Staurosporine enhances parathyroid hormone-induced calcium signal in UMR-106 osteoblastic cells

Archives of Pharmacal Research

Volumn 22, Issue 2, 1999, Pages 119-123

  Lee, Suk Kyeong ^a   Stern, Paula H ^b  

^a The Catholic University of Korea   (South Korea)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Calcium signal; H 7; Osteoblast; PTH; Staurosporine; thrombin

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; CALCIUM; ENZYME INHIBITOR; GENISTEIN; PARATHYROID HORMONE; PROTEIN KINASE C; STAUROSPORINE; THROMBIN;

ARTICLE; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; OSTEOBLAST;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; CALCIUM; ENZYME INHIBITORS; GENISTEIN; OSTEOBLASTS; PARATHYROID HORMONE; PROTEIN KINASE C; STAUROSPORINE; THROMBIN;

EID: 0033113305     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02976534     Document Type: Article

References (17)

1. Abou Samra, A. B., Juppner, H., Westerberg, D., Potts, J. T., Jr. and Segre, G. V., Parathyroid Hormone Causes Translocation of Protein Kinase C from Cytosol to Membranes in Rat Osteosarcoma Cells. Endocrinology, 124, 1107-1113 (1989).
2. Abou Samra, A. B., Juppner, H., Force, T., Freeman, M. W., Kong, X. F., Schipani, E., Urena, P., Richards, J., Bonventre, J. V., Potts, J. T., Jr., Kronenberg, H. M. and Segre, G. V., Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone related peptide from rat osteoblast like cells. Proc. Natl. Acad Sci. USA., 89, 2732-2736 (1992).
3. Bilbe, G., Roberts, E., Birch, M. and Evans, D. B., PCR phenotyping of cytokines, growth factors and their receptors and bone matrix proteins in human osteoblast-like cell lines. Bone, 19, 437-445 (1996).
4. Civitelli, R., Reid, I. R., Westbrook, S., Avioli, L. V. and Hruska, K. A., PTH elevates inositol polyphosphates and diacylglycerol in a rat osteoblast like cell line. Am. J. Physiol., 255, E660-E667 (1988).
5. Falzon, M. Serum stimulation of parathyroid hormone-related peptide gene expression in ROS 17/2.8 osteosarcoma cells through transcriptional and posttranscriptional mechanisms. Endocrinology, 137, 3681-3688 (1996).
6. Fukayama, S., Tashjian, A. H., Jr. and Bringhurst, R., Mechanism of desensitization to parathyroid hormone in human osteoblast like SaOS 2 cells. Endocrinology, 131, 1757-1769 (1992).
7. Inglese, J., Freedman, N. J., Koch, W. J. and Lefkowitz, R. J., Structure and mechanism of the G protein coupled receptor kinases. J. Biol. Chem., 268, 23735-23738 (1993).
8. Izbicka, E., Niewolna, M., Yoneda, T., Lowe, C., Boyce, B., and Mundy, G., pp60 c src Expression and activity in MG 63 osteoblastic cells modulated by PTH but not required for PTH mediated adenylate cyclase response. J. Bone Miner. Res., 9, 127-132 (1994).
9. Juppner, H., Abou Samra, A. B., Freeman, M., Kong, X. F., Schipani, E., Richards, J., Kolakowski, L. F., Jr., Hock, J., Potts, J. T., Jr., Kronenberg, H. M. and Segre, G. V., A G Protein Linked Receptor for Parathyroid Hormone and Parathyroid Hormone Related Peptide. Science, 254, 1024-1026 (1991).
10. Lee, S. K. and Stern, P. H., Studies on the mechanism of desensitization of the PTH stimulated calcium signal in UMR 106 cells: reversal of desensitization by alkaline phosphatase but not by protein kinase C down regulation. J. Bone Miner. Res., 9, 781-789 (1994).
11. Nissenson, R. A., Diep, D. and Strewler, G. J., Synthetic Peptides Comprising the Amino terminal Sequence of a Parathyroid Hormone like Protein from Human Malignancies. J. Biol. Chem., 263, 12866-12871 (1988).
12. Potts, J. T., Jr., Kronenberg, H. M. and Rosenblatt, M., Parathyroid hormone: chemistry, biosynthesis, and mode of action. Adv. Protein Chem., 35, 323-396 (1982).
13. Ruegg, U. T. and Burgess, G. M., Staurosporine, K 252 and UCN 01: potent but nonspecific inhibitors of protein kinases. Trends Pharmacol. Sci., 10, 218-220 (1989).
14. Sanders, J. L. and Stern, P. H., Expression and phorbol ester-induced down-regulation of protein kinase C isozymes in osteoblasts. J. Bone Miner. Res., 11, 1862-1872 (1996).
15. Schipani, E., Karga, H., Karaplis, A. C., Potts, J. T., Jr., Kronenberg, H. M., Segre, G. V., Abou Samra, A. B. and Juppner, H., Identical complementary deoxyribonucleic acids encode a human renal and bone parathyroid hormone (PTH)/PTH related peptide receptor. Endocrinology, 132, 2157-2165 (1993).
16. Shigeno, C., Hiraki, Y., Westerberg, D. P., Potts, J. T., Jr. and Segre, G. V., Parathyroid hormone receptors are plasma membrane glycoproteins with asparagine linked oligosaccharides. J. Biol. Chem., 263, 3872-3878 (1988).
17. 2+ signaling and endothelial permeability increase. J. Cellular Physiology, 175, 379-387 (1998).