An enantioselective synthesis of benzylidene-protected syn-3,5-dihydroxy carboxylate esters via osmium, palladium, and base catalysis

Organic Letters

Volumn 3, Issue 7, 2001, Pages 1049-1052

  Hunter, Thomas J ^a   O'Doherty, George A ^a  

^a University of Minnesota   (United States)

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ARTICLE;

EID: 0000417893     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol0156188     Document Type: Article

References (45)

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41. Furthermore, the ratios of 9/6a and 10/6a for both reactions were equivalent at both low and high conversion.
42. These results do not preclude the mechanistic possibility for the formation of ethyl sorbate via a β,γ-unsaturated regioisomer of 9 and 10 and subsequent base-and/or palladium-catalyzed elimination.
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45. Benzaldehyde (1.1 equiv) with 0.1 equiv of KOt-Bu; after 15 min more benzaldehyde (1.1 equiv) and KOt-Bu (0.1 equiv).