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Volumn , Issue 6, 1999, Pages 669-671

Polymer-supported hypervalent iodine reagents in 'clean' organic synthesis with potential application in combinatorial chemistry

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EID: 0001645943     PISSN: 0300922X     EISSN: None     Source Type: Journal    
DOI: 10.1039/a809799b     Document Type: Article
Times cited : (157)

References (23)
  • 16
    • 33746578694 scopus 로고    scopus 로고
    • 2a: The resin (PSDIB) (2.0 mmol) was added to a solution of the quinol la-e (1.0 mmol) in DCM (5 ml) and the resulting mixture stirred at room temperature for 4 hours. Filtration to remove the resin followed by evaporation of the filtrate afforded the pure quinones (Table 1); Oxidative spirocyclisation reactions: The resin (PSDIB) (2.0 mmol) was added to a solution of the tyrosine derivative (1.0 mmol) in DCM-MeCN (1:1, 8 ml) and the resulting mixture heated at 60 °C for 2 h. After cooling, the suspension was filtered to remove the resin followed by evaporation of the filtrate afforded the spirocyclic dienones lOa-e (Table 1).
    • General procedure for oxidative reactions using PSDIB: Oxidation to quinones 2a: The resin (PSDIB) (2.0 mmol) was added to a solution of the quinol la-e (1.0 mmol) in DCM (5 ml) and the resulting mixture stirred at room temperature for 4 hours. Filtration to remove the resin followed by evaporation of the filtrate afforded the pure quinones (Table 1); Oxidative spirocyclisation reactions: The resin (PSDIB) (2.0 mmol) was added to a solution of the tyrosine derivative (1.0 mmol) in DCM-MeCN (1:1, 8 ml) and the resulting mixture heated at 60 °C for 2 h. After cooling, the suspension was filtered to remove the resin followed by evaporation of the filtrate afforded the spirocyclic dienones lOa-e (Table 1).
    • For Oxidative Reactions Using PSDIB: Oxidation to Quinones
    • Procedure, G.1
  • 19
    • 33746538018 scopus 로고    scopus 로고
    • 1992,201; the low yields reported for the oxidative spirolactonisation step prompted McKillop and Taylor to report an improved synthesis of the Aranorosin nucleus; A. McKillop, R. J. K. Taylor, R. J. Watson and N. Lewis, Synlett, 1992,1005.
    • (a) A. McKillop, L. McLaren, R.J.K. Taylor, R. J. Watson and N. Lewis, Synlett, 1992,201; the low yields reported for the oxidative spirolactonisation step prompted McKillop and Taylor to report an improved synthesis of the Aranorosin nucleus; A. McKillop, R. J. K. Taylor, R. J. Watson and N. Lewis, Synlett, 1992,1005.
    • L. McLaren, R.J.K. Taylor, R. J. Watson and N. Lewis, Synlett
    • McKillop, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.