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Volumn 65, Issue 5, 1996, Pages 620-626

Inhibition of cell growth of human hepatoma cell line (Hep G2) by a farnesyl protein transferase inhibitor: A preferential suppression of ras farnesylation

Author keywords

[No Author keywords available]

Indexed keywords

MANUMYCIN; SQUALENE SYNTHASE;

EID: 0029940817     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19960301)65:5<620::AID-IJC11>3.0.CO;2-B     Document Type: Article
Times cited : (48)

References (37)
  • 2
    • 0026667497 scopus 로고
    • Tetrapeptide inhibitors of protein farnesyltransferase: Amino-terminal substitution in phenylalanine-containing tetrapeptides restores farnesylation
    • BROWN, M.S., GOLDSTEIN, J.L., PARIS, K.J., BURNIER, J.P. and MARSTERS, J.C., JR., Tetrapeptide inhibitors of protein farnesyltransferase: amino-terminal substitution in phenylalanine-containing tetrapeptides restores farnesylation. Proc. nat. Acad. Sci. (Wash.), 89, 8313-8316 (1992).
    • (1992) Proc. Nat. Acad. Sci. (Wash.) , vol.89 , pp. 8313-8316
    • Brown, M.S.1    Goldstein, J.L.2    Paris, K.J.3    Burnier, J.P.4    Marsters Jr., J.C.5
  • 3
    • 0026063559 scopus 로고
    • The COOH-terminal domain of the RaplA (Krev-1) protein is isoprenylated and supports transformation by an H-Ras:Rap1A chimeric protein
    • BUSS, J.E., QUILLIAM, L.A., KATO, K., CASEY, P.J., SOLSKI, P.A., WONG, G., CLARK, R., MCCORNICK, F., BOKOCH, G.M. and DER, C.J., The COOH-terminal domain of the RaplA (Krev-1) protein is isoprenylated and supports transformation by an H-Ras:Rap1A chimeric protein. Mol. Cell Biol., 11, 1523-1530 (1991).
    • (1991) Mol. Cell Biol. , vol.11 , pp. 1523-1530
    • Buss, J.E.1    Quilliam, L.A.2    Kato, K.3    Casey, P.J.4    Solski, P.A.5    Wong, G.6    Clark, R.7    Mccornick, F.8    Bokoch, G.M.9    Der, C.J.10
  • 5
    • 0027304607 scopus 로고
    • Extracellular signals and reversible protein phosphorylation: What to mek of it all
    • CREWS, C.M. and ERIKSON, R.L., Extracellular signals and reversible protein phosphorylation: What to mek of it all. Cell, 74, 215-217 (1993).
    • (1993) Cell , vol.74 , pp. 215-217
    • Crews, C.M.1    Erikson, R.L.2
  • 6
    • 0025952954 scopus 로고
    • Selective inhibition of isoprenylation of 21-26-kDa proteins by the anticarcinogen d-limonene and its metabolites
    • CROWELL, P.L., CHANG, R.R., REN, Z., ELSON, C.E. and GOULD, M.N., Selective inhibition of isoprenylation of 21-26-kDa proteins by the anticarcinogen d-limonene and its metabolites. J. biol. Chem., 266, 17679-17685 (1991).
    • (1991) J. Biol. Chem. , vol.266 , pp. 17679-17685
    • Crowell, P.L.1    Chang, R.R.2    Ren, Z.3    Elson, C.E.4    Gould, M.N.5
  • 7
    • 0025020641 scopus 로고
    • Identification of geranylgeranyl-modified proteins in Hela cells
    • FARNSWORTH, C.C., GELB, M.H. and GLOMSET, J.A., Identification of geranylgeranyl-modified proteins in Hela cells. Science (Wash.), 247, 320-322 (1990).
    • (1990) Science (Wash.) , vol.247 , pp. 320-322
    • Farnsworth, C.C.1    Gelb, M.H.2    Glomset, J.A.3
  • 8
    • 0025877861 scopus 로고
    • Ras C-terminal processing enzymes - New drus targets?
    • GIBBS, J.B., Ras C-terminal processing enzymes - new drus targets? Cell, 65, 1-4 (1991).
    • (1991) Cell , vol.65 , pp. 1-4
    • Gibbs, J.B.1
  • 10
    • 0342595409 scopus 로고
    • Xenopus oocyte germinal-vesicle breakdown induced by [Val 12]ras is inhibited by a cytosol-localized ras mutant
    • GIBBS, J.B., SCHABER, M.D., SCHOFIELD, T.L., SCOLNICK, E.M. and SIGAL, I.S. Xenopus oocyte germinal-vesicle breakdown induced by [Val 12]ras is inhibited by a cytosol-localized ras mutant. Proc. nat. Acad. Sci. (Wash.), 86, 6630-6634 (1989).
    • (1989) Proc. Nat. Acad. Sci. (Wash.) , vol.86 , pp. 6630-6634
    • Gibbs, J.B.1    Schaber, M.D.2    Schofield, T.L.3    Scolnick, E.M.4    Sigal, I.S.5
  • 11
    • 0022364924 scopus 로고
    • Biochemical properties of normal and oncogenic ras p 21
    • GIBBS, J.B., SIGAL, I.S. and SCOLNICK, E.M., Biochemical properties of normal and oncogenic ras p 21. TIBS, 10, 350-353 (1985).
    • (1985) TIBS , vol.10 , pp. 350-353
    • Gibbs, J.B.1    Sigal, I.S.2    Scolnick, E.M.3
  • 12
    • 0026040193 scopus 로고
    • Nonfarnesylated tetrapeptide inhibitors of protein farnesyltransferase
    • GOLDSTEIN, J.L., BROWN, M.S., STRDLEY, S.J. REISS, Y. and GIERASH, L.M., Nonfarnesylated tetrapeptide inhibitors of protein farnesyltransferase. J. biol. Chem., 266, 15575-15578 (1991).
    • (1991) J. Biol. Chem. , vol.266 , pp. 15575-15578
    • Goldstein, J.L.1    Brown, M.S.2    Strdley, S.J.3    Reiss, Y.4    Gierash, L.M.5
  • 13
    • 0024406286 scopus 로고
    • All ras proteins are polyisoprenylated but only some are palmitoylated
    • HANCOCK, J.F., MAGEE, A.I., CHILDS, J.E. and MARSHALL, C.J., All ras proteins are polyisoprenylated but only some are palmitoylated. Cell, 57, 1167-1177 (1989).
    • (1989) Cell , vol.57 , pp. 1167-1177
    • Hancock, J.F.1    Magee, A.I.2    Childs, J.E.3    Marshall, C.J.4
  • 16
    • 0028063058 scopus 로고
    • Benzodiazepine peptidomimetic BZA-5B interrupts the MAP kinase activation pathway in H-Ras-transformed Rat-1 cells, but not in untransformed cells
    • JAMES, G.L., BROWN, M.S., COBB, M.H. and GOLDSTEIN, J.L., Benzodiazepine peptidomimetic BZA-5B interrupts the MAP kinase activation pathway in H-Ras-transformed Rat-1 cells, but not in untransformed cells. J. biol. Chem., 269, 27705-27714 (1994).
    • (1994) J. Biol. Chem. , vol.269 , pp. 27705-27714
    • James, G.L.1    Brown, M.S.2    Cobb, M.H.3    Goldstein, J.L.4
  • 18
    • 0025203316 scopus 로고
    • Post-translationally processed structure of the human platelet protein smg p21B: Evidence for geranylgeranylation and carboxyl methylation of the C-terminal cysteine
    • KAWATA, M., FARNSWORTH, C.C., YOSHIDA, Y., GELB, M.H., GLOMSET, J.A. and TAKAI, Y., Post-translationally processed structure of the human platelet protein smg p21B: evidence for geranylgeranylation and carboxyl methylation of the C-terminal cysteine. Proc. nat. Acad. Sci. (Wash.), 87, 8960-8964 (1990a).
    • (1990) Proc. Nat. Acad. Sci. (Wash.) , vol.87 , pp. 8960-8964
    • Kawata, M.1    Farnsworth, C.C.2    Yoshida, Y.3    Gelb, M.H.4    Glomset, J.A.5    Takai, Y.6
  • 19
    • 0025291799 scopus 로고
    • Increase in the active form of 3-hydroxy-3-methylglutaryl coenzyme A reductase in human hepatocellular carcinoma: Possible mechanism for alteration of cholesterol biosynthesis
    • KAWATA, S., TAKAISHI, K., NAGASE, T., ITO, N., MATSUDA, Y., TAMURA, S., MATSUZAWA, Y and TARUI, S., Increase in the active form of 3-hydroxy-3-methylglutaryl coenzyme A reductase in human hepatocellular carcinoma: possible mechanism for alteration of cholesterol biosynthesis. Cancer Res., 50, 3270-3273 (1990b).
    • (1990) Cancer Res. , vol.50 , pp. 3270-3273
    • Kawata, S.1    Takaishi, K.2    Nagase, T.3    Ito, N.4    Matsuda, Y.5    Tamura, S.6    Matsuzawa, Y.7    Tarui, S.8
  • 20
    • 0024600222 scopus 로고
    • A ras-related gene with transformation suppressor activity
    • KITAYAMA, H., SUGIMOTO, Y., MATSUZAKI, Y., IKAWA, Y. and NODA, M., A ras-related gene with transformation suppressor activity. Cell. 56, 77-84 (1989).
    • (1989) Cell , vol.56 , pp. 77-84
    • Kitayama, H.1    Sugimoto, Y.2    Matsuzaki, Y.3    Ikawa, Y.4    Noda, M.5
  • 22
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • LAEMMLI, U.K., Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond.), 227, 680-685 (1970).
    • (1970) Nature (Lond.) , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 24
    • 0025649688 scopus 로고
    • Post-translational modification of proteins by isoprenoids in mammalian cells
    • MALTESE, W.A., Post-translational modification of proteins by isoprenoids in mammalian cells. FASEB J., 4, 3319-3328 (1990).
    • (1990) FASEB J. , vol.4 , pp. 3319-3328
    • Maltese, W.A.1
  • 25
    • 0022413876 scopus 로고
    • Suppression of murine neuroblastoma growth in vivo by mevinolin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase
    • MALTESE, W.A., DEFENDINI, R., GREEN, R.A., SHERIDAN, K.M. and DONLEY, D.K., Suppression of murine neuroblastoma growth in vivo by mevinolin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. J. clin. Invest., 76, 1748-1754 (1985).
    • (1985) J. Clin. Invest. , vol.76 , pp. 1748-1754
    • Maltese, W.A.1    Defendini, R.2    Green, R.A.3    Sheridan, K.M.4    Donley, D.K.5
  • 28
    • 0025318985 scopus 로고
    • Characterization of a transforming N-ras gene in the human hepatoma cell line Hep G2: Additional evidence for the importance of c-myc and ras cooperation in hepatocarcinogenesis
    • RICHARDS, C.A., SHORT, S.A., THORGEIRSSON, S.S. and HUBER, B.E., Characterization of a transforming N-ras gene in the human hepatoma cell line Hep G2: additional evidence for the importance of c-myc and ras cooperation in hepatocarcinogenesis. Cancer Res., 50, 1521-1527 (1990).
    • (1990) Cancer Res. , vol.50 , pp. 1521-1527
    • Richards, C.A.1    Short, S.A.2    Thorgeirsson, S.S.3    Huber, B.E.4
  • 29
    • 0025710317 scopus 로고
    • Prenylated proteins: The structure of the isoprenoid group
    • RILLING, H.C., BREUNGER, E., EPSTEIN, W.W. and CRAIN, P.F., Prenylated proteins: the structure of the isoprenoid group. Science (Wash.), 247, 318-320 (1990).
    • (1990) Science (Wash.) , vol.247 , pp. 318-320
    • Rilling, H.C.1    Breunger, E.2    Epstein, W.W.3    Crain, P.F.4
  • 30
    • 0024316475 scopus 로고
    • Genetic and pharmacological suppression of oncogenic mutations in RAS genes of yeast and humans
    • SCHAFER, W.R., KIM, R., STERNE, R., THORNER, J., KIM, S.H. and RINE, J., Genetic and pharmacological suppression of oncogenic mutations in RAS genes of yeast and humans. Science, 245, 379-385 (1989).
    • (1989) Science , vol.245 , pp. 379-385
    • Schafer, W.R.1    Kim, R.2    Sterne, R.3    Thorner, J.4    Kim, S.H.5    Rine, J.6
  • 31
  • 32
    • 0027905014 scopus 로고
    • Altered growth of human colon cancer cell lines disrupted at activated Ki-ras
    • SHIRASAWA, S., FURUSE, M., YOKOYAMA, N. and SASAZUKI, T., Altered growth of human colon cancer cell lines disrupted at activated Ki-ras. Science (Wash.), 260, 85-88 (1993).
    • (1993) Science (Wash.) , vol.260 , pp. 85-88
    • Shirasawa, S.1    Furuse, M.2    Yokoyama, N.3    Sasazuki, T.4
  • 33
    • 0025883047 scopus 로고
    • Dominant inhibitory ras mutants selectively inhibit the activity of either cellular or oncogenic ras
    • STACEY, D.W., FEIG, L.A. and GIBBS, J.B., Dominant inhibitory ras mutants selectively inhibit the activity of either cellular or oncogenic ras. Mol. Cell Biol., 11, 4053-4064 (1991).
    • (1991) Mol. Cell Biol. , vol.11 , pp. 4053-4064
    • Stacey, D.W.1    Feig, L.A.2    Gibbs, J.B.3
  • 34
    • 0024505982 scopus 로고
    • Activated N-ras gene was found in human hepatoma tissue but only in a small fraction of the tumor cells
    • TAKADA, S. and KOIKE, K., Activated N-ras gene was found in human hepatoma tissue but only in a small fraction of the tumor cells. Oncogene, 4, 189-193 (1989).
    • (1989) Oncogene , vol.4 , pp. 189-193
    • Takada, S.1    Koike, K.2
  • 36
    • 0023128710 scopus 로고
    • The expression of oncogenes in human developing liver and hepatomas
    • ZHANG, X.K., HUANG, D.P., CHIU, D.K. and CHIU, J.F., The expression of oncogenes in human developing liver and hepatomas. Biochem. biophys. Res. Comm., 142, 932-938 (1987).
    • (1987) Biochem. Biophys. Res. Comm. , vol.142 , pp. 932-938
    • Zhang, X.K.1    Huang, D.P.2    Chiu, D.K.3    Chiu, J.F.4
  • 37
    • 0025367299 scopus 로고
    • The expression of c-myc and c-N-ras in human cirrhotic livers, hepatocellular carcinomas and liver tissue surrounding the tumors
    • ZHANG, X.K., HUANG, D.P., QIU, D.K. and CHIU, J.F., The expression of c-myc and c-N-ras in human cirrhotic livers, hepatocellular carcinomas and liver tissue surrounding the tumors. Oncogene, 5, 909-914 (1990).
    • (1990) Oncogene , vol.5 , pp. 909-914
    • Zhang, X.K.1    Huang, D.P.2    Qiu, D.K.3    Chiu, J.F.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.