Design and synthesis of 2-[4-[4-(m-(ethylsulfonamido)-phenyl)piperazin- 1-yl]butyl]-1,3-dioxoperhydropyrrolo[1,2c]imidazole (EF-7412) using neural networks. A selective derivative with mixed 5-HT(1A)/D2 antagonist properties

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 12, 1999, Pages 1679-1682

  López Rodríguez, María L ^a   Morcillo, M José ^b   Fernández, Esther ^a   Rosado, M Luisa ^a   Orensanz, Luis ^c   Beneytez, M Eugenia ^d   Manzanares, Jorge ^d   Fuentes, José A ^d   Schaper, Klaus Jürgen ^e  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b UNIVERSIDAD NACIONAL DE EDUCACIÓN A DISTANCIA   (Spain)

^c HOSPITAL RAMÓN Y CAJAL   (Spain)

^d UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^e RESEARCH CENTER BORSTEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 [4 [3 (ETHYLSULFONAMIDO)PHENYL]PIPERAZIN 1 YL]BUTYL]1,3 DIOXOPERHYDROPYRROLO[1,2 C]IMIDAZOLE; ALPHA ADRENERGIC RECEPTOR; DOPAMINE 2 RECEPTOR; DOPAMINE 2 RECEPTOR BLOCKING AGENT; EF 7412; IMIDAZOLE DERIVATIVE; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGENATION; HYPOTHALAMUS; MEMBRANE MODEL; MOTOR ACTIVITY; NERVE CELL NETWORK; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RECEPTOR AFFINITY;

DOPAMINE ANTAGONISTS; DRUG DESIGN; NEURAL NETWORKS (COMPUTER); PIPERAZINES; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, DOPAMINE D2; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN ANTAGONISTS; SULFONAMIDES;

EID: 0005429026     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00254-1     Document Type: Article

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