Reduced Drug Accumulation in Multiply Drug-resistant Human KB Carcinoma Cell Lines

Cancer Research

Volumn 45, Issue 7, 1985, Pages 3002-3007

  Fojo, Antonio ^a   Akiyama, Shin Ichi ^a   Gottesman, Michael M ^a   Pastan, Ira ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLCHICINE; DACTINOMYCIN; DAUNORUBICIN; DEXAMETHASONE; RADIOISOTOPE; VERAPAMIL; VINBLASTINE; VINCRISTINE;

CANCER CELL CULTURE; COLCHICINE H 3; DACTINOMYCIN H 3; DAUNORUBICIN H 3; DRUG ACCUMULATION; DRUG RESISTANCE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; VINBLASTINE H 3; VINCRISTINE H 3;

ANTINEOPLASTIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE; HUMAN; KB CELLS; NEOPLASMS; TIME FACTORS; VERAPAMIL;

EID: 0021856764     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Beck, W. T. Vinca alkaloid-resistant phenotype in cultured leukemic lympho-blasts. Cancer Treat. Rep., 67: 875-882, 1983.
2. Beck, W. T., Mueller, T. J., and Tanzer, L. R. Altered surface membrane glycoproteins in vinca alkaloid-resistant human leukemic lymphoblasts. Cancer Res., 39: 2070-2076, 1979.
3. Biedler, J. L., and Riehm, H. Cellular resistance to actinomycin D in Chinese hamster eels in vitro: cross-resistance, radioautographic, and cytogenetic studies. Cancer Res., 30: 1174-1184, 1970.
4. Carlsen, S. A., Ti, J. E., and Ling, V. Modulation of membrane drug permea-bility in Chinese hamster ovary cells. Biochim. Btophys. Acta., 455: 900-912, 1976.
5. Ling, V., and Thompson, L. H. Reduced permeability in Chinese hamster ovary cells as a mechanism of resistance to colchicine. J. Cell Physiol., 83: 103-116, 1973.
6. Riehm, H., and Biedler, J. L. Cellular resistance to daunomycin in Chinese hamster eels in vitro. Cancer Res., 37: 409-412, 1971.
7. See, Y. P., Carlsen, S. A., Ti, J. E., and Ling, V. Increased drug permeability in Chinese hamster ovary eels in the presence of cyanide. Biochim. Btophys. Acta., 373: 242-252, 1974.
8. Siegfried, J. A., Tritton, T. R., and Sartorelli, A. C. Comparison of anthracycline concentrations in S180 eel lines of varying sensitivity. Eur. J. Cancer Clin. Oncol, 79: 1133-1141, 1983.
9. Akiyama, S.-L., Pastan, I., and Gottesman, M. M. Isolation of human eel lines resistant to multiple drugs. J. Cell Biol., 97: 218a, 1983.
10. Bleyer, W. A., Frisby, S. A., and Olivero, V. T. Uptake and Binding of Vincristine by Murine Leukemia Cells. Btochem. Pharmacol., 24: 633-639, 1975.
11. Roninson, I. B., Abelson, H. T., Housman, D. E., Howell, N., and Varshavsky, A. Amplification of specific DNA sequences correlates with multi-drug resistance in Chinese hamster cells. Nature (Lond.), 309: 626-628, 1984.
12. Cabral, F., Sobel, M. E., and Gottesman, M. M. Chinese rtamster ovary mutants resistant to Colchicine, colcemid, or griseofulvin have an altered β-tubulin. Cel, 20: 29-36, 1980.
13. Rogan, A. M., Hamilton, T. C., Young, R. C., Klecker, R. W., and Ozols, R. F. Reversal of adriamycin resistance by verapamil in human ovarian cancer. Science (Wash. DC), 224: 994-996, 1984.
14. Tsuruo, T., Lida, H., Tsukagoshi, S., and Sakurai, Y. Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil. Cancer Res., 47: 1967-1972, 1981.
15. Akiyama, S.-L., Gottesman, M. M., Hanover, J. A., Fitzgerald, D. J. P., Willingham, M. C., and Pastan, I. Verapamil enhances the toxicity of conjugates of epidermal growth factor with Pseudomonas exotoxin and antitransferrin receptor with Pseudomonas exotoxin. J. Ceil Physiol., 120: 271-279, 1984.