Modulation of the non-specific defence of fish by structurally conserved microbial polymers

Fish and Shellfish Immunology

Volumn 9, Issue 4, 1999, Pages 269-290

  Robertsen, Børre ^a  

^a UNIVERSITY OF TROMSØ   (Norway)

Author keywords

Immunostimulants; non specific defence; glucan; LPS; peptidoglycan; double stranded RNA; macrophage activation; acute phase proteins; antiviral; Mx protein

Indexed keywords

BACTERIA (MICROORGANISMS); MYXOVIRUS; RNA VIRUSES; SALMONIDAE; VERTEBRATA;

EID: 0000160078     PISSN: 10504648     EISSN: None     Source Type: Journal    
DOI: 10.1006/fsim.1998.0186     Document Type: Article

References (125)

1. Ainsworth A. J. A β-glucan inhibitable zymosan receptor on channel catfish neutrophils. Veterinary Immunology and Immunopathology. 41:1994;141-152.
2. Alexander J. B., Ingram G. A. Noncellular nonspecific defence mechanisms of fish. Annual Review of Fish Diseases. 2:1992;249-279.
3. Anderson D. P. Immunostimulants, adjuvants, and vaccine carriers in fish: Applications to aquaculture. Annual Review of Fish Diseases. 2:1992;281-307.
4. Anderson D. P., Moritomo T., De Grooth R. Neutrophil, glass-adherent, nitroblue tetrazolium assay gives early indication of immunization effectiveness in rainbow trout. Veterinary Immunology and Immunopathology. 30:1992;419-429.
5. Anderson D. P., Siwicki A. K. Duration of protection against Aeromonas salmonicida in brook trout immunostimulated with glucan or chitosan by injection or immersion. The Progressive Fish-Culturist. 56:1994;258-261.
6. Anonymous. Interferon nomenclature. Nature. 286:1980;110.
7. Arnheiter H., Frese M., Kambadur R., Meier E., Haller O. Mx transgenic mice-animal models of health. Current Topics in Microbiology and Immunology. 206:1996;119-147.
8. Baumann H., Gauldie J. The acute phase response. Immunology Today. 15:1994;74-80.
9. Berczi I. Neurohormonal host defense in endotoxin shock. Annals New York Academy of Sciences. 840:1998;787-802.
10. Berczi I., Bertok L., Bereznai T. Comparative studies of the toxicity of Escherichia coli lipopolysaccharide endotoxin in various animal species. Canadian Journal of Microbiology. 12:1966;1070-1071.
11. Bohn J. A., Bemiller J. N. (1-3)-β-D-glucans as biological response modifiers: A review of structure-functional activity relationships. Carbohydrate Polymers. 28:1995;3-14.
12. Brattgjerd S., Evensen O., Lauve A. Effect of injected yeast glucan on the activity of macrophages in Atlantic salmon, Salmo salar L., as evaluated by in vitro hydrogen peroxide production and phagocytic capacity. Immunology. 83:1994;288-294.
13. Burrell R. Immunomodulation by bacterial endotoxin. Critical Reviews in Microbiology. 17:1990;189-208.
14. Campos Perez J. J., Ellis A. E., Secombes C. J. Investigation of factors influencing the ability of Renibacterium salmoninarum to stimulate rainbow trout macrophage respiratory burst activity. Fish & Shellfish Immunology. 7:1997;555-566.
15. Chen D., Ainsworth A. J. Glucan administration potentiates immune defence mechanisms of channel catfish, Ictalurus punctatus Rafinesque. Journal of Fish Diseases. 15:1992;295-304.
16. Cole A. M., Weis P., Diamond G. Isolation and characterization of pleurocidin, an antimicrobial peptide in the skin secretions of winter flounder. Journal of Biological Chemistry. 272:1997;12008-12013.
17. Congleton J. L., Wagner E. J. Acute-phase hypoferremic response to lipopolysaccharide in rainbow trout (Oncorhynchus mykiss). Comparative Biochemistry and Physiology. 98A:1991;195-200.
18. Czop J. K., Kay J. Isolation and characterization of β-glucan receptors on human mononuclear phagocytes. Journal of Experimental Medicine. 173:1991;1511-1520.
19. Dalmo R. A., Ingebrigtsen K., Bøgwald J. Non-specific defence mechanisms in fish, with particular reference to the reticuloendothelial system (RES). Journal of Fish Diseases. 20:1997;241-273.
20. Denis M. Interferon-gamma-treated murine macrophages inhibit growth of tubercle bacilli via the generation of reactive nitrogen intermediates. Cellular Immunology. 132:1991;150-157.
21. Di Luzio N. R. Lysozyme, glucan-activated macrophages and neoplasia. Journal of the Reticuloendothelial Society. 26:1979;67-81.
22. Eaton W. D. Anti-viral activity in four species of salmonids following exposure to poly inosinic:cytidylic acid. Diseases of Aquatic Organisms. 9:1990;193-198.
23. Efthimiou S. Dietary intake of β-1,3/1,6 glucans in juvenile dentex (Dentex dentex), Sparidae: Effects on growth performance, mortalities and non-specific defense mechanisms. Journal of Applied Ichthyology. 12:1996;1-7.
24. Ellouz F., Adam A., Ciorbaru R., Lederer E. Minimal structural requirements for adjuvant activity of bacterial peptidoglycan derivatives. Biochemical Biophysical Research Communications. 59:1974;1317-1325.
25. Engstad R. E., Robertsen B. Recognition of yeast cell wall glucan by Atlantic salmon (Salmo salar L.) macrophages. Developmental and Comparative Immunology. 17:1993;319-330.
26. Engstad R. E., Robertsen B. Specificity of a β-glucan receptor on macrophages from Atlantic salmon (Salmo salar L.). Developmental and Comparative Immunology. 18:1994;397-408.
27. Engstad R. E., Robertsen B. Effect of structurally different β-glucans on immune responses in Atlantic salmon (Salmo salar L.). Journal of Marine Biotechnology. 3:1995;203-207.
28. Engstad R. E., Robertsen B., Frivold E. Yeast glucan induces increase in lysozyme and complement-mediated haemolytic activity in Atlantic salmon blood. Fish & Shellfish Immunology. 2:1992;287-297.
29. Fujiki, K. Nakao, M. Shin, D. Yano, T. 1998, cDNA cloning of a carp homologue of mammalian interleukin-1 betas. GenBank accession AB010701.
30. Grabowski P. S., Laing K., McGuigan F. E., Hardie L. J., Ralston S. H., Secombes C. J. Detection of messenger-RNA for a nitric oxide synthase in macrophages and gill of rainbow trout challenged with an attenuated bacterial pathogen. Moncada, Stamler, Gross, Higgs. The biology of nitric oxide. 1996;48 Portland Press, London.
31. Graham S., Jeffries A. H., Secombes C. J. A novel assay to detect macrophage bactericidal activity in fish: Factors influencing the killing of Aeromonas salmonicida. Journal of Fish Diseases. 11:1988;389-396.
32. Graham S., Secombes C. J. The production of a macrophage-activating factor from rainbow trout Salmo gairdneri leucocytes. Immunology. 65:1988;293-297.
33. Graham S., Secombes C. J. Do fish lymphocytes secrete interferon-gamma. Journal of Fish Biology. 36:1990;563-573.
34. Gupta D., Kirkland T. N., Viriyakosol S., Dziarski R. CD14 is a cell-activating receptor for bacterial peptidoglycan. Journal of Biological Chemistry. 271:1996;23310-23316.
35. Haller O., Frese M., Kochs G. Mx proteins: mediators of innate resistance to RNA viruses. Revue Scientifique et Technique de L'office International des Epizooties. 17:1998;220-230.
36. Harbell S. C., Hodkins H. O., Schiewe M. H. Studies on the pathogenesis of vibriosis in coho salmon Onchorynchus kisutch (Walbaum). Journal of Fish Diseases. 2:1979;391-404.
37. Hardie L. J., Chappell L. H., Secombes C. J. Human tumor necrosis factor alpha influences rainbow trout Oncorhynchus mykiss leucocyte responses. Veterinary Immunology and Immunopathology. 40:1994;73-84.
38. Hashimoto K., Suzuki I., Yadomae T. Oral administration of SSG, a β-glucan obtained from Sclerotinia sclerotiorum, affects the function of Peyer's patch cells. International Journal of Immunopharmacology. 13:1991;437-442.
39. Havell E. A. Evidence that tumor necrosis factor has an important role in antibacterial resistance. Journal of Immunology. 143:1989;2894-2899.
40. Hughes A. L. The evolution of the type I interferon gene family in mammals. Journal of Molecular Evolution. 41:1995;539-548.
41. Itami T., Kondo M., Uozu M., Suganuma A., Abe T., Nakagawa A., Suzuki N., Takahashi Y. Enhancement of resistance against Enterococcus seriolicida infection in yellowtail, Seriola quinqueradiata (Temminck & Schlegel), by oral administration of peptidoglycan derived from Bifidobacterium thermophilum. Journal of Fish Diseases. 19:1996;185-187.
42. Jack R. S., Fan X., Bernheiden M., Rune G., Ehlers M., Weber A., Kirsch G., Mentel R., Furll B., Freudenberg M., Schmitz G., Stelter F., Schutt C. Lipopolysaccharide-binding protein is required to combat a murine Gram-negative bacterial infection. Nature. 389:1997;742-745.
43. Jacobs B. L., Langland J. O. When two strands are better than one: the mediators and modulators of the cellular responses to double-stranded RNA. Virology. 219:1996;339-349.
44. Jang S. I., Hardie L. J., Secombes C. J. Elevation of rainbow trout Oncorhynchus mykiss macrophage respiratory burst activity with macrophage-derived supernatants. Journal of Leukocyte Biology. 57:(1995a);943-947.
45. Jang S. I., Mulero V., Hardie L. J., Secombes C. J. Inhibition of rainbow trout phagocyte responsiveness to human tumor necrosis factor α (hTNFα) with monoclonal antibodies to the hTNFα 55 kDa receptor. Fish & Shellfish Immunology. 5:(1995b);61-69.
46. Jeney G., Anderson D. P. Glucan injection or bath exposure given alone or in combination with a bacterin enhance the non-specific defence mechanisms in rainbow trout (Oncorhynchus mykiss). Aquaculture. 116:1993;315-329.
47. Jensen I., Nygaard R., Sommer A.-I., Leong J. C., Robertsen B. Effect of poly I:C on the expression of Mx-proteins and resistance against infection with infectious salmon anaemia virus in Atlantic salmon. In programme abstracts of The Fourth International Symposium on Viruses of Lower Vertebrates , May 12-15, Weymouth, UK. 1998.
48. Jensen L. E., Hiney M. P., Shields D. C., Uhlar C. M., Lindsay A. J., Whitehead A. S. Acute phase proteins in salmonids: evolutionary analyses and acute phase response. Journal of Immunology. 158:1997;384-392.
49. Jørgensen J. B., Lunde H., Jensen L. E., Whitehead A. S., Robertsen B. Serum amyloid A (SAA) mRNA expression in Atlantic salmon (Salmo salar) hepatocytes stimulated with salmonid macrophage supernatants or recombinant human IL-1, IL-6 and TNFα. In programme abstracts of The 4th Nordic Symposium on Fish Immunology, Hirtshals, Denmark. 1998.
50. Jørgensen J. B., Lunde H., Robertsen B. Peritoneal and head kidney cell response to intraperitoneally injected yeast glucan in Atlantic salmon, Salmo salar L. Journal of Fish Diseases. 16:(1993a);313-325.
51. Jørgensen J. B., Robertsen B. Yeast β-glucan stimulates respiratory burst activity of Atlantic salmon (Salmo salar L.) macrophages. Developmental and Comparative Immunology. 19:1995;43-57.
52. Jørgensen J. B., Sharp G. J. E., Secombes C. J., Robertsen B. Effect of a yeast-cell-wall glucan on the bactericidal activity of rainbow trout macrophages. Fish & Shellfish Immunology. 3:(1993b);267-277.
53. Kajita Y., Sakai M., Atsuta S., Kobayashi M. Immunopotentiation activity of Freund's complete adjuvant in rainbow trout Oncorhynchus mykiss. Nippon Suisan Gakkaishi. 58:1992;433-437.
54. Kodama H., Hirota Y., Mukamoto M., Baba T., Azuma I. Activation of rainbow trout (Oncorhynchus mykiss) phagocytes by muramyl dipeptide. Developmental and Comparative Immunology. 17:1993;129-140.
55. Kodama H., Mukamoto M., Baba T., Mule D. M. Macrophage-colony stimulating activity in rainbow trout (Onchorynchus mykiss) serum. In. Stolen J., Fletcher T. C. Modulators of Fish Immune Response. 1994;59-66 SOS Publications, Fair Haven.
56. Kokoshis P. L., Di Luzio N. R. Serum lysozyme: An index of macrophage function. Journal of the Reticuloendothelial Society. 25:1979;85-99.
57. LaPatra S. E., Lauda K. A., Jones G. R., Shewmaker W. S., Bayne C. J. Resistance to IHN virus infection in rainbow trout is increased by glucan while subsequent production of serum neutralizing activity is decreased. Fish & Shellfish Immunology. 8:1998;435-446.
58. Lemaitre C., Orange N., Saglio P., Saint N., Gagnon J., Molle G. Characterization and ion channel activities of novel antibacterial proteins from the skin mucosa of carp (Cyprinus carpio). European Journal of Biochemistry. 240:1996;143-149.
59. Locksley R. M. Interleukin 12 in host defense against microbial pathogens [comment]. Proceedings of the National Academy of Sciences of the USA. 90:1993;5879-5880.
60. Lorsbach R. B., Murphy W. J., Lowenstein C. J., Snyder S. H., Russell S. W. Expression of the nitric oxide synthase gene in mouse macrophages activated for tumor cell killing: Molecular basis for the synergy between interferon-gamma and lipopolysaccharide. Journal of Biological Chemistry. 268:1993;1908-1913.
61. Lunde H., Robertsen B. The complement component C3 is produced by hepatocytes and behaves as an acute-phase protein in Atlantic salmon, Salmo salar L., after injection of β-glucan. Developmental and Comparative Immunology. 21:1997;150.
62. MacMicking J. D., Nathan C., Hom G., Chartrain N., Fletcher D. S., Trumbauer M., Stevens K., Xie Q. W., Sokol K., Hutchinson N. Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell. 81:1995;641-650.
63. Madigan M. T., Martinko J. M., Parker J. Biology of Microorganisms , 8th ed. Prentice Hall International, Inc. 1997.
64. Maeda Y. Y., Takahama S., Kohara Y., Yonekawa H. Two genes controlling acute phase responses by the antitumor polysaccharide, lentinan. Immunogenetics. 43:1996;215-219.
65. Marcus, P. I. 1984, Interferon induction by viruses: Double-stranded RNA as the common proximal inducer molecule. In Interferon: Mechanisms of Production and Action (Friedman, ed.), pp. 113, 175, Elsevier Biomedical Press.
66. Matsuo K., Miyazono I. The influence of long-term administration of peptidoglycan on disease resistance and growth of juvenile rainbow trout. Nippon Suisan Gakkaishi. 59:1993;1377-1379.
67. Matsuyama H., Mangindaan R. E. P., Yano T. Protective effect of schizophyllan and scleroglucan against Streptococcus sp. infection in yellowtail (Seriola quinqueradiata). Aquaculture. 101:1992;197-203.
68. Moritoma T., Noda H., Yamaguchi I., Watanabe T. Enhancement of granulocytepoiesis by Freund's complete adjuvant in carp. Nippon Suisan Gakkaishi. 58:1992;1145-1149.
69. Muller U., Steinhoff U., Reis L. F., Hemmi S., Pavlovic J., Zinkernagel R. M., Aguet M. Functional role of type I and type II interferons in antiviral defense. Science. 264:1994;1918-1921.
70. Nakanishi Y., Kodama H., Murai T., Mikami T., Izawa H. Activation of rainbow trout complement by C-reactive protein. American Journal of Veterinary Research. 52:1991;397-401.
71. Nathan C. F., Murray H. W., Wiebe M. E., Rubin B. Y. Identification of interferon-γ as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity. Journal of Experimental Medicine. 158:1983;670-689.
72. Nemes M. M., Tytell A. A., Lampson G. P., Field A. K., Hilleman M. R. Inducers of interferon and host resistance, VI. Antiviral efficacy of poly I:C in animal models. Proceedings of the Society for Experimental Biology and Medicine. 132:1969;776-783.
73. Neumann N. F., Fagan D., Belosevic M. Macrophage activating factor(s) secreted by mitogen stimulated goldfish kidney leukocytes synergize with bacterial lipopolysaccharide to induce nitric oxide production in teleost macrophages. Developmental and Comparative Immunology. 19:1995;473-482.
74. Neumann N. F., Belosevic M. Deactivation of primed respiratory burst response of goldfish macrophages by leukocyte-derived macrophage activating factor(s). Developmental and Comparative Immunology. 20:1996;427-429.
75. Nicoletti A., Nicoletti G., Ferraro G., Palmieri G., Mattaboni P., Germogli R. Preliminary evaluation of immunoadjuvant activity of an orally administred glucan extract from Candida albicans. Arzneimittelforschung. 42:1992;1246-1250.
76. Nikl L., Albright L. J., Evelyn T. P. T. Influence of seven immunostimulants on the immune response of coho salmon to Aeromonas salmonicida. Diseases of Aquatic Organisms. 12:1991;7-12.
77. Nikl L., Evelyn T. P. T., Albright L. J. Trials with an orally and immersion-administered β-1,3 glucan as an immunoprophylactic against Aeromonas salmonicida in juvenile chinook salmon Oncorhynchus tshawytscha. Diseases of Aquatic Organisms. 17:1993;191-196.
78. Nowotny A. Beneficial effects of endotoxins . New York, London: Plenum Press. 1983.
79. Ogier de Baulny M., Quentel C., Fournier V., Lamour F., Le Gouvello R. Effect of long-term oral administration of β-glucan as an immunostimulant or an adjuvant on some non-specific parameters of the immune response of turbot Scophthalmus maximus. Diseases of Aquatic Organisms. 26:1996;139-147.
80. Olivier G., Eaton C. A., Campbell N. Interaction between Aeromonas salmonicida and peritoneal macrophages of brook trout (Salvelinus fontinalis). Veterinary Immunology and Immunopathology. 12:1986;223-234.
81. Olivier G., Evelyn T. P., Lallier R. Immunity to Aeromonas salmonicida in coho salmon (Oncorhynchus kisutch) induced by modified Freund's complete adjuvant: its non-specific nature and the probable role of macrophages in the phenomenon. Developmental and Comparative Immunology. 9:1985;419-432.
82. Pabst M. J., Johnston R. B. Jr. Increased production of superoxide anion by macrophages exposed in vitro to muramyl dipeptide or lipopolysaccharide. Journal of Experimental Medicine. 151:1980;101-114.
83. Pestka S. Interferons. Part A. Methods in Enzymology , Vol. 78. New York: Academic Press. 1981.
84. Raa J. The use of immunostimulatory substances in fish and shellfish farming. Reviews in Fishery Science. 4:1996;229-288.
85. Raa J., Roerstad G., Engstad R., Robertsen B. The use of immunostimulants to increase resistance of aquatic organisms to microbial infections. Shariff I. M., Subasinghe R. P., Arthur J. R. Diseases In Asian Aquaculture. 1990;39-50 Fish Health Section, Asian Fisheries Society, Manila.
86. Raetz C. R. Biochemistry of endotoxins. Annual Review of Biochemistry. 59:1990;129-170.
87. Raetz C. R., Ulevitch R. J., Wright S. D., Sibley C. H., Ding A., Nathan C. F. Gram-negative endotoxin: an extraordinary lipid with profound effects on eukaryotic signal transduction. FASEB Journal. 5:1991;2652-2660.
88. Robertsen B., Trobridge G., Leong J. C. Molecular cloning of double-stranded RNA inducible Mx genes from Atlantic salmon (Salmo salar L.). Developmental and Comparative Immunology. 21:1997;397-412.
89. Robertsen B. Immunology of Fishes. Cytokines. Pastoret P.-P., Griebel P., Bazin H., Goaverts A. Handbook of Vertebrate Immunology. 1998;11-13 Academic Press, London.
90. Robertsen B., Engstad R., Jørgensen J. B. β-Glucans as immunostimulants in fish. Stolen J., Fletcher T. C. Modulators of Fish Immune Response. 1994;83-99 SOS Publications, Fair Haven.
91. Robertsen B., Roerstad G., Engstad R., Raa J. Enhancement of non-specific disease resistance in Atlantic salmon, Salmo salar L., by a glucan from Saccharomyces cerevisiae cell walls. Journal of Fish Diseases. 13:1990;391-400.
92. Samuel C. E. Antiviral actions of interferon. Interferon-regulated cellular proteins and their surprisingly selective antiviral activities. Virology. 183:1991;1-11.
93. Santarem M., Novoa B., Figueras A. Effects of β-glucans on the non-specific immune responses of turbot (Scophthalmus maximus L.). Fish & Shellfish Immunology. 7:1997;429-437.
94. Sasaki S., Miura T., Nishikawa S., Yamada K., Hirasue M., Nakane A. Protective role of nitric oxide in Staphylococcus aureus infection in mice. Infection and Immunity. 66:1998;1017-1022.
95. Secombes C. J. Enhancement of fish phagocyte activity. Fish & Shellfish Immunology. 4:(1994a);421-436.
96. Secombes, C. J. (1994b), Macrophage Activation in Fish. Modulators of Fish Immune Responses, J. StolenT. C. Fletcher, 49, 57, Fair Haven, NJ, SOS Publications.
97. Sekellick M. J., Ferrandino A. F., Hopkins D. A., Marcus P. I. Chicken interferon gene: cloning, expression, and analysis. Journal of Interferon Research. 14:1994;71-79.
98. Sen G. C., Lengyel P. The interferon system. A bird's eye view of its biochemistry. Journal of Biological Chemistry. 267:1992;5017-5020.
99. Siwicki A. K., Anderson D. P., Rumsey G. L. Dietary intake of immunostimulants by rainbow trout affects non-specific immunity and protection against furunculosis. Veterinary Immunology and Immunopathology. 41:1994;125-139.
100. Solem S. T., Jørgensen J. B., Robertsen B. Stimulation of respiratory burst and phagocytic activity in Atlantic salmon (Salmo salar L.) macrophages by lipopolysaccharide. Fish & Shellfish Immunology. 5:1995;475-491.
101. Staeheli P., Yu Y. X., Grob R., Haller O. A double-stranded RNA-inducible fish gene homologous to the murine influenza virus resistance gene Mx. Molecular and Cellular Biology. 9:1989;3117-3121.
102. Steel D. M., Whitehead A. S. The major acute phase reactants: C-reactive protein, serum amyloid P component and serum amyloid A protein. Immunology Today. 15:1994;81-88.
103. Stewart-Tull D. E. Immunostimulation with peptidoglycan or its synthetic derivatives. Progress in Drug Research. 32:1988;305-328.
104. Suzuki I., Hashimoto K., Ohno N., Tanaka H., Yadomae T. Immunomodulation by orally administered β-glucan in mice. International Journal of Immunopharmacology. 11:1989;761-769.
105. Suzuki I., Tanaka H., Kinoshita A., Oikawa S., Osawa M., Yadomae T. Effect of orally administered β-glucan on macrophage function in mice. International Journal of Immunopharmacology. 12:1990;675-684.
106. Szalai A. J., Norcum M. T., Bly J. E., Clem L. W. Isolation of an acute-phase phosphorylcholine-reactive pentraxin from channel catfish (Ictalurus punctatus). Comparative Biochemistry and Physiology. B102:1992;535-543.
107. Tahir A., Secombes C. J. Modulation of dab (Limanda limanda , L.) macrophage respiratory burst activity. Fish & Shellfish Immunology. 6:1996;135-146.
108. Thornton B. P., Vetvicka V., Pitman M., Goldman R. C., Ross G. D. Analysis of the sugar specificity and molecular location of the β-glucan-binding lectin site of complement receptor type 3 (CD11b/CD18). Journal of Immunology. 156:1996;1235-1246.
109. Toranzo A. E., Devesa S., Romalde J. L., Lamas J., Riaza A., Leiro J., Barja J. L. Efficacy of intraperitoneal and immersion vaccination against Enterococcus sp. infection in turbot. Aquaculture. 134:1995;17-27.
110. Trobridge G. D., Chiou P. P., Kim C. H., Leong J. C. Analysis of rainbow trout Mx protein expression after induction by poly IC and IHNV. Diseases of Aquatic Organisms. 30:(1997a);91-98.
111. Trobridge G. D., Chiou P. P., Leong J. C. Cloning of the rainbow trout (Onchorynchus mykiss) Mx2 and Mx3 cDNAs and characterization of trout Mx protein in salmon cells. Journal of Virology. 71:(1997b);5304-5311.
112. Trobridge G. D., Leong J. A. C. Characterization of a rainbow trout Mx gene. Journal of Interferon and Cytokine Research. 15:1995;691-702.
113. Verlhac V., Obach A., Gabaudan J., Schüep W., Hole R. Immunomodulation by dietary vitamin C and glucan in rainbow trout (Oncorhynchus mykiss). Fish & Shellfish Immunology. 8:1998;409-424.
114. Vilček J., Sen G. C. Interferons and other cytokines. Fields, Knipe, Howley. Fields' Virology. 1996;375-399 Raven Publishers, New York.
115. Wang W. S., Wang D. H. Enhancement of the resistance of tilapia and grass carp to experimental Aeromonas hydrophila and Edwardsiella tarda infections by several polysaccharides. Comparative Immunology, Microbiology and Infectious Disease. 20:1997;261-270.
116. Warr G. W., Simon R. C. The mitogenic response potential of lymphocytes from the rainbow trout (Salmo gairdneri) re-examined. Developmental and Comparative Immunology. 7:1983;379-384.
117. Wedemeyer G., Ross A. J., Smith L. Some metabolic effects of bacterial endotoxins in salmonid fishes. Journal of the Fisheries Research Board of Canada. 26:1969;115-119.
118. Werner G. H., Jolles P. Immunostimulating agents: what next? A review of their present and potential medical applications. European Journal of Biochemistry. 242:1996;1-19.
119. Wessels M. R., Butko P., Ma M., Warren H. B., Lage A. L., Carroll M. C. Studies of group B streptococcal infection in mice deficient in complement component C3 or C4 demonstrate an essential role for complement in both innate and acquired immunity. Proceedings of the National Academy of Sciences of the USA. 92:1995;11490-11494.
120. Wright S. D., Ramos R. A., Tobias P. S., Ulevitch R. J., Mathison J. C. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science. 249:1990;1431-1433.
121. Yamamoto S., Yamamoto T., Shimada S., Kuramoto E., Yano O., Kataoka T., Tokunaga T. DNA from bacteria, but not from vertebrates, induces interferons, activates natural killer cells and inhibits tumor growth. Microbiology and Immunology. 36:1992;983-997.
122. Yano T., Mangindaan R. E. P., Matsuyama H. Enhancement of the resistance of carp Cyprinus carpio to experimental Edwardsiella tarda infection, by some β-1,3-glucans. Nippon Suisan Gakkaishi. 55:1989;1815-1819.
123. Yano T., Matsuyama H., Mangindaan R. E. P. Polysaccharide-induced protection of carp, Cyprinus carpio L., against bacterial infection. Journal of Fish Diseases. 14:1991;577-582.
124. Yoshida T., Kruger R., Inglis V. Augmentation of non-specific protection in African catfish, Clarias gariepinus (Burchell), by the long-term oral administration of immunostimulants. Journal of Fish Diseases. 18:1995;195-198.
125. Zou J., Cunningham C., Secombes C. J. Rainbow trout recombinant interleukin 1β: Expression, renaturation and determination of the biological activities. Developmental and Comparative Immunology. 21:1997;192.