Transplacental passage of Pt after treatment with the new triamine complex cis-diaminechloro-[2-(diethylamino) ethyl 4-amino-benzoate, N 4]-chloride platinum (II) monohydrochloride monohydrate

Archives of Toxicology

Volumn 78, Issue 10, 2004, Pages 584-588

  Ognio, Emanuela ^a   Chiavarina, Barbara ^a   Caviglioli, Gabriele ^b   Lapide, Maddalena ^a   Viale, Maurizio ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

Author keywords

Atomic absorption spectroscopy; Cisplatin DPR; Embryotoxicity; Transplacental passage

Indexed keywords

CISPLATIN DERIVATIVE; PLATINUM COMPLEX;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD PLACENTA BARRIER; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; EMBRYOTOXICITY; FETUS; GESTATIONAL AGE; HEART; KIDNEY; MOUSE; NONHUMAN; PLACENTA CIRCULATION; PRIORITY JOURNAL; SPECIES COMPARISON; TISSUE DISTRIBUTION; TISSUE SECTION;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; ANTINEOPLASTIC AGENTS; CISPLATIN; EMBRYO; FEMALE; FETAL WEIGHT; FETUS; GESTATIONAL AGE; INJECTIONS, INTRAPERITONEAL; MALE; MICE; ORGANOPLATINUM COMPOUNDS; PLATINUM; PREGNANCY; PROCAINE; SPECTROPHOTOMETRY, ATOMIC;

EID: 9744278350     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-004-0576-x     Document Type: Article

References (15)

1. Cafaggi S, Esposito M, Parodi B, Vannozzi MO, Viale M, Pellecchia C, Fulco RA, Merlo F, Zicca A, Cadoni A, Bignardi G (1992) Synthesis and antitumour activity of a new cis-diammineplatinum(II) complex containing procaine hydrochloride. Anticancer Res 12:2285-2292
2. Fulco RA, Vannozzi M, Collecchi P, Merlo F, Parodi B, Civalleri D, Esposito M (1990) Effect of normal saline on cisplatin pharmacokinetics and antitumor activity in mice bearing P388 leukemia. Anticancer Res 10:1603-1610
3. Giavini E, Lemonica IP, Lou Y, Broccia ML, Prati M (1990) Induction of micronuclei and toxic effects in embryos of pregnant rats treated before implantation with anticancer drugs: cyclophosphamide, cis-platinum, adriamycin. Teratogenesis Carcinog Mutagen 10:417-426
4. Keller KA, Aggarwal SK (1983) Embryotoxicity of cisplatin in rats and mice. Toxicol Appl Pharmacol 69:245-256
5. 195Pt after cis-platinum treatment. Eur J Cancer Clin Oncol 19:533-536
6. Lazar R, Conran PC, Damjanov I (1978) Embryotoxicity and teratogenicity of cis-diamminedichloroplatinum. Experientia 35:647-648
7. Mandys V, Viale M, Cafaggi S, Esposito M (1998) Neurotoxic effect of cisplatin and the cisplatin-procaine complex DPR studied in organotypic cultures of chick embryonic dorsal root ganglia. Anti-Cancer Drugs 9:659-663
8. 4]-chloride platinum (II) monohydrochloride monohydrate. Invest New Drug 22:3-16
9. Ognio E, Lapide M, Ottone M, Mandys V, Peterka M, Parodi B, Viale M (2003) Embryo-lethal and teratogenic effect of the new platinum compound DPR in pregnant mice. Arch Toxicol 77:584-590
10. Pastrone I, Viale M, Cafaggi S, Mariggiò MA, Parodi A, Esposito M (1999) Effect of the cisplatin-procaine complex DPR in combination with several anticancer agents on murine P388 leukemic cells in vitro and in vivo. Invest New Drugs 16:297-302
11. Peterka M, Mandys V, Viale M, Cafaggi S, Peterkovà R, Esposito M (2002) Embryotoxicity of cisplatin and a cisplatin-procaine complex (DPR) studied in chick embryo. Neoplasma 49:394-400
12. Viale M, Cafaggi S, Parodi B, Esposito M (1995) Cytotoxicity and cellular accumulation of a new cis-diammineplatinum(II) complex containing procaine in murine L1210 cells sensitive and resistant to cis-diamminedichloroplatinum (II). Cancer Chemother Pharmacol 35:371-376
13. Viale M, Vannozzi MO, Merlo F, Cafaggi S, Parodi B, Esposito M (1996) Cisplatin combined with the new cisplatin-procaine complex DPR: in vitro and in vivo studies. Eur J Cancer 32A:2327-2333
14. Viale M, Pastrone I, Pellecchia C, Vannozzi MO, Cafaggi S, Esposito M (1998) Combination of cisplatin-procaine complex DPR with anticancer drugs increases cytotoxicity against ovarian cancer cell lines. Anti-Cancer Drugs 9:457-463
15. Zhang JG, Esposito M, Cafaggi S, Lindup WE (1996) Comparison of the toxicities of cisplatin and a new cisplatin-procaine complex to rat renal cortical slices. Hum Exp Toxicol 15:59-63