Anti-apoptotic actions of cycloheximide: Blockade of programmed cell death or induction of programmed cell life?

Apoptosis

Volumn 2, Issue 3, 1997, Pages 257-264

  Mattson, M P ^a,b   Furukawa, K ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Antioxidant enzymes; Apoptosis; Bcl 2; Free radicals; NF B; Protein synthesis; Transcription factors

Indexed keywords

EID: 0000333909     PISSN: 13608185     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1026433019210     Document Type: Article

References (40)

1. Du C, Hu R, Csernansky CA, Hsu CY, Choi DW. Very delayed infarction after mild focal cerebral ischemia: a role for apoptosis? J Cereb Blood Flow Metab 1996; 16: 195-201.
2. Ciutat D, Esquerda JE, Caldero J. Evidence for calcium regulation of spinal cord motorneuron death in the chick embryo in vivo. Dev Brain Res 1995; 86: 167-179.
3. Kobayashi T, Tominaga T, Yoshimoto T. Cell death due to ACNU-induced DNA fragmentation: inhibition by cycloheximide. J Neurooncol 1994; 22: 23-31.
4. Wyllie AH, Martin RG, Smith AL, Dunlop D. Chromatin cleavage in apoptosis: association with condensed chromatin morphology and dependence on macromolecular synthesis. J Pathol 1984; 142: 67-77.
5. Martin DP, Schmidt RE, DiStefano PS, Lowry OH, Carter JG, Johnson EM Jr. Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation. J Cell Biol 1988; 106: 829-844.
6. Scott SA, Davies AM. Inhibition of protein synthesis prevents cell death in sensory and parasympathetic neurons deprived of neurotrophic factor in vitro. J Neurobiol 1990; 21: 630-638.
7. Oppenheim RW, Prevette D, Tytell M, Homma S. Naturally occurring and induced neuronal death in the chick embryo in vivo requires protein and RNA synthesis evidence for the role of cell death genes. Dev Biol 1990; 138: 104-113.
8. Rehen SK, Vareita MH, Freitas FG, Morses MO, Linden R. Contrasting effects of protein synthesis inhibition and of cyclic AMP on apoptosis in the developing retina. Development 1996; 122: 1438-1448.
9. Furukawa K, Estus S, Fu W, Mark RJ, Mattson MP. Neuroprotective action of cycloheximide involves induction of Bcl-2 and antioxidant pathways. J Cell Biol 1997; 136: 1137-1150.
10. Yonish-Rouach E, Deguin V, Zaitchouk T, et al. Transcriptional activation plays a role in the induction of apoptosis by transiently transfected wild-type p53. Oncogene 1995; 11: 2197-2205.
11. Schulz JB, Weller M, Klockgether T. Potassium deprivation-induced apoptosis of cerebellar granule neurons: a sequential requirement for new mRNA and protein synthesis, ICE-like protease activity, and reactive oxygen species. J Neurosci 1996; 16: 4696-4706.
12. Horvitz HR, Shaham S, Hengartner MO. The genetics of programmed cell death in the nematode Caenorhabditis elegans. Cold Spring Harb Symp Qunt Biol 1994; 59: 377-385.
13. Villa P, Miehe M, Sensenbrenner M, Pettmann B. Synthesis of specific proteins in trophic factor-deprived neurons undergoing apoptosis. J Neurochem 1994; 62: 1468-1475.
14. Loo DT, Copani A, Pike CJ, Whittemore ER, Walencewicz AJ, Cotman CW. Apoptosis is induced by β-amyloid in cultured central nervous system neurons. Proc Natl Acad Sci USA 1993; 90: 7951-7955.
15. Mattson MP, Furukawa K. Programmed cell life: anti-apoptotic signaling and therapeutic strategies for neurodegenerative disorders. Retorative Neurol Neurosci 1996; 9: 191-205.
16. Okuda A, Matsuzaki A, Kimura G. Transient increase in the c-fos mRNA level after change of culture condition from serum absence to serum presence and after cycloheximide addition in rat 3Y1 fibroblasts. Biochem Biophys Res Commun 1989; 159: 501-507.
17. Edwards DR, Mahadevan LC. Protein synthesis inhibitors differentially superinduce c-fos and c-jun by three distinct mechanisms: lack of evidence for labile repressors. EMBO J 1992; 11: 2415-2424.
18. Penhoat A, Jaillard C, Begeot M, Durand P, Saez JM. Cycloheximide enhances ACTH-receptor mRNA through transcriptional and post-transcriptional mechanisms in bovine adrenocortical cells. Mol Cell Endocrinol 1996; 121: 57-63.
19. Zinck R, Cahill MA, Kracht M, Sachsenmaier C, Hipskind RA, Nordheim A. Protein synthesis inhibitors reveal differential regulation of mitogen-activated protein kinase and stress-activated protein kinase pathways that converge on Elk-1. Mol Cell Biol 1995; 15: 4930-4938.
20. Gardner AM, Johnson GL. Fibroblast growth factor-2 suppression of tumor necrosis factor α-mediated apoptosis requires Ras and the activation of mitogen-activated protein kinase. J Biol Chem 1996; 271: 14560-14566.
21. Nishina H, Fischer KD, Radvanyi L, et al. Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3. Nature 1997; 385: 350-353.
22. Kimura K, Yamamoto M. Modification of the alternative splicing process of testosterone-repressed prostate message-2 (TRPM-2) gene by protein synthesis inhibitors and heat shock treatment. Biochim Biophys Acta 1996; 1307: 83-88.
23. Carter DA. Up-regulation of β1-adrenoceptor messenger ribonucleic acid in the rat pineal gland: nocturnally, through a β-adrenoceptor-linked mechanism, and in vitro, through a novel posttranscriptional mechanism activated by specific protein synthesis inhibitors. Endocrinology 1993; 133: 2263-2268.
24. Ledda-Columbano GM, Coni P, Faa P, Manenti G, Columbano A. Rapid induction of apoptosis in rat liver by cycloheximide. Am J Pathol 1992; 140: 545-549.
25. Ishii HH, Etheridge MR, Gobe GC. Cycloheximide-induced apoptosis in Burkitt lymphoma (BJA-B) cells with and without Epstein-Barr virus infection. Immunol Cell Biol 1995; 73: 463-468.
26. Millar CG, Baxter GF, Thiemermann C. Protection of the myocardium by ischaemic preconditioning: mechanisms and therapeutic implications. Pharmacol Ther 1996; 69: 143-151.
27. Wong HR, Mannix RJ, Rusnak JM, et al. The heat-shock response attenuates lipopolysaccharide-mediated apoptosis in cultured sheep pulmonary artery endothelial cells. Am J Respir Cell Mol Biol 1996; 15: 745-751.
28. Barger SW, Mattson MP. Excitatory amino acids and growth factors: biological and molecular interactions regulating neuronal survival and plasticity. In: CNS Neurotransmitters and Neuromodulators Vol. 2. Boca Raton, FL (USA): CRC Press, 1995: 273-294.
29. Mattson MP. Free radicals, calcium, and the synaptic plasticity - cell death continuum: emerging roles of the transcription factor NFκB. 1997; Int Rev Neurobiol (in press.)
30. Cheng B, Christakos S, Mattson MP. Tumor necrosis factors protect neurons against excitotoxic/metabolic insults and promote maintenance of calcium homeostasis. Neuron 1994; 12: 139-153.
31. 2+ accumulation. Proc Natl Acad Sci USA 1995; 92: 9328-9332.
32. Barger SW, Mattson MP. Induction of neuroprotective κB-dependent transcription by secreted forms of the Alzheimer's β-amyloid precursor. Mol Brain Res 1995; 40: 116-126.
33. Bruce AJ, Boling W, Kindy MS, et al. Altered neuronal and microglial responses to brain injury in mice lacking TNF receptors. Nature Medicine 1996; 2: 788-794.
34. Menegazzi M, Guerriero C, Carcereri de Prati A, Cardinale C, Suzuki H, Armato U. TPA and cycloheximide modulate the activation of NF-κB and the induction and stability of nitric oxide synthase transcript in primary neonatal rat hepatocytes. FEBS Lett 1996; 379: 279-285.
35. Morris EJ, Geller HM. Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-1: evidence for cell cycle-independent toxicity. J Cell Biol 1996; 134: 757-770.
36. Goto K, Ishige A, Sekiguchi K, Iizuka S, Sugimoto A, Yuzurihara M. Effects of cycloheximide on delayed neuornal death in rat hippocampus. Brain Res 1990; 534: 299-302.
37. Linnik MD, Zobrist RH, Hatfield MD. Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats. Stroke 1993; 24: 2002-2008.
38. MacManus JP, Buchan AM, Hill IE, Rasquinha I, Preston E. Global ischemia can cause DNA fragmentation indicative of apoptosis in rat brain. Neurosci Lett 1993; 164: 89-92.
39. Svendsen CN, Kew JN, Staley K, Safroniew MV. Death of developing septal cholinergic neurons following NGF withdrawal in vitro: protection by protein synthesis inhibition. J Neurosci 1994; 14: 75-87.
40. Tortosa A, Rivera R, Ferrer I. Dose-related effects of cycloheximide on delayed neuronal death in the gerbil hippocampus after bilateral transitory forebrain ischemia. J Neurol Sci 1994; 121: 10-17.