Mathematical models of parasite responses to host immune defences

Parasitology

Volumn 115, Issue 7, 1997, Pages 155-167

  Antia, R ^a   Lipsitch, M ^a  

^a EMORY UNIVERSITY   (United States)

Author keywords

between parasite multiplication and a clonally expanding response by the host immune system resulting either in immune mediated clearance or host death. In this very simple model in which there is only a single parasite and host genotype maximum transmission is obtained by parasites with intermediate rates of growth (and virulence). We examine how these predictions depend on key assumptions about the parasite and the host and consider how this model may be expanded to incorporate the effect of additional complexities such as host ; parasite co evolution host polymorphism and multiple infections. Key words parasite host evolutlon; race ; We examine the evolution of microparasites in response to the immune system of vertebrate hosts. We first describe a simple model for an acute infection. This model suggests that the within host dynamics of the microparasite will be a

Indexed keywords

EID: 0000082061     PISSN: 00311820     EISSN: 14698161     Source Type: Journal    
DOI: 10.1017/S003118209700200X     Document Type: Article

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