Complement as a mediator of allograft injury: An inflammatory view

Transplantation Reviews

Volumn 14, Issue 1, 2000, Pages 41-51

  Baldwin III, William M ^a,b   Samaniego, Milagros ^a   Qian, Zhiping ^a   Ota, Hirofumi ^a   Wasowska, Barbara A ^a   Sanfilippo, Fred ^a   Hruban, Ralph H ^a  

^a Hopkins University   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0002906885     PISSN: 0955470X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-470X(00)80009-9     Document Type: Article

References (103)

1. Wetsel RA: Structure, function and cellular expression of complement anaphylatoxin receptors. Curr Opin Immunol 1995, 7:48
2. Martin U, Bock D, Arseniev L, et al: The human C3a receptor is expressed on neutrophils and monocytes, but not on B or T lymphocytes. J Exp Med 1997, 86:199
3. Barton PA, Warren JS: Complement component C5 modulates the systemic tumor necrosis factor response in murine endotoxic shock. Infect Immun 1993, 61:1474
4. Morgan EL, Ember JA, Sanderson SD, et al: Anti-C5a receptor antibodies: Characterization of neutralizing antibodies specific for a peptide, C5aR-(9-29), derived from the predicted amino-terminal sequence of the human C5a receptor. J Immunol 1993, 151:377
5. Ember JA, Sanderson SD, Hugh TE, et al: Induction of interleukin-8 synthesis from monocytes by human C5a anaphylatoxin. Am J Pathol 1994, 144:393
6. Arnaout MA, Spits H, Terhorst C, et al: Deficiency of a leukocyte surface glycoprotein (LFA-1) in two patients with Mol deficiency: Effects of cell activation on Mol/LFA-1 surface expression in normal and deficient leukocytes. J Clin Invest 1984, 74:1291
7. Fearon DT, Collins LA: Increased expression of C3b receptors on polymorphonuclear leukocytes induced by chemotactic factors and by purification procedures. J Immunol 1983, 130:370
8. Werfel T, Oppermann M, Schulze M, et al: Binding of fluorescein-labeled anaphylatoxin C5a to human peripheral blood, spleen, and bone marrow leukocytes. Blood 1992, 79:152
9. Wahlin B, Perlmann H, Perlmann P, et al: C3 receptors on human lymphocyte subsets and recruitment of ADCC effector cells by C3 fragments. J Immunol 1983, 130:2831
10. Tedesco F, Pausa M, Nardon E, et al: The cytolytically inactive terminal complement complex activates endothelial cells to express adhesion molecules and tissue factor procoagulant activity. J Exp Med 1997, 185:1619
11. Torzewski J, Oldroyd R, Lachmann P, et al: Complement-induced release of monocyte chemotactic protein-1 from human smooth muscle cells: A possible initiating event in atherosclerotic lesion formation. Arterioscler Thromb Vasc Biol 1996, 16:673
12. Kilgore KS, Flory CM, Miller BF, et al: The membrane attack complex of complement induces interleukin-8 and monocyte chemoattractant protein-1 secretion from human umbilical vein endothelial cells. Am J Pathol 1996, 149:953
13. Carroll MC, Alicot EM, Katzman PJ, et al: Organization of the genes encoding complement receptors type 1 and 2, decay-accelerating factor, and C4-binding protein in the RCA locus on human chromosome 1. J Exp Med 1988, 167:1271
14. Liszewski MK, Post TW, Atkinson JP: Membrane cofactor protein (MCP or CD46): Newest member of the regulators of complement activation gene cluster. Annu Rev Immunol 1991, 9:431
15. Ollert MW, Kadlec JV, David K, et al: Antibody-mediated complement activation on nucleated cells. A quantitative analysis of the individual reaction steps. J Immunol 1994, 153:2213
16. Johnson E, Hetland G: Mononuclear phagocytes have the potential to synthesize the complete functional complement system. Scand J Immunol 1988, 27:489
17. Botto M, Lissandrini D, Sorio C, et al: Biosynthesis and secretion of complement component (C3) by activated human polymorphonuclear leukocytes. J Immunol 1992, 149: 1348
18. Johnson E, Hetland G: Human umbilical vein endothelial cells synthesize functional C3, C5, C6, C8 and C9 in vitro. Scand J Immunol 1991, 33:667
19. Brooimans RA, Stegmann AP, van Dorp WT, et al: Interleukin-2 mediates stimulation of complement C3 biosynthesis in human proximal tubular epithelial cells. J Clin Invest 1991, 88:379
20. Witte DP, Welch TR, Beischel LS: Detection and cellular localization of human C4 gene expression in the renal tubular epithelial cells and other extrahepatic epithelial sources. Am J Pathol 1991, 139:717
21. van den Dobbelstein MEA, Verhasselt V, Kasshoek JGJ, et al: Regulation of C3 and factor H synthesis of human glomerular mesangial cells by IL-1 and interferon-gamma. Clin Exp Immunol 1994, 95:173
22. Sacks S, Zhou W, Campbell RD, et al: C3 and C4 gene expression and interferon-gamma-mediated regulation in human glomerular mesangial cells. Clin Exp Immunol 1993, 93:411
23. Khirwadkar K, Zilow G, Oppermann M, et al: Interleukin-1 augments production of the third complement component by the alveolar epithelial cell line A549. Int Arch Allergy Immunol 1993, 100:35
24. Brooimans RA, van der Ark AA, Buurman WA, et al: Differential regulation of complement factor H and C3 production in human umbilical vein endothelial cells by IFN-gamma and IL-1. J Immunol 1990, 144:3835
25. Terasaki PI, Cecka JM, Gjertson DW, et al: High survival rates of kidney transplants from spousal and living unrelated donors. N Engl J Med 1995, 333:333
26. Takada M, Nadeau KC, Hancock WW, et al: Effects of explosive brain death on cytokine activation of peripheral organs in the rat. Transplantation 1998, 65:1533
27. Bittner HB, Kendall SW, Chen EP, et al: The combined effects of brain death and cardiac graft preservation on cardiopulmonary hemodynamics and function before and after subsequent heart transplantation. J Heart Lung Transplant 1996, 15:764
28. Marshall R, Ahsan N, Dhillon S, et al: Adverse effect of donor vasopressor support on immediate and one-year kidney allograft function. Surgery 1996, 120:663
29. Herijgers P, Leunens V, Tjandra-Maga T, et al: Changes in organ perfusion after brain death in the rat and its relation to circulating catecholamines. Transplantation 1996, 62:330
30. Novitzky D, Rhodin J, Cooper DK, et al: Ultrastructure changes associated with brain death in the human donor heart. Transpl Int 1997, 10:24
31. Mollnes TE: Biocompatibility. Complement as mediator of tissue damage and as indicator of incompatibility. Exp Clin Immunogenet 1997, 14:24
32. Halloran PF, Homik J, Goes N, et al: The "injury response": A concept linking non-specific injury, acute rejection, and long-term transplant outcomes. Transplant Proc 1997, 29:79
33. Maroko PR, Carpenter CD, Chiariello M, et al: Reduction by cobra venom factor of myocardial necrosis after coronary artery occlusion. J Clin Invest 1978, 61:661
34. Weisman HF, Bartow T, Leppo MK, et al: Soluble human complement receptor type 1: In vivo inhibitor of complement suppressing post-ischemic myocardial inflammation and necrosis. Science 1990, 249:146
35. Halloran PF, Autenried P, Ramassar V, et al: Local T cell responses induce widespread MHC expression: Evidence that INFg induces its own expression in remote sites. J Immunol 1992, 148:3837
36. Kilgore KS, Friedrichs GS, Homeister JW, et al: The complement system in myocardial ischaemia/reperfusion injury. Cardiovasc Res 1994, 28:437
37. Weiser MR, Williams JP, Moore FD Jr, et al: Reperfusion injury of ischemic skeletal muscle is mediated by natural antibody and complement. J Exp Med 1996, 183:2343
38. Kagiyama A, Savage HE, Michael LH, et al: Molecular basis of complement activation in ischemic myocardium: Identification of specific molecules of mitochondrial origin that bind human C1q and fix complement. Circ Res 1989, 64:607
39. Kovacsovics TJ, Peitsch MC, Kres A, et al: Antibody-independent activation of C1: I. Differences in the mechanism of C1 activation by nonimmune activators and by immune complexes: C1r-independent activation of C1s by cardiolipin vesicles. J Immunol 1987, 138:1864
40. Pemberton M, Anderson G, Vetvicka V, et al: Microvascular effects of complement blockade with soluble recombinant CR1 on ischemia/reperfusion injury of skeletal muscle. J Immunol 1993, 150:5104
41. Baldwin WM III, Samaniego-Picota M, Kasper EK, et al: Complement deposition in early cardiac transplant biopsies is associated with ischemic injury and subsequent rejection episodes. Transplantation 1999, 68:894
42. Qian Z, Pfaff-Ameese T, Behrens E, et al: C6 produced by macrophages contributes to cardiac allograft rejection. Transplantation 1998, 65:S77
43. Linas SL, Whittenburg D, Parsons PE, et al: Mild renal ischemia activates primed neutrophils to cause acute renal failure. Kidney Int 1992, 42:610
44. Seekamp A, Mulligan MS, Till GO, et al: Requirements for neutrophil products and L-arginine in ischemia-reperfusion injury. Am J Pathol 1993, 142:1217
45. Baldwin WM III, Pruitt SK, Brauer RB, et al: Complement in organ transplantation: Contribution to inflammation, injury and rejection. Transplantation 1995, 59:797
46. Halloran PF, Schlaut J, Solez K, et al: The significance of the anti-class I response: II. Clinical and pathological features of renal transplants with anti-class I-Iike antibody. Transplantation 1992, 53:550
47. Lobo PI, Spencer CE, Stevenson WC, et al: Evidence demonstrating poor kidney graft survival when acute rejections are associated with IgG donor-specific lymphocytotoxin. Transplantation 1995, 59:357
48. Feucht HE, Opelz G: The humoral immune response towards HLA class II determinants in renal transplantation. Kidney Int 1996, 50:1464
49. Gracie JA, Bolton EM, Porteous C, et al: T cell requirements for the rejection of renal allografts bearing an isolated class I MHC disparity. J Exp Med 1990, 172:1547
50. Bradley JA, Mowat AM, Bolton EM: Processed MHC class I alloantigen as the stimulus for CD4+ T-cell dependent antibody-mediated graft rejection. Immunol Today 1992, 13:434
51. Brandie D, Joergensen J, Zenke G, et al: Contribution of donor-specific antibodies to acute allograft rejection: Evidence from B cell-deficient mice. Transplantation 1998, 65:1489
52. Wasowska BA, Qian Z, Behrens E, et al: Elimination of antibody responses inhibits acute and chronic cardiac allograft rejection in mice. Transplantation 1998, 65:S90
53. Larsen CP, Alexander DZ, Hollenbaugh D, et al: CD40-gp39 interactions play a critical role during allograft rejection. Suppression of allograft rejection by blockade of the CD40-gp39 pathway. Transplantation 1996, 61:4
54. Collins P, Wilkie M, Razak K, et al: Cyclosporine and cremaphor modulate von Willebrand factor release from cultured human endothelial cells. Transplantation 1993, 56:1218
55. Wasowska BA, Qian Z, Behrens E, et al: Inhibition of acute cardiac allograft rejection in immunoglobulin-deficient mice. Transplant Proc 1999, 31:136
56. Wasowska BA, Qian Z, Behrens E, et al: Elimination of antibody responses inhibits acute and chronic cardiac allograft rejection in mice. J Immunol (submitted)
57. Suzuki T: Signal transduction mechanisms through Fc gamma receptors on the mouse macrophage surface. FASEB J 1991, 5:187
58. Ravetch JV, Clynes RA: Divergent roles for Fc receptors and complement in vivo. Annu Rev Immunol 1998, 16:421
59. Yamazaki S, Isobe M, Suzuki J, et al: Role of selectin-dependent adhesion in cardiac allograft rejection. J Heart Lung Transplant 1998, 17:1007
60. Salom RN, Maguire JA, Hancock WW: Endothelial activation and cytokine expression in human acute cardiac allograft rejection. Pathology 1998, 30:24
61. Saadi S, Holzknecht RA, Patte CP, et al: Complement-mediated regulation of tissue factor activity in endothelium. J Exp Med 1995, 182:1807
62. Brauer RB, Baldwin WM III, Wang D, et al: Hepatic and extrahepatic biosynthesis of complement factor C6 in the rat. J Immunol 1994, 153:3168
63. Bradley JA, Sarawar SR, Porteous C, et al: Allograft rejection in CD4+ T cell-reconstituted athymic nude rats - the nonessential role of host-derived CD8+ cells. Transplantation 1992, 53:477
64. Qian Z, Jakobs FM, Pfaff-Amesse T, et al: Complement contributes to the rejection of complete and class I MHC-incompatible cardiac allografts. J Heart Lung Transplant 1998, 17:470
65. Brauer RB, Baldwin WM III, Ibrahim S, et al: The contribution of terminal complement components to acute and hyperacute allograft rejection in the rat. Transplantation 1995, 59:288
66. Tannenbaum SH, Gralnick HR: Gamma-interferon modulates von Willebrand factor release by cultured human endothelial cells. Blood 1990, 75:2177
67. Russell PS, Chase CM, Colvin RB: Accelerated atheromatous lesions in mouse hearts transplanted to apolipoprotein-E-deficient recipients. Am J Pathol 1996, 149:91
68. Russell PS, Chase CM, Colvin RB: Alloantibody- and T cell-mediated immunity in the pathogenesis of transplant arteriosclerosis: Lack of progression to sclerotic lesions in B cell-deficient mice. Transplantation 1997, 64:1531
69. Shi C, Lee W-S, He Q, et al: Immunological basis of transplant-associated ateriosclerosis. Proc Natl Acad Sci USA 1996, 93:4051
70. Shi C, Russell ME, Bianchi C, et al: Murine model of accelerated transplant arteriosclerosis. Circ Res 1994, 75:199
71. Russell PS, Chase CM, Winn HJ, et al: Coronary atherosclerosis in transplanted mouse hearts: II. Importance of humoral immunity. J Immunol 1994, 152:5135
72. Brauer RB, Baldwin WM III, Pruitt SK, et al: Rat strain differences in complement activity correlate with hyperacute rejection of guinea pig cardiac xenografts. Transplant Proc 1993, 25:2848
73. Brauer RB, Baldwin WM III, Daha MR, et al: The use of Co-deficient rats to evaluate the mechanism of hyperacute rejection of discordant cardiac xenografts. J Immunol 1993, 151:7240
74. Qian Z, Wasowska BA, Behrens E, et al: C6 produced by macrophages contributes to cardiac allograft rejection. Am J Pathol 1999, 1293
75. Benzaquen LR, Nicholson-Weller A, Halperin JA: Terminal complement proteins C5b-9 release basic fibroblast growth factor and platelet-derived growth factor from endothelial cells. J Exp Med 1994, 179:985
76. Halperin JA, Taratuska A, Nicholson-Weller A: Terminal complement complex C5b-C9 stimulates mitogenesis in 3T3 cells. J Clin Invest 1993, 91:1974
77. Adams DH, Russell ME, Hancock WW, et al: Chronic rejection in experimental cardiac transplantation: Studies in the Lewis-F334 model. Immunol Rev 1993, 134:5
78. Wasowska B, Baldwin WM III, Sanfilippo F: IgG alloantibody responses to donor-specific blood transfusion in different rat strain combinations are predictive of renal allograft survival. Transplantation 1992, 53:175
79. Wasowska B, Baldwin WM III, Howell DN, et al: The association of enhancement of renal allograft survival by donor-specific blood transfusion with host MHC-linked inhibition of IgG anti-donor class I alloantibody responses. Transplantation 1993, 56:672
80. Wray DW, Baldwin WM III, Sanfilippo F: IgM and IgG alloantibody responses to MHC class I and II following rat renal allograft rejection: Effects of transplantectomy and posttransplantation blood transfusions. Transplantation 1992, 53:167
81. Wray DW, Baldwin WM III, Sanfilippo F: Different patterns of sensitization following renal allograft rejection in an inbred rat strain combination. Transplantation 1993, 55: 1132
82. Moen O, Fosse E, Dregelid E, et al: Centrifugal pump and heparin coating improves cardiopulmonary bypass biocompatibility. Ann Thorac Surg 1996, 62:1134
83. Ashraf S, Butler J, Tian Y, et al: Inflammatory mediators in adults undergoing cardiopulmonary bypass: Comparison of centrifugal and roller pumps. Ann Thorac Surg 1998, 65:480
84. Rose ML: Antibody-mediated rejection following cardiac transplantation. Transplant Rev 1993, 7:140
85. de Heer E, Davidoff A, van der Wal A, et al: Chronic renal allograft rejection in the rat. Transplantation-induced antibodies against basement membrane antigens. Lab Invest 1994, 70:494
86. Paul LC: Chronic renal transplant loss. Kidney Int 1995, 47:1491
87. Rose ML: Role of antibody and indirect antigen presentation in transplant-associated coronary artery vasculopathy. J Heart Lung Transplant 1996, 15:342
88. Paul LC, Muralidharan J, Muzaffar SA, et al: Antibodies against mesangial cells and their secretory products in chronic renal allograft rejection in the rat. Am J Pathol 1998, 152:1209
89. Samaniego M, Qian Z, Elshimi T, et al: Heat shock proteins are the target on immune reactions in warm ischemic injury. Transplantation 1999, 67:S37
90. Davis EA, Wang BH, Stagg CA, et al: Induction of heat shock protein in a model of acute cardiac allograft rejection. Transplantation 1996, 61:279
91. Baba HA, Schmid C, Wilhelm MJ, et al: Inducible heat shock protein 70 in rat cardiac allograft and its immunohistochemical localization in cardiac myocytes. Transplantation 1997, 64:1035
92. Weiss RA, Madaio MP, Tomaszewski JE, et al: T cells reactive to an inducible heat shock protein induce disease in toxin-induced interstitial nephritis. J Exp Med 1994, 180: 2239
93. Van Why SK, Mann AS, Thulin G, et al: Activation of heat-shock transcription factor by graded reductions in renal ATP, in vivo, in the rat. J Clin Invest 1994, 94:1518
94. Van Why SK, Hildebrandt F, Ardito T, et al: Induction and intracellular localization of HSP-72 after renal ischemia. Am J Physiol 1992, 263:F769
95. Sato H, Miyata M, Kasukawa R: Expression of heat shock protein on lymphocytes in peripheral blood and synovial fluid from patients with rheumatoid arthritis. J Rheumatol 1996, 23:2027
96. Vendetti S, Bach S, Amendola A, et al: Heat-shock protein expression on the membrane of T cells undergoing apoptosis. Immunology 1996, 88:6
97. Chicz RM, Urban RG, Gorga JC, et al: Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles. J Exp Med 1993, 178:27
98. Newcomb JR, Cresswell P: Characterization of endogenous peptides bound to purified HLA-DR molecules and their absence from invariant chain-associated alpha beta dimers. J Immunol 1993, 150:499
99. Koga T, Wrand-Wurttenberger A, DeBruyn J, et al: T cells against a bacterial heat shock protein recognize stressed macrophages. Science 1989, 245:1112
100. Moliterno R, Woan M, Bentlejewski C, et al: Heat shock protein-induced T-lymphocyte propagation from endomyocardial biopsies in heart transplantation. J Heart Lung Transplant 1995, 14:329
101. Liu K, Moliterno RA, Qian J, et al: Role of heat shock proteins in heart transplant rejection. J Heart Lung Transplant 1996, 15:222
102. Trieb K, Grubeck-Loebenstein B, Eberl T, et al: T cells from rejected human kidney allografts respond to heat shock protein 72. Transpl Immunol 1996, 4:43
103. Baldwin WM III: Complement in graft injury. Graft 1999, 2 (in press)