  • 443
    • 84965826780 scopus 로고
    • Hormonal pathogenesis of adenocarcinoma of the breast
    • Lacassagne A 1936 Hormonal pathogenesis of adenocarcinoma of the breast. Am J Cancer 27:217
    • (1936) Am J Cancer , vol.27 , pp. 217
    • Lacassagne, A.1
  • 445
    • 0022729999 scopus 로고
    • Postmenopausal estrogens in prevention of osteoporosis
    • Hillner BE, Hollenberg JP, Pauker SG 1986 Postmenopausal estrogens in prevention of osteoporosis. Am J Med 80:1115
    • (1986) Am J Med , vol.80 , pp. 1115
    • Hillner, B.E.1    Hollenberg, J.P.2    Pauker, S.G.3
  • 446
    • 0022573037 scopus 로고
    • Bone changes occurring spontaneously and caused by oestrogen in early postmenopausal women: A local or genrealized phenomenon
    • Gotfredsen A, Nilas L, Riis BJ, Thomsen K, Christiansen C 1986 Bone changes occurring spontaneously and caused by oestrogen in early postmenopausal women: a local or genrealized phenomenon. Br Med J 292:1098
    • (1986) Br Med J , vol.292 , pp. 1098
    • Gotfredsen, A.1    Nilas, L.2    Riis, B.J.3    Thomsen, K.4    Christiansen, C.5
  • 447
    • 0024852672 scopus 로고
    • Estrogen replacement and cardiovascular disease: Serum lipids and blood pressure effects
    • Hazzard WR 1989 Estrogen replacement and cardiovascular disease: serum lipids and blood pressure effects. Am J Obstet Gynecol 161:1847
    • (1989) Am J Obstet Gynecol , vol.161 , pp. 1847
    • Hazzard, W.R.1
  • 448
    • 0024550043 scopus 로고
    • Postmenopausal estrogen use and heart disease risk factors in the 1980s
    • Barrett-Connor E, Wingard DL, Criqui MH 1989 Postmenopausal estrogen use and heart disease risk factors in the 1980s. JAMA 261:2095
    • (1989) JAMA , vol.261 , pp. 2095
    • Barrett-Connor, E.1    Wingard, D.L.2    Criqui, M.H.3
  • 449
    • 0025307936 scopus 로고
    • Cardiovascular implication of estrogen replacement therapy
    • Lobo RA 1990 Cardiovascular implication of estrogen replacement therapy. Obstet Gynecol 75:185
    • (1990) Obstet Gynecol , vol.75 , pp. 185
    • Lobo, R.A.1
  • 451
    • 0025276754 scopus 로고
    • Node negative breast cancer, tamoxifen and chemosuppression
    • Jordan VC 1990 Node negative breast cancer, tamoxifen and chemosuppression. J Natl Cancer Inst 82:1068
    • (1990) J Natl Cancer Inst , vol.82 , pp. 1068
    • Jordan, V.C.1
  • 452
    • 0025127112 scopus 로고
    • The forgotten group at risk for breast cancer
    • Jordan VC 1990 The forgotten group at risk for breast cancer. J Clin Oncol 8:1445
    • (1990) J Clin Oncol , vol.8 , pp. 1445
    • Jordan, V.C.1
  • 453
    • 0025180859 scopus 로고
    • Prelude to breast cancer prevention with an antiestrogen
    • Jordan VC 1990 Prelude to breast cancer prevention with an antiestrogen. Annal Oncology 1:327
    • (1990) Annal Oncology , vol.1 , pp. 327
    • Jordan, V.C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.