Conjugated antisense oligonucleotides

Nucleosides and Nucleotides

Volumn 16, Issue 7-9, 1997, Pages 1129-1138

  Manoharan, Muthiah ^a   Tivel, Kathleen L ^a   Condon, Thomas P ^a   Andrade, Laura K ^a   Barber Peoch, Isabelle ^a   Inamati, Gopal ^a   Shah, Shefali ^a   Mohan, Venkatraman ^a   Graham, Mark J ^a   Frank Bennett, C ^a   Crooke, Stanley T ^a   Dan Cook, P ^a  

^a ISIS PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; CHOLESTEROL; INTERCELLULAR ADHESION MOLECULE 1; POLYAMINE; POLYETHYLENE; VASCULAR CELL ADHESION MOLECULE 1;

CELL ADHESION; CHEMICAL ANALYSIS; CONFERENCE PAPER; CONJUGATION; DRUG ABSORPTION; GENE EXPRESSION; LIGAND BINDING; LIPID ANALYSIS; NUCLEIC ACID PROBE;

EID: 9844254479     PISSN: 07328311     EISSN: None     Source Type: Journal    
DOI: 10.1080/07328319708006147     Document Type: Conference Paper

References (8)

1. Letsinger, R. L., Zhang, G., Sun, D. K., Ikeuchi, T, and Sarin, P. S., Cholesteryl-conjugated oligonucleotides: Synthesis, properties, and activity as inhibitors or replication of human immunodeficiency virus in cell culture. Proc. Natl. Acad. Sci. 86; 6553, 1989.
2. de Smidt, P.C., Le Doan, T., de Falco, S., van Berkel, T.J.C. Association of antisense oligonucleotides with lipoproteins prolongs the plasma half-life and modifies the tissue distribution. Nucleic Acids Res. 19: 4695, 1991.
3. Krieg, A.M., Tonkinson, J., Matson, S., Zhao, Q., Saxon, L-M., Bhanja, U., Yakubov, L. and Stein, C.A. Modification of antisense phosphodiester oligodeoxynucleotides by a 5′ cholesterol moiety increases cellularassociation and improves efficacy. Proc. Natl. Acad. Sci. 90: 1048, 1993.
4. MacKellar, C., Graham, D., Will, D. W., Burgess, S., and Brown, T., Synthesis and Physical Properties of Anti-HIV Antisense Oligonucleotides Bearing Terminal Lipophilic Groups, Nucleic Acids Res. 20: 3411, 1992.
5. Manoharan, M., Tivel, K.L., Cook, P.D. Lipidic Nucleic Acids. Tetrahedron Lett. 36: 3651, 1995.
6. Manoharan, M., Tivel, K.L., Andrade, L.K., Mohan, V., Condon, T.P., Bennett, C.F., Cook, P.D. Oligonucleotide conjugates: Alteration of the pharmacokinetic properties of antisense agents. Nucleosides Nucleotides. 14: 969, 1995.
7. Crooke, S.T., Graham, M.J., Zuckerman, J.E., Brooks, D., Conklin, B.S., Cummins, L.L., Greig, M.J., Guinosso, C.J., Kornbrust, D., Manoharan, M., Sasmor, H.M., Schleich, T., Tivel, K.L., Griffey, R.H. Pharmacokinetic properties of several novel oligonucleotide analogs in mice. J. Pharm. & Exp. Therap. 277, 923, 1996.
8. Desjardins, J., Mata, J., Brown, T., Graham, D., Zon, G., Iversen, P. Cholesteryl-conjugated phosphorothiate oligodeoxynucleotides modulate CYP2B1 expression in vivo . Journal of Drug Targeting 2, 477, 1995.