Simple Silyl Linker for the Solid Phase Organic Synthesis of Aryl-Containing Molecules

Journal of Organic Chemistry

Volumn 62, Issue 20, 1997, Pages 6726-6729

  Newlander, Kenneth A ^a   Chenera, Balan ^a   Veber, Daniel F ^a   Yim, Nelson C F ^a   Moore, Michael L ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0001443662     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo9620472     Document Type: Article

References (13)

1. Plunkett, M. J.; Ellman, J. A. J. Org. Chem. 1995, 60, 6006-6007.
2. Chenera, B.; Finkelstein, J. A.; Veber, D. F. J. Am. Chem. Soc. 1995, 117, 11999-12000.
3. Kaiser, E.; Colescott, R. L.; Bossinger, C. D.; Cook, P. I. Anal. Biochem. 1970, 34, 594-598.
4. Cunico, R. F.; Gill, H. S. Organometallics 1982, 1, 1-3.
5. Han, Y.; Walker, S. D.; Young, R. N Tetrahedron Lett. 1996, 37, 2703-2706.
6. Subsequent experiments demonstrated that the desired product 18 could be obtained from 15 using conditions less suitable for combinatorial synthesis, such as HF or CsF (see ref 2).
7. Jayawickreme, C. K.; Graminski, G. F.; Quillan, J. M.; Lerner, M. R. Proc. Natl. Acad. Sci. U.S.A. 1994, 91, 1614-1618.
8. Salmon, S. E.; Lam, K. S.; Lebl, M.; Kandola, A.; Khattri, P. S.; Wade, S.; Patek, M.; Kocis, P.; Krchnak, V.; Thorpe, D.; Felder, S. Proc. Natl. Acad. Sci. U.S.A. 1993, 90, 11708-11712.
9. Zambias, R. A.; Boulton, D. A.; Griffin, P. R. Tetrahedron Lett. 1994, 35, 4283-4286.
10. Krebs, J. F.; Siuzdak, G.; Dyson, H. J.; Stewart, J. D.; Benkovic, S. J. Biochemistry 1995, 34, 720-723.
11. Stewart, J. M.; Young, J. D. Solid Phase Peptide Synthesis; Pierce Chemical Co.: Rockford, IL, 1984.
12. Krchnak, V.; Flegelova, Z.; Wiechsel, A. S.; Lebl, M. Tetrahedron Lett. 1995, 36, 6193-6196.
13. Bryan, W. M. J. Org. Chem. 1986, 51, 3371-3372.