메뉴 건너뛰기




Volumn 4, Issue 2, 1997, Pages 130-137

Multiple endocrine neoplasia type 2 and glial cell line-derived neurotrophic factor

Author keywords

[No Author keywords available]

Indexed keywords


EID: 0013596764     PISSN: 10683097     EISSN: None     Source Type: Journal    
DOI: 10.1097/00060793-199704000-00009     Document Type: Article
Times cited : (7)

References (91)
  • 1
    • 4644256817 scopus 로고    scopus 로고
    • The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2: International RET Mutation Consortium analysis
    • Eng C, Clayton D, Schuffenecker I, Lenoir GM, Cote GJ, Gagel RF, Ploos van Amstel H, Lips CJM, Nishisho I, Takai S-I, et al.: The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2: International RET Mutation Consortium analysis. JAMA 1996, 276:1575-1579. The largest and most recent analysis of genotype-phenotype correlations in MEN 2. It includes information that will guide clinical decision making.
    • (1996) JAMA , vol.276 , pp. 1575-1579
    • Eng, C.1    Clayton, D.2    Schuffenecker, I.3    Lenoir, G.M.4    Cote, G.J.5    Gagel, R.F.6    Ploos Van Amstel, H.7    Lips, C.J.M.8    Nishisho, I.9    Takai, S.-I.10
  • 6
    • 0022330363 scopus 로고
    • Activation of a novel human transforming gene, ret by DNa rearrangement
    • Takahashi M, Ritz J, Cooper GM: Activation of a novel human transforming gene, ret by DNA rearrangement. Cell 1985, 42:581-588.
    • (1985) Cell , vol.42 , pp. 581-588
    • Takahashi, M.1    Ritz, J.2    Cooper, G.M.3
  • 8
    • 0028862490 scopus 로고
    • Characterization of RET proto-oncogene 3′ splicing variants and polyadenylation sites: A novel C-terminus for RET
    • Myers SM, Eng C, Ponder BAJ, Mulligan LM: Characterization of RET proto-oncogene 3′ splicing variants and polyadenylation sites: a novel C-terminus for RET. Oncogene 1995, 11:2039-2045.
    • (1995) Oncogene , vol.11 , pp. 2039-2045
    • Myers, S.M.1    Eng, C.2    Ponder, B.A.J.3    Mulligan, L.M.4
  • 11
    • 0024208663 scopus 로고
    • Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains
    • Takahashi M, Buma Y, Iwamoto T, Inaguma Y, Ikeda H, Hiai H: Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains. Oncogene 1988, 3:571-578.
    • (1988) Oncogene , vol.3 , pp. 571-578
    • Takahashi, M.1    Buma, Y.2    Iwamoto, T.3    Inaguma, Y.4    Ikeda, H.5    Hiai, H.6
  • 12
    • 0024323273 scopus 로고
    • Isolation of ret proto-oncogene cDNA with an amino-terminal signal sequence
    • Takahashi M, Buma Y, Hiai H: Isolation of ret proto-oncogene cDNA with an amino-terminal signal sequence. Oncogene 1989, 4:805-806.
    • (1989) Oncogene , vol.4 , pp. 805-806
    • Takahashi, M.1    Buma, Y.2    Hiai, H.3
  • 13
    • 0028153711 scopus 로고
    • An epidermal growth factor receptor/ret chimera generates mitogenic and transforming signals: Evidence for a ret-specific signaling pathway
    • Santoco M, Wong WT, Aroca P, Santos E, Matoskova B, Grieco M, Fusco A, Di Fiore PP: An epidermal growth factor receptor/ret chimera generates mitogenic and transforming signals: evidence for a ret-specific signaling pathway. Mol Cell Biol 1994, 14:663-675.
    • (1994) Mol Cell Biol , vol.14 , pp. 663-675
    • Santoco, M.1    Wong, W.T.2    Aroca, P.3    Santos, E.4    Matoskova, B.5    Grieco, M.6    Fusco, A.7    Di Fiore, P.P.8
  • 14
    • 0028914683 scopus 로고
    • Activation of RET as a dominant transforming gene by germline mutations of MEN2a and MEN2B
    • Santoro M, Carlomagno F, Romano A, Boltaro DP, Dathan NA, Grieco M, Fusco A, Vecchio G, Matoskova B, Kraus MH, Di Fiore PP: Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B. Science 1995, 267:381-383. This paper demonstrates dimerization of RET in the presence of MEN 2 mutations with consequent activation of RET tyrosine kinase activity. The codon 918 mutation is also shown to alter the substrate specificity of the RET tyrosine kinase.
    • (1995) Science , vol.267 , pp. 381-383
    • Santoro, M.1    Carlomagno, F.2    Romano, A.3    Boltaro, D.P.4    Dathan, N.A.5    Grieco, M.6    Fusco, A.7    Vecchio, G.8    Matoskova, B.9    Kraus, M.H.10    Di Fiore, P.P.11
  • 17
    • 15844375862 scopus 로고    scopus 로고
    • Direct association between the Ret receptor tyrosine kinase and the Src homology 2-containing adapter protein Grb7
    • Pandey A, Liu X, Dixon JE, Di Fiore PP, Dixit VM: Direct association between the Ret receptor tyrosine kinase and the Src homology 2-containing adapter protein Grb7. J Biol Chem 1996, 271:10607-10610.
    • (1996) J Biol Chem , vol.271 , pp. 10607-10610
    • Pandey, A.1    Liu, X.2    Dixon, J.E.3    Di Fiore, P.P.4    Dixit, V.M.5
  • 18
    • 0028824296 scopus 로고
    • Tyrosines outside the kinase core and dimerization are required for the mitogenic activity of RET/ptc2
    • Durick K, Yao VJ, Borrello MG, Bongarzone I, Pierotti MA, Taylor SS: Tyrosines outside the kinase core and dimerization are required for the mitogenic activity of RET/ptc2. J Biol Chem 1995, 270:24642-24645.
    • (1995) J Biol Chem , vol.270 , pp. 24642-24645
    • Durick, K.1    Yao, V.J.2    Borrello, M.G.3    Bongarzone, I.4    Pierotti, M.A.5    Taylor, S.S.6
  • 19
    • 0029006925 scopus 로고
    • Ret gene silencing is associated with Raf-1-induced medullary thyroid carcinoma cell differentiation
    • Carson EB, McMahon M, Baylin SB, Nelkin BD: Ret gene silencing is associated with Raf-1-induced medullary thyroid carcinoma cell differentiation. Cancer Res 1995, 55:2048-2052.
    • (1995) Cancer Res , vol.55 , pp. 2048-2052
    • Carson, E.B.1    McMahon, M.2    Baylin, S.B.3    Nelkin, B.D.4
  • 20
    • 0028838086 scopus 로고
    • Mechanism of activation of the rat proto-oncogene by multiple endocrine neoplasia 2A mutations
    • Asai N, Iwashita T, Matsuyama M, Takahashi M: Mechanism of activation of the rat proto-oncogene by multiple endocrine neoplasia 2A mutations. Mol Cell Biol 1995, 15:1613-1619. This study demonstrates ligand-independent dimerization of RET in the presence of the MEN 2A mutations.
    • (1995) Mol Cell Biol , vol.15 , pp. 1613-1619
    • Asai, N.1    Iwashita, T.2    Matsuyama, M.3    Takahashi, M.4
  • 27
    • 0029774070 scopus 로고    scopus 로고
    • Ret activation in adult and childhood papillary thyroid carcinoma using a reverse transcriptase-n-polymerase chain reaction approach on archival-nested material
    • Williams GH, Rooney S, Thomas GA, Cummins G, Williams ED: Ret activation in adult and childhood papillary thyroid carcinoma using a reverse transcriptase-n-polymerase chain reaction approach on archival-nested material. Br J Cancer 1996, 74:585-589.
    • (1996) Br J Cancer , vol.74 , pp. 585-589
    • Williams, G.H.1    Rooney, S.2    Thomas, G.A.3    Cummins, G.4    Williams, E.D.5
  • 31
    • 0028174023 scopus 로고
    • Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret
    • Schuchardt A, D'Agati V, Larsson-Blomberg L, Costantini F, Pachnis V: Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret. Nature 1994, 367:380-383.
    • (1994) Nature , vol.367 , pp. 380-383
    • Schuchardt, A.1    D'Agati, V.2    Larsson-Blomberg, L.3    Costantini, F.4    Pachnis, V.5
  • 32
    • 0029923448 scopus 로고    scopus 로고
    • Oncogenic RET receptors display different autophosphorylation sites and substrate binding specificities
    • Liu X, Vega QC, Decker RA, Pandey A, Worby CA, Dixon JE: Oncogenic RET receptors display different autophosphorylation sites and substrate binding specificities. J Biol Chem 1996, 271:5309-5312.
    • (1996) J Biol Chem , vol.271 , pp. 5309-5312
    • Liu, X.1    Vega, Q.C.2    Decker, R.A.3    Pandey, A.4    Worby, C.A.5    Dixon, J.E.6
  • 33
    • 9344234978 scopus 로고    scopus 로고
    • Mutations of the ret protooncogene in German multiple endocrine neoplasia families: Relation between genotype and phenotype
    • Frank Raue K, Hoppner W, Frilling A, Kotzerke J, Dralle H, Haase R, Mann K, Seif F, Kirchner R, Rendl J, et al. for the German Medullary Thyroid Carcinoma Study Group: Mutations of the ret protooncogene in German multiple endocrine neoplasia families: relation between genotype and phenotype. J Clin Endocrinol Metab 1996, 81:1780-1783.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 1780-1783
    • Frank Raue, K.1    Hoppner, W.2    Frilling, A.3    Kotzerke, J.4    Dralle, H.5    Haase, R.6    Mann, K.7    Seif, F.8    Kirchner, R.9    Rendl, J.10
  • 36
    • 0029919364 scopus 로고    scopus 로고
    • Detection of RET mutations in multiple endocrine neoplasia type 2A and familial medullary thyroid carcinoma by denaturing gradient gel electrophoresis
    • Peacock ML, Borst MJ, Sweet JD, Decker RA: Detection of RET mutations in multiple endocrine neoplasia type 2A and familial medullary thyroid carcinoma by denaturing gradient gel electrophoresis. Hum Mutat 1996, 7:100-104.
    • (1996) Hum Mutat , vol.7 , pp. 100-104
    • Peacock, M.L.1    Borst, M.J.2    Sweet, J.D.3    Decker, R.A.4
  • 37
    • 0028095123 scopus 로고
    • A rapid screening method for mutations in the RET proto-oncogene in multiple endocrine neoplasia type 2a and familial medullary thyroid carcinoma families
    • Marsh DJ, Robinson BG, Andrew S, Richardson A-L, Pojer R, Schnitzler M, Mulligan LM, Hyland VJ: A rapid screening method for mutations in the RET proto-oncogene in multiple endocrine neoplasia type 2a and familial medullary thyroid carcinoma families. Genomics 1994, 23:477-479.
    • (1994) Genomics , vol.23 , pp. 477-479
    • Marsh, D.J.1    Robinson, B.G.2    Andrew, S.3    Richardson, A.-L.4    Pojer, R.5    Schnitzler, M.6    Mulligan, L.M.7    Hyland, V.J.8
  • 40
    • 0028838578 scopus 로고
    • Mutations of codon 918 in the RET proto-oncogene correlate to poor prognosis in sporadic medullary thyroid carcinomas
    • Zedenius J, Larsson C, Bergholm U, Bovee J, Svensson A, Hallengren B, Grimelius L, Backdahl M, Weber G, Wallin G: Mutations of codon 918 in the RET proto-oncogene correlate to poor prognosis in sporadic medullary thyroid carcinomas. J Clin Endocrinol Metab 1995, 80:3088-3090. This is the first large series in which the poor prognosis associated with the presence of a somatic codon 918 mutation was demonstrated. This was supported by subsequent data from Romei et al. (J Clin Endocrinol Metab 1996, 81:1619-1622).
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 3088-3090
    • Zedenius, J.1    Larsson, C.2    Bergholm, U.3    Bovee, J.4    Svensson, A.5    Hallengren, B.6    Grimelius, L.7    Backdahl, M.8    Weber, G.9    Wallin, G.10
  • 41
    • 0029986851 scopus 로고    scopus 로고
    • Zedenius J, Larsson C, Bergholm U, Bovee J, Svensson A, Hallengren B, Grimelius L, Backdahl M, Weber G, Wallin G: Mutations of codon 918 in the RET proto-oncogene correlate to poor prognosis in sporadic medullary thyroid carcinomas. J Clin Endocrinol Metab 1995, 80:3088-3090. This is the first large series in which the poor prognosis associated with the presence of a somatic codon 918 mutation was demonstrated. This was supported by subsequent data from Romei et al. (J Clin Endocrinol Metab 1996, 81:1619-1622).
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 1619-1622
    • Romei1
  • 42
    • 13344270364 scopus 로고    scopus 로고
    • Germline and somatic mutations in an oncogene: RET mutations in inherited medullary thyroid carcinoma
    • Marsh DJ, Andrew SD, Eng C, Learoyd DL, Capes AG, Pojer R, Richardson AL, Houghton C, Mulligan LM, Ponder BA, Robinson BG: Germline and somatic mutations in an oncogene: RET mutations in inherited medullary thyroid carcinoma. Cancer Res 1996, 56:1241-1243. This study demonstrated somatic mutations in addition to germline mutations in hereditary MTCs. This was the first example of Knudson's two-hit hypothesis (Proc Natl Acad Sci U S A 1971, 68:820-823) being described in an oncogene.
    • (1996) Cancer Res , vol.56 , pp. 1241-1243
    • Marsh, D.J.1    Andrew, S.D.2    Eng, C.3    Learoyd, D.L.4    Capes, A.G.5    Pojer, R.6    Richardson, A.L.7    Houghton, C.8    Mulligan, L.M.9    Ponder, B.A.10    Robinson, B.G.11
  • 43
    • 0015043748 scopus 로고
    • Marsh DJ, Andrew SD, Eng C, Learoyd DL, Capes AG, Pojer R, Richardson AL, Houghton C, Mulligan LM, Ponder BA, Robinson BG: Germline and somatic mutations in an oncogene: RET mutations in inherited medullary thyroid carcinoma. Cancer Res 1996, 56:1241-1243. This study demonstrated somatic mutations in addition to germline mutations in hereditary MTCs. This was the first example of Knudson's two-hit hypothesis (Proc Natl Acad Sci U S A 1971, 68:820-823) being described in an oncogene.
    • (1971) Proc Natl Acad Sci U S A , vol.68 , pp. 820-823
  • 44
    • 0015043748 scopus 로고
    • Mutation and cancer: Statistical study of retinoblastoma
    • Knudson AG: Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci U S A 1971, 68:820-823.
    • (1971) Proc Natl Acad Sci U S A , vol.68 , pp. 820-823
    • Knudson, A.G.1
  • 48
    • 0028101170 scopus 로고
    • Somatic and MEN2A de novo mutations identified in the RET proto-oncogene by screening of sporadic MTCs
    • Zedenius J, Wallin G, Hamberger B, Nordenskjold M, Weber G, Larsson C: Somatic and MEN2A de novo mutations identified in the RET proto-oncogene by screening of sporadic MTCs. Hum Mol Genet 1994, 3:1259-1262.
    • (1994) Hum Mol Genet , vol.3 , pp. 1259-1262
    • Zedenius, J.1    Wallin, G.2    Hamberger, B.3    Nordenskjold, M.4    Weber, G.5    Larsson, C.6
  • 51
    • 0029986851 scopus 로고    scopus 로고
    • Somatic mutations of the ret protooncogene in sporadic medullary thyroid carcinoma are not restricted to exon 16 and are associated with tumor recurrence
    • Romei C, Elisei R, Pinchera A, Ceccherini I, Molinaro E, Mancusi F, Martino E, Romeo G, Pacini F: Somatic mutations of the ret protooncogene in sporadic medullary thyroid carcinoma are not restricted to exon 16 and are associated with tumor recurrence. J Clin Endocrinol Metab 1996, 81:1619-1622.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 1619-1622
    • Romei, C.1    Elisei, R.2    Pinchera, A.3    Ceccherini, I.4    Molinaro, E.5    Mancusi, F.6    Martino, E.7    Romeo, G.8    Pacini, F.9
  • 52
    • 0032246147 scopus 로고    scopus 로고
    • Deletion-insertion encompassing RET codon 634 is associated with medullary thyroid carcinoma
    • in press
    • Marsh DJ, Andrew SD, Learoyd DL, Pojer R, Eng C, Robinson BG: Deletion-insertion encompassing RET codon 634 is associated with medullary thyroid carcinoma. Hum Mutat 1997, in press.
    • (1997) Hum Mutat
    • Marsh, D.J.1    Andrew, S.D.2    Learoyd, D.L.3    Pojer, R.4    Eng, C.5    Robinson, B.G.6
  • 53
    • 0029930893 scopus 로고    scopus 로고
    • Ret mutation screening in men2 patients and discovery of a novel mutation in a sporadic medullary thyroid carcinoma
    • Jhiang SM, Fithian L, Weghorst CM, Clark OH, Falko JM, Odorisio TM, Mazzaferri EL: Ret mutation screening in men2 patients and discovery of a novel mutation in a sporadic medullary thyroid carcinoma. Thyroid 1996, 6:115-121.
    • (1996) Thyroid , vol.6 , pp. 115-121
    • Jhiang, S.M.1    Fithian, L.2    Weghorst, C.M.3    Clark, O.H.4    Falko, J.M.5    Odorisio, T.M.6    Mazzaferri, E.L.7
  • 61
    • 0028866313 scopus 로고
    • Absence of RET proto-oncogene point mutations in sporadic hyperplastic and neoplastic lesions of the parathyroid gland
    • Padberg BC, Schroder S, Jochum W, Kastendieck H, Roth J, Heitz PU, Komminoth P: Absence of RET proto-oncogene point mutations in sporadic hyperplastic and neoplastic lesions of the parathyroid gland. Am J Pathol 1995, 147:1600-1607.
    • (1995) Am J Pathol , vol.147 , pp. 1600-1607
    • Padberg, B.C.1    Schroder, S.2    Jochum, W.3    Kastendieck, H.4    Roth, J.5    Heitz, P.U.6    Komminoth, P.7
  • 63
    • 15844365303 scopus 로고    scopus 로고
    • GDNF-induced activation of the RET protein tyrosine kinase is mediated by GDNFR-α, a novel receptor for GDNF
    • Jing S, Wen D, Yu Y, Hoist PL, Luo Y, Fang M, Tamir R, Antonio L, Hu Z, Cupples R, et al.: GDNF-induced activation of the RET protein tyrosine kinase is mediated by GDNFR-α, a novel receptor for GDNF. Cell 1996, 85:1113-1124. One of the first studies to identify GDNF as a ligand for RET. A new protein, GDNFR-α, was also identified as a component of the ligand-receptor interaction.
    • (1996) Cell , vol.85 , pp. 1113-1124
    • Jing, S.1    Wen, D.2    Yu, Y.3    Hoist, P.L.4    Luo, Y.5    Fang, M.6    Tamir, R.7    Antonio, L.8    Hu, Z.9    Cupples, R.10
  • 66
    • 0027285510 scopus 로고
    • GDNF: A glial cell line- Derived neurotrophic factor for midbrain dopaminergic neurons
    • Lin LF, Doherty DH, Lile JD, Bektesh S, Collins F: GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science 1993, 260:1130-1132.
    • (1993) Science , vol.260 , pp. 1130-1132
    • Lin, L.F.1    Doherty, D.H.2    Lile, J.D.3    Bektesh, S.4    Collins, F.5
  • 67
    • 0028979805 scopus 로고
    • The gene coding for glial cell line derived neurotrophic factor (GDNF) maps to chromosome 5p12-p13.1
    • Schindelhauer D, Schuffenhauer S, Gasser T, Steinkasserer A, Meitinger T: The gene coding for glial cell line derived neurotrophic factor (GDNF) maps to chromosome 5p12-p13.1. Genomics 1995, 28:605-607.
    • (1995) Genomics , vol.28 , pp. 605-607
    • Schindelhauer, D.1    Schuffenhauer, S.2    Gasser, T.3    Steinkasserer, A.4    Meitinger, T.5
  • 68
    • 0028901367 scopus 로고
    • cDNA sequence and differential mRNA regulation of two forms of glial cell line-derived neurotrophic factor in Schwann cells and rat skeletal muscle
    • Springer JE, Seeburger JL, He J, Gabrea A, Blankenhorn EP, Bergman LW: cDNA sequence and differential mRNA regulation of two forms of glial cell line-derived neurotrophic factor in Schwann cells and rat skeletal muscle. Exp Neurol 1995, 131:47-52.
    • (1995) Exp Neurol , vol.131 , pp. 47-52
    • Springer, J.E.1    Seeburger, J.L.2    He, J.3    Gabrea, A.4    Blankenhorn, E.P.5    Bergman, L.W.6
  • 69
    • 0028981289 scopus 로고
    • Glial cell line-derived neurotrophic factor promotes the survival and morphologic differentiation of Purkinje cells
    • Mount HT, Dean DO, Alberch J, Dreyfus CF, Black IB: Glial cell line-derived neurotrophic factor promotes the survival and morphologic differentiation of Purkinje cells. Proc Natl Acad Sci U S A 1995, 92:9092-9096.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 9092-9096
    • Mount, H.T.1    Dean, D.O.2    Alberch, J.3    Dreyfus, C.F.4    Black, I.B.5
  • 71
    • 0029007011 scopus 로고
    • Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons
    • Trupp M, Ryden M, Jornvall H, Funakoshi H, Timmusk T, Arenas E, Ibanez CF: Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons. J Cell Biol 1995, 130:137-148.
    • (1995) J Cell Biol , vol.130 , pp. 137-148
    • Trupp, M.1    Ryden, M.2    Jornvall, H.3    Funakoshi, H.4    Timmusk, T.5    Arenas, E.6    Ibanez, C.F.7
  • 72
    • 0029901727 scopus 로고    scopus 로고
    • Renal agenesis and the absence of enteric neurons in mice lacking GDNF
    • Sanchez MP, Silos Santiago I, Frisen J, He B, Lira SA, Barbacid M: Renal agenesis and the absence of enteric neurons in mice lacking GDNF. Nature 1996, 382:70-73. Describes the effects of mutation or deletion of the GDNF gene in mice, high-lighting the phenotypic similarities to the ret-deficient mouse (see Schuchardt et al., Nature 1994, 367:380-383).
    • (1996) Nature , vol.382 , pp. 70-73
    • Sanchez, M.P.1    Silos Santiago, I.2    Frisen, J.3    He, B.4    Lira, S.A.5    Barbacid, M.6
  • 73
    • 0028174023 scopus 로고
    • Sanchez MP, Silos Santiago I, Frisen J, He B, Lira SA, Barbacid M: Renal agenesis and the absence of enteric neurons in mice lacking GDNF. Nature 1996, 382:70-73. Describes the effects of mutation or deletion of the GDNF gene in mice, high-lighting the phenotypic similarities to the ret-deficient mouse (see Schuchardt et al., Nature 1994, 367:380-383).
    • (1994) Nature , vol.367 , pp. 380-383
    • Schuchardt1
  • 74
    • 15844426332 scopus 로고    scopus 로고
    • Defects in enteric innervation and kidney development in mice lacking GDNF
    • Pichel JG, Shen L, Sheng HZ, Granholm AC, Drago J, Grinberg A, Lee EJ, Huang SP, Saarma M, Hoffer BJ, et al.: Defects in enteric innervation and kidney development in mice lacking GDNF. Nature 1996, 382:73-76. Describes the effects of mutation or deletion of the GDNF gene in mice, high-lighting the phenotypic similarities to the ret-deficient mouse (see Schuchardt et al., Nature 1994, 367:380-383).
    • (1996) Nature , vol.382 , pp. 73-76
    • Pichel, J.G.1    Shen, L.2    Sheng, H.Z.3    Granholm, A.C.4    Drago, J.5    Grinberg, A.6    Lee, E.J.7    Huang, S.P.8    Saarma, M.9    Hoffer, B.J.10
  • 75
    • 0028174023 scopus 로고
    • Pichel JG, Shen L, Sheng HZ, Granholm AC, Drago J, Grinberg A, Lee EJ, Huang SP, Saarma M, Hoffer BJ, et al.: Defects in enteric innervation and kidney development in mice lacking GDNF. Nature 1996, 382:73-76. Describes the effects of mutation or deletion of the GDNF gene in mice, high-lighting the phenotypic similarities to the ret-deficient mouse (see Schuchardt et al., Nature 1994, 367:380-383).
    • (1994) Nature , vol.367 , pp. 380-383
    • Schuchardt1
  • 77
    • 0028174023 scopus 로고
    • Moore MW, Klein RD, Farinas I, Sauer H, Armanini M, Phillips H, Reichardt LF, Ryan AM, Carver Moore K, Rosenthal A: Renal and neuronal abnormalities in mice lacking GDNF. Nature 1996, 382:76-79. Describes the effects of mutation or deletion of the GDNF gene in mice, high-lighting the phenotypic similarities to the ret-deficient mouse (see Schuchardt et al., Nature 1994, 367:380-383).
    • (1994) Nature , vol.367 , pp. 380-383
    • Schuchardt1
  • 78
    • 0027374562 scopus 로고
    • Expression of the c-ret proto-onco-gene during mouse embryogenesis
    • Pachnis V, Mankoo B, Costantini F: Expression of the c-ret proto-onco-gene during mouse embryogenesis. Development 1993, 119:1005-1017.
    • (1993) Development , vol.119 , pp. 1005-1017
    • Pachnis, V.1    Mankoo, B.2    Costantini, F.3
  • 79
    • 0030024846 scopus 로고    scopus 로고
    • Embryonic expression of glial cell-line derived neurotrophic factor (GDNF) suggests multiple developmental roles in neural differentiation and epithelial-mesenchymal interactions
    • Hellmich HL, Kos L, Cho ES, Mahon KA, Zimmer A: Embryonic expression of glial cell-line derived neurotrophic factor (GDNF) suggests multiple developmental roles in neural differentiation and epithelial-mesenchymal interactions. Mech Dev 1996, 54:95-105.
    • (1996) Mech Dev , vol.54 , pp. 95-105
    • Hellmich, H.L.1    Kos, L.2    Cho, E.S.3    Mahon, K.A.4    Zimmer, A.5
  • 80
    • 0029846514 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor signals through the RET receptor and activates mitogen-activated protein kinase
    • Worby CA, Vega OC, Zhao Y, Chao HH-J, Seasholtz AF, Dixon JE: Glial cell line-derived neurotrophic factor signals through the RET receptor and activates mitogen-activated protein kinase. J Biol Chem 1996, 271:619-622. Previous studies of second-messenger systems linked to RET activation have utilized chimeric receptors. This study was the first to examine these systems using the recently identified RET ligand GDNF.
    • (1996) J Biol Chem , vol.271 , pp. 619-622
    • Worby, C.A.1    Vega, O.C.2    Zhao, Y.3    Chao, H.H.-J.4    Seasholtz, A.F.5    Dixon, J.E.6
  • 81
    • 0029748327 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor activates the receptor tyrosine kinase RET and promotes kidney morphogenesis
    • Vega QC, Worby CA, Lechner MS, Dixon JE, Dressier GR: Glial cell line-derived neurotrophic factor activates the receptor tyrosine kinase RET and promotes kidney morphogenesis. Proc Natl Acad Sci U S A 1996, 93:10657-10661.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 10657-10661
    • Vega, Q.C.1    Worby, C.A.2    Lechner, M.S.3    Dixon, J.E.4    Dressier, G.R.5
  • 82
    • 0030292383 scopus 로고    scopus 로고
    • Germline mutations in glial cell line-derived neurotrophic factor (GDNF) and RET in a Hirschsprung disease patient
    • Angrist M, Bolk S, Halushka M, Lapchak PA, Chakravarti A: Germline mutations in glial cell line-derived neurotrophic factor (GDNF) and RET in a Hirschsprung disease patient. Nat Genet 1996, 14:341-344.
    • (1996) Nat Genet , vol.14 , pp. 341-344
    • Angrist, M.1    Bolk, S.2    Halushka, M.3    Lapchak, P.A.4    Chakravarti, A.5
  • 86
    • 0028807798 scopus 로고
    • Presymptomatic DNA screening in families with multiple endocrine neoplasia type 2 and familial medullary thyroid carcinoma
    • Frilling A, Dralle H, Eng C, Raue F, Broelsch CE: Presymptomatic DNA screening in families with multiple endocrine neoplasia type 2 and familial medullary thyroid carcinoma. Surgery 1995, 118:1099-1103.
    • (1995) Surgery , vol.118 , pp. 1099-1103
    • Frilling, A.1    Dralle, H.2    Eng, C.3    Raue, F.4    Broelsch, C.E.5
  • 87
    • 0028850673 scopus 로고
    • Early treatment of hereditary medullary thyroid carcinoma after attribution of multiple endocrine neoplasia type 2 gene carrier status by screening for ret gene mutations
    • Pacini F, Romei C, Miccoli P, Elisei R, Molinaro E, Mancusi F, Iacconi P, Basolo F, Martino E, Pinchera A: Early treatment of hereditary medullary thyroid carcinoma after attribution of multiple endocrine neoplasia type 2 gene carrier status by screening for ret gene mutations. Surgery 1995, 118:1031-1035.
    • (1995) Surgery , vol.118 , pp. 1031-1035
    • Pacini, F.1    Romei, C.2    Miccoli, P.3    Elisei, R.4    Molinaro, E.5    Mancusi, F.6    Iacconi, P.7    Basolo, F.8    Martino, E.9    Pinchera, A.10
  • 88
    • 0029929841 scopus 로고    scopus 로고
    • Bilateral adrenalectomy with autotransplantation of adrenocortical tissue or unilateral adrenalectomy: Treatment options for pheochromocytomas in multiple endocrine neoplasia type 2A
    • Okamoto T, Obara T, Ito Y, Yamashita T, Kanbe M, Iihara M, Hirose K, Yamazaki K: Bilateral adrenalectomy with autotransplantation of adrenocortical tissue or unilateral adrenalectomy: treatment options for pheochromocytomas in multiple endocrine neoplasia type 2A. Endocr J 1996, 43:169-175.
    • (1996) Endocr J , vol.43 , pp. 169-175
    • Okamoto, T.1    Obara, T.2    Ito, Y.3    Yamashita, T.4    Kanbe, M.5    Iihara, M.6    Hirose, K.7    Yamazaki, K.8
  • 90
    • 0029810636 scopus 로고    scopus 로고
    • Prophylactic surgery for multiple endocrine neoplasia type iia after genetic diagnosis: Is parathyroid transplantation indicated?
    • Decker RA, Geiger JD, Cox CE, Mackovjak M, Sarkar M, Peacock ML: Prophylactic surgery for multiple endocrine neoplasia type iia after genetic diagnosis: is parathyroid transplantation indicated? World J Surg 1996, 20:814-821.
    • (1996) World J Surg , vol.20 , pp. 814-821
    • Decker, R.A.1    Geiger, J.D.2    Cox, C.E.3    Mackovjak, M.4    Sarkar, M.5    Peacock, M.L.6
  • 91
    • 0029772557 scopus 로고    scopus 로고
    • Medullary thyroid cancer: Analyses of survival and prognostic factors and the role of radiation therapy in local control
    • Brierley J, Tsang R, Simpson WJ, Gospodarowicz M, Sutcliffe S, Panzarella T: Medullary thyroid cancer: analyses of survival and prognostic factors and the role of radiation therapy in local control. Thyroid 1996, 6:305-310.
    • (1996) Thyroid , vol.6 , pp. 305-310
    • Brierley, J.1    Tsang, R.2    Simpson, W.J.3    Gospodarowicz, M.4    Sutcliffe, S.5    Panzarella, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.