-
2
-
-
0026667497
-
Tetrapeptide inhibitors of protein farnesyltransferase: Amino-terminal substitution in phenylalanine-containing tetrapeptides restores farnesylation
-
BROWN, M.S., GOLDSTEIN, J.L., PARIS, K.J., BURNIER, J.P. and MARSTERS, J.C., JR., Tetrapeptide inhibitors of protein farnesyltransferase: amino-terminal substitution in phenylalanine-containing tetrapeptides restores farnesylation. Proc. nat. Acad. Sci. (Wash.), 89, 8313-8316 (1992).
-
(1992)
Proc. Nat. Acad. Sci. (Wash.)
, vol.89
, pp. 8313-8316
-
-
Brown, M.S.1
Goldstein, J.L.2
Paris, K.J.3
Burnier, J.P.4
Marsters Jr., J.C.5
-
3
-
-
0026063559
-
The COOH-terminal domain of the RaplA (Krev-1) protein is isoprenylated and supports transformation by an H-Ras:Rap1A chimeric protein
-
BUSS, J.E., QUILLIAM, L.A., KATO, K., CASEY, P.J., SOLSKI, P.A., WONG, G., CLARK, R., MCCORNICK, F., BOKOCH, G.M. and DER, C.J., The COOH-terminal domain of the RaplA (Krev-1) protein is isoprenylated and supports transformation by an H-Ras:Rap1A chimeric protein. Mol. Cell Biol., 11, 1523-1530 (1991).
-
(1991)
Mol. Cell Biol.
, vol.11
, pp. 1523-1530
-
-
Buss, J.E.1
Quilliam, L.A.2
Kato, K.3
Casey, P.J.4
Solski, P.A.5
Wong, G.6
Clark, R.7
Mccornick, F.8
Bokoch, G.M.9
Der, C.J.10
-
4
-
-
0026010983
-
Inhibition of ras-induced germinal vesicle breakdown in Xenopus oocytes by rap-1B
-
CAMPA, M.J., CHANG, K.-J., VEDIA, L.M., REEP, B.R. and LAPETINA, E.G., Inhibition of ras-induced germinal vesicle breakdown in Xenopus oocytes by rap-1B. Biochem. biophys. Res. Comm., 174, 1-5 (1991).
-
(1991)
Biochem. Biophys. Res. Comm.
, vol.174
, pp. 1-5
-
-
Campa, M.J.1
Chang, K.-J.2
Vedia, L.M.3
Reep, B.R.4
Lapetina, E.G.5
-
5
-
-
0027304607
-
Extracellular signals and reversible protein phosphorylation: What to mek of it all
-
CREWS, C.M. and ERIKSON, R.L., Extracellular signals and reversible protein phosphorylation: What to mek of it all. Cell, 74, 215-217 (1993).
-
(1993)
Cell
, vol.74
, pp. 215-217
-
-
Crews, C.M.1
Erikson, R.L.2
-
6
-
-
0025952954
-
Selective inhibition of isoprenylation of 21-26-kDa proteins by the anticarcinogen d-limonene and its metabolites
-
CROWELL, P.L., CHANG, R.R., REN, Z., ELSON, C.E. and GOULD, M.N., Selective inhibition of isoprenylation of 21-26-kDa proteins by the anticarcinogen d-limonene and its metabolites. J. biol. Chem., 266, 17679-17685 (1991).
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 17679-17685
-
-
Crowell, P.L.1
Chang, R.R.2
Ren, Z.3
Elson, C.E.4
Gould, M.N.5
-
7
-
-
0025020641
-
Identification of geranylgeranyl-modified proteins in Hela cells
-
FARNSWORTH, C.C., GELB, M.H. and GLOMSET, J.A., Identification of geranylgeranyl-modified proteins in Hela cells. Science (Wash.), 247, 320-322 (1990).
-
(1990)
Science (Wash.)
, vol.247
, pp. 320-322
-
-
Farnsworth, C.C.1
Gelb, M.H.2
Glomset, J.A.3
-
8
-
-
0025877861
-
Ras C-terminal processing enzymes - New drus targets?
-
GIBBS, J.B., Ras C-terminal processing enzymes - new drus targets? Cell, 65, 1-4 (1991).
-
(1991)
Cell
, vol.65
, pp. 1-4
-
-
Gibbs, J.B.1
-
9
-
-
0027413551
-
Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo
-
GIBBS, J.B., POMPLIANO, D.L., MOSSER, S.D., RANDS, E., LINGHAM, R.B., SINGH, S.B., SCOLNICK, E.M., KOHL, N.E. and OLIFF, A., Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo. J. biol. Chem , 268, 7617-7620 (1993).
-
(1993)
J. Biol. Chem
, vol.268
, pp. 7617-7620
-
-
Gibbs, J.B.1
Pompliano, D.L.2
Mosser, S.D.3
Rands, E.4
Lingham, R.B.5
Singh, S.B.6
Scolnick, E.M.7
Kohl, N.E.8
Oliff, A.9
-
10
-
-
0342595409
-
Xenopus oocyte germinal-vesicle breakdown induced by [Val 12]ras is inhibited by a cytosol-localized ras mutant
-
GIBBS, J.B., SCHABER, M.D., SCHOFIELD, T.L., SCOLNICK, E.M. and SIGAL, I.S. Xenopus oocyte germinal-vesicle breakdown induced by [Val 12]ras is inhibited by a cytosol-localized ras mutant. Proc. nat. Acad. Sci. (Wash.), 86, 6630-6634 (1989).
-
(1989)
Proc. Nat. Acad. Sci. (Wash.)
, vol.86
, pp. 6630-6634
-
-
Gibbs, J.B.1
Schaber, M.D.2
Schofield, T.L.3
Scolnick, E.M.4
Sigal, I.S.5
-
11
-
-
0022364924
-
Biochemical properties of normal and oncogenic ras p 21
-
GIBBS, J.B., SIGAL, I.S. and SCOLNICK, E.M., Biochemical properties of normal and oncogenic ras p 21. TIBS, 10, 350-353 (1985).
-
(1985)
TIBS
, vol.10
, pp. 350-353
-
-
Gibbs, J.B.1
Sigal, I.S.2
Scolnick, E.M.3
-
12
-
-
0026040193
-
Nonfarnesylated tetrapeptide inhibitors of protein farnesyltransferase
-
GOLDSTEIN, J.L., BROWN, M.S., STRDLEY, S.J. REISS, Y. and GIERASH, L.M., Nonfarnesylated tetrapeptide inhibitors of protein farnesyltransferase. J. biol. Chem., 266, 15575-15578 (1991).
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 15575-15578
-
-
Goldstein, J.L.1
Brown, M.S.2
Strdley, S.J.3
Reiss, Y.4
Gierash, L.M.5
-
13
-
-
0024406286
-
All ras proteins are polyisoprenylated but only some are palmitoylated
-
HANCOCK, J.F., MAGEE, A.I., CHILDS, J.E. and MARSHALL, C.J., All ras proteins are polyisoprenylated but only some are palmitoylated. Cell, 57, 1167-1177 (1989).
-
(1989)
Cell
, vol.57
, pp. 1167-1177
-
-
Hancock, J.F.1
Magee, A.I.2
Childs, J.E.3
Marshall, C.J.4
-
14
-
-
0027409561
-
Identification of ras farnesyltransferase inhibitors by microbial screening
-
HARA, M., AKASAKA, K., AKINAGA, S., OKABE, M., NAKANO, H., GOMEZ, R., WOOD, D., UH, M. and TAMANOI, F., Identification of ras farnesyltransferase inhibitors by microbial screening. Proc. nat. Acad. Sci. (Wash.), 90, 2281-2285 (1993).
-
(1993)
Proc. Nat. Acad. Sci. (Wash.)
, vol.90
, pp. 2281-2285
-
-
Hara, M.1
Akasaka, K.2
Akinaga, S.3
Okabe, M.4
Nakano, H.5
Gomez, R.6
Wood, D.7
Uh, M.8
Tamanoi, F.9
-
15
-
-
0025212684
-
Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation
-
JACKSON, J.H., COCHRANE, C.G., BOURNE, J.R., SOLSKI, P.A., BUSS, J.E. and DER, C.J., Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation. Proc. nat. Acad. Sci (Wash.), 87, 3042-3046 (1990).
-
(1990)
Proc. Nat. Acad. Sci (Wash.)
, vol.87
, pp. 3042-3046
-
-
Jackson, J.H.1
Cochrane, C.G.2
Bourne, J.R.3
Solski, P.A.4
Buss, J.E.5
Der, C.J.6
-
16
-
-
0028063058
-
Benzodiazepine peptidomimetic BZA-5B interrupts the MAP kinase activation pathway in H-Ras-transformed Rat-1 cells, but not in untransformed cells
-
JAMES, G.L., BROWN, M.S., COBB, M.H. and GOLDSTEIN, J.L., Benzodiazepine peptidomimetic BZA-5B interrupts the MAP kinase activation pathway in H-Ras-transformed Rat-1 cells, but not in untransformed cells. J. biol. Chem., 269, 27705-27714 (1994).
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 27705-27714
-
-
James, G.L.1
Brown, M.S.2
Cobb, M.H.3
Goldstein, J.L.4
-
17
-
-
0027323459
-
Benzodiazepine peptidomimetics: Potent inhibitors of ras farnesylation in animal cells
-
JAMES, G.L , GOLDSTEIN, J.L., BROWN, M.S., RAWSON, T.E., SOMERS, T.C., MCDOWELL, R.S., CROWLEY, C W., LUCAS, B.K., LEVINSON, A.D. and MARSTERS, J.M., JR., Benzodiazepine peptidomimetics: potent inhibitors of ras farnesylation in animal cells. Science (Wash.), 260, 1937-1942 (1993).
-
(1993)
Science (Wash.)
, vol.260
, pp. 1937-1942
-
-
James, G.L.1
Goldstein, J.L.2
Brown, M.S.3
Rawson, T.E.4
Somers, T.C.5
Mcdowell, R.S.6
Crowley, C.W.7
Lucas, B.K.8
Levinson, A.D.9
Marsters Jr., J.M.10
-
18
-
-
0025203316
-
Post-translationally processed structure of the human platelet protein smg p21B: Evidence for geranylgeranylation and carboxyl methylation of the C-terminal cysteine
-
KAWATA, M., FARNSWORTH, C.C., YOSHIDA, Y., GELB, M.H., GLOMSET, J.A. and TAKAI, Y., Post-translationally processed structure of the human platelet protein smg p21B: evidence for geranylgeranylation and carboxyl methylation of the C-terminal cysteine. Proc. nat. Acad. Sci. (Wash.), 87, 8960-8964 (1990a).
-
(1990)
Proc. Nat. Acad. Sci. (Wash.)
, vol.87
, pp. 8960-8964
-
-
Kawata, M.1
Farnsworth, C.C.2
Yoshida, Y.3
Gelb, M.H.4
Glomset, J.A.5
Takai, Y.6
-
19
-
-
0025291799
-
Increase in the active form of 3-hydroxy-3-methylglutaryl coenzyme A reductase in human hepatocellular carcinoma: Possible mechanism for alteration of cholesterol biosynthesis
-
KAWATA, S., TAKAISHI, K., NAGASE, T., ITO, N., MATSUDA, Y., TAMURA, S., MATSUZAWA, Y and TARUI, S., Increase in the active form of 3-hydroxy-3-methylglutaryl coenzyme A reductase in human hepatocellular carcinoma: possible mechanism for alteration of cholesterol biosynthesis. Cancer Res., 50, 3270-3273 (1990b).
-
(1990)
Cancer Res.
, vol.50
, pp. 3270-3273
-
-
Kawata, S.1
Takaishi, K.2
Nagase, T.3
Ito, N.4
Matsuda, Y.5
Tamura, S.6
Matsuzawa, Y.7
Tarui, S.8
-
20
-
-
0024600222
-
A ras-related gene with transformation suppressor activity
-
KITAYAMA, H., SUGIMOTO, Y., MATSUZAKI, Y., IKAWA, Y. and NODA, M., A ras-related gene with transformation suppressor activity. Cell. 56, 77-84 (1989).
-
(1989)
Cell
, vol.56
, pp. 77-84
-
-
Kitayama, H.1
Sugimoto, Y.2
Matsuzaki, Y.3
Ikawa, Y.4
Noda, M.5
-
21
-
-
0027248872
-
Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor
-
KOHL, N.E., MOSSER, S.D., DESOLMS, S.J., GILLIANI, E.A., POMPLIANO, D.L., GRAHAM, S.L. and SMITH, R.L., Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor. Science (Wash.), 260, 1934-1937 (1993).
-
(1993)
Science (Wash.)
, vol.260
, pp. 1934-1937
-
-
Kohl, N.E.1
Mosser, S.D.2
Desolms, S.J.3
Gilliani, E.A.4
Pompliano, D.L.5
Graham, S.L.6
Smith, R.L.7
-
22
-
-
0014949207
-
Cleavage of structural proteins during the assembly of the head of bacteriophage T4
-
LAEMMLI, U.K., Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond.), 227, 680-685 (1970).
-
(1970)
Nature (Lond.)
, vol.227
, pp. 680-685
-
-
Laemmli, U.K.1
-
23
-
-
71849104860
-
Protein measurement with the Folin phenol reagent
-
LOWRY, O.H., ROSEBROUGH, N.J., FARR, A.L. and RANDALL, R.J., Protein measurement with the Folin phenol reagent. J. biol. Chem., 193, 265-275 (1951).
-
(1951)
J. Biol. Chem.
, vol.193
, pp. 265-275
-
-
Lowry, O.H.1
Rosebrough, N.J.2
Farr, A.L.3
Randall, R.J.4
-
24
-
-
0025649688
-
Post-translational modification of proteins by isoprenoids in mammalian cells
-
MALTESE, W.A., Post-translational modification of proteins by isoprenoids in mammalian cells. FASEB J., 4, 3319-3328 (1990).
-
(1990)
FASEB J.
, vol.4
, pp. 3319-3328
-
-
Maltese, W.A.1
-
25
-
-
0022413876
-
Suppression of murine neuroblastoma growth in vivo by mevinolin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase
-
MALTESE, W.A., DEFENDINI, R., GREEN, R.A., SHERIDAN, K.M. and DONLEY, D.K., Suppression of murine neuroblastoma growth in vivo by mevinolin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. J. clin. Invest., 76, 1748-1754 (1985).
-
(1985)
J. Clin. Invest.
, vol.76
, pp. 1748-1754
-
-
Maltese, W.A.1
Defendini, R.2
Green, R.A.3
Sheridan, K.M.4
Donley, D.K.5
-
26
-
-
0023193953
-
Rapid analysis of cellular lipids without extraction
-
MAZIERE, C., MAZIERE, J.C., MORA, L. and POLONOVSKI, J., Rapid analysis of cellular lipids without extraction. J. biochem. biophys. Meth., 14, 267-272 (1987).
-
(1987)
J. Biochem. Biophys. Meth.
, vol.14
, pp. 267-272
-
-
Maziere, C.1
Maziere, J.C.2
Mora, L.3
Polonovski, J.4
-
28
-
-
0025318985
-
Characterization of a transforming N-ras gene in the human hepatoma cell line Hep G2: Additional evidence for the importance of c-myc and ras cooperation in hepatocarcinogenesis
-
RICHARDS, C.A., SHORT, S.A., THORGEIRSSON, S.S. and HUBER, B.E., Characterization of a transforming N-ras gene in the human hepatoma cell line Hep G2: additional evidence for the importance of c-myc and ras cooperation in hepatocarcinogenesis. Cancer Res., 50, 1521-1527 (1990).
-
(1990)
Cancer Res.
, vol.50
, pp. 1521-1527
-
-
Richards, C.A.1
Short, S.A.2
Thorgeirsson, S.S.3
Huber, B.E.4
-
29
-
-
0025710317
-
Prenylated proteins: The structure of the isoprenoid group
-
RILLING, H.C., BREUNGER, E., EPSTEIN, W.W. and CRAIN, P.F., Prenylated proteins: the structure of the isoprenoid group. Science (Wash.), 247, 318-320 (1990).
-
(1990)
Science (Wash.)
, vol.247
, pp. 318-320
-
-
Rilling, H.C.1
Breunger, E.2
Epstein, W.W.3
Crain, P.F.4
-
30
-
-
0024316475
-
Genetic and pharmacological suppression of oncogenic mutations in RAS genes of yeast and humans
-
SCHAFER, W.R., KIM, R., STERNE, R., THORNER, J., KIM, S.H. and RINE, J., Genetic and pharmacological suppression of oncogenic mutations in RAS genes of yeast and humans. Science, 245, 379-385 (1989).
-
(1989)
Science
, vol.245
, pp. 379-385
-
-
Schafer, W.R.1
Kim, R.2
Sterne, R.3
Thorner, J.4
Kim, S.H.5
Rine, J.6
-
31
-
-
0016357487
-
Micro assay for 3-hydroxy-3-methylglutaryl-CoA reductase in rat liver and in L-cell fibroblasts
-
SHAPIRO, D.J., NORDSTROM, J.L., MITSCHELEN, J.J., ROSWELL, V.W. and SCHIMKE, R.T., Micro assay for 3-hydroxy-3-methylglutaryl-CoA reductase in rat liver and in L-cell fibroblasts. Biochim. biophys. Acta. 370, 369-377 (1974).
-
(1974)
Biochim. Biophys. Acta
, vol.370
, pp. 369-377
-
-
Shapiro, D.J.1
Nordstrom, J.L.2
Mitschelen, J.J.3
Roswell, V.W.4
Schimke, R.T.5
-
32
-
-
0027905014
-
Altered growth of human colon cancer cell lines disrupted at activated Ki-ras
-
SHIRASAWA, S., FURUSE, M., YOKOYAMA, N. and SASAZUKI, T., Altered growth of human colon cancer cell lines disrupted at activated Ki-ras. Science (Wash.), 260, 85-88 (1993).
-
(1993)
Science (Wash.)
, vol.260
, pp. 85-88
-
-
Shirasawa, S.1
Furuse, M.2
Yokoyama, N.3
Sasazuki, T.4
-
33
-
-
0025883047
-
Dominant inhibitory ras mutants selectively inhibit the activity of either cellular or oncogenic ras
-
STACEY, D.W., FEIG, L.A. and GIBBS, J.B., Dominant inhibitory ras mutants selectively inhibit the activity of either cellular or oncogenic ras. Mol. Cell Biol., 11, 4053-4064 (1991).
-
(1991)
Mol. Cell Biol.
, vol.11
, pp. 4053-4064
-
-
Stacey, D.W.1
Feig, L.A.2
Gibbs, J.B.3
-
34
-
-
0024505982
-
Activated N-ras gene was found in human hepatoma tissue but only in a small fraction of the tumor cells
-
TAKADA, S. and KOIKE, K., Activated N-ras gene was found in human hepatoma tissue but only in a small fraction of the tumor cells. Oncogene, 4, 189-193 (1989).
-
(1989)
Oncogene
, vol.4
, pp. 189-193
-
-
Takada, S.1
Koike, K.2
-
35
-
-
0026653977
-
Small GTP-binding proteins
-
TAKAI, Y., KAIBUCHI, K., KIKUCHI, A. and KAWATA, M., Small GTP-binding proteins. Int. Rev. Cytol., 133, 187-230 (1992).
-
(1992)
Int. Rev. Cytol.
, vol.133
, pp. 187-230
-
-
Takai, Y.1
Kaibuchi, K.2
Kikuchi, A.3
Kawata, M.4
-
36
-
-
0023128710
-
The expression of oncogenes in human developing liver and hepatomas
-
ZHANG, X.K., HUANG, D.P., CHIU, D.K. and CHIU, J.F., The expression of oncogenes in human developing liver and hepatomas. Biochem. biophys. Res. Comm., 142, 932-938 (1987).
-
(1987)
Biochem. Biophys. Res. Comm.
, vol.142
, pp. 932-938
-
-
Zhang, X.K.1
Huang, D.P.2
Chiu, D.K.3
Chiu, J.F.4
-
37
-
-
0025367299
-
The expression of c-myc and c-N-ras in human cirrhotic livers, hepatocellular carcinomas and liver tissue surrounding the tumors
-
ZHANG, X.K., HUANG, D.P., QIU, D.K. and CHIU, J.F., The expression of c-myc and c-N-ras in human cirrhotic livers, hepatocellular carcinomas and liver tissue surrounding the tumors. Oncogene, 5, 909-914 (1990).
-
(1990)
Oncogene
, vol.5
, pp. 909-914
-
-
Zhang, X.K.1
Huang, D.P.2
Qiu, D.K.3
Chiu, J.F.4
|