Divergent effects of protein kinase C (PKC) inhibitors staurosporine and bisindolylmaleimide I (GF109203X) on bone resorption

Biochemical Pharmacology

Volumn 60, Issue 7, 2000, Pages 923-926

  Lee, Suk Kyeong ^a   Stern, Paula H ^b  

^a The Catholic University of Korea   (South Korea)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Bone resorption; GF109203X; Parathyroid hormone; Protein kinase C; Staurosporine

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; BISINDOLYLMALEIMIDE; ISOENZYME; PARATHYROID HORMONE; PARATHYROID HORMONE RECEPTOR; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; STAUROSPORINE; THROMBIN; THYROXINE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; FETUS; NONHUMAN; OSTEOLYSIS; PRIORITY JOURNAL; RAT;

ANIMALS; BONE AND BONES; BONE RESORPTION; CALCIUM; CALCIUM RADIOISOTOPES; DRUG INTERACTIONS; ENZYME INHIBITORS; INDOLES; MALEIMIDES; MICE; PARATHYROID HORMONE; PROTEIN KINASE C; STAUROSPORINE;

EID: 0003867268     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(00)00418-4     Document Type: Article

References (17)

1. Bos M.P., Most W., van Leeuwen J.P.T.M., Herrmann-Erlee M.P.M. Role of protein kinase C (PKC) in bone resorption Effect of the specific PKC inhibitor 1-alkyl-2-methylglycerol . Biochim Biophys Res Commun. 184:1992;1317-1323.
2. Van Leeuwen J.P., Birkenhager J.C., van den Bemd G.J., Buurman C.J., Staal A., Bos M.P., Pols H.A. Evidence for the functional involvement of protein kinase C in the action of 1,25-dihydroxyvitamin D3 in bone. J Biol Chem. 267:1992;12562-12569.
3. Tashjian A.H. Jr, Ivey J.L., Delclos B., Levine L. Stimulation of prostaglandin production in bone by phorbol esters and melittin. Prostaglandins. 16:1978;221-232.
4. Lorenzo J.A., Sousa S. Phorbol esters stimulate bone resorption in fetal rat long-bone cultures by mechanisms independent of prostaglandin synthesis. J Bone Miner Res. 3:1988;63-67.
5. Abraham D.C., Wadkins C.L., Conaway H.H. Enhancement of fetal rat limb bone resorption by phorbol ester (PMA) and ionophore A-23187. Calcif Tiss Intl. 42:1988;191-195.
6. Ransjö M., Lerner U.H. 12-O-Tetradecanoylphorbol-13-acetate, a phorbol ester stimulating protein kinase C, inhibits bone resorption in vitro induced by parathyroid hormone and parathyroid hormone-related peptide of malignancy. Acta Physiol Scand. 139:1990;249-250.
7. Tullec D., Pianetti P., Coste H., Bellevergue P., Grand-Perret T., Ajakane M., Baudet V., Boissin P., Noursier E., Loriolle F., Duhamel L., Charon D., Kirilovsky J. The bisindolymaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J Biol Chem. 266:1989;15771-15781.
8. 3 . Calcif Tiss Intl. 35:1983;172-176.
9. Bradshaw D., Hill C.H., Nixon J.S., Wilkinson S.E. Therapeutic potential of protein kinase C inhibitors. Agents Actions. 38:1993;135-147.
10. Harkin S.T., Cohen G.M., Gesher A. Modulation of apoptosis in rat thymocytes by analogs of staurosporine Lack of direct association with inhibition of protein kinase C . Mol Pharmacol. 54:1998;663-670.
11. Dlugosz A., Yuspa S.H. Staurosporine induces protein kinase C agonist effects and maturation of normal and neoplastic keratinocytes in vitro. Cancer Res. 51:1991;4677-4684.
12. Lee S.K., Stern P.H. Staurosporine enhances parathyroid hormone-induced calcium signal in UMR-106 osteoblastic cells. Arch Pharm Res. 22:1999;119-123.
13. Babich M., Foti L.R.P., Mathias K.L. Protein kinase C modulates effects on parathyroid hormone-induced changes in UMR 106-H5 osteoblastic cells. J Cell Biochem. 65:1997;276-285.
14. Lee SK, Sanders JL, Hunzicker-Dunn M, Ohno S and Stern PH, Differential effects of phorbol ester and parathyroid hormone on protein kinase C isozymes in UMR-106 and primary osteoblastic cells. J Bone Miner Res 9 Suppl 1: S238, 1994.
15. Sanders J.L., Stern P.H. Expression and phorbol ester-induced down-regulation of protein kinase C isozymes in osteoblasts. J Bone Miner Res. 11:1996;1862-1870.
16. Murrills R.J., Stein L.S., Horbert W.R., Dempster D.W. Effects of phorbol myristate acetate on rat and chick osteoclasts. J Bone Miner Res. 7:1992;415-423.
17. Alessi A.R. The protein kinase C inhibitors Ro 318220 and GF 109203X are equally potent inhibitors of MAPKAP kinase-1β (Rsk-2) and p70 S6 kinase. FEBS Lett. 402:1997;121-123.