Ionic selectivity of the coupled and uncoupled currents carried by the amino acid transporter KAAT1

Pflugers Archiv European Journal of Physiology

Volumn 438, Issue 6, 1999, Pages 788-796

  Bossi, Elena ^a   Sacchi, V Franca ^b   Peres, Antonio ^a  

^a UNIVERSITY OF INSUBRIA   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

Intestinal cotransport; KAAT1; Xenopus oocyte

Indexed keywords

AMINO ACID TRANSPORT; ANIMAL CELL; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENERGY TRANSFER; INTESTINE; ION TRANSPORT; NONHUMAN; OOCYTE; POTASSIUM CURRENT; PRIORITY JOURNAL; SODIUM CURRENT; VOLTAGE CLAMP; XENOPUS;

AMINO ACID TRANSPORT SYSTEMS, NEUTRAL; ANIMALS; CARRIER PROTEINS; DRUG COMBINATIONS; ELECTRIC CONDUCTIVITY; FEMALE; INSECT PROTEINS; INTESTINES; IONS; KINETICS; LITHIUM; MEMBRANE GLYCOPROTEINS; MODELS, BIOLOGICAL; OOCYTES; PATCH-CLAMP TECHNIQUES; SODIUM; XENOPUS LAEVIS;

EID: 0000397349     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004240051108     Document Type: Article

References (20)

1. 1. Bossi E, Centinaio E, Castagna M, Giovannardi S, Vincenti S, Sacchi VF, Peres A (1999) Ion binding and permeation through the lepidopteran amino acid transporter KAAT1 expressed in Xenopus oocytes. J Physiol (Lond) 515:729-742
2. 2. Cammack JN, Kakhilin SV, Schwartz EA (1994) A GABA transporter operates asymmetrically and with variable stoichiometry. Neuron 13:949-960
3. 3. Castagna M, Shayakul C, Trotti D, Sacchi VF, Harvey WR, Hediger MA (1998) Cloning and characterization of a potassium-coupled umino acid transporter. Proc Natl Acad Sci USA 95:5395-5400
4. 4. Dascal N, Lotan I, Karni E, Gigi A (1992) Calcium channel currents in Xenopus oocytes injected with rat skeletal muscle RNA. J Physiol (Lond) 450:469-490
5. 5. Eisenman G (1962) Cation selective glass electrodes and Their mode of operation. Biophys J 2:259-323
6. 6. Galli A, DeFelice LJ, Duke B-J, Moore KR, Blakely RD (1995) Sodium-dependent norepinephrine-induced currents in norepinephrine-transporter-transfected HEK-293 cells blocked by cocaine and antidepressant. J Exp Biol 198:2197-2212
7. 7. Giordana B, Sacchi VF, Hanozet GM (1982) Intestinal amino acid absorption in lepidopteran larvae. Biochim Biophys Acta 692:81-88
8. +/glucose cotransporter (SGLT1). J Membr Biol 155:175-186
9. 9. Hennigan BB, Wolfersberger MG, Parthasarathy R, Harvey WR (1993) Cation-dependent leucine, alanine, and phenylalanine uptake at pH 10 in brush-border membrane vesicles from larval Manduca sexta midgut. Biochim Biophys Acta 1148; 209-215
10. 10. Hille B (1992) Ionic channels of excitable membranes, 2nd edn. Sinauer, Sunderland
11. 11. Lester HA, Mager S, Quick MW, Corey JL (1994) Permeation properties of neurotransmitter transporters. Annu Rev Pharmacol Toxicol 34:219-249
12. +/glucose cotransporter. Proc Natl Acad Sci USA 90:5767-5771
13. 13. Loo DDF, Hirayama BA, Gallardo EM, Lam JT, Turk E, Wright EM (1998) Conformational changes couple Na+ and glucose transport. Proc Natl Acad Sci USA 95:7789-7794
14. 14. Lu C-C, Kabakov A, Markin VS, Mager S, Frazier GA, Hilgemann DW (1995) Membrane transport mechanisms probed by capacitance measurements with megahertz voltage clamp. Proc Natl Acad Sci USA 92:11220-11224
15. 15. Mager S, Naeve J, Quick M, Labarca C, Davidson N, Lester HA (1993) Steady states, charge movements, and rates for a cloned GABA transporter expressed in Xenopus oocytes. Neuron 10:177-188
16. 16. Mager S, Min C, Henry DJ, Chavkin C, Hoffman BJ, Davidson N, Lester HA (1994) Conducting states of a mammalian serotonin transporter. Neuron 12:845-859
17. +/glucose cotransporter. II. A transport model under nonrapid equilibrium conditions. J Membr Biol 125:63-79
18. +-dependent amino acid transport in midgut brush border membrane vesicles from Philosamia cynthia larvae. J Insect Physiol 40:69-74
19. 19. Sonders MS, Amara SG (1996) Channels in transporters. Curr Opin Neurobiol 6:294-302
20. 20. Su A, Mager S, Mayo SL, Lester HA (1996) A multi-substrate single-file model for ion-coupled transporters. Biophys J 70: 762-777