Factors mediating cell growth in lung injury

Chronic Lung Disease in Early Infancy

Volumn , Issue , 1999, Pages 493-534

  Tanswell, A Keith ^a   Buch, Shilpa ^a   Liu, Mingyao ^a   Post, Martin ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0001181667     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (322)

1. Northway WH, Rosan RC, Porter DY. Pulmonary disease following respirator therapy of hyaline membrane disease: bronchopulmonary dysplasia. N Engl J Med 1967; 276:357-368.
2. Bonikos DS, Bensch KG, Northway WH, Edwards DK. Bronchopulmonary dysplasia: the pulmonary pathological sequel of necrotizing bronchiolitis and pulmonary fibrosis. Hum Pathol 1976; 7:643-666.
3. Chambers HM, van Velzen D. Ventilator-related pathology in the extremely immature lung. Pathology 1989; 21:79-83.
4. Van Lierde S, Cornelis A, Devlieger H, Moerman P, Lauweryns J, Eggermont E. Different patterns of pulmonary sequelae after hyaline membrane disease: heterogeneity of bronchopulmonary dysplasia? Biol Neonate 1991; 60:152-163.
5. Margraf LR, Tomashefski JF, Bruce MC, Dahms BB. Morphometric analysis of the lung in bronchopulmonary dysplasia. Am Rev Respir Dis 1991; 143:391-400.
6. Smith JC, Stiles CD. Cytoplasmic transfer of the mitogenic response to platelet- derived growth factor. Proc Natl Acad Sci USA 1981; 78:4363-4367.
7. Stiles AD, Smith BT, Post M. Reciprocal autocrine and paracrine regulation of growth of mesenchymal and alveolar epithelial cells. Exp Lung Res 1986; 11:165177.
8. Tanswell AK. Cellular interactions in pulmonary oxygen toxicity in vitro: I. Hyper-oxic induction of fibroblast factors which alter growth and lipid metabolism of pulmonary epithelial cells. Exp Lung Res 1983; 5:23-36.
9. Tzaki MG, Byrne PJ, Tanswell AK. Cellular interactions in pulmonary oxygen toxicity in vitro. II. Hyperoxia causes adult rat lung fibroblast cultures to produce apparently autocrine growth factors. Exp Lung Res 1988; 14:403-419.
10. Sara VR, Hall K. Insulin-like growth factors and their binding proteins. Physiol Rev 1990; 70:591-614.
11. Loewenstein WR. Cell-to-cell communication and the control of growth. Am Rev Respir Dis 1990; 142 (suppl):48-53.
12. Munari-Silem Y, Audebet C, Rousset B. Hormonal control of cell to cell communication: regulation by thyrotropin of the gap-junction mediated dye transfer between thyroid cells. Endocrinology 1991; 128:3299-3309.
13. Massague J. Transforming growth factor-a. A model for membrane-anchored growth factors. J Biol Chem 1990; 265:21393-21396.
14. Farago A, Nishizuka Y. Protein kinase C in transmembrane signalling. FEBS Lett 1990; 268:350-354.
15. Yarden Y, Ullrich A. Growth factor receptor protein kinases. Annu Rev Biochem 1988; 57:443-478.
16. Dumont JE, Jauniaux JC, Roger PP. The cyclic AMP-mediated stimulation of cell proliferation. Trends Biochem Sci 1989; 14:67-71.
17. Ihle JN, Wirtthuhn BA, Quelle FW, Yamamoto K, Thierfelder WE, Kreider B, Silvennoinen O. Signalling by the cytokine receptor superfamily: JAKs and STATs. Trends Biochem Sci 1994; 19:222-227.
18. Pines J. Cyclins and cyclin-dependent kinases: take your partners. Trends Biochem Sci 1993; 18:95-99.
19. Hackney JD, Evans MJ, Spier CE, Anzar UT, Clark KW. Effect of high concentrations of oxygen on reparative regeneration of damaged alveolar epithelium in mice. Exp Mol Pathol 1981; 34:338-344.
20. Weiss P, Kavanau JL. A model of growth and growth control in mathematical terms. J Gen Physiol 1957; 41:1-47.
21. Simnett J, Fisher JM, Heppelston AG. Tissue-specific inhibition of lung alveolar cell mitosis in organ culture. Nature 1969; 223:944-946.
22. Tanswell AK, Fraher LJ, Grose EC. Circulating factors that modify lung cell DNA synthesis following exposure to inhaled oxidants. I. Effect of serum and lavage on lung fibroblasts following exposure of adult rats to 1 ppm ozone. J Toxicol Environ Health 1989; 27:239-254.
23. Tanswell AK, Fraher LJ, Grose EC. Circulating factors that modify lung cell DNA synthesis following exposure to inhaled oxidants. II. Effect of serum and lavage on lung pneumocytes following exposure of adult rats to 1 ppm ozone. J Toxicol Environ Health 1990; 29:131-144.
24. Miyazaki K, Horio T. Growth inhibitors: molecular diversity and roles in cell proliferation. In Vitro Cell Dev Biol 1989; 25:866-872.
25. Caniggia I, Tseu I, Rolland G, Edelson J, Tanswell AK, Post M. Inhibition of fibroblast growth by epithelial cells in fetal rat lung. Am J Respir Mol Cell Biol 1995; 13:91-98.
26. Ueda N, Shah SV. Apoptosis. J Lab Clin Med 1994; 124:169-177.
27. Harrington EA, Bennett MR, Fanidi A, Evan GI. c-myc-induced apoptosis in fibroblasts is inhibited by specific cytokines. EMBO J 1994; 13:3286-3296.
28. Raghu G, Striker LJ, Hudson LD, Striker GE. Extracellular matrix in normal and fibrotic human lungs. Am Rev Respir Dis 1985; 131:281-289.
29. Dunnill MS. Pulmonary fibrosis. Histopathology 1990; 16:321-329.
30. Crouch E. Pathobiology of pulmonary fibrosis. Am J Physiol 1990; 259:L159-L184.
31. McGowan SE. Extracellular matrix and the regulation of lung development and repair. FASEB J 1992; 6:2895-2904.
32. Jassal D, Han RNN, Caniggia I, Post M, Tanswell AK. Growth of distal fetal rat lung epithelial cells in a defined serum-free medium. In Vitro Cell Dev Biol 1991; 27:625-632.
33. Tanswell K, Rolland G, Jassal D, Buch S, Post M. The fibroblast hyperplasia observed in pulmonary O2 toxicity may depend on both a local increase in growth factors and a change in subcellular matrix composition [abstr]. Am Rev Respir Dis 1992; 145:828.
34. Tanswell AK, Han RNN, Jassal D, Fraher LJ, Post M. The response of small vessel endothelial cells from fetal rat lung to growth factors. J Dev Physiol 1991; 15:199-209.
35. Engel J. EGF-like domains in extracellular matrix proteins: localized signals for growth and differentiation? FEBS Lett 1989; 251:1-7.
36. Ingber D. Extracellular matrix and cell shape: potential control points for inhibition of angiogenesis. J Cell Biochem 1991; 47:236-241.
37. Vlodavsky I, Fuks Z, Ishai-Michaeli R, Bashkin P, Levi E, Korner G, Bar-Shavit R, Klagsbrun M. Extracellular matrix-resident basic fibroblast growth factor: implications for the control of angiogenesis. J Cell Biochem 1991; 45:167-176.
38. Murphy-Ullrich JE, Schultz-Cherry S, Hook M. Transforming growth factor-P complexes with thrombospondin. Mol Biol Cell 1992; 3:181-188.
39. Raines EW, Lane TF, Iruela-Arispe ML, Ross R, Sage EH. The extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB and inhibits the binding of PDGF to its receptors. Proc Natl Acad Sci USA 1992; 89:1281-1285.
40. Gitay-Goren H, Soker S, Vlodavsky I, Neufeld G. The binding of vascular endothelial growth factor to its receptors is dependent on cell surface-associated heparinlike molecules. J Biol Chem 1992; 267:6093-6098.
41. Roghani M, Moscatelli D. Basic fibroblast growth factor is internalized through both receptor-mediated and heparan sulfate-mediated mechanisms. J Biol Chem 1992; 267:22156-22162.
42. Han RNN, Buch S, Freeman BA, Post M, Tanswell AK. Platelet-derived growth factor and growth-related genes in rat lung II. Effect of exposure to 85% O2. Am J Physiol 1992; 262:L140-L146.
43. Buch S, Han RNN, Liu J, Moore A, Edelson JD, Freeman BA, Post M, Tanswell AK. Basic fibroblast growth factor and growth factor receptor gene expression in 85% O2-exposed rat lung. Am J Physiol 1995; 268:L455-L464.
44. Giri SN, Hyde DM, Hollinger MA. Effect of antibody to transforming growth factor P on bleomycin induced accumulation of lung collagen in mice. Thorax 1993; 48: 959-966.
45. Kauffmann SL. Cell proliferation in the mammalian lung. Int Rev Exp Pathol 1980; 22:131-191.
46. Adamson IYR, Bowden DH. Derivation of type 1 epithelium from type 2 cells in the developing rat lung. Lab Invest 1975; 32:736-745.
47. Adamson IYR, King, GM. Sex differences in development of fetal rat lung. I. Autoradiographic and biochemical studies. Lab Invest 1984; 50:456-460.
48. O’Hare KH, Townes PL. Morphogenesis of albino rat lung: an autoradiographic analysis of the embryological origin of the type I and II pulmonary epithelial cells. J Morphol 1970; 132:69-82.
49. Buch S, Jassal D, Han R, Liu J, Caniggia I, Edelson J, Tanswell K, Post M. Ontogeny and regulation of platelet-derived growth factor gene expression in distal fetal rat lung epithelial cells. Am J Respir Cell Mol Biol 1994; 11:251-261.
50. Post M, Smith BT. Hormonal control of surfactant metabolism. In: Robertson B, Van Golde LMG, Batenburg JJ, eds. Pulmonary Surfactant: From Molecular Biology to Clinical Practice. New York: Elsevier, 1992:379-424.
51. Post M. Tissue interactions. In: Crystal RG, West J, eds. The Lung: Scientific Foundations. New York: Raven Press, 1997:1003-1011.
52. Alescio T, Colombo Piperno E. A quantitative assessment of mesenchymal contribution to epithelial growth rate in mouse embryonic lung developing in vitro. J Embryol Exp Morphol 1967; 17:213-227.
53. Alescio T, DiMichelle M. Relationship of epithelial growth to mitotic rate in mouse embryonic lung developing in vitro. J Embryol Exp Morphol 1968; 19:227-237.
54. Alescio T, Cassini A. Induction in vitro of tracheal buds by pulmonary mesenchyme grafted on tracheal epithelium. J Exp Zool 1962; 150:83-94.
55. Goldin GV, Wessels NK. Mammalian lung development: the possible role of cell proliferation in the formation of supernumerary tracheal buds and in branching morphogenesis. J Exp Zool 1979; 208:337-346.
56. Shannon JM. Induction of alveolar type II cell differentiation in fetal tracheal epithelium by grafted distal lung mesenchyme. Dev Biol 1994; 166:600-614.
57. Lawson KA. Stage specificity in the mesenchyme requirement of rodent lung epithelium in vitro: a matter of growth control? J Embryol Exp Morphol 1983; 74: 183-206.
58. Caniggia I, Tseu I, Han RNN, Smith BT, Tanswell K, Post M. Spatial and temporal differences in fibroblast behaviour in fetal rat lung. Am J Physiol 1991; 261:L424-L433.
59. Lawson KA. The role of mesenchyme in the morphogenesis and functional differentiation of rat salivary epithelium. J Embryol Exp Morphol 1972; 27:497-513.
60. Kratochwil K. Organ specificity in mesenchymal induction demonstrated in the embryonic development of the mammary gland of the mouse. Dev Biol 1969; 20: 46-71.
61. Sakakura T, Sakagami S, Niskizyka Y. Persistence of responsiveness of adult mouse mammary gland to induction by embryonic mesenchyme. Dev Biol 1979; 72:201-210.
62. Snead ML, Luo W, Olizer P, Don-Wheeler G, Bessem C, Bell GI, Rall LB, Slavkin HC. Localization of epidermal growth factor precursors in tooth and lung during embryonic mouse development. Dev Biol 1989; 134:420-429.
63. Partanen A-M. Epidermal growth factor and transforming growth factor-a in the development of epithelium-mesenchymal organs of the mouse. Curr Top Dev Biol 1990; 24:31-55.
64. Ebner R, Derynck R. Epidermal growth factor and transforming growth factor-a: differential routing and processing of ligand-receptor complexes. Cell Regul 1991; 2:599-612.
65. Freemark M, Comer M. Epidermal growth factor (EGF)-like transforming growth factor (TGF) activity and EGF receptors in ovine fetal tissues: possible role for TGF in ovine fetal development. Pediatr Res 1987; 22:609-615.
66. Standjord TP, Clark JG, Madtes DK. Expression of TGF-a, EGF, and EGF receptor in fetal rat lung. Am J Physiol 1994; 267:L384-L389.
67. Snead ML, Luo W, Olizer P, Don-Wheeler G, Bessem C, Bell GI, Rall LB, Slavkin HC. Localization of epidermal growth factor precursors in tooth and lung during embryonic mouse development. Dev Biol 1989; 134:420-429.
68. Warburton D, Seth R, Shum L, Horcher PG, Hall FL, Werb Z, Slavkin HC. Epigenetic role of epidermal growth factor expression and signalling in embryonic mouse lung morphogenesis. Dev Biol 1992; 149:123-133.
69. Raaberg L, Nex0 E, Buckley S, Luo W, Snead ML, Warburton D. Epidermal growth factor transcription, translation and signal transduction by rat type II pneu- mocytes in culture. Am J Respir Cell Mol Biol 1992; 6:44-49.
70. Johnson MD, Gray ME, Carpenter G, Pepinsky RB, Sundell H, Stahlman MT. Ontogeny of epidermal growth factor receptor/kinase and of lipocortin-1 in the ovine lung. Pediatr Res 1989; 25:535-541.
71. Johnson MD, Gray ME, Carpenter G, Pepinsky RB, Stahlman MT. Ontogeny of epidermal growth factor receptor and lipocortin-1 in fetal and neonatal human lungs. Hum Pathol 1990; 21:182-191.
72. Ruocco S, Lallemand A, Tournier JM, Gaillard D. Expression and localization of epidermal growth factor-a, and localization of their common receptor in fetal human lung development. Pediatr Res 1996; 39:448-455.
73. Aida S, Tamai S, Sekiguchi S, Shimizu N. Distribution of epidermal growth factor and epidermal growth factor receptor in human lung: immunohistochemical and immunoelectron-microscopic studies. Respiration 1994; 61:161-166.
74. Ganser GL, Stricklin GP, Matrisian LM. EGF and TGFa influence in vitro lung development by the induction of matrix-degrading metalloproteinases. Int J Dev Biol 1991; 35:453-461.
75. Threadgill DW, Dlugosz AA, Hansen LA, Tennenbaum T, Lichti U, Yee D, La- Mantia C, Mourton T, Herrup K, Harris RC, Barnard JA, Yuspa SH, Coffey RJ, Mjagnuson T. Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Science 1995; 269:230-234.
76. Hardie WD, Kerlakian CB, Bruno MD, Huelsman KM, Wert SE, Glasser SW, Whitsett JA, Korfhagen TR. Reversal of lung lesions in transgenic transforming growth factor a mice by expression of mutant epidermal growth factor receptor. Am J Respir Cell Mol Biol 1996; 15:499-508.
77. Miettinen PJ, Berger JE, Meneses J, Phung Y, Pederson RA, Werb Z, Derynck R. Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature 1995; 376:337-341.
78. Catteron WZ, Escobedo MB, Sexson, WR, Gray E, Sundell HW, Stahlman MT. Effects of epidermal growth factor on lung maturation in fetal lambs. Pediatr Res 1979; 13:104-108.
79. Sundell HW, Gray ME, Serenius FS, Escobedo MB, Stahlman MT. Effects of epidermal growth factor on lung maturation in fetal lambs. Am J Pathol 1980; 100: 707-726.
80. Plopper CG, St George JA, Read LC, Nishio SJ. Weir AJ, Edwards L, Tarabtal AF, Pinkerton KE, Merritt TA, Whitsett JA. Acceleration of alveolar type II cell differentiation in fetal rhesus monkey lung by administration of EGF. Am J Physiol 1992; 262:L313-L321.
81. Sen N, Cake MH. Enhancement of desaturated phosphatidylcholine synthesis by epidermal growth factor in cultured fetal lung cells involves a fibroblast-epithelial cell interaction. Am J Respir Cell Mol Biol 1991; 5:337-343.
82. Nielsen HC. Epidermal growth factor influences the developmental clock regulating maturation of the fetal lung fibroblasts. Biochim Biophys Acta 1989; 1012:201206.
83. Stiles AD, D’Ercole AJ. The insulin-like growth factors and the lung. Am J Respir Cell Mol Biol 1990; 3:93-100.
84. Han VKM, Hill DJ, Strain A, Towle AC, Lauder JM, Underwood LE, D’Ercole AJ. Identification of somatomedin/insulin-like growth factor immunoreactive cells in the human fetus. Pediatr Res 1987; 22:245-249.
85. Klempt M, Hutchins A-M, Gluckman PD, Skinner SJM. IGF binding protein-2 gene expression and location of IGF-I and IGF-II in fetal rat lung. Development 1992; 115:765-772.
86. Retsch-Bogart GZ, Moats-Staats BM, Howard K, D’Ercole AJ, Stiles AD. Cellular localization of messenger RNAs for insulin-like growth factors (IGFs), their receptors and binding proteins during fetal rat lung development. Am J Respir Cell Mol Biol 1996; 14:61-69.
87. Wallen LD, Han VKM. Spatial and temporal distribution of insulin-like growth factors I and II during development of rat lung. Am J Physiol 1994; 267:L531- L542.
88. Liu JP, Baker J, Perkins AS, Robertson EJ, Efstratiadis A. Mice carrying null mutations of the genes encoding insulin-like growth factor I (IGF-1) and type 1 IGF receptor (IGFlr). Cell 1993; 75:59-72.
89. DeChiara TM, Efstratiadas A, Robertson EJ. A growth-deficiency phenotype in heterozygous mice carrying an insulin-growth factor II gene disrupted by targeting. Nature 1990; 345:78-80.
90. Han RNN, Liu J, Tanswell AK, Post M. Expression of basic fibroblast growth factor and receptor. Immunolocalization studies in developing rat fetal lung. Pediatr Res 1992; 31:435-440.
91. Fu Y, Spirito P, Yu Z-X, Biro S, Sasse J, Lei J, Ferrans VJ, Epstein SE, Casscells W. Acidic fibroblast growth factor in the developing rat embryo. J Cell Biol 1991; 114:1261-1273.
92. Sannes PL, Burch KK, Khosla J. Immunohistochemical localization of epidermal growth factor and acidic and basic fibroblast growth factors in postnatal developing and adult rat lungs. Am J Respir Cell Mol Biol 1992; 7:230-237, 1992.
93. Orr-Utreger A, Givol D, Yayon A, Yarden Y, Lonai P. Developmental expression of two murine fibroblast growth factor receptors, flg and bek. Development 1991; 113:1419-1434.
94. Mason JJ, Fuller-Pace F, Smith R, Dickson C. FGF-7 (keratinocyte growth factor) expression during mouse development suggests roles in myogenesis, forebrain re- gionalisation and epithelial-mesenchymal interactions. Mech Dev 1994; 45:1530.
95. Panos RJ, Rubin JS, Csaky KG, Aaronson SA, Mason RJ. Keratinocyte growth factor and hepatocyte growth factor/scatter factor are heparin-binding growth factors for alveolar type II cells in fibroblast-conditioned medium. J Clin Invest 1993; 92:969-977.
96. Peters K, Werner S, Liao X, Wert S, Whitsett JA, Williams LT. Targeted expression of a dominant negative FGF receptor blocks branching morphogenesis and epithelial differentiation of the mouse lung. EMBO J 1994; 13:3296-3301.
97. Post M, Souza P, Liu J, Tseu I, Wang J, Kuliszewski M, Tanswell AK. Keratinocyte growth factor and its receptor are involved in regulating early lung branching. Development 1996; 122:3107-3115.
98. Heine UI, Munoz EF, Flanders KC, Roberts AB, Sporn MB. Colocalization of TGF-beta 1 and collagen I and III, fibronectin and glycosaminoglycans during lung branching morphogenesis. Development 1990; 109:29-36.
99. Sera R, Pelton RW, Moses HL. TGFPj inhibits branching morphogenesis and N- myc expression in lung bud organ cultures. Development 1994; 120:2153-2161.
100. Kulkarni AB, Huh C-G, Becker D, Geiser A, Light M, Flanders KC, Roberts AB, Sporn MB, Ward JM, Karlsson S. Transforming growth factor-Pj null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci USA 1993; 90:770-774.
101. Sanford LP, Ormsby I, Gittenberg-de Groot AC, Sariola H, Friedman R, Biovin GP, Cardell EL, Doetschman T. TGFP2 knockout mice have multiple developmental defects that are nonoverlapping with other TGFP knockout phenotypes. Development 1997; 124:2659-2670.
102. Kaartinen V, Voncken JW, Shuler C, Warburton D, Bui D, Heisterkamp N, Groffen J. Abnormal lung development and cleft palate in mice lacking TGF-P3 indicates defects of epithelial-mesenchymal interaction. Nature Genet 1995; 11:415-421.
103. Whitsett JA, Weaver TE, Lieberman MA, Clark JC, Daugerty C. Differential effects of epidermal growth factor and transforming growth factor-P on synthesis of MR = 35,000 surfactant-associated protein in fetal lung. J Biol Chem 1987; 262: 7908-7913.
104. Torday JS, Kourembanas S. Fetal rat lung fibroblasts produce a TGFP homolog that blocks alveolar type II cell maturation. Dev Biol 1990; 139:35-41.
105. Catlin EA, Manganaro TF, Donahoe PK. Mullerian inhibiting substance depresses accumulation in vitro of disaturated phosphatidylcholine in fetal rat lung. Am J Obstet Gynecol 1988; 159:1299-1303.
106. Catlin EA, Powell SM, Manganaro TF, Hudson PL, Ragin C, Epstein J, Donahoe PK. Sex-specific fetal lung development and miillerian inhibiting substance. Am Rev Respir Dis 1990; 141:466-470.
107. Han RNN, Mawdsley C, Souza P, Tanswell AK, Post M. Platelet-derived growth factors and growth-related genes in rat lung III. Immunolocalization during fetal development. Pediatr Res 1992; 31:323-329.
108. Han RNN, Liu J, Tanswell AK, Post M. Ontogeny of platelet-derived growth factor receptor (PDGFR) in fetal rat lung. Microsc Res Tech 1993; 26:381-388.
109. Souza P, Sedlackova L, Kuliszewski M, Wang J, Liu J, Tseu I, Tanswell K, Post M. Antisense oligonucleotides targeting PDGF-B mRNA inhibit cell proliferation during embryonic rat lung development. Development 1994; 120:2163-2173.
110. Leveen P, Pekny M, Gebre-Medhin S, Swolin B, Larsson E, Betsholtz C. Mice deficient for PDGFB show renal, cardiovascular, and hematological abnormalities. Genes Dev 1994; 8:1875-1887.
111. Soriano P. Abnormal kidney development and hematological disorders in PDGF P-receptor mutant mice. Genes Dev 1994; 8:1888-1896.
112. Souza P, Kuliszewski M, Wang J, Tseu I, Tanswell AK, Post M. PDGF-AA and its receptor influence early lung branching morphogenesis via an epithelial-mesenchymal interaction. Development 1995; 121:2559-2567.
113. Orr-Utreger A, Lonai P. Platelet-derived growth factor-A and its receptor are expressed in separate, but adjacent cell layers of the mouse embryo. Development 1992; 115:1045-1058.
114. Souza P, Tanswell AK, Post M. Different roles for PDGF-a and -P receptors in embryonic lung development. Am J Respir Cell Mol Biol 1996; 15:551-562.
115. Bostrom H, Willetts K, Pekny M, Leveen P, Lindahl P, Hedstrand H, Pekna M, Hellstrom M, Gebre-Medhin S, Schalling M, Nilsson M, Kurland S, Tornell J, Heath JK, Betsholtz C. PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis. Cell 1996; 85:863-873.
116. Soriano P. The PDGFa receptor is required for neural crest cell development and for normal patterning of the somites. Development 1997; 124:2691-2700.
117. Buch S, Jones C, Sweezey N, Tanswell AK, Post M. Platelet-derived growth factor and growth related genes in rat fetal lung: I. Developmental expression. Am J Res- pir Cell Mol Biol 1991; 5:371-376.
118. Carson SH, Taeusch HW, Avery ME. Inhibition of lung cell division after hydrocortisone injection in fetal rabbits. J Appl Physiol 1973; 34:660-664.
119. Kotas RV, Avery ME. Accelerated appearance of pulmonary surfactant in the fetal lung. J Appl Physiol 1971; 30:358-361.
120. Kotas RV, Mims L, Hart L. Reversible inhibition of lung cell numbers after glucocorticoid injection. Pediatrics 1974; 53:358-361.
121. Kikkawa Y, Kaibaira M, Motoyama EK, Orzalesi MM, Cook CD. Morphologic development of fetal rabbit lung and its acceleration with cortisol. Am J Pathol 1971; 64:423-433.
122. Motoyama E, Orzalesi M, Kikkawa Y, Kaibaira M, Wu B, Zigas C, Cook CD. Effect of cortisol on the maturation of fetal rabbit lungs. Pediatrics 1971; 48:547-555.
123. Franco G, Stiles AD, Carlson KS, Post M. Endogenous and exogenous growth potential of fetal lung cells [abstr]. Pediatr Res 1986; 20:187.
124. Price WA, Stiles AD, Moats-Staats BM, D’Ercole AJ. Gene expression of insulinlike growth factors (IGFs), the type I IGF receptor, and IGF-binding proteins in dexamethasone-induced fetal growth retardation. Endocrinology 1992; 130:14241432.
125. Liggins GC. Growth of fetal lung. J Dev Physiol 1984; 6:237-248.
126. Cooney TP, Thurlbeck WM. Lung growth and development in anencephaly and hydrancephaly. Am Rev Respir Dis 1985; 132:596-601.
127. Latimer AM, Hausman GJ, McCusker RH, Buonomo FC. The effects of thyroxine on serum and tissue concentrations of insulin-like growth factors (IGF-I and -II) and IGF-binding proteins in the fetal pig. Endocrinology 1993; 133:1312-1319.
128. Pfeifle B, Ditschuneit H. Regulation of receptors for insulin-like growth factors in cultured arterial smooth muscle cells by thyroid hormone. Endocrinology 1983; 98: 373-379.
129. Walker P. Thyroxine increases neonatal mouse submandibular gland mRNA-di- rected synthesis of epidermal growth factor. Biochem Cell Biol 1986; 64:290-296.
130. Fernandez-Pol JA, Klos DJ, Hamilton PD. Modulation of transforming growth factor alpha-dependent expression of epidermal growth factor receptor gene by transforming growth factor beta, triiodothyronine, and retinoic acid. J Cell Biochem 1989; 41:159-170.
131. Bartlett D. Postnatal growth of the mammalian lung: influence of exercise and thyroid activity. Respir Physiol 1970; 9:50-57.
132. Erenberg A, Rhodes RL, Weinstein MM, Kennedy RL. The effect of thyroidectomy on ovine fetal lung maturation. Pediatr Res 1969; 13:230-235.
133. Adamson IYR, King GM. Sex-related differences in cellular composition and surfactant synthesis of developing fetal rat lungs. Am Rev Respir Dis 1984; 129:130134.
134. Robert MF, Neff RK, Hubell JF, Taeusch HW, Avery ME. Association between maternal diabetes and the respiratory-distress syndrome in the newborn. N Engl J Med 1976; 294:357-360.
135. Horger EO, Miller MC, Conner ED. Relation of large birthweights to maternal diabetes mellitus. Obstet Gynecol 1975; 45:150-159.
136. Gluckman PD. The role of pituitary hormones, growth factors and insulin in the regulation of fetal growth. Oxford Rev Reprod Biol 1986; 8:1-60.
137. Harding R, Hooper SB. Regulation of lung expansion and lung growth before birth. J Appl Physiol 1996; 81:209-224.
138. Kitterman JA. The effects of mechanical forces on fetal lung growth. Clin Perinatol 1996; 23:727-740.
139. Alcorn D, Adamson TM, Lambert TE, Maloney JE, Ritchie BC, Robinson PM. Morphological effects of chronic ligation and drainage in the fetal lamb lung. J Anat 1977; 130:683-695.
140. Carmal JA, Friedman F, Adamson FH. Fetal tracheal ligation and lung development. Am J Dis Child 1965; 109:450-456.
141. Griscom NT, Harris GBS, Wohl ME, Vawter GF, Eraklis AJ. Fluid filled lung during airway obstruction in the newborn. Pediatrics 1969; 48:383-390.
142. Perelman M, Levin M. Fetal pulmonary hypoplasia, anuria and oligohydramnios: clinicopathologic observations and review of the literature. Am J Obstet Gynecol 1974; 118:1119-1123.
143. Thomas IT, Smith DW. Oligohydramnios, cause of non-renal features of Potter’s syndrome, including pulmonary hypoplasia. J Pediatr 1974; 84:811-814.
144. deLorimier AA, Tierney DF, Parker HR. Hypoplastic lungs in fetal lambs with surgically produced congenital diaphragmatic hernia. Surgery 1967; 62:12-17.
145. Finegold MJ, Katzew H, Genieser NB, Becker MH. Lung structure in thoracic dystrophy. Am J Dis Child 1971; 122:153-159.
146. George DK, Cooney TP, Chiu BK, Thurlbeck WM. Hypoplasia and immaturity of the terminal lung unit (acinus) in congenital diaphragmatic hernia. Am Rev Respir Dis 1987; 136:947-950.
147. Harrison MR, Bressack MA, Chung AM, deLorimier AA. Correction of congenital diaphragmatic hernia in utero. Stimulated correction permits fetal lung growth with survival at birth. Surgery 1980; 88:260-268.
148. Reale FR, Esterly JR. Pulmonary hypoplasia: a morphometric study of the lungs of infants with diaphragmatic hernia, anencephaly, and renal malformations. Pediatrics 1973; 51:91-96.
149. Liggins GC, Campos GA, Kitterman JA, Lee CH. The effect of spinal cord transection on lung development in fetal sheep. J Dev Physiol 1981; 3:267-274.
150. Moessinger AC, Marone P, James LS, Blanc WA. Fetal akinesia and lung growth [abstr]. Lab Invest 1980; 42:175.
151. Wigglesworth JS, Desai R. Effects on fetal lung growth of cervical cord section in the rabbit fetus. Early Hum Dev 1979; 3:51-65.
152. Moessinger AC, Collins MH, Blanc WA, Rey HR, James LS. Oligohydramnios- induced lung hypoplasia: the influence of timing and duration in gestation. Pediatr Res 1986; 20:951-954.
153. Nakayama DK, Glick PL, Harrison MR, Villar RL, Noall R. Experimental hypoplasia due to oligohydramnios and its reversal by relieving thoracic compression. J Pediatr Surg 1983; 18:347-353.
154. Higuchi M, Kato T, Yoshino H, Matsuda K, Gotoch K, Hirano H, Koyama K, Maki M. The influence of experimentally produced oligohydramnios on lung growth and pulmonary surfactant content in fetal rabbits. J Dev Physiol 1991; 16:223-227.
155. Wilson JM, DiFiori JW, Peters CA. Experimental fetal tracheal ligation prevents the pulmonary hypoplasia associated with fetal nephrectomy: possible application for congenital diaphragmatic hernia. J Pediatr Surg 1993; 28:1433-1439.
156. Peters CA, Reid LM, Docimo S, Lutetic T, Carr M, Retik AB, Mandell J. The role of the kidney in lung growth and maturation in the setting of obstructive uropathy and oligohydramnios. J Urol 1991; 146:597-600.
157. Hislop A, Sanderson M, Reid L. Unilateral congenital dysplasia of lung associated with vascular anomalies. Thorax 1973; 28:435-441.
158. Wallen LD, Perry SF, Alson JT, Maloney JE. Fetal lung growth; influence of pulmonary arterial flow and surgery in sheep. Am J Respir Crit Care Med 1994; 149: 1005-1011.
159. Wallen LD, Kulisz E, Maloney JE. Main pulmonary artery ligation reduces lung fluid production in fetal sheep. J Dev Physiol 1991; 16:173-179.
160. Souza P, O’Brodovich H, Post M. Lung fluid restriction affects growth but not airway branching of embryonic rat lung. Int J Dev Biol 1995; 39:629-635.
161. Neilson IR, Russo P, Laberge JM, Filiatrault D, Nguyen LT, Collin PP, Guttman FM. Congenital adenomatoid malformation of the lung: current management and prognosis. J Pediatr Surg 1991; 26:975-980.
162. DiFiori JW, Fauza DO, Slavin R, Peters CA, Fackler JC, Wilson JM. Experimental fetal tracheal ligation reverses the structural and physiological effects of pulmonary hypoplasia in congenital diaphragmatic hernia. J Pediatr Surg 1994; 29:248256.
163. Fewell JE, Lee C, Kitterman JA. Effects of phrenic nerve section on the respiratory system of fetal lambs. J Appl Physiol 1981; 51:293-297.
164. Nagai A, Thurlbeck WM, DeBoeck C, Ioffe S, Chernick V. The effect of maternal CO2 breathing on lung development of fetuses in the rabbit. Am Rev Respir Dis 1987; 135:130-136.
165. Liggins GC, Vilos GA, Campos GA, Kitterman JA, Lee CH. The effect of bilateral thoracoplasty on lung development in fetal sheep. J Dev Physiol 1981; 3:275-282.
166. Savich RD, Guerra FA, Lee CC, Kitterman JA. The effect of fetal breathing movements on pulmonary blood flow in fetal sheep. Pediatr Res 1994; 35:484-489.
167. Harding R, Hooper SB, Han VKM. Abolition of fetal breathing movements by spinal cord transection leads to reductions in fetal lung liquid volume, lung growth, and IGF-II gene expression. Pediatr Res 1993; 34:148-153.
168. Murai D, Lee C, Kitterman JA. Breathing movements transiently increase lung volume [abstr]. Pediatr Res 1983; 17:385.
169. Frangos JA. Physical Forces and the Mammalian Cell. San Diego: Academic Press, 1993.
170. Liu M, Liu J, Buch S, Tanswell AK, Post M. Antisense oligonucleotides against PDGF-B and its receptor inhibit mechanical strain-induced fetal lung cell growth. Am J Physiol 1995; 269:L178-L184.
171. Liu M, Skinner SJM, Xu J, Han RNN, Tanswell AK, Post M. Stimulation of fetal rat lung cell proliferation in vitro by mechanical stretch. Am J Physiol 1992; 263: L376-L383.
172. Liu M, Xu J, Souza P, Tanswell B, Tanswell AK, Post M. The effect of mechanical strain on fetal rat lung cell proliferation: comparison of two- and three-dimensional culture systems. In Vitro Cell Dev Biol 1995; 31:858-866.
173. Resnick N, Collins T, Atkinson W, Bonthron DT, Dweey CF Jr, Gimbrone MA Jr. Platelet-derived growth factor B chain promoter contains a cis-acting fluid shear-stress-responsive element. Proc Natl Acad Sci USA 1993; 90:4591-4595.
174. Hsieh H-J, Li N-Q, Frangos JA. Shear-induced platelet-derived growth factor gene expression in human endothelial cells is mediated by protein kinase C. J Cell Physiol 1992; 150:552-558.
175. Hooper SB, Han VKM, Harding R. Changes in lung expansion alter pulmonary DNA synthesis and IGF-II gene expression in fetal sheep. Am J Physiol 1993; 265: L403-L409.
176. Perrone CE, Fenwick-Smith D, Vandenburgh A. Collagen and stretch modulate autocrine secretion of insulin-like growth factor-1 and insulin-like growth factor binding proteins from differentiated skeletal muscle cells. J Biol Chem 1995; 270: 2099-2106.
177. Singhvi R, Kumar A, Lopez GP, Stephanopoulos GN, Wand DIC, Whitesides GM, Ingber DE. Engineering cell shape and function. Science 1994; 264:696-698.
178. Bishop JE, Mitchell JJ, Absher PM, Baldor L, Geller HA, Woodcock-Mitchell J, Hamblin MJ, Vacek P, Low RB. Cyclic mechanical deformation stimulates human lung fibroblast proliferation and autocrine growth factor activity. Am J Respir Cell Mol Biol 1993; 9:126-133.
179. Scott JE, Yang S-Y, Stanik E, Anderson JE. Influence of strain on [3H]thymidine incorporation, surfactant phospholipid synthesis, and cAMP levels in fetal type II alveolar cells. Am J Respir Cell Mol Biol 1993; 8:258-265.
180. Skinner SJM. Fetal breathing movements: a mechanical stimulus for fetal lung cell growth and differentiation. In: Johnston BM, Gluckman PD, eds. Research in Perinatal Medicine (VIII), Advances in Fetal Physiology. Ithaca, NY: Perinatology Press, 1989:133-141.
181. Liu M, Xu J, Tanswell AK, Post M. Stretch-induced growth-promoting activities stimulate fetal rat lung epithelial cell proliferation. Exp Lung Res 1993; 19:505-517.
182. Wirtz HRW, Dobbs LG. Calcium mobilization and exocytosis after one mechanical stretch of lung epithelial cells. Science 1990; 250:1266-1269.
183. Liu M, Xu J, Tanswell AK, Post M. Inhibition of mechanical strain-induced fetal rat lung cell proliferation by gadolinium, a stretch-activated channel blocker. J Cell Physiol 1994; 161:501-507.
184. Liu M, Xu J, Liu J, Kraw ME, Tanswell AK, Post M. Mechanical strain-enhanced fetal lung cell proliferation is mediated by phospholipases C and D and protein kinase C. Am J Physiol 1995; 268:L729-L738.
185. Liu M, Qin Y, Liu J, Tanswell AK, Post M. Mechanical strain induces pp60src activation and translocation to cytoskeleton in fetal rat lung cells. J Biol Chem 1996; 271:6625-6630.
186. Skinner SJM, Somervell CE, Olson DM. The effects of mechanical stretching on fetal rat lung cell prostacyclin production. Prostaglandins 1992; 43:413-433.
187. Aoyagi T, Izumo S. Mapping of the pressure response element of the c-fosgene by direct DNA injection into beating hearts. J Biol Chem 1993; 268:27176-27179.
188. Riley DJ, Rannels DE, Low RB, Jensen L, Jacobs TP. Effect of physical forces on lung structure, function, and metabolism. Am Rev Respir Dis 1990; 142:910914.
189. Thurlbeck WM. Postnatal growth and development of the lung. Am Rev Respir Dis 1975; 111:803-844.
190. Zhang S, Garbutt V, McBride JT. Strain-induced growth of the immature lung. J Appl Physiol 1996; 81:1471-1476.
191. Marcy TW. Barotrauma: detection, recognition, and management. Chest 1993; 104: 578-584.
192. Dreyfuss D, Soler P, Basset G, Saumon G. High inflation pressure pulmonary edema. Am Rev Respir Dis 1988; 137:1159-1164.
193. Carlton DP, Cummings JJ, Scheerer RG, Poulain FR, Bland RD. Lung overexpansion increases pulmonary microvascular protein permeability in young lambs. J Appl Physiol 1990; 69:577-583.
194. Manning HL. Peak airway pressure: why the fuss? Chest 1994; 105:242-247.
195. Parker JC, Hernandez LA, Peevy KJ. Mechanisms of ventilator-induced lung injury. Crit Care Med 1993; 21:131-143.
196. Tremblay L, Valenza F, Ribeiro S, Li J, Slutsky AS. Injurious ventilation strategies increase cytokines and c-fos mRNA expression in an isolated rat lung model. J Clin Invest 1997; 99:944-952.
197. Adkins WK, Hernandez LA, Coker PJ, Buchanan B, Parker JC. Age affects susceptibility to pulmonary barotrauma in rabbits. Crit Care Med 1991; 19:390-393.
198. Todd DA, John E. Lung injury and repair in rabbits from ventilation with moist air. Br J Exp Pathol 1989; 70:637-645.
199. Pohlandt F, Saule H, Schroder H, Leonhardt A, Hornchen H, Wolff C, Bernsau U, Oppermann H-C, Obladen M, Feilen K-D, and the study group. Decreased incidence of extra-alveolar air leakage or death prior to air leakage in high versus low rate positive pressure ventilation: results of a randomised seven-centre trial in preterm infants. Eur J Pediatr 1992; 151:904-909.
200. Rodeberg DA, Maschinot NE, Housinger TA, Warden GD. Decreased pulmonary barotrauma with the use of volumetric diffusive respiration in paediatric patients with burns. J Burn Care Rehabil 1992; 13:506-511.
201. Saran M, Bors W. Oxygen radicals acting as chemical messengers: a hypothesis. Free Radic Res Commun 1989; 7:3-6.
202. Burdon RH. Superoxide and hydrogen peroxide in relation to mammalian cell proliferation. Free Radic Biol Med 1995; 18:775-794.
203. Randell SH, Mercer RR, Young SL. Postnatal growth of pulmonary acini and alveoli in normal and oxygen exposed rats studied by serial section reconstruction. Am J Anat 1989; 186:55-68.
204. Youngson C, Nurse C, Yeger H, Cutz E. Oxygen sensing in airway chemoreceptors. Nature 1993; 365:153-155.
205. Gardner PR, Fridovich I. Effect of glutathione on aconitase in Escherichia coli. Arch Biochem Biophys 1993; 301:98-102.
206. Gardner PR, Nguyen D-DH, White CW. Aconitase is a sensitive and critical target of oxygen poisoning in cultured mammalian cells and in rat lungs. Proc Natl Acad Sci USA 1994; 91:12248-12252.
207. Halliwell B, Gutteridge JMC. Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem J 1984; 219:1-14.
208. Gillies NE, Alper T. Reduction in the lethal effects of radiations on Escherichia coli P by treatment with chloramphenicol. Nature 1959; 183:237-238.
209. Minakami H, Fridovich I. Relationship between growth of Escherichia coli and susceptibility to the lethal effect of paraquat. FASEB J 1990; 4:3239-3244.
210. Hassan HM, Fridovich I. Regulation of the synthesis of superoxide dismutase in Escherichia coli. J Biol Chem 1977; 252:7667-7672.
211. Horowitz S, Dafni N, Shapiro D, Holm BA, Notter RH, Quible DJ. Hyperoxic exposure alters gene expression in the lung: induction of the tissue inhibitor of metalloproteinase mRNA and other mRNAs. J Biol Chem 1989; 264:70927-095.
212. Horowitz S, Shapiro DL, Finkelstein JN, Notter RH, Johnston CJ, Quible DJ. Changes in gene expression in hyperoxia-induced lung injury. Am J Physiol 1990; 258:L107-L111.
213. Veness-Meehan KA, Cheng ERY, Mercier CE, Blixt SL, Johnston CJ, Watkins RH, Horowitz S. Cell-specific alterations in expression of hyperoxia-induced mRNAs of lung. Am J Respir Cell Mol Biol 1991; 5:516-521.
214. Piedboeuf B, Johnston CJ, Watkins RH, Hudak BB, Lazo JS, Cherian MG, Horowitz S. Increased expression of tissue inhibitor of metalloproteinases (TIMP-I) and metallothionein in murine lungs after hyperoxic exposure. Am J Respir Cell Mol Biol 1994; 10:123-132.
215. Adamson IYR, Hedgecock C, Bowden DH. Epithelial cell-fibroblast interactions in lung injury and repair. Am J Pathol 1990; 137:385-392.
216. Bui KC, Buckley S, Wu F, Uhal B, Joshi I, Liu J, Hussain M, Makhoul I, Warburton D. Induction of A- and D-type cyclins and cdc2 kinase activity during recovery from short-term hyperoxic lung injury. Am J Physiol 1995; 268:L625-L635.
217. Crapo JD, Barry BE, Foscue HA, Shelburne J. Structural and biochemical changes in rat lungs occurring during exposures to lethal and adaptive doses of oxygen. Am Rev Respir Dis 1980; 122:123-143.
218. Stortz G, Tartaglia LA, Ames B. Transcriptional regulator of oxidative stress inducible genes: direct activation by oxidation. Science 1990; 248:189-194.
219. Stortz G, Tartaglia LA. OxyR: a regulator of antioxidant genes. J Nutr 1990; 122: 627-630.
220. Christman MF, Morgan RW, Jacobson FS, Ames BN. Positive control of a regulon for defences against oxidative stress and some heat shock proteins in Salmonella typhimurium. Cell 1985; 41:753-762.
221. Morgan RW, Christman MF, Jacobson FS, Storz G, Ames BN. Hydrogen peroxide- inducible proteins in Salmonella typhimurium: overlap with heat shock and other proteins. Proc Natl Acad Sci USA 1986; 83:8059-8063.
222. Hidalgo E, Demple B. An iron-sulphur centre essential for transcriptional activation by redox sensing SoxR protein. EMBO J 1994; 13:138-146.
223. Storz G, Tartaglia LA, Farr SB, Ames BN. Bacterial defences against oxidative stress. Trends Genet 1990; 6:1-6.
224. Cowan DB, Weisel RD, Williams WG, Mickle DAG. Identification of oxygen responsive elements in the 5'-flanking region of the human glutathione peroxidase gene. J Biol Chem 1993; 36:26904-26910.
225. Clerch LB, Massaro D. Rat lung antioxidant enzymes: differences in perinatal gene expression and regulation. Am J Physiol 1992; 263:L466-L470.
226. Tanswell AK, Olson DM, Freeman BA. Response of fetal rat lung fibroblasts to elevated oxygen concentrations after liposome-mediated augmentation of antioxidant enzymes. Biochim Biophys Acta 1990; 1044:269-274.
227. Tanswell AK, Olson DM, Freeman BA. Liposome-mediated augmentation of antioxidant defences in fetal rat pneumocytes. Am J Physiol 1990; 258:L165-L172.
228. Dell KR, Severson DI. Effects of cis-unsaturated fatty acids on aortic protein kinase C. Biochem J 1989; 258:171-175.
229. Kass GEN, Duddy SK, Orrenius S. Activation of protein kinase C by redox-cycling quinones. Biochem J 1989; 260:499-507.
230. Christie NA, Slutsky AS, Freeman BA, Tanswell AK. A critical role for thiol, but not ATP, depletion in 95% O2-mediated injury in preterm pneumocytes. Arch Biochem Biophys 1994; 313:131-138.
231. Keyse SM, Emslie EA. Oxidative stress and heat shock induce a human gene encoding a protein tyrosine phosphatase. Nature 1992; 359:644-647.
232. Suzuki A, Kozawa O, Saito H, Oiso Y. Effects of prostaglandin F2A on Ca2+ influx in osteoblast-like cells: function of tyrosine kinase. J Cell Biochem 1994; 54:487-493.
233. Abate C, Patel L, Rauscher FJ, Curran T. Redox regulation of Fos and Jun DNA- binding in vitro. Science 1990; 249:1157-1161.
234. Xanthoudakis S, Curran T. Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity. EMBO J 1992; 11:653-665.
235. Xanthoudakis S, Miao G, Wang F, Pan Y-CE, Curran T. Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme. EMBO J 1992; 11:3323-3335.
236. Schreck R, Rieber P, Baeuerle PA. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-B transcription factor and HIV-1. EMBO J 1991; 10:2247-2258.
237. Galter D, Mihm S, Droge W. Distinct effects of glutathione disulphide on the nuclear transcription factors B and the activator protein-1. Eur J Biochem 1994; 221: 639-648.
238. Amstad PA, Krupitza G, Cerutti P. Mechanism of c-fos induction by active oxygen. Cancer Res 1992; 52:3952-3960.
239. Datta R, Taneja N, Sukhatme VP, Qreshi SA, Weichselbaum R, Kufe DW. Reactive oxygen intermediates target CC(A/T)6GG sequence to mediate activation of early growth response 1 transcription factor gene by ionising radiation. Proc Natl Acad Sci USA 1993; 90:2419-2422.
240. Treisman RH. Identification of a protein binding site that mediates transcriptional response of the c-fos gene to serum factors. Cell 1986; 46:567-574.
241. Abman SH, Wolfe RR, Accurso FJ, Koops BL, Bowman CM, Wiggins JWJ. Pulmonary vascular response to oxygen in infants with severe bronchopulmonary dysplasia. Pediatrics 1985; 75:80-84.
242. Vender RL, Clemmons DR, Kwock L, Friedman M. Reduced oxygen tension induces pulmonary endothelium to release a pulmonary smooth muscle mitogen(s). Am Rev Respir Dis 1987; 135:622-627.
243. Liland AE, Zapol WM, Qvist J, Nash G, Skoskiewicz M, Pontopoppidan H, Lo- wenstein E, Laver MB. Positive airway pressure in lambs spontaneously breathing air and oxygen. J Surg Res 1976; 20:85-92.
244. Raj JU, Bland RD. Neutrophil depletion does not prevent oxygen-induced lung injury in rabbits. Chest 1983; 83(suppl):20-21.
245. Kreiger BP, Loomis WH, Spragg RG. Granulocytes and hyperoxia act synergisti- cally in causing acute lung injury. Exp Lung Res 1984; 7:77-83.
246. Raj JU, Hazinski TA, Bland RD. Oxygen-induced lung microvascular injury in neutropenic rabbits and lambs. J Appl Physiol 1985; 58:921-927.
247. Boyce NW, Campbell D, Holdsworth SR. Granulocyte independence of pulmonary oxygen toxicity in the rat. Exp Lung Res 1989; 15:491-498.
248. Wegner CD, Wolyniec WW, LaPlante AM, Marschman K, Lubbe K, Haynes N, Rothlein R, Letts LG. Intercellular adhesion molecule-1 contributes to pulmonary oxygen toxicity in mice: role of leukocytes revised. Lung 1992; 267-279.
249. Kubo K, King LS, Kobayashi T, Newman JH. Differing effects of nitrogen mustard and hydroxyurea on lung O2 toxicity in adult sheep. Am Rev Respir Dis 1992; 145: 13-18.
250. Kawano T, Mori S, Cybulsky M, Burger A, Ballin A, Cutz E, Bryan AC. Effect of granulocyte depletion in a ventilated surfactant-depleted lung. J Appl Physiol 1987:27-33.
251. Haschek WM, Witschi H. Pulmonary fibrosis—a possible mechanism. Toxicol Appl Pharmacol 1979; 51:475-487.
252. Witschi HP, Haschek WM, Klein-Sjanto AJP, Hakkinen PJ. Potentiation of diffuse lung damage by oxygen: determining variables. Am Rev Respir Dis 1981; 123: 98-103.
253. Pierce GF. Macrophages: important physiologic and pathologic sources of polypeptide growth factors. Am J Respir Cell Mol Biol 1990; 2:233-234.
254. Terzaghi M, Nettesheim P, Williams ML. Repopulation of denuded tracheal grafts with normal, preneoplastic and neoplastic epithelial cell populations. Cancer Res 1979; 38:4546-4553.
255. Adamson IYR, Young L, Bowden DH. Relationship of alveolar epithelial injury and repair to the induction of pulmonary fibrosis. Am J Pathol 1988; 130:377-383.
256. Adamson IYR, Young L, King GM. Reciprocal epithelial: fibroblast interactions in the control of fetal and adult rat lung cells in culture. Exp Lung Res 1991; 17: 821-835.
257. Scott CD, Ballesteros M, Baxter RC. Increased expression of insulin-like growth factor-II/mannose-6-phosphate receptor in regenerating rat liver. Endocrinology 1990; 127:2210-2216.
258. Stiles AD, Sosenko IRS, D’Ercole AJ, Smith BT. Relation of kidney tissue soma- tomedin-C/insulin-like growth factor I to postnephrectomy renal growth in the rat. Endocrinology 1985; 117:2397-2401.
259. Perkett EA, Badesch DB, Roessler MK, Stenmark KR, Meyrick B. Insulin-like growth factor I and pulmonary hypertension induced by continuous air embolization in sheep. Am J Respir Cell Mol Biol 1992; 6:82-87.
260. Han RNN, Han VKM, Buch S, Freeman BA, Post M, Tanswell AK. Insulin-like growth factor-I and type I insulin-like growth factor receptor in 85% O2-exposed rat lung. Am J Physiol 1996; 271:L139-L149.
261. Han RNN, Buch S, Tseu I, Young J, Christie NA, Frndova H, Lye SJ, Post M, Tanswell AK. Changes in structure, mechanics, and insulin-like growth factor- related gene expression in the lungs of newborn rats exposed to 60% oxygen. Pedi- atr Res 1996; 39:921-929.
262. Veness-Meehan KA, Moats-Staats BM, Price WA, Stiles AD. Re-emergence of a fetal pattern of insulin-like growth factor expression during hyperoxic rat lung injury. Am J Respir Cell Mol Biol 1997; 16:538-548.
263. Korfhagen TR, Swanz RJ, Wert SE, McCarty JM, Kerlakian CB, Glasser SW, Whitsett JA. Respiratory epithelial cell expression of human transforming growth factor-a induces lung fibrosis in transgenic mice. J Clin Invest 1994; 93:1691-1699.
264. Finkelstein JN, Kramer CM. Alveolar epithelial proliferation and production of growth factors and cytokines in pulmonary fibrosis [abstr]. Am Rev Respir Dis 1993; 147:153.
265. Vivekananda J, Lin A, Coalson JJ, King RJ. Acute inflammatory injury in the lung precipitated by oxidant stress induces fibroblasts to synthesize and release transforming growth factor-a. J Biol Chem 1994; 269:25057-25061.
266. Stahlman MT, Orth DN, Gray ME. Immunocytochemical localization of epidermal growth factor in the developing human respiratory system and in acute and chronic lung disease in the neonate. Lab Invest 1989; 60:539-547, 1989.
267. Strandjord TP, Clark JG, Guralnick DE, Madtes DK. Immunolocalization of transforming growth factor-a, epidermal growth factor (EGF), and EGF-receptor in normal and injured developing human lung. Pediatr Res 1995; 38:851-856.
268. Antoniades HN, Bravo MA, Avila RE, Galanopoulos T, Neville-Golden J, Maxwell M, Selman M. Platelet-derived growth factor in idiopathic pulmonary fibrosis. J Clin Invest 1990; 86:1055-1064.
269. Vignaud JM, Allam M, Martinet N, Pech M, Plenat F, Martinet Y. Presence of platelet-derived growth factor in normal and fibrotic lung is specifically associated with interstitial macrophages, while both interstitial macrophages and alveolar epithelial cells express the c-cis proto-oncogene. Am J Respir Cell Mol Biol 1991; 5: 531-538.
270. Marinelli WA, Polunovsky VA, Harmon KR, Bitterman PB. Role of platelet-derived growth factor in pulmonary fibrosis. Am J Respir Cell Mol Biol 1991; 5: 503-504.
271. Brody AR. Control of lung fibroblast proliferation by macrophage-derived platelet- derived growth factor. Ann NY Acad Sci 1994; 725:193-199.
272. Fabisiak JP, Evans JN, Kelley J. Increased expression of PDGF-B (c-cis) mRNA in rat lung precedes DNA synthesis and tissue repair during chronic hyperoxia. Am J Respir Cell Mol Biol 1989; 1:181-189.
273. Powell PP, Chung Wang C, Jones R. Differential regulation of the genes encoding platelet-derived growth factor receptor and its ligand in rat lung during microvascu- lar and alveolar wall remodelling in hyperoxia. Am J Respir Cell Mol Biol 1992; 7:278-285, 1992.
274. Buch S, Moore A, Post M, Tanswell AK. In vitro expression of the genes for platelet-derived growth factor and its receptors in fetal lung cells exposed to hyperoxia [abstr]. Pediatr Res 1992; 31:303.
275. Hertz MI, Henke CA, Nakleh RE, Harmon KR, Marinelli WA, Fox JMK, Kubo SH, Shumway SJ, Bolman RM, Bitterman PB. Obliterative bronchiolitis after lung transplantation: a fibroproliferative disorder associated with platelet-derived growth factor. Proc Natl Acad Sci USA 1992; 89:10385-10389.
276. Moscatelli D, Flaumenhaft R, Saksela O. Interaction of basic fibroblast growth factor with extracellular matrix and receptors. Ann NY Acad Sci 1991; 638:177-181.
277. Roghani M, Moscatelli D. Basic fibroblast growth factor is internalized through both receptor-mediated and heparan sulfate-mediated mechanisms. J Biol Chem 1992; 267:22156-22162.
278. Henke C, Marinelli W, Jessurun J, Fox J, Harms D, Peterson M, Chiang L, Doran P. Macrophage production of basic fibroblast growth factor in the fibroproliferative disorder of alveolar fibrosis after lung injury. Am J Pathol 1993; 134:1189-1199.
279. Leslie CC, McCormick-Shannon K, Mason RJ. Heparin-binding growth factors stimulate DNA synthesis in rat alveolar type II cells. Am J Respir Cell Mol Biol 1990; 2:99-106.
280. Mason RJ, Leslie CC, McCormick-Shannon K, Deterding RR, Nakamura T, Rubin JS, Shannon JM. Hepatocyte growth factor is a growth factor for rat alveolar type II cells. Am J Respir Cell Mol Biol 1994; 11:561-567.
281. Yanagita K, Nagaike M, Ishibashi H, Niho Y, Matsumoto K, Nakamura T. Lung may have an endocrine function producing hepatocyte growth factor in response to injury of distal organs. Biochem Biophys Res Commun 1992; 182:802-809.
282. Sporn MB, Roberts AB. The transforming growth factor-betas: past, present, and future. Ann NY Acad Sci 1990; 593:1-9.
283. Williams AO, Flanders KC, Saffiotti U. Immunohistochemical localization of transforming growth factor-Pj in rats with experimental silicosis, alveolar type II hyperplasia, and lung cancer. Am J Pathol 1993; 142:1831-1840.
284. Khalil N, O’Connor RN, Flanders KC, Shing W, Whitman CI. Regulation of type II alveolar cell proliferation by TGF-P during bleomycin-induced lung injury in rats. Am J Physiol 1994; 11:498-507.
285. Perdue TD, Brody AR. Distribution of transforming growth factor-P fibronectin, and smooth muscle actin in asbestos-induced pulmonary fibrosis in rats. J Histo- chem Cytochem 1994; 42:1061-1070.
286. Denis M, Ghadirian E. Transforming growth factor-P is generated in the course of hypersensitivity pneumonitis: contribution to collagen synthesis. Am J Respir Cell Mol Biol 1992; 7:156-160.
287. Moore AM, Buch S, Han RNN, Freeman BA, Post M, Tanswell AK. Altered expression of type I collagen, TGF-P1, and related genes in rat lung exposed to 85% O2. Am J Physiol 1995; 268:L78-L84.
288. Khalil N, O’Connor R, Unruh H, Warren P, Kemp A, Greenberg A. Enhanced expression and immunohistochemical distribution of transforming growth factor- P in idiopathic pulmonary fibrosis. Chest 1991; 99 (suppl):65-66.
289. Khalil N, Bereznay O, Sporn M, Greenberg AH. Macrophage production of transforming growth factor-P and fibroblast collagen synthesis in chronic pulmonary inflammation. J Exp Med 1989; 170:727-737.
290. Grande J, Melder D, Zinsmeister A, Killen P. Transforming growth factor induces collagen IV gene expression in NIH-3T3 cells. Lab Invest 1993; 69:387-395.
291. Katchman SD, Hsu-Wong S, Ledo I, Wu M, Uitto J. Transforming growth factor- P up-regulates human elastin promoter activity in transgenic mice. Biochem Biophys Res Commun 1994; 203:485-490.
292. Maniscalco WM, Campbell. Transforming growth factor-P induces a chondroi- tin sulfate/dermatan sulfate proteoglycan in alveolar type II cells. Am J Physiol 1994; 266:672-680.
293. Raghow R, Irish P, Kang AH. Coordinate regulation of transforming growth factor- P gene expression and cell proliferation in hamster lungs undergoing bleomycin- induced pulmonary fibrosis. J Clin Invest 1989; 84:1836-1842.
294. Moses HL, Coffey RJ, Leof EB, Lyons RM, Keski-Oja J. Transfroming growth factor-P regulation of cell proliferation. J Cell Physiol 1987; 5 (suppl):1-7.
295. Psarras S, Kletsas D, Stathakos D. Restoration of down-regulated PDGF receptors by TGF-P in human embryonic fibroblasts. FEBS Lett 1994; 339:84-88.
296. Chess PR, Ryan RM, Finkelstein JN. Tyrosine kinase activity is necessary for growth factor-stimulated rabbit type II pneumocyte proliferation. Pediatr Res 1994; 36:481-486.
297. Perrella MA, Yoshizumi M, Fen Z, Tsai J-C, Hsieh C-M, Kourembanas S, Lee M. Transforming growth factor-Pj, but not dexamethasone, down regulates nitric-oxide synthase mRNA after its induction by interleukin-1P in rat smooth muscle cells. J Biol Chem 1994; 269:14595-14600.
298. Goureau O, Lepoivre M, Becquet F, Courtois Y. Differential regulation of inducible nitric oxide synthase by fibroblast growth factors and transfroming growth factor- P in bovine retinal pigmented epithelial cells: inverse correlation with cellular proliferation. Proc Natl Acad Sci USA 1993; 90:4276-4280.
299. Maniscalco WM, Watkins RH, D’Angio CT, Ryan RM. Hyperoxic injury decreases alveolar epithelial cell expression of vascular endothelial growth factor (VEGF) in neonatal rabbit lung. Am J Respir Cell Mol Biol 1997; 16:557-567.
300. Fries KM, Felch ME, Phipps RP. Interleukin-6 is an autocrine growth factor for murine lung fibroblast subsets. Am J Respir Cell Mol Biol 1994; 11:552-560.
301. Kovacs EJ, Kelley J. Lymphokine regulation of macrophage-derived growth factor secretion following pulmonary injury. Am J Pathol 1985; 121:261-268.
302. Sunday ME, Kaplan LM, Motoyama E, Chin WW, Soindel ER. Gastrin-releasing peptide (mammalian bombesin) gene expression in health and disease. Lab Invest 1988; 59:5-24.
303. Aldenborg F, Nilsson K, Jarlshammer B, Bjermer L, Enerback L. Mast cells and biogenic amines in radiation-induced pulmonary fibrosis. Am J Respir Cell Mol Biol 1993; 8:112-117.
304. Gaid A, Michel RP, Stewart DJ, Sheppard M, Corrin B, Hamid Q. Expression of endothelin-1 in the lungs of patients with cryptogenic fibrosing alveolitis. Lancet 1993; 341:1550-1554.
305. Komoro I, Kurihara H, Sagiyama T, Takaku F, Yazaki Y. Endothelin stimulates c-fos and c-myc expression and proliferation of vascular smooth muscle cells. FEBS Lett 1988; 238:249-252.
306. Weiss RH, Maduri M. The mitogenic effect of thrombin in vascular smooth muscle cells is largely due to basic fibroblast growth factor. J Biol Chem 1993; 268:5724-5727.
307. Fernandez-Pol JA, Hamilton PD, Klos DJ. Transcriptional regulation of proto-oncogene expression by epidermal growth factor, transfroming growth factor and triiodothyronine in MDA-468 cells. J Biol Chem 1989; 264:4151-4156.
308. Leholta L, Nister M, Hciltia E, Westermark B, Alitalo K. Down-regulation of cellular platelet-derived growth factor receptors induced by an activated neu receptor tyrosine kinase. Cell Regulation 1991; 2:651-661.
309. Rosenthal SM, Brown EJ, Brunetti A, Goldfine ID. Fibroblast growth factor inhibits insulin-like growth factor-II (IGF-II) gene expression and increases IGF-I receptor abundance in BC3H-1 muscle cells. Mol Endocrinol 1991; 5:678-684.
310. Yoshinouchi M, Baserga R. The role of the IGF-I receptor in the stimulation of cells by short pulses of growth factors. Cell Prolif 1993; 26:139-146.
311. Barreca A, Voci A, Minuto F, deMarchis M, Cecchelli E, Fugassa E, Giordano G, Gallo G. Effect of epidermal growth factor and insulin-like growth factor-I (IGF-I) and IGF-binding protein synthesis by adult rat hepatocytes. Mol Cell Endocrinol 1992; 84:119-126.
312. Gohda E, Matsunaga T, Kataoka H, Takebe T, Yamamoto I. Induction of hepato- cyte growth factor in human skin fibroblasts by epidermal growth factor, platelet- derived growth factor and fibroblast growth factor. Cytokine 1994; 6:633-640.
313. Silviera MR, Sempowski GD, Phipps RP. Expression of TGFP isoforms in THY- 1+ and Thy-1 “pulmonary fibroblast subsets: evidence for TGFP as a regulator of IL-1-dependent stimulation of IL-6. Lymphokine Cytokine Res 1994; 13:277-285.
314. Lugano EM, Dauber JH, Elias JA, Bashey RI, Jiminez SA, Daniele RP. The regulation of lung fibroblast proliferation by alveolar macrophages in experimental silicosis. Am Rev Respir Dis 1984; 129:767-771.
315. Lemaire I, Beaudoin H, Dubois C. Cytokine regulation of lung fibroblast proliferation: pulmonary and systemic changes in asbestos-induced pulmonary fibrosis. Am Rev Respir Dis 1986; 134:653-658.
316. Goldstein RH. Control of type I collagen formation in the lung. Am J Physiol 1991; 261:L29-L40.
317. Noguchi A, Nelson T. IGF-I stimulates tropoelastin synthesis in neonatal rat pulmonary fibroblasts. Pediatr Res 1991; 30:248-251.
318. Brettell LM, McGowan SE. Basic fibroblast growth factor decreases elastin production by neonatal rat lung fibroblasts. Am J Respir Cell Mol Biol 1994; 10:30-6315.
319. Tan EML, Rouda S, Greenbaum SS, Moore JH, Fox JW, Solberg S. Acidic and basic fibroblast growth factors down-regulate collagen gene expression in keloid fibroblasts. Am J Pathol 1993; 142:463-470.
320. Beck F, Samani NJ, Senior P, Byrne S, Morgan K, Gebhard R, Brammer WJ. Control of IGF-II mRNA levels by glucocorticoids in the neonatal rat. J Mol Endocrinol 1988; 1:5-8.
321. Matsumoto K, Tajima H, Okazaki H, Nakamura T. Negative regulation of hepato- cyte growth factor gene expression in human lung fibroblasts and leukemic cells by transforming growth factor-Pj and glucocorticoids. J Biol Chem 1992; 267:2491724920.
322. Haynes AR, Shaw RJ. Dexamethasone-induced increase in platelet-derived growth factor (B) mRNA in human alveolar macrophages and myelomonocytic HL60 macrophage-like cells. Am J Respir Cell Mol Biol 1992; 7:198-206.