Preparation and toxicity of triptolide-loaded poly (D, L-lactic acid) nanoparticles

Yaoxue Xuebao

Volumn 39, Issue 7, 2004, Pages 556-560

  Liu, Ming Xing ^a   Dong, Jing ^a   Yang, Ya Jiang ^a   Yang, Xiang Liang ^a   Xu, Hui Bi ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Modified SESD; Nanoparticles; Poly (D, L lactic acid); Toxicity; Triptolide

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; DRUG CARRIER; NITROGEN DERIVATIVE; POLYLACTIC ACID; PROTEIN; SOLVENT; SURFACTANT; TRIPTOLIDE; UREA DERIVATIVE;

AQUEOUS SOLUTION; ARTICLE; CONCENTRATION (PARAMETERS); DISPERSION; DRUG SYNTHESIS; EMULSION; LASER; LIGHT SCATTERING; LIVER TOXICITY; MEASUREMENT; NANOPARTICLE; NEPHROTOXICITY; PARTICLE SIZE; PHYSICAL CHEMISTRY; PROTEIN URINE LEVEL; RAT STRAIN; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TRANSMISSION ELECTRON MICROSCOPY; UREA NITROGEN BLOOD LEVEL; X RAY POWDER DIFFRACTION;

ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; BLOOD UREA NITROGEN; DELAYED-ACTION PREPARATIONS; DITERPENES; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; LACTIC ACID; MALE; NANOTECHNOLOGY; PARTICLE SIZE; PHENANTHRENES; POLYMERS; PROTEINURIA; RATS; RATS, WISTAR; TRIPTERYGIUM;

EID: 9744280574     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Gang YY, Zhang ZX. Progress in pharmacological study of Tripterygium wilfordii and its active compounds [J]. J China Pharm Univ, 1995,26(4):252-256.
2. Chang J, Liu HF, Yao KD. Recent advances in medical nanoparticles [J]. Chin J Biomed Engineer, 2000,19(4):423-430.
3. Gorner T, Gref R, Michenot D, et al. Dellacherie, lidocaine-loaded biodegradable nanospheres. I. Optimization of the drug incorporation into the polymer matrix [J]. J Controlled Release, 1999,57:259-268.
4. Hideki M, Masao K, Hirofumi T, et al. Preparation of poly (DL-lactide-co-glycolide) nanoparticles by modified spontaneous emulsification solvent diffusion method [J]. Int J Pharm, 1999,187:143-152.
5. Feng SS, Huang GF. Effects of emulsifiers on the controlled release of paclitaxel (Taxol) from nanospheres of biodegradable polymers [J]. J Controlled Release, 2001,71:53-69.
6. Zambaux MF, Bonneaux F, Gref R, et al. Influence of experimental parameters on the characteristics of poly (lactic acid) nanoparticles prepared by a double emulsion method [J]. J Controlled Release, 1998,50:31-40.
7. Lamprecht A, Ubrich N, Hombreiro M, et al. Influences of process parameters on nanoparticle preparation preformed by a double emulsion pressure homogenization technique [J]. Int J Pharm, 2000,196:177-182.
8. Injoon O, Kayoung L, Hye-Young K, et al. Release of adriamycin from poly (γ-benzyl-L-glutamate)/poly (ethylene oxide) nanoparticles [J]. Int J Pharm, 1999, 181:107-115.
9. Wei SL. Biopharmaceutics and Pharmacokinetics [M]. Beijing: Peking Union Medical College and Beijing Medical University Press. 1997. 9-14.
10. [ 10] Mu L, Feng SS. Vitamin E TPGS used as emulsifier in the solvent evaporation/extraction technique for fabrication of polymeric nanospheres for controlled release of paclitaxel ( Taxol ) [J]. J Controlled Release, 2002, 80:129-144.
11. Sun X, Zhang SM, Tian CH, et al. Safety of tripterygium wilfordii [J]. Chin J New Drugs, 2001, 10(7):539-543.
12. Xu CQ, Zhang ZR, He Q, et al. Study on the liver targeting property of the liver targeted mitoxantrone poly (lactic acid) extended release nanoparticles [J]. West China J Pharm Sci, 2000,15 (3):164 -169.