Chemoenzymatic and electrochemical oxidations in the synthesis of octahydroisoquindines for conversion to morphine. Relative merits of radical vs. acid-catalyzed cyclizations

Tetrahedron Letters

Volumn 38, Issue 51, 1997, Pages 8833-8836

  Endoma, Mary Ann ^a   Butora, Gabor ^a   Claeboe, Christopher D ^a   Hudlicky, Tomas ^a   Abboud, Khalil A ^a  

^a University of Florida ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ISOQUINOLINE DERIVATIVE; MORPHINE;

ARTICLE; DRUG SYNTHESIS; ELECTROCHEMISTRY; IN VITRO STUDY; REACTION ANALYSIS; STEREOCHEMISTRY;

EID: 0030733065     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)10384-7     Document Type: Article

References (24)

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18. The relative stereochemistry of intermediates 15 was not determined. In the case of successful cyclization of the succinimide derivatives 13 the crude mixtures were converted to 3.
19. Full x-ray crystallography data will be published in Acta Cryst. by Khalil Abboud, University of Florida.
20. All analytical and spectral data obtained were consistent with the structural assignments.
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