Building chirality from the ground up

Modern Drug Discovery

Volumn 3, Issue 6, 2000, Pages 29-34

  Mccague, Ray ^a  

^a Ascot Fine Chemicals' Site   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0007380297     PISSN: 10998209     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. Caldwell, J. Through the looking glass in chiral drug development. Modern Drug Discovery 1999, 2 (4), 51-59.
2. Powers, D. G.; Coffen D. L. Convergent automated parallel synthesis. Drug Discovery Today 1999, 4, 377-383.
3. Peng, G.; Sohn, A.; Gallop, M. A. Stereoselective solid-phase synthesis of a triazatricyclic ring system: A new chemotype for lead discovery. J. Org. Chem. 1999, 64, 8342-8349.
4. Potyak, F.; Lubell, W. D. Rigid dipeptide mimics: Synthesis of enantiopure 5- and 7-benzyl and 5,7-dibenzyl indolizidinone amino acids via enolisation and alkylation of δ-oxo α,ω-di-[N-(9-phenylfluorenyl)amino]azelate esters. J. Org. Chem. 1998, 63, 5937-5949.
5. Sofia, M. J.; Hunter, R.; Chan, T. Y.; Vaughan, A; Dulina, R.; Wang, H.; Gange, D. Carbohydrate-based small-molecule scaffolds for the construction of universal pharmacophore mapping libraries. J. Org. Chem. 1998, 63, 2802-2803.
6. Smith, M.E.B.; Lloyd, M. C.; Derrien, N.; Lloyd, R. C.; Taylor S.J.C.; Chaplin, D. A.; McCague, R. Scaffolds of varied stereochemistry to deliver additional diversity for pharmaceutical discovery. Submitted for publication.
7. Qui, J.; Silverman, R. B. A new class of conformationally rigid analogues of 4-amino-5-halopentanoic acids, potent inactivators of γ-aminobutyric acid aminotransferase. J. Med. Chem. 2000, 43, 706-720.