The pharmacokinetics of a single dose of artemisinin in subjects with liver cirrhosis

Tropical Medicine and International Health

Volumn 2, Issue 10, 1997, Pages 957-962

  De Vries, Peter J ^a   Khanh, Nguyen Xuan ^b   Dien, Tran Khac ^a,b   Binh, Le Nguyen ^c   Yen, Nguyen Thi ^c   Duc, Dao Dinh ^b   Van Boxtel, Chris J ^a   Kager, Piet A ^a   Van De Berg, Bob ^a   Butter, Jan ^a   Hien, Bui ^b   Koopman, R ^a   Portier, Els ^a   Song, Pham ^b   Thach, Nguyen Cam ^c  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b BACH MAI HOSPITAL   (Viet Nam)

^c Inst Malariology   (Viet Nam)

Author keywords

artemisinin; liver cirrhosis; pharmacokinetics

Indexed keywords

ARTEMISIN;

ARTICLE; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; EXTRACTION; HUMAN; LIVER CIRRHOSIS; MALE; ORAL DRUG ADMINISTRATION; PHARMACOKINETICS;

EID: 9844252870     PISSN: 13602276     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3156.1997.d01-155.x     Document Type: Article

References (16)

1. Benoit JN, Womack WA, Hernandez L & Granger DN (1985) "Forward" and "backward" How mechanisms of portal hypertension. Gastroenterology 89, 1092-1096.
2. Dien TK, Vries de PJ, Khanh NX, Koopmans R, Binh LN, Due DD et al. (1997) Effect of food intake on pharmacokinetics of oral artemisinin in healthy Vietnamese subjects. Antimicrobial Agents and Chemotherapy 41, 1069-1072.
3. Due DD, Vries de PJ, Khanh NX, Binh LN, Kager PA & Boxtel van CJ (1994) The pharmacokinetics of a single dose artemisinin in healthy Vietnamese volunteers. American Journal of Tropical Medicine and Hygiene 51, 785-790.
4. Hassan Alin M, Ashton M, Kihamia CM, Mtey GJB & Björkman A (1996) Multiple dose pharmacokinetics of oral artemisinin and comparison of its efficacy with that of oral artesunate in falciparum malaria patients. Transactions of the Royal Society of Tropical Medicine and Hygiene 980, 61-65.
5. Keiding S (1991) Dynamic aspects of hepatic removal of circulating substances. In Oxford Textbook of Clinical Hepatology. Oxford Medical Publications, Oxford. Volume 1 pp 78-87.
6. Lee IS & Hufford CD (1990) Metabolism of antimalarial sesquiterpene lactones. Pharmacology and Therapeutics 48, 345-355.
7. Leskovac V & Theoharides AD (1991a) Hepatic metabolism of artemisinin drugs I. Drug metabolism in rat liver microsomes. Comparative Biochemistry and Physiology 99C, 383-390.
8. Leskovac V &: Theoharides AD (1991b) Hepatic metabolism of artemisinin drugs II. Metabolism of arteether in rat liver cytosol. Comparative Biochemistry and Physiology 99C, 391-396.
9. Luo De X & Shen CC (1987) The chemistry, pharmacology, and clinical applications of qinghaosu (artemisinin) and its derivatives. Medical Research Reviews 7, 29-52.
10. Melendez V, Peggins JO, Brewer TG & Theoharides AD (1991) Determination of the antimalarial arteether and its deethylated metabolite dihydroartemisinin in plasma by high-performance liquid chromatography with reductive electrochemical detection. Journal of Pharmaceutical Sciences 80, 131-132.
11. Pugh RNH, Murray-Lyon IM, Dawson JL, Pietroni MC & Williams R (1973) Transsection of the oesophagus for bleeding oesophageal varices. British Journal of Surgery 60, 646-649.
12. Titulaer HAC, Zuidema J, Kager PA, Wetsteyn JCFM, Lugt ChB & Merkus FWHM (1990) The pharmacokinetics of artemisinin after oral, intramuscular and rectal administration to volunteers. Journal of Pharmacy and Pharmacology 42, 810-813.
13. Vries de PJ, Hoekstra JBL, Hooge de P & Hattum van J (1994) Portal venous How and followup in patients with liver disease and healthy subjects. Scandinavian Journal of Gastroenterology 29, 172-177.
14. Vries de PJ, Dien TK, Khanh NX, Binh LN, Yen PT, Due DD, Boxtel van CJ & Kager PA (1997) The pharmacokinetics of a single dose of artemisinin in patients with uncomplicated falciparum malaria. American Journal of Tropical Medicine and Hygiene 56, 503-507.
15. Wanwimolruk S, Edwards G, Ward SA & Breckenridge AM (1991) The binding of the antimalarial arteether to human plasma proteins in vitro. Journal of Pharmacy Pharmacology 44, 940-942.
16. Yamaoka K, Nakagawa T & Uno T (1978) Application of Akaike's information criterion (AIC) in the evaluation of lineair pharmacokinetic equations. Journal of Pharmacokinetics and Biopharmaceutics 6, 165-175.