Transgenic mouse models: New tools for psychiatric research

Neuroscientist

Volumn 3, Issue 5, 1997, Pages 328-336

  Holsboer, Florian ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

Aggression; Conditional knock out; Drug addiction; Learning and memory; Stress systems; Transgenic mice

Indexed keywords

EID: 0000764846     PISSN: 10738584     EISSN: None     Source Type: Journal    
DOI: 10.1177/107385849700300514     Document Type: Review

References (60)

1. Wagner EF, Stewart TA, Mintz B. The human betaglobin gene and a functional viral thymidine kinase gene in developing mice. Proc Natl Acad Sci U S A 1981;78:5016-5020.
2. Jaenisch R. Transgenic animals. Science 1988;240:1468-1472.
3. Hanks M, Wurst W, Anson-Cartwright L, Auerbach AB, Joyner AL. Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2. Science 1995;269:679-682.
4. Wurst W, Rossant J, Prideaux V, et al. A large-scale gene-trap screen for insertional mutations in developmentally regulated genes in mice. Genetics 1995;139:889-899.
5. Munir MI, Rossiter BJF, Caskey CT. Antisense RNA production in transgenic mice. Somat Cell Mol Genet 1990;16:383-394.
6. Capecchi MR. The new mouse genetics: altering the genome by gene targeting. Trends Genet 1989;5:70-76.
7. Sauer B, Henderson N. Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1. Proc Natl Acad Sci U S A 1988;85:5166-5170.
8. Lakso M, Sauer B, Mosinger B Jr, et al. Targeted oncogene activation by site-specific recombination in transgenic mice. Proc Natl Acad Sci U S A 1992;89:6232-6236.
9. Gu H, Zou YR, Rajewsky K. Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting. Cell 1993;73: 1155-1164.
10. Mann JJ. Violence and aggression. In: Bloom FE, Kupfer DJ, editors. Psychopharmacology: The fourth generation of progress. New York: Raven Press; 1995; p. 1919-1928.
11. Cases O, Seif I, Grimsby J, et al. Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA. Science 1995;268:1763-1776.
12. Brunner HG, Nelen MR, van Zandvoort P, et al. X-linked borderline mental retardation with prominent behavioral disturbance: phenotype, genetic localization, and evidence for disturbed monoamine metabolism. Am J Hum Genet 1993;52:1032-1039.
13. 1B receptor. Science 1994;265:1875-1878.
14. A receptors in transgenic mice over-expressing TGFα. Pharmacol Biochem Behav 1995;40:593-600.
15. Chen D, Rainnie DG, Greene RW, Tonegawa S. Abnormal fear response and aggressive behavior in mutant mice deficient for α-calcium-calmodulin kinase II. Science 1994;266:291-294.
16. König M, Zimmer AM, Steiner H, et al. Pain responses, anxiety and aggression in mice deficient in pre-proenkephalin. Nature 1996;383:535-538.
17. Nelson RJ, Demas GE, Huang PL, et al. Behavioural abnormalities in male mice lacking neuronal nitric oxide synthase. Nature 1995;378:383-386.
18. Bliss TVP, Collingridge GL. A synaptic model of memory: long-term potentiation in the hippocampus. Nature 1993;361:31-39.
19. Silva AJ, Stevens CF, Tonegawa S, Wang Y. Deficient hippocampal long-term potentiation in α-calcium-calmodulin kinase II mutant mice. Science 1992;257:201-206.
20. Grant SGN, O'Dell TJ, Karl KA, et al. Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice. Science 1992;258:1903-1910.
21. Silva AJ, Paylor R, Wehner JM, Tonegawa S. Impaired spatial learning in α-calcium-calmodulin kinase II mutant mice. Science 1992;257:206-211.
22. Malenka RC. Synaptic plasticity in the hippocampus: LTP and LTD. Cell 1994;78:535-538.
23. Nosten-Bertrand M, Errington ML, Murphy KPSJ, et al. Normal spatial learning despite regional inhibition of LTP in mice lacking Thy-1. Nature 1996;379:826-829.
24. Montkowski A, Holsboer F. Intact spatial learning and memory in transgenic mice with reduced BDNF. Neuroreport 1997;8: 779-782.
25. Miyakawa T, Yagi T, Watanabe S, Niki H. Increased fearfulness of Fyn tyrosine kinase deficient mice. Mol Brain Res 1994;27: 179-182.
26. Rogan MT, LeDoux JE. Emotion: systems, cells, synaptic plasticity. Cell 1996;85:469-475.
27. Gordon JA, Cioffi D, Silva AJ, Stryker MP. Deficient plasticity in the primary visual cortex of αcalcium/calmodulin-dependent protein kinase II mutant mice. Neuron 1996;17:491-499.
28. Huerta PT, Scearce KA, Farris SM, Empson RM, Prusky GT. Preservation of spatial learning in fyn tyrosine kinase knockout mice. Neuroreport 1996;7:1685-1689.
29. Kwok R, Lundblad PS, Chrivia JR, et al. Nuclear protein CBP is a coactivator for the transcription factor CREB. Nature 1994; 370:223-226.
30. Bourtchuladze R, Frenguelli B, Blendy J, et al. Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein. Cell 1994;79:59-68.
31. Giros B, Jaber M, Jones SR, Wightman RM, Caron MG. Hyper-locomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature 1996;379:606-612.
32. Maldonado R, Blendy JA, Tzavara E, et al. Reduction of morphine abstinence in mice with a mutation in the gene encoding CREB. Science 1996;273:657-659.
33. Holsboer F. Neuroendocrinology of affective disorders. In: Bloom FE, Kupfer DJ, editors. Psychopharmacology: the fourth generation of progress. New York: Raven Press; 1995. p. 957-969.
34. De Kloet ER. Steroids, stability and stress. Front Neuroendocrinol 1995;16:416-425.
35. Meaney MJ, Aitken DH, Bhatnagar S, Sapolsky RM. Postnatal handling attenuates certain neuroendocrine, anatomical, and cognitive dysfunctions associated with aging in female rats. Neurobiol Aging 1991;12:31-38.
36. Reul JMHM, Stec I, Wiegers GJ, et al. Prenatal immune challenge alters the hypothalamic-pituitary-adrenocortical axis in adult rats. J Clin Invest 1994;93:2600-2607.
37. Holsboer F, Spengler D, Heuser I. The role of corticotropin-releasing hormone in the pathogenesis of Cushing's disease, anorexia nervosa, alcoholism, affective disorders and dementia. Prog Brain Res 1992;93:385-417.
38. Stenzel-Poore MP, Heinrichs SC, Rivest S, Koob GF, Vale WW. Overproduction of corticotropin-releasing factor in transgenic mice: a genetic model of anxiogenic behavior. J Neurosci 1994; 14:2579-2584.
39. Heinrichs SC, Stenzel-Poore MP, Gold LH, et al. Learning impairment in transgenic mice with central overexpression of corticotropin-releasing factor. Neuroscience 1996;74:303-311.
40. Owens MJ, Nemeroff CB. Physiology and pharmacology of corticotropin-releasing factor. Pharmacol Rev 1991;43:425-473.
41. Skutella T, Criswell H, Moy S, et al. Corticotropin-releasing hormone (CRH) antisense oligodeoxynucleotide induces anxiolytic effects in rat. Neuroreport 1994;5:2181-2185.
42. 1 receptor antisense oligodeoxynucleotide into the central nucleus of the amygdala reduced anxiety-related behavior in socially defeated rats. Regul Pept 1995;59:229-239.
43. Holsboer F, Lauer CJ, Schreiber W, Krieg J-C. Altered hypothalamic-pituitary-adrenocortical regulation in healthy subjects at high familial risk for depression. Neuroendocrinology 1995;62: 659-664.
44. Modell S, Yassouridis A, Huber J, Holsboer F. Corticosteroid receptor function is decreased in depressed patients. Neuroendocrinology 1997;16:216-222.
45. Joëls M, de Kloet ER. Coordinative mineralocorticoid and glucocorticoid receptor-mediated control of responses to serotonin in rat hippocampus. Neuroendocrinology 1992;55:344-350.
46. Pepin M-C, Pothier F, Barden N. Impaired type II glucocorticoid receptor function in mice bearing antisense RNA trangsgene. Nature 1992;355:725-728.
47. Montkowski A, Barden N, Wotjak C, et al. Long-term antidepressant treatment reduces behavioural deficits in transgenic mice with impaired glucocorticoid receptor function. J Neuroendocrinol 1995;7:841-845.
48. Spanagel R, Stöhr T, Barden N, Holsboer F. Morphine-induced locomotor and neurochemical stimulation os enhanced in transgenic mice with impaired glucocorticoid receptor function. J Neuroendocrinol 1996;8:93-97.
49. Gerlai R. Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype? Trends Neurosci 1996; 19:177-181.
50. Montkowski A, Poettig M, Mederer A, Holsboer F. Behavioural performance in three substrains of mouse strain 129. Brain Res 1997;762:12-18.
51. Zimmer A. Gene targeting and behaviour: a genetic problem requires a genetic solution. Trends Neurosci 1996;19:470.
52. Gossen M, Bujard H. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci U S A 1992;89:5547-5551.
53. Gossen M, Freundlieb S, Bender G, et al. Transcriptional activation by tetracyclines in mammalian cells. Science 1995;268: 1766-1769.
54. Rajewsky K, Gu H, Kühn R, et al. Perspective series: molecular medicine in genetically engineered animals. Conditional gene targeting. J Clin Invest 1996;98:600-603.
55. Kühn R, Schwenk F, Aguet M, Rajewsky K. Inducible gene targeting in mice. Science 1995;269:1427-1429.
56. Kistner A, Gossen M, Zimmermann F, et al. Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice. Proc Natl Acad Sci U S A 1996;93:10933-10938.
57. Mayford M, Bach ME, Huang Y-Y, et al. Control of memory formation through regulated expression of a CaMKII transgene. Science 1996;274:1678-1683.
58. Feil R, Brocard J, Mascrez B, et al. Ligand-activated site-specific recombination in mice. Proc Natl Acad Sci U S A 1996;93:10887-10890.
59. Brown SDM, Peters J. Combining mutagenesis and genomics in the mouse-closing the phenotype gap. Trends Genet 1996;12:433-435.
60. Takahashi JS, Pinto LH, Hotz Vitaterna M. Forward and reverse genetic approaches to behavior in the mouse. Science 1994;264: 1724-1733.