Evolutionary design of glutathione-linked proteins in vivo and in vitro based on sampling of modules from pre-existing structures

Chemico-Biological Interactions

Volumn 133, Issue 1-3, 2001, Pages 3-6

  Mannervik, Bengt ^a   Bolton Grob, Robyn ^a   Cameron, Alexander D ^a   Etahadieh, Maryam ^a   Gustafsson, Ann ^a   Hansson, Lars O ^a   Hubatsch, Ina ^a   Jemth, Per ^a   Johansson, Ann Sofie ^a   Jones, T Alwyn ^a   Larsson, Anna Karin ^a   Nilsson, Lisa O ^a   Olin, Birgit ^a   Pettersson, Par L ^a   Ridderström, Marianne ^a   Stenberg, Gun ^a   Widersten, Mikael ^a   Wisén, Susanne ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Combinatorial protein chemistry; Glyoxalases; Protein design; Structural modules

Indexed keywords

EID: 0003282702     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(00)00216-7     Document Type: Article

References (10)

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2. A.D. Cameron, M. Ridderström, B. Olin, B. Mannervik, Crystal structure of human glyoxalase II and its complex with a glutathione thiolester substrate analogue, Struct. Fold. Des. 7 (1999) 1067-1078.
3. M. Ridderström, B. Mannervik, The primary structure of monomeric yeast glyoxalase I indicates a gene duplication resulting in two similar segments homologous to the subunit of dimeric human glyoxalase I, Biochem. J. 316 (1996) 1005-1006.
4. B. Mannervik, I. Carlberg, K. Larson, Glutathione: general review of mechanism of action, in: D. Dolphin, R. Poulson, O. Avramovic (Eds.), Coenzymes and Cofactors, vol. 3A, Wiley, New York, 1989, pp. 475-516.
5. B. Mannervik, H. Jensson, Binary combinations of four protein subunits with different catalytic specificities explain the relationship between six basic glutathione S-transferases in rat liver cytosol, J. Biol. Chem. 257 (1982) 9909-9912.
6. L.O. Nilsson, A. Gustafsson, B. Mannervik, Redesign of substrate-selectivity determining modules of glutathione transferase Al-1 installs high catalytic efficiency with toxic alkenal products of lipid peroxidation, Proc. Natl. Acad. Sci. USA, 97 (2000) 9408-9412.
7. L.O. Hansson, R. Bolton-Grob, T. Massoud, B. Mannervik, Evolution of differential substrate specificities in Mu class glutathione transferases probed by DNA shuffling, J. Mol. Biol. 287 (1999) 265-276.
8. C.M. Bruns, I. Hubatsch, M. Ridderström, B. Mannervik, J.A. Tainer, Human glutathione transferase A4-4 crystal structures and mutagenesis reveal the basis of high catalytic efficiency with toxic lipid peroxidation products, J. Mol. Biol. 288 (1999) 427-439.
9. J. Segura-Aguilar, S. Baez, M. Widersten, C.J. Welch, B. Mannervik, Human class Mu glutathione transferases, in particular isoenzyme M2-2, catalyze detoxication of the dopamine metabolite aminochrome, J. Biol. Chem. 272 (1997) 5727-5731.
10. S. Baez, J. Segura-Aguilar, M. Widersten, A.-S. Johansson, B. Mannervik, Glutathione transferases catalyse the detoxication of oxidized metabolites (o-quinones) of catecholamines and may serve as an antioxidant system preventing degenerative cellular processes, Biochem. J. 324 (1997) 25-28.