The role of immunotoxic environmental contaminants in facilitating the emergence of infectious diseases in marine mammals

Human and Ecological Risk Assessment

Volumn 8, Issue 2, 2002, Pages 277-292

  Ross, Peter S ^a  

^a INSTITUTE OF OCEAN SCIENCES   (Canada)

Author keywords

Contaminants; Disease; Emergence; Immunotoxicity; Marine mammals

Indexed keywords

ANIMALIA; MAMMALIA;

EID: 0013460576     PISSN: 10807039     EISSN: None     Source Type: Journal    
DOI: 10.1080/20028091056917     Document Type: Conference Paper

References (108)

1. Adams SM, Greeley MSJr, and Ryon MG. 2000. Evaluating effects of contaminants on fish health at multiple levels of biological organisation: extrapolating from lower to higher levels. Human Ecol Risk Assess 6(1):15-27
2. Addison RF and Brodie PF. 1987. Transfer of organochlorine residues from blubber through the circulatory system to milk in the lactating gray seal Halichoerus grypus. Can J Fish Aquat Sci 44:782-6
3. Aguilar A and Borrell A. 1994. Abnormally high polychlorinated biphenyl levels in striped dolphins (Stenella coeruleoalba ) affected by the 1990-1992 Mediterranean epizootic. Sci Total Environ 154:237-47
4. Arkoosh MR, Casillas E, Clemons E, et al. 1997. Effect of pollution on fish diseases: potential impacts on salmonid populations. J Aquatic Animal Health 10(2):182-90
5. Auman HJ, Ludwig JP, Summer CL, et al. 1997. PCBs, DDE, DDT, and TCDD-EQ in two species of albatross on Sand Island, Midway atoll, North Pacific Ocean. Environ Toxicol Chem 16:498-504
6. Bacon CE, Jarman WM, Estes JA, et al. 1999. Comparison of organochlorine contaminants among sea otter (Enhydra lutris) populations in California and Alaska. Environ Toxicol Chem 18(3):452-8
7. Belamarich PR. 1998. Measles and malnutrition. Pediatr Rev 19(2):70-1
8. Binder S, Levitt AM, Sacks JJ, et al. 1999. Emerging infectious diseases: public health issues for the 21st century. Science 284:1311-3
9. Birkun AJr, Kuiken T, Krivokhizhin S, et al. 1999. Epizootic of morbilliviral disease in common dolphins (Delphinus delphis ponticus) from the Black sea. Vet Rec 144:85-92
10. Birnbaum LS. 1994. The mechanism of dioxin toxicity: Relationship to risk assessment. Environ Health Perspect 102:157-67
11. Borrell A, Aguilar A, Corsolini S, et al. 1996. Evaluation of toxicity and sex-related variation of PCB levels in Mediterranean striped dolphins affected by an epizootic. Chemosphere 32:2359-69
12. Brouwer A, Morse DC, Lans MC, et al. 1998. Interactions of persistent environmental organohalogens with the thyroid hormone system: mechanisms and possible consequences for animal and human health. Toxicol Ind Health 14:59-84
13. Brouwer A, Reijnders PJH, and Koeman JH. 1989. Polychlorinated biphenyl (PCB)-contaminated fish induces vitamin A and thyroid hormone deficiency in the common seal (Phoca vitulina). Aquat Toxicol 15:99-106
14. Brouwer A and Van den Berg KJ. 1986. Binding of a metabolite of 3,4,3',4'-tetrachlorobiphenyl to transthyretin reduces serum vitamin A transport by inhibiting the formation of the protein complex carrying both retinol and thyroxin. Toxicol Appl Pharmacol 85:301-12
15. Colborn T. 1994. The wildlife/human connection: modernizing risk decisions. Environ Health Perspect 102(suppl 12):55-9
16. Daszak P, Cunningham AA, and Hyatt AD. 2000. Emerging infectious diseases of wildlife-Threats to biodiversity and human health. Science 287:443-9
17. Daszak P, Cunningham AA, and Hyatt A. 2001. Anthropogenic environmental change and the emergence of infectious diseases in wildlife. Acta Trop 78:103-16
18. De Guise S, Martineau D, Beland P, et al. 1995. Possible mechanisms of action of environmental contaminants on St. Lawrence beluga whales (Delphinapterus leucas). Environ Health Perspect 103:73-7
19. De Heer C, Verlaan APJ, Penninks AH, et al. 1994. Time course of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced thymic atrophy in the Wistar rat. Toxicol Appl Pharmacol 128:97-104
20. De Swart RL, Harder TC, Ross PS, et al. 1995a. Morbilliviruses and morbillivirus diseases of marine mammals. Infect Agent Dis 4:125-30
21. De Swart RL, Ross PS, Timmerman HH, et al. 1995b. Impaired cellular immune response in harbour seals (Phoca vitulina) feeding on environmentally contaminated herring. Clin Exp Immunol 101:480-6
22. De Swart RL, Ross PS, Vedder LJ, et al. 1994. Impairment of immune function in harbor seals (Phoca vitulina) feeding on fish from polluted waters. Ambio 23:155-9
23. De Swart RL, Ross PS, Vos JG, et al. 1996. Impaired immunity in harbour seals (Phoca vitulina) exposed to bioaccumulated environmental contaminants: review of a long-term study. Environ Health Perspect 104(suppl 4):823-8
24. Dietz R, Ansen CT, and Have P 1989. Clue to seal epizootic? Nature 338:627-7
25. Dohms JE and Metz A. 1991. Stress-mechanisms of immunosuppression. Vet Immunol Immunopathol 30:89-109
26. Domingo M, Ferrer L, Pumarola M, et al. 1990. Morbillivirus in dolphins. Nature 348:21-21
27. Duignan PJ, House C, Geraci JR, et al. 1995. Morbillivirus infection in cetaceans of the western Atlantic. Vet Microbiol 44:241-9
28. Duignan PJ, Nielsen O, House C, et al. 1997. Epizootiology of morbillivirus infection in harp, hooded, and ringed seals from the Canadian arctic and western Atlantic. J Wildlife Dis 33:7-19
29. Duncan CJ, Duncan SR, and Scott S. 1997. The dynamics of measles epidemics. Theoretical Population Biology 52(2):155-63
30. Elliott JE, Norstrom RJ, and Smith GE. 1996. Patterns, trends, and toxicological significance of chlorinated hydrocarbon and mercury contaminants in bald eagle eggs from the Pacific coast of Canada, 1990-1994. Arch Environ Contam Toxicol 31:354-67
31. Forsyth MA, Kennedy S, Wilson S, et al. 1998. Canine distemper virus in a Caspian seal. Vet Rec 143:662-4
32. Gilbertson M, Kubiak T, Ludwig J, et al. 1991. Great Lakes embryo mortality, edema, and deformities syndrome (GLEMEDS) in colonial fish-eating birds: similarity to chick-edema disease. J Tox Environ Health 33:455-520
33. Gilmartin WG, Delong RL, Smith AW, et al. 1976. Premature parturition in the California sea lion. J Wildl Dis 12:104-15
34. Grachev MA, Kumarev VP, Mamaev LV, et al. 1989. Distemper virus in Baikal seals. Nature 338:209
35. Grasman KA, Fox GA, Scanlon PF, et al. 1996. Organochlorine-associated immunosuppression in prefledgling Caspian Terns and Herring gulls from the Great Lakes: An ecoepidemiological study. Environ Health Perspect Suppl 104:829-42
36. Hahn ME. 1998. The Aryl hydrocarbon receptor: A comparative perspective. Comp Biochem Physiol C 121:23-53
37. Hall AJ, Duck CD, Law RJ, et al. 1999. Organochlorine contaminants in Caspian and harbour seal blubber. Environ Pollut 106:203-12
38. Hall AJ, Law RJ, Harwood J, et al. 1992. Organochlorine levels in common seals (Phoca vitulina) which were victims and survivors of the 1988 phocine distemper epizootic. Sci Total Environ 115:145-62
39. Hall LW and Giddings JM. 2000. The need for multiple lines of evidence for predicting site-specific ecological effects. Human Ecol Risk Assess 6(4):679-710
40. Harvell CD, Kim K, Burkholder JM, et al. 1999. Emerging marine diseases - climate links and anthropogenic factors. Science 285:1505-10
41. Helle E, Olsson M, and Jensen S. 1976b. DDT and PCB levels and reproduction in ringed seal from the Bothnian Bay. Ambio 5:188-9
42. Helle E, Olsson M, and Jensen S. 1976a. PCB levels correlated with pathological changes in seal uteri. Ambio 5:261-3
43. Henderson G, Trudgett A, Lyons C, et al. 1992. Demonstration of antibodies in archival sera from Canadian seals reactive with a European isolate of phocine distemper virus. Sci Total Environ 115:93-8
44. House RV, Lauer LD, Murray MJ, et al. 1990. Examination of immune parameters and host resistance mechanisms in B6C3F1 mice following adult exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Tox Environ Health 31:203-15
45. Jepson PD, Bennett PM, Allchin CR, et al 1999. Investigating potential associations between chronic exposure to polychlorinated biphenyls and infectious disease mortality in harbour porpoises from England and Wales. Sci Total Environ 244:339-48
46. Kannan K, Tanabe S, Borrell A, et al. 1993. Isomer-specific analysis and toxic evaluation of polychlorinated biphenyls in striped dolphins affected by an epizootic in the western Mediterranean Sea. Arch Environ Contam Toxicol 25:227-33
47. Kennedy S, Kuiken T, Jepson PD, et al. 2000. Mass die-off of Caspian seals caused by canine distemper virus. Emerging Infectious Diseases 6(6):637-9
48. Kerkvliet NI, Baecher Steppan L, Smith BB, et al. 1990. Role of the Ah locus in suppression of cytotoxic T lymphocyte activity by halogenated aromatic hydrocarbons (PCBs and TCDD): Structure-activity relationships and effects in C57BI/6 mice congenic at the Ah locus. Fundam Appl Toxicol 14:532-41
49. Kim E-Y and Hahn ME. 2002 cDNA cloning and character ??? of an aryl hydrocarbon receptor fro mteh harbor seal a biomarker of dioxin susceptibility? Aquat Toxicol (in press)
50. Lavigne DM and Schmitz OJ. 1990. Global warming and increasing population densities: a prescription for seal plagues. Mar Pollut Bull 21:280-4
51. Lebrec H and Burleson GR. 1994. Influenza virus host resistance models in mice and rats: utilization for immune function assessment and immunotoxicology. Toxicology 91:179-88
52. Luebke RW, Copeland CB, Diliberto JJ, et al. 1994. Assessment of host resistance to Trichinella spiralis in mice following preinfection exposure to 2,3,7,8-TCDD. Toxicol Appl Pharmacol 125:7-16
53. Luebke RW, Hodson PV, Faisal M, et al. 1997. Aquatic pollution-induced immunotoxicity in wildlife species. Fundam Appl Toxicol 37:1-15
54. Luster MI, Portier C, Pait DG, et al. 1994. Use of animal studies in risk assessment for immunotoxicology. Toxicology 92:229-43
55. Mahy BWJ and Brown CC. 2000. Emerging zoonoses: crossing the species barrier. Revue Scientifique et Technique de l'Office International des Epizootics 19(1):33-40
56. Mahy BWJ, Barrett T, Evans S, et al. 1988. Characterization of a seal morbillivirus. Nature 336:115-6
57. Markussen NH and Have P. 1992. Phocine distemper virus infection in harp seals (Phoca groenlandica). Mar Mammal Sci 8:19-26
58. Mortensen P, Bergman A, Bignert A, et al. 1992. Prevalence of skull lesions in harbor seals (Phoca vitulina) in Swedish and Danish museum collections: 1835-1988. Ambio 21:520-4
59. Muir DCG, Ford CA, Rosenberg B, et al. 1996. Persistent organochlorines in beluga whales (Delphinapterus leucas) from the St Lawrence River estuary. I. Concentrations and patterns of specific PCBs, chlorinated pesticides and polychlorinated dibenzo-p-dioxins and dibenzofurans. Environ Pollut 93:219-34
60. Nakata H, Tanabe S, Tatsukawa R, et al. 1997. Bioaccumulation profiles of polychlorinated biphenyls including coplanar congeners and possible toxicological implications in Baikal seal (Phoca sibirica). Environ Pollut 95:57-65
61. Nichol ST, Arikawa J, and Kawaoka Y. 2000. Emerging viral diseases. Proc Natl Acad Sci 97(23):12411-2
62. Olsson M, Karlsson B, and Ahnland E. 1994. Diseases and environmental contaminants in seals from the Baltic and the Swedish west coast. Sci Total Environ 154:217-27
63. O'Shea TJ. 2000b. Cause of seal die-off in 1988 is still under debate. Science 290:1097-8
64. O'Shea TJ. 2000a. PCBs not to blame. Science 288:1965-6
65. Osterhaus ADME and Vedder EJ. 1988. Identification of virus causing recent seal deaths. Nature 335:20
66. Osterhaus ADME. 2001 Catastrophes after crossing species barriers. Philos Trans R Soc Lond B Biol Sci 356: 791-3
67. Osterhaus ADME, De Swart RL, Vos HW, et al. 1995. Morbillivirus infections of aquatic mammals: newly identified members of the genus. Vet Microbiol 44:219-27
68. Osterhaus ADME, Groen J, UytdeHaag FGCM, et al. 1989. Distemper virus in Baikal seals. Nature 338:209-10
69. Osterhaus ADME, Rimmelzwaan GF, Martina BE, et al. 2000. Influenza B virus in seals. Science 288:1051-3
70. Pimm SL, Russell GJ, Gittleman JL, et al. 1995. The future of biodiversity. Science 269:347-50
71. Reidarson TH, McBain J, House C, et al. 1998. Morbillivirus infection in stranded common dolphins from the Pacific Ocean. J Wildl Dis 34:771-6
72. Reijnders PJH. 1980. Organochlorine and heavy metal residues in harbour seals from the Wadden Sea and their possible effects on reproduction. Neth J Sea Res 14:30-65
73. Rhyan JC, Gidlewski T Ewalt DR, Hennager SG, Lambourn DM, Olsen SC. 2001 Serocon version and abortion in cattle experimentally infected with Brucella sp. isolated from a Pacific harbor seal( ???) J Vet Diagn Invest 13: 379-82
74. Rolland RM. 2000. A review of chemically-induced alterations in thyroid and vitamin A status from field studies of wildlife and fish. J Wildl Dis 36(4):615-35
75. Ross PS. 2000. Marine mammals as sentinels in ecological risk assessment. Human Ecol Risk Assess 6:29-46
76. Ross PS, Visser IKG, Broeders HWJ, et al. 1992. Antibodies to phocine distemper virus in Canadian seals. Vet Rec 130:514-6
77. Ross PS, De Swart RL, Visser IKG, et al. 1994. Relative immunocompetence of the newborn harbour seal, Phoca vitulina. Vet Immunol Immunopathol 42:331-48
78. Ross PS, De Swart RL, Reijnders PJH, et al. 1995. Contaminant-related suppression of delayed-type hypersensitivity and antibody responses in harbor seals fed herring from the Baltic Sea. Environ Health Perspect 103:162-7
79. Ross PS, De Swart RL, Addison RF, et al. 1996a. Contaminant-induced immunotoxicity in harbour seals: wildlife at risk? Toxicology 112:157-69
80. Ross PS, De Swart RL, Timmerman HH, et al. 1996b. Suppression of natural killer cell activity in harbour seals (Phoca vitulina) fed Baltic Sea herring. Aquat Toxicol 34:71-84
81. Ross PS, Van Loveren H, De Swart RL, et al. 1996c. Host resistance to rat cytomegalovirus (RCMV) and immune function in adult PVG rats fed herring from the contaminated Baltic Sea. Arch Toxicol 70:661-71
82. Ross PS, De Swart RL, Van Loveren H, et al. 1996d. The immunotoxicity of environmental contaminants to marine wildlife: A review. Ann Rev Fish Dis 6:151-65
83. Ross PS, De Swart RL, Van der Vliet H, et al. 1997. Impaired cellular immune response in rats exposed perinatally to Baltic Sea herring oil or 2,3,7,8-TCDD. Arch Toxicol 17:563-74
84. Ross PS, Ellis GM, Ikonomou MG, et al. 2000a. High PCB concentrations in free-ranging Pacific killer whales, Orcinus orca: effects of age, sex and dietary preference. Mar Pollut Bull 40:504-15
85. Ross PS, Vos JG, Birnbaum LS, et al. 2000b. PCBs are a health risk for humans and wildlife. Science 289:1878-9
86. Silkworth JB and Antrim L. 1985. Relationship between Ah receptor-mediated polychlorinated biphenyl (PCB)-induced humoral immunosuppression and thymic atrophy. J Pharmacol Exp Ther 235:606-11
87. Simmonds MP and Mayer SJ. 1997. An evaluation of environmental and other factors in some recent marine mammal mortalities in Europe: implications for conservation and management. Environ Rev 5:89-98
88. Simms W and Ross PS. 2000. Developmental changes in circulatory vitamin A (retinol) and its transport proteins in free-ranging harbour seal (Phoca vitulina) pups. Can J Zool 78(10):1862-8
89. Simms W, Jeffries SJ, Ikonomou MG, et al. 2000. Contaminant-related disruption of vitamin A dynamics in free-ranging harbor seal (Phoca vitulina) pups from British Columbia, Canada and Washington State, USA. Environ Toxicol Chem 19(11):2844-9
90. Smialovvicz RJ, Riddle MM, Rogers RR, et al. 1989. Immunotoxicity of tributyltin oxide in rats exposed as adults or pre-weanlings. Toxicology 57:97-111
91. Spraker TR, Hibler CP, Schoonveld GG, et al. 1984. Pathologic changes and microorganisms found in bighorn sheep during a stress-related die-off. J Wildl Dis 20:319-27
92. Stahl RGJr, Orme-Zavaleta J, Austin K, et al. 2000. Ecological indicators in risk assessment: workshop summary. Human Ecol Risk Assess 6(4):671-7
93. Tanabe S, Iwata H, and Tatsukawa R. 1994. Global contamination by persistent organochlorines and their ecotoxicological impact on marine mammals. Sci Total Environ 154:163-77
94. Tillitt DE, Ankley GT, Giesy JP, et al. 1992. Polychlorinated biphenyl residues and egg mortality in double- crested cormorants from the Great Lakes. Environ Toxicol Chem 11:1281-8
95. Tomkins A. 2000. Malnutrition, morbidity and mortality in children and their mothers. Proc Nutr Soc 59(1):135-46
96. Tryphonas H. 1995. Immunotoxicity of PCBs (Aroclors) in relation to Great Lakes. Environ Health Perspect 103(suppl 9):35-46
97. Van Bressem MF, Van Waerebeek K, and Raga JA. 1999. A review of virus infections of cetaceans and the potential impact of morbilliviruses, poxviruses and papillomaviruses on host population dynamics. Diseases Aquatic Organisms 38:53-65
98. Van Bressem MF, Visser IKG, Van de Bildt MWG, et al. 1991. Morbillivirus infection in Mediterranean striped dolphins (Stenella coeruleoalba). Vet Rec 129:471-2
99. van Oostdam J, Gilman A, Dewailly E, et al. 1999. Human health implications of environmental contaminants in Arctic Canada: a review. Sci Total Environ 230:1-82
100. Verdier F, Virat M, Schweinfurth H, et al. 1991. Immunotoxicity of bis(tri-n-butyltin) oxide in the rat. J Toxicol Environ Health 32:307-17
101. Vethaak AD, Jol JG, Meijboom A, et al. 1996. Skin and liver diseases induced in flounder (Platichthys flesus) long-term exposure to contaminated sediments in large-scale mesocosms. Environ Health Perspect 104(11):1218-29
102. Villamor E and Fawzi WW. 2000. Vitamin A in supplementation: implications for morbidity and mortality in children. J Infectious Diseases 182(suppl 1):S122-S33
103. Visser IKG, Kumarev VP, Harvell C, et al. 1990. Comparison of two morbilliviruses isolated from seals during outbreaks of distemper in North West Europe and Siberia. Arch Virol 111:149-64
104. Vos JG, Kreeftenberg JG, Engel HWB, et al. 1978. Studies on 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced immune suppression and decreased resistance to infection: endotoxin hypersensitivity, serum zinc concentrations and effect of thymosin treatment. Toxicology 9:75-86
105. Vos JG, Van Loveren H, Wester PW, et al. 1989. Toxic effects of environmental chemicals on the immune system. Trends Pharmacol Sci 10:289-92
106. Vos JG, De Klerk A, Krajnc EI, et al. 1990. Immunotoxicity of bis(tri-n-butyltin)oxide in the rat: effects on thymus-dependent immunity and on nonspecific resistance following long-term exposure in young versus aged rats. Toxicol Appl Pharmacol 105:144-55
107. Weisglas-Kuperus N, Patandin S, Berbers GUM, et al. 2000. Immunologic effects of background exposure to polychlorinated biphenyls and dioxins in Dutch preschool children. Environ Health Perspect 108(12):1203-7
108. West CE. 2000. Vitamin A and measles. Nutr Rev 58:S46-S54