Administration of anti-IL-12 antibody in vivo inhibits rejection of a rat histiocytoma and suppresses cytokine response in a tumour- bearing host

Immunology

Volumn 92, Issue 3, 1997, Pages 381-387

  Lakshmi Rao, K ^a   Varalakshmi, Ch ^a   Mubarak Ali, A ^a   Khar, A ^a  

^a CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 12;

ANIMAL CELL; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; DENDRITIC CELL; HISTIOCYTOMA; IMMUNE RESPONSE; KILLER CELL; MACROPHAGE ACTIVATION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION; SUPPRESSOR CELL; T LYMPHOCYTE ACTIVATION;

EID: 9844229904     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.1997.00362.x     Document Type: Article

References (42)

1. BRUNDA M.J., LEUISTRO L., WARRIER R.R. et al. (1993) Antitumor and antimetastatic activity of IL-12 against murine tumors. J Exp Med 178, 1223.
2. D'ANDREA A., RENGARAJU M., VALIANTE N.M. et al. (1992) Production of natural killer cell stimulatory factor (NKSF/IL-12) by peripheral blood mononuclear cells. J Exp Med 176, 1387.
3. WOLF S.F., TEMPLE P.A., KOBAYASHI M. et al. (1991) Cloning of cDNA for natural killer cell stimulatory factor. A heterodimeric cytokine with multiple biologic effects on T and natural killer cells. J Immunol 146, 3074.
4. KOBAYASHI M., FITZ L., RYAN M. et al. (1989) Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J Exp Med 170, 827.
5. LING P., GATELY M.K., GUBLER U. et al. (1995) Human Interleukin (IL)-12 P40 homodimer binds to the IL-12 receptor but does not mediate biologic activity. J Immunol 154, 116.
6. WOLK S.F., SEIBURTH D., PERUSSIA B., VETZ J., D'ANDREA A. & TRINCHIERI G. (1992) Cell sources of NK cell stimulatory factor (NKSF/IL-12) transcripts and subunit expression. FASEB J 6, 1335a.
7. GUBLER U., CHUA A.O., SCHOENHAUNT D.S. et al. (1991) Coexpression of 2 distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor. Proc Natl Acad Sci USA 88, 4143.
8. SEUBERTH D., JABS E.W., WARRINGTON J.A. et al. (1992) Assignment of genes encoding a unique cytokine IL-12 composed of 2 regulated subunits to chromosomes 3 and 5. Genomics 14, 59.
9. TRINCHIERI G. (1994) IL-12: a cytokine produced by Ag presenting cells with immunoregulatory functions in the generation of T helper cells Type 1 and cytotoxic lymphocytes. Blood 84, 4008.
10. FALLARINO F., UYTTENHOVE C., BOON T. & GAJEWSKI T.F. (1996) Endogenous IL-12 is necessary for rejection of P815 tumor variants in vivo. J Immunol 156, 1095.
11. HEGDE S.P., BRIGHT J.J., KAUSALYA S. & KHAR A. (1995) AK-5 tumor induced expression of IL-12; role of IL-12 in NK-mediated AK-5 regression. Cell Immunol 162, 241.
12. WU C.V., DEMEURE C., GATELY M.K. & DELESPASSE G. (1993) IL-12 induces production of IFN-γ by neonatal human CD4 T cells. J Immunol 151, 1938.
13. MANETTI R., GEROSA F., GIUDIZI M.G. et al. (1994) IL-12 induces stable priming for IFN-γ production during differentiation of human T helper (Th) cells and transient IFN-γ production in established Th2 cell clones. J Exp Med 179, 1273.
14. SEDER R.A., GAZZINELLI R., SHER A. & PAUL W.E. (1993) Interleukin-12 acts directly on CD4 T cells to enhance priming for IFN-γ production and diminishes IL-4 inhibition of such priming. Proc Natl Acad Sci USA 90, 10 188.
15. GATELY M.K., WOLIZKY A.G., QUINN P.M. & CHIZZONITE R. (1992) Regulation of human cytolytic lymphocyte responses by interleukin-12. Cell Immunol 143, 127.
16. CHEHIMI J., STARR S.E., FRANK I. et al. (1992) Natural killer (NK) cell stimulatory factor increase the cytotoxic activity of NK cells from both healthy donors and human immunodeficiency virus infected patients. J Exp Med 175, 789.
17. ROBERTSON M.J., SOIFFER R.J., WOLF S.F. et al. (1992) Response of human natural killer (NK) cells to NK cell stimulatory factor (NKSF). Cytolytic activity and proliferation of NK cells are differentially regulated by NKSF. J Exp Med 175, 779.
18. MANETTI R., PARRONCHI P., GIUDIZI M.G. et al. (1993) NKSF induces Th1 type specific immune responses and inhibits the development of IL-4 producing Th cells. J Exp Med 177, 779.
19. TRINCHIERI G. (1993) IL-12 and its role in the generation of Th1 cells. Immunol Today 14, 335.
20. COUGHLIN C.M., WYSOCKA M., KURZAWA H.L., LEE W.M.F., TRINCHIERI G. & ECK S.L. (1995) B7-1 and Interleukin-12 synergistically induce effective antitumor immunity. Cancer Res 35, 4980.
21. MA X., CHOW J.M. GI G., CARRA F.G., WOLF S.F., DIZIALO R. & TRINCHIERI G. (1996) The IL-12 P40 gene promoter is primed by IFN-γ in monocytic cells. J Exp Med 183, 147.
22. CASSETELLA M.A., MEDA L., GASPERINI S., D'ANDREA A., MA X. & TRINCHIERI G. (1995) IL-12 production by human polymorphonuclear leukocytes. Eur J Immunol 25, 1.
23. KUBIN M., CHOW J.M. & TRINCHIERI G. (1993) Differential regulation of IL-12, TNF-α and IL-1β production in human myeloid leukemia cell lines and peripheral blood mononuclear cells. Blood 83, 1847.
24. D'ANDREA A., ASTE-AMEZAGA M., VALIANTE N.M., MA X., KUBIN M. & TRINCHIERI G. (1993) IL-10 inhibits human lymphocyte IFN-γ production by suppressing NKSF/IL-12 synthesis in accessory cells. J Exp Med 178, 1041.
25. D'ANDREA A., MA X., ASTE-AMEZAGA M., PAGANIN C. & TRINCHIERI G. (1995) Stimulatory and inhibitory effects of IL-4 and IL-13 on production of cytokines by human peripheral blood mononuclear cells; priming for IL-12 and TNF-α production. J Exp Med 181, 537.
26. KHAR A. (1986) Development and characterization of a rat histiocytoma marcophage tumor line. J Natl Cancer Inst 76, 871.
27. KAUSALYA S., VARALAKSHMI C. & KHAR A. (1995) Correlation of in vitro and in vivo effects of interferon-γ with the spontaneous regression of a rat histiocytoma. J Interferon Cytokine Res 15, 647.
28. KHAR A., KAUSALYA S. & KAMAL M.A. (1996) AK-5 tumor induced modulation of host immune function; upregulation of Th1 type cytokine response mediates early tumor regression. Cytokines Mol Therapy 2, 39.
29. MOSSMANN T., CHERWINSKI H., BOND M., GIEDLIN M. & COFFMAN R. (1994) Two types of murine helper T cell clone: Difinition according to profile of lymphokine activities and secreted proteins. J Immunol 136, 2348.
30. CHERWINSKI H., SCHUMACHER J., BROWN K. & MOSMANN T. (1987) Two types of mouse helper Tcell clone: further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays and monoclonal antibodies. J Exp Med 166, 1229.
31. OHARA J. & PAUL W.E. (1985) Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1. Nature 315, 333.
32. MOSMANN T., SCHUMACHER J.H., FIORENTINO D.E., LEVERAH, J. MOORE K.W. & BOND M.W. (1990) Isolation of monoclonal antibodies specific for IL-4, IL-5, IL-6 and a new Th2-specific cytokine IL-10, cytokine synthesis inhibitory factor, by using a solid phase radio-immuno-adsorbent assay. J Immunol 145, 2938.
33. D'ANDREA A., RENGARAJU M., VALIANTE N.M. et al. (1992) Production of NK cell stimulatory factor (interleukin-12) by peripheral blood mononuclear cells. J Exp Med 176, 1387.
34. BRIGHT J.J., HEGDE S.P., BEGUM Z. & KHAR A. (1994) Modulation of natural killer cell function leading to spontaneous regression of a histiocytoma. Cell Immunol 154, 54.
35. IJSSELMUIDEN O.E., HERBRINK P., MEDDENS M.J.M., TANK B., STOLZ E. & VANEIJK R.V.W. (1989) Optimizing the solid-phase immunofiltration assay: a rapid alternative to immunoassays. J Immunol Methods 119, 117.
36. KHAR A., VARALAKSHMI, CH., PARDHASARADHI B.V.V. & ALI M.A. (1992) Generation of cytotoxic monoclonals against AK-5 histiocytoma: conjugation with daunomycin and use in chemotherapy. Cancer Lett 64, 163.
37. KHAR A. (1993) Characterisation of spontaneous immunological regression in a histiocytoma: I. role of NK cells and antitumor antibodies. Int J Oncol 2, 393.
38. NASTALA C.L., EDINGTON H.D., MCKINNEY T.G. et al. (1994) Recombinant IL-12 administration induces tumor regression in association with IFN-γ production. J Immunol 153, 1697.
39. DEWAAL M.R., ABRAMS J., BENNETT B., FIGDOR G.C. & DEVRIES J.E. (1991) Interleukin-10 inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 175, 1209.
40. MOSMANN T.F. & MORRE K.W. (1991) The role of IL-10 in cross regulation of Th1 and Th2 responses. Immunoparasitol Today 12, A49.
41. LI L., YOUNG D., WOLF S.F. & CHOI Y.S. (1996) Interleukin-12 stimulates B cell growth by inducing IFN-γ. Cell Immunol 168, 133.
42. GAZZINELLI R.T. (1996) Molecular and cellular basis of interleukin 12 activity in prophylaxis and therapy against infectious diseases. Mol Med Today 2, 258.