Characterization and functional analysis of the human inducible nitric oxide synthase gene promoter

Molecular Medicine

Volumn 2, Issue 2, 1996, Pages 226-235

  Spitsin, Sergei V ^a   Koprowski, Hilary ^a   Michaels, Frank H ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NITRIC OXIDE SYNTHASE;

ANIMAL CELL; ARTICLE; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC TRANSFECTION; HUMAN; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; SEQUENCE HOMOLOGY; TRANSCRIPTION REGULATION;

EID: 0029773518     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf03401619     Document Type: Article

References (30)

1. Moncada S, Higgs A. (1993) The L-Arginine-nitric oxide pathway. N. Engl. J. Med. 329: 2002-2012.
2. Garthwaite J, Charles SL, Chess-Williams R. (1988) Endothelium-derived relaxing factor release on activation of NMDA receptors suggests a role as intracellular messenger in the brain. Nature 336: 385-388.
3. Wu HH, Williams CV, McLoon SC. (1994) Involvement of nitric oxide in the elimination of a transient retinotectal projection in development. Science 265: 1593-1596.
4. Nathan C, Hibbs Jr JB. (1991) Role of nitric oxide synthesis in macrophage antimicrobial activity. Curr. Opin. Immunol. 3: 65-70.
5. Koprowski H, Zheng YM, Heber-Katz E, et al. (1993) In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic disease. Proc. Natl. Acad. Sci. U.S.A. 90: 3024-3027.
6. Weinberg JB, Granger DL, Pisetsky DS, et al. (1994) The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: Increased nitric oxide production and nitric oxide synthase expression in MRL-/lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered NG-monomethyl-L-arginine. J. Exp. Med. 179: 651-660.
7. Hibbs JB, Vavrin Z, Taintor RR. (1987) L-Arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells. J. Immunol. 138: 550-565.
8. G-methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: Implications for the involvement of nitric ozide. Proc. Natl. Acad. Sci. U.S.A. 87: 3629-3632.
9. G-methyl-L-arginine, an inhibitor of nitric oxide synthesis. Biochem. Biophys. Res. Commun. 172: 1132-1138.
10. Knowles RG, Moncada S. (1994) Nitric oxide synthases in mammals. Biochem. J. 298: 249-258.
11. Charles IG, Palmer RMJ, Hickery MS, et al. (1993) Cloning, characterization and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte. Proc. Natl. Acad. Sci. U.S.A. 90: 11419-11423.
12. Chartrain NA, Geller DA, Koty PP, et al. (1994) Molecular cloning, structure, and chromosomal location of the human inducible nitric oxide synthase gene. J. Biol. Chem. 269: 6765-6772.
13. Geller DA, Lowenstein CJ, Shapiro RA, et al. (1993) Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes. Proc. Natl. Acad. Sci. U.S.A. 90: 3491-3495.
14. Nathan C, Xie Q-W. (1994) Nitric oxide synthases: roles, tolls, and controls. Cell 78: 915-918.
15. Nathan C, Xie Q-W. (1994) Regulation of biosynthesis of nitric oxide. J. Biol. Chem. 269: 13725-13728.
16. Xie Q-W, Whisnant R, Nathan C. (1993) Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide. J. Exp. Med. 177: 1779-1784.
17. Nunokawa Y, Ishida N, Tanaka S. (1994) Promoter analysis of human inducible nitric oxide synthase gene associated with cardiovascular hemostasis. Biochem. Biophys. Res. Commun. 200: 802-807.
18. Asano K, Chee CBE, Gaston B, et al. (1994) Constitutive and inducible nitric oxide synthase gene expression, regulation, and activity in human lung epithelial cells. Proc. Natl. Acad. Sci. U.S.A. 91: 10089-10093.
19. Lowenstein CJ, Alley EW, Raval P, et al. (1993) Macrophage nitric oxide synthase gene: Two upstream regions mediate induction by interferon gamma and lipopolysaccharide. Proc. Natl. Acad. Sci. U.S.A. 90: 9730-9734.
20. Wright SD, Ramos RA, Tobias PS, Ulevitch RJ, Mathison JC. (1990) CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249: 1431-1433.
21. Evans T, Carpenter A, Cohen J. (1994) Inducible nitric-oxide-synthase mRNA is transiently expressed and destroyed by a cyclohexamide-sensitive process. Eur. J. Biochem. 219: 563-569.
22. Geller DA, Nussler AK, DiSilvio M, et al. (1993) Cytokines, endotoxin, and glucocorticoids regulate the expression on inducible nitric oxide synthase in hepatocytes. Proc. Natl. Acad. Sci. U.S.A. 90: 522-526.
23. Caput D, Beutler B, Hartog K, Thayer R, Brown-Shimer S, Cerami A. (1986) Identification of a common nucleotide sequence in the 3′-untranslated region of mRNA molecules specifying inflammatory mediators. Proc. Natl. Acad. Sci. U.S.A. 83: 1670-1674.
24. Pearse RN, Feinman R, Ravetch JV. (1991) Characterization of the promoter of the human gene encoding the high-affinity IgG receptor: Transcriptional induction by gamma-interferon is mediated through common DNA response elements. Proc. Natl. Acad. Sci. U.S.A. 88: 11305-11309.
25. Mackman N, Brand K, Edgington T. (1991) Lipopolysaccharide-mediated transcriptional activation of the human tissue factor gene in THP-1 monocytic cells requires both activator protein 1 and nuclear factor kappaB binding sites. J. Exp. Med. 174: 1517-1526.
26. Poli V, Cortese R. (1989) Interleukin 6 induces a liver-specific nuclear protein that binds to the promoter of acute-phase genes. Proc. Natl. Acad. Sci. U.S.A. 86: 8202-8206.
27. Leonardo MJ, Baltimore D. (1989) NF-kappaB: A pleiotropic mediator of inducible and tissue-specific gene control. Cell 58: 227-229.
28. Leitman DC, Ribeiro RC, Mackow ER, Baxter JD, West BL. (1991) Identification of a tumor necrosis factor-responsive element in the tumor necrosis factor alpha gene. J. Biol. Chem. 266: 9343-9346.
29. Martin E, Nathan C, Xie Q-W. (1994) Role of interferon regulatory factor-1 in induction of nitric oxide synthase. J. Exp. Med. 180: 977-984.
30. Levy DE, Kessler DS, Pine R, Reich N, Darnell Jr JE. (1988) Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transcriptional control. Genes Dev. 2: 383-393.