Synthesis of 7-methyl derivatives of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF), 5,10-dideaza-5,6,7,8-tetrahydrohomofolic acid (HDDATHF), and LY254155

Heterocycles

Volumn 48, Issue 8, 1998, Pages 1537-1554

  Taylor, Edward C ^a   Wang, Yao ^a  

^a PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0001109796     PISSN: 03855414     EISSN: None     Source Type: Journal    
DOI: 10.3987/com-98-8174     Document Type: Article

References (17)

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2. (b) E. C. Taylor, J. Heterocycl. Chem., 1990, 27, 1;
3. (c) E. C. Taylor, Adv. Exp. Med. Biol., 1993, 338, 387.
4. (a) E. C. Taylor, US Patent 5,344,932, Sept. 6, 1994;
5. (b) E. C. Taylor, D. Kuhnt, C. Shih, S. M. Rinzel, G. B. Grindey, J. Barredo, M. Jannatipour, and R. G. Moran, J. Med. Chem., 1992, 35, 4450.
6. (c) E. C. Taylor, D. Kuhnt, and C. Shih, In Chemistry and Biology of Pteridines and Folates 1997, ed. by W. Pfleiderer and H. Rokos, Blackwell Science, Berlin, 1997, p. 83.
7. (a) D. A. Rinaldi, H. A. Burris, F. A. Dorr, J. R. Woodworth, J. G. Kuhn, J. G.; J. R. Eckardt, G. Rodriguez, S. W. Corso, S. M. Fields, C. Langley, G. Clark, D. Faries, P. Lu, and D. D. Van Hoff, J. Clin. Oncol., 1995, 13, 2842.
8. (b) D. E. Thornton, W. John, P. Loerher, and E. Eisenhauer, In Chemistry and Biology of Pteridines and Folates 1997, ed by W. Pfleiderer and H. Rokos, Blackwell Science, Berlin, 1997, p. 195.
9. (a) C. Shih, V. J. Chen, L. S. Gossett, S. B. Gates, W. C. MacKellar, L. L. Habeck, K. A. Shackelford, L. G. Mendelsohn, D. J. Soose, V. F. Patel, S. L. Andis, J. R. Bewley, E. A. Rayl, B. A. Moroson, G. P. Beardsley, W. Kohler, M. Ratnam, and R. M. Schultz, Cancer Res., 1997, 57, 1116.
10. (b) C. Shih, G. P. Beardsley, V. J. Chen, W. J. Ehlhardt, W. C. MacKellar, L. G. Mendelsohn, M. Ratnam, R. M. Schultz, E. C. Taylor, and J. F. Worzella, In Chemistry and Biology of Pteridines and Folates 1997, ed.by W. Pfleiderer and H. Rokos, Blackwell Science, Berlin, 1997, p. 181.
11. (a) C. Shih and E. C. Taylor, US Patent 4,882,334, Nov. 21, 1989;
12. (b) L. L. Habeck, T. A. Leitner, K A. Shackelford, L. S. Gossett, R. M. Schultz, S. L. Andis, C. Shih, G. B. Grindey, and L. G. Mendelsohn, Cancer Res., 1994, 54, 1021.
13. (a) E. C. Taylor and B. Hu, Heterocycles, 1996, 43, 323;
14. (b) Subsequent studies on this compound showed that it was a very poor substrate for FPGS (C. Shih, Eli Lilly & Co., Indianapolis, IN, private communcication).
15. E. C. Taylor and P. M. Harrington, J. Org. Chem., 1990, 55, 3222.
16. (a) E. C. Taylor and S. R. Fletcher, J. Org. Chem., 1984, 49, 3226.
17. (b) E. Stark and E. Breitmaier, Tetrahedron, 1973, 29, 2209.