Lack of modifying effects of cinnamaldehyde on development of lung proliferative lesions induced by urethane in transgenic mice carrying the human prototype c-Ha-ras gene

Journal of Toxicologic Pathology

Volumn 13, Issue 4, 2000, Pages 249-255

  Tamura, Toru ^a   Yasuhara, Kazuo ^a   Koujitani, Takatoshi ^a   Onodera, Hiroshi ^a   Takagi, Hisayoshi ^a   Takizawa, Tamotsu ^a   Hirose, Masao ^a   Hayashi, Yuzo ^b   Mitsumori, Kunitoshi ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b KITASATO UNIVERSITY   (Japan)

Author keywords

C Ha ras gene; Cinnamaldehyde; Lung tumor; rasH2 mouse; Urethane

Indexed keywords

EID: 0000980664     PISSN: 09149198     EISSN: 09149198     Source Type: Journal    
DOI: 10.1293/tox.13.249     Document Type: Article

References (39)

1. Hoffmann D and Hoffmann I. The changing cigarette, 1950-1995. Environ Health Perspect 1997; 50: 307-364.
2. International Agency for Research on Cancer. Certain polycyclic aromatic hydrocarbons and heterocyclic compounds. In: IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man, IARC, Lyon, IARC Scientific Publications No. 3, 45-268, 1972.
3. International Agency for Research on Cancer. Polynuclear aromatic compounds, part 1, chemical, environmental, and experimental data. In: IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, IARC, Lyon, IARC Scientific Publications No. 32, 33-451, 1983.
4. International Agency for Research on Cancer. Tobacco smoking. In: IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, IARC, Lyon, IARC Scientific Publications No. 38, 199-314, 1986.
5. Demole D and Berthet D. A chemical study of burley tobacco flavour (Nicotiana tabacum L.) I. Volatile to medium-volatile constituents. Helv Chem Acta 1972; 55: 1866-1882.
6. Opdyke DLJ. Monographs on fragrance raw materials, Cinnamaldehyde. Fd Cosmet Toxicol 1979; 19: 253-258.
7. Stoner GD, Shimkin MB, Kniazeff AJ, Weisburger JH, Weisburger EK. and Gori GB. Test for carcinogenicity of food additives and chemotherapeutic agents by the pulmonary tumor response in strain A mice. Cancer Res 1973; 33: 3069-3085.
8. Ishidate M Jr, Sofuni T, Yoshikawa K, Hayashi M, Nohmi T, Sawada M, and Matsuoka A. Primary mutagenicity screening of food additives currently used in Japan. Fd Chem Toxicol. 1984; 22: 623-636.
9. Palmer KA. L5178Y TK+/- assay of cinnamaldehyde and several structurally related compounds. Environ Mutagen 1984; 6: 423-434.
10. Mereto E, Brambilla-Campert G, Ghia M, Martelli A, and Brambilla G. Cinnamaldehyde-induced micronuclei in rodent liver. Mutat Res 1994; 322: 1-8.
11. Hebert CD, Yuan J, and Dieter MP. Comparison of the toxicity of cinnamaldehyde when administered by microencap-sulation in feed or by corn oil gavage. Food Chem Toxicol 1994; 32: 1107-1115
12. Bos JL. ras oncogenes in human cancer: a review. Cancer Res 1989; 49: 4682-4689
13. Capella G, Cronauer-Mitra S. Peinado MA, and Perucho M. Frequency and spectrum of mutaions at codons 12 and 13 of the c-K-ras gene in human tumors. Environ Health Perspect 1991; 93: 125-131
14. Yamamoto S, Mitsumori K, Kodama Y, Matsunuma N, Manabe S, Okamiya H, Suzuki H, Fukuda T, Sakamaki Y, Sunaga M, Nomura G, Hioki K, Wakana S, Nomura T, and Hayashi Y. Rapid induction of more malignant tumors by various genotoxic carcinogens in transgenic mice harboring a human prototype c-Ha-ras gene than in control non-transgenic mice. Carcinogenesis 1996; 17: 2455-2461.
15. Yamamoto S, Urano K, Koizumi H, Wakana S, Hioki K, Mitsumori K, Kurokawa K, Hayashi Y, and Nomura T. Validation of transgenic mice carrying the human prototype c-Ha-ras gene as a bioassay model for rapid carcinogenicity testing. Environ Health Perspect 1998; 106: 54-69.
16. Mitsumori K, Koizumi H, Nomura T, and Yamamoto S. Pathological features of spontaneous and induced tumors in transgenic mice carrying a human prototype c-Ha-ras gene used for 6-month carcinogenicity studies. Toxicol Patol 1998; 26: 520-531.
17. Doi ST, Kimura M, and Katsuki M. Sight-specific mutation of the human c-Ha-ras transgene induced by dimethylbenzanthracene causes tissue-specific tumors in mice. Jpn J Cancer Res 1994; 85: 801-807.
18. Ogawa K, Imaida K, Masui T, Kawabe M, Hasegawa R, Kato K, Ito N, and Shirai T. Chemically indued lung and forestomach neoplasias in transgenic mice carrying mutant forms of the human c-Ha-ras transgene. Carcinogenesis 1996; 17: 341-345.
19. Mitsumori K, Wakana S, Yamamoto S, Kodama Y, Yasuhara K, Nomura T, Hayashi Y, and Maronpot RR. Susceptibility of transgenic mice carrying human prototype c-Ha-ras gene in a short-term carcinogenicity study of vinyl carbamate and ras gene analyses on the induced tumors. Mol Carcinog 1997; 20: 298-307.
20. Umemura T, Kodama Y, Hioki K, Inoue T, Nomura T, and Kurokawa Y. Susceptibility to urethane Carcinogenesis of transgenic mice carrying a human prototype c-Ha-ras gene (rasH2 mice) and its modification by butylhydroxytoluene. Cancer Lett 1999; 145: 101-106.
21. Saitoh A, Kimura M, Takahashi R, Yokoyama M, Nomura T, Izawa M, Sekiya, T, Nishimura S, and Katsuki M. Most tumors in transgenic mice with human c-Ha-ras gene contained somatically activated transgenes. Oncogene 1990; 5: 1195-1200.
22. Mitsumori K, Yasuhara K, Mori I, Hayashi S, Shimo T, Onodera H, Nomura T, and Hayashi Y. Pulmonary fibrosis caused by N-methyl-N-nitrosourethane inihibits lung tumorigenesis by urethane in transgenic mice carrying the human prototype c- Ha-ras gene. Cancer Lett 1998; 129: 181-190.
23. Fisher RA. Fisher's exact test for 2×2 contingency table; statistical methods for research workers, para. 21.02, Edinburgh: Oliver and Boyd, 1950.
24. Gad S and Weil CS. Statistics for toxicologist. In: Principles and Methods of Toxicology, HA Wallance (ed), New York: Raven Press, 273-320, 1982.
25. Yasuhara K, Mitsumori K, Shimo T, Onodera H, Takahashi M, and Hayashi Y. Mice with focal pulmonary fibrosis caused by monocrotaline are insensitive to urethane induction of lung tumorigenesis. Toxicol Pathol 1997; 25: 574-581.
26. Witschi HP, Williamson D, and Lock S. Enhancement of urethan tumorigenesis in mouse lung by butylated hydroxytoluene. J Natl Cancer Inst 1977; 58: 301-305.
27. Malkinson AM and Thaete LG. Effects of strain and age on prophylaxis and co-carcinogenesis of urethan-induced mouse lung adenomas by butylated hydroxytoluene. Cancer Res 1986; 46: 1694-1697.
28. Kasamaki A, Takahashi H, Tsumura N, Niwa J, Fujita T, and Urasawa S. Genotoxicity of flavoring agents. Mutation Res 1982; 12: 383-396.
29. Sekizawa J and Shibamoto T. Genotoxicity of safrole-related chemicals in microbial test systems. Mutation Res 1982; 101: 127-140.
30. Blazak WF, Stewart BE, Galperin I, Allen KL, Rudd CJ, Mitchell AD, and Caspary WJ. Chromosome analysis of trifluolothymidine-resisitant L5178Y mouse lymphoma cell colonies. Environ Mutagen 1986; 8: 229-240.
31. Hagen EC, Hansen WH, Fitzhugh OG, Jenner PM, Jones WI, Taylor JM, Long EL, Nelson AA, and Brouwer JB. Food flavourings and compounds of related structure. II. Subacute and chronic toxicity. Fd Cosmet Toxicol 1967; 5: 141-157.
32. Slebos RJC, Hruban RH, Dalesio O, Mooi WJ, Offerhaus GJA, and Rodenhuis S. Relationship between K-ras oncogene activation and smoking in adenocarcionoma of the human lung. J Natl Cancer Inst 1991; 83: 1024-1027.
33. Rodenhuis SH and Slebos, RJC. Clinical significance of ras oncogene activation in human lung cancer. Cancer Res (suppl.) 1992; 52: 2665-2669.
34. Goodrow T, Reynold S, Maronpot R, and Anderson M. Activation of K-ras by codon 13 mutations in C57/6×C3H F1 mouse tumors induced by exposure to 1,3-butadiene. Cancer Res 1990; 50: 4818-4823.
35. Nuzum EO, Malkinson AM, and Beer DG. Specific K-ras codon 61 mutations may determine the development of urethane-induced mouse lung adenomas or adenocarcinomas. Mol. Carcinogenesis 1990; 3: 287-295.
36. Mori I, Yasuhara K, Hayashi SM, Nonoyama T, Nomura T, and Mitsumori K. Carcinogen dose-dependent variation in the transgene mutation spectrum in urethane-induced lung tumors in transgenic mice carrying the human prototype c-Ha-ras gene. Cancer Lett 2000; 153: 199-209.
37. Fujino M, Dosaka-Akita H, Harada M, Hiroumi H, Kinoshita I, Akie K, and Kawakami Y. Prognostic significance of p53 and ras p21 expression in nonsmall cell lung cancer. Cancer 1995; 76: 2457-2463.
38. International Agency for Research on Cancer. Some anti-thyroid and related substances, nitrofurans and industrial chemicals. In: IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man, IARC, Lyon, IARC Scientific Publications No. 7, 111-140, 1974.
39. Hoffmann D, Castonguay A, Rivenson A, and Hecht SS. Comparative carcinogenicity and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N′-nitroso-nornicotine in Syrian golden hamsters. Cancer Res 1981; 41: 2386-2393.