Model study for a general approach to morphine and noroxymorphone via a rare heck cyclization

Organic Letters

Volumn 1, Issue 13, 1999, Pages 2085-2087

  Frey, Dean A ^a   Duan, Caiming ^a   Hudlicky, Tomas ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0000171881     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol991135g     Document Type: Article

References (14)

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12. In a study to determine the regiochemistry of elimination, the two isomers of intermediate halides from the cyclization of 14, 19, and 21 were subjected to elimination conditions with neat DBU. Isomer 19 gave selectively 20 in 97% yield, while isomer 21 produced enol ester 22 as a major product. matrix presented
13. All compounds were fully characterized by physical and spectral data.
14. Coop, A.; Rice, K. Tetrahedron 1999, 55, 11429.