Somatic mutations of the RET proto-oncogene are not required for tumor development in multiple endocrine neoplasia type 2 (MEN 2) gene carriers

Cancer Research

Volumn 56, Issue 21, 1996, Pages 4853-4855

  Landsvater, Rudy M ^a   De Wit, Mireille J ^a   Zewald, Richard A ^a   Hofstra, Robert M W ^b   Buys, Charles H C M ^b   Ploos Van Amstel, Hans Kristian ^c   Höppener, Jo W M ^a   Lips, Cornelis J M ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

^c Clinical Genetics Center Utrecht   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; MESSENGER RNA; RNA;

AMINO ACID SUBSTITUTION; ARTICLE; CANCER SUSCEPTIBILITY; CASE REPORT; FAMILIAL CANCER; GENE MUTATION; GENETIC SUSCEPTIBILITY; HUMAN; HUMAN TISSUE; MULTIPLE ENDOCRINE NEOPLASIA; NEUROFIBROMATOSIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTO ONCOGENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIPPLE SYNDROME; SOMATIC MUTATION; TUMOR SUPPRESSOR GENE;

DNA, COMPLEMENTARY; DROSOPHILA PROTEINS; HETEROZYGOTE; HUMANS; MALE; MULTIPLE ENDOCRINE NEOPLASIA TYPE 2A; MUTATION; POLYMORPHISM, GENETIC; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-RET; PROTO-ONCOGENES; RECEPTOR PROTEIN-TYROSINE KINASES;

EID: 0029854132     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Mulligan, L. M., Kwok, J. B J., Healey, C. S, Elsdon, M J., Eng, C., Gardner, E., Love, D. R, Mole, S. E, Moore, J K., Papi, L, Ponder, M. A., Telenius, H., Tunnacliffe, A, and Ponder, B. A J. Germline mutations of the RET proto-oncogene in multiple endocrine neoplasia syndrome type 2A. Nature (Lond.), 363 458-460, 1993.
2. Donis-Keller, H., Dou, S, Chi, D, Carlson, K M., Toshima, K., Lairmore, T. C., Howe, J. R., Moley, J. F., Goodfellow, P J., and Wells, S A Mutations in the RET proto-oncogene are associated with MEN 2A and FMTC. Hum. Mol. Genet., 2: 851-856, 1993
3. Hofstra, R M. W., Landsvater, R M., Ceccherini, I., Stulp, R. P., Stelwagen, T., Luo, Y., Pasini, B., Hoppener, J. W. M., Ploos van Amstel, H-K., Romeo, G., Lips, C J. M, and Buys, C H C M. A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma Nature (Lond.), 367: 375-376, 1994
4. Carlson, K. M, Dou, S., Chi, D, Scavarda, N., Toshima, K, Jackson, C E., Wells, S. A, Jr, Goodfellow, P. J., and Donis-Keller, H Single missense mutation in the tyrosine kinase catalytic domain of the RET proto-oncogene is associated with multiple endocrine neoplasia type 2B Proc. Natl. Acad. Sci. USA, 91: 1579-1583, 1994.
5. Eng, C . Smith, D. P, Mulligan, L. M., Nagai, M. A, Healey, C. S., Ponder, M. A., Gardner, E., Scheumann, G F W., Jackson, C. E, Tunnacliffe, A., and Ponder, B. A. J Point mutation within the tyrosine kinase domain of the RET proto-oncogene in multiple endocrine neoplasia type 2B and related sporadic tumours. Hum. Mol. Genet., 3 237-241, 1994
6. Sipple, J. H The association of pheochromocytoma with carcinoma of the thyroid gland Am J. Med, 31: 163-166, 1961.
7. Schimke, R. N., Hartmann, W. H., Prout, T. E., and Rimoin, D. L. Syndrome of bilateral pheochromocytomas, medullary thyroid carcinoma, and multiple neuromas. A possible regulatory defect in the differentiation of chromaffin tissue. N. Engl. J. Med, 279: 1-7, 1968.
8. Knudson, A. G., Jr. Hereditary cancer, oncogenes, and anti-oncogenes. Cancer Res., 45, 1437-1443, 1985.
9. Landsvater, R. M., Mathew, C G. P, Smith, B. A., Marcus, E. M, Te Meerman, G J., Lips, C. J. M., Geerdink, R. A., Nakamura, Y., Ponder, B A. J., and Buys, C. H C M Development of multiple endocrine neoplasia type 2A does not involve substantial deletions of chromosome 10. Genomics, 4: 246-250, 1989.
10. Nelkin, B. D., Nakamura, Y., White, R. W, de Bustros, A. C., Herman, J., Wells, S. A, and Baylin, S B. Low incidence of loss of chromosome 10 in sporadic and hereditary human medullary thyroid carcinoma Cancer Res, 49: 4114-4119, 1989.
11. Mulligan, L. M. Gardner, E, Smith, B. A., Mathew, C G P., and Ponder, B. A. J Genetic events in tumour initiation and progression in multiple endocrine neoplasia type 2. Genes Chromosomes & Cancer, 6: 166-177, 1992.
12. Takahashi, M., Buma, Y., Iwamoto, T., Inaguma, Y., Ikeda, H, and Hiai, H. Cloning and expression of the RET proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains. Oncogene, 3, 571-578, 1988.
13. Nelkin, B D, and Baylin, S. B. RET oncogene responsible for MEN 2A Curr Biol., 3: 477-480, 1993.
14. Landsvater, R. M., Jansen, R. P. M., Hofstra, R. M. W., Buys, C. H. C M, Lips, C J. M., and Ploos van Amstel, J. K. Mutation analysis of the RET proto-oncogene in Dutch families with MEN 2A, MEN 2B, and FMTC, two novel mutations and one de novo mutation for MEN 2A. Hum. Genet., 97: 11-14, 1995.
15. Santoro, M., Carlomagno, F., Romano, A., Bottaro, D. P, Dathan, N. A., Gneco, M., Fusco, A., Vecchio, G., Matoskova, B., Kraus, M. H., and Di Fiore, P. P. Activation of RET as a dominant transforming gene by germline mutations of MEN 2A and MEN 2B. Science (Washington DC), 267: 381-383, 1994.
16. Asai, N., Iwashita, T, Matsuyama, M., and Takahashi, M Mechanism of activation of the RET proto-oncogene by multiple endocrine neoplasia 2A mutations. Mol Cell. Biol., 15, 1613-1619, 1995.
17. Ceccherini, I., Hofstra, R. M. W, Luo, Y., Stulp, R. P, Barone, V, Stelwagen, T., Bocciardi, R, Nijveen, H, Bolino, A., and Seri, M DNA polymorphisms and conditions for SSCP analysis of the 20 exons of the RET proto-oncogene. Oncogene, 9: 3025-3029, 1994.
18. Lips, C. J M, Landsvater, R M., Höppener, J. W M., Geerdink, R A., Blijham, G. H., Jansen-Schilhorn van Veen, J M., Van Gils, A. P G., De Wit, M. J., Zewald, R. A., Berends, M. J. H., Beemer, F A., Brouwers-Smalbraak, J., Jansen, R. P. M., Ploos van Amstel, J. K., Van Vroonhoven, T. J. M. V, and Vroom, T. M. Clinical screening as compared with DNA analysis in families with multiple endocrine neoplasia type 2A N. Engl. J. Med., 331 828-835, 1994
19. Hoppener, J W M, and Lips, C. J. M. Ret receptor tyrosine kinase gene mutations: molecular biological, physiological, and clinical aspects Eur. J Clin. Invest., 26: 613-624, 1996.
20. Marsh, D J, Andrew, S D., Eng, C., Learoyd, D. L. Capes, A. G., Pojer, R, Richardson, A-L, Houghton, C., Mulligan, L. M, Ponder, B A J., and Robinson, B G. Germline and somatic mutations in an oncogene RET mutations in inherited medullary thyroid carcinoma. Cancer Res, 56: 1241-1243, 1996
21. Ponder, B A. J., Smith, B A., Marcus, E. M., Nakamura, Y., Landsvater, R. M, Buys, C. H. C M., and Mathew, C G. P. Genetic events in tumongenesis in multiple endocrine neoplasia type 2. Cancer Cells (Cold Spnng Harbor), 7, 219-221, 1989.
22. Pachnis, V., Mankoo, B., and Constantini, F. Expression of the c-ret proto-oncogene during mouse embryogenesis. Development (Camb). 119: 1005-1017, 1993.