Preradiotherapy hemoglobin level but not microvessel density predicts locoregional control and survival in laryngeal cancer treated with primary radical radiotherapy

Clinical Cancer Research

Volumn 10, Issue 23, 2004, Pages 7941-7949

  Haugen, Hedda ^a   Magnusson, Bengt ^a   Svensson, Marie ^a   Mercke, Claes ^a  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CISPLATIN; FLUOROURACIL; HEMOGLOBIN;

ADULT; AGED; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER CONTROL; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER SURVIVAL; FEMALE; FOLLOW UP; HEMOGLOBIN DETERMINATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LARYNX CANCER; MAJOR CLINICAL STUDY; MALE; MICROVASCULATURE; PRIORITY JOURNAL; PROGNOSIS; RADIATION DOSE FRACTIONATION; SQUAMOUS CELL CARCINOMA; TREATMENT OUTCOME;

ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; CARCINOMA, SQUAMOUS CELL; CELL DIFFERENTIATION; FOLLOW-UP STUDIES; HEMOGLOBIN A; HUMANS; IMMUNOENZYME TECHNIQUES; LARYNGEAL NEOPLASMS; MICROCIRCULATION; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; PREOPERATIVE CARE; PROGNOSIS; RADIOTHERAPY DOSAGE; SURVIVAL RATE;

EID: 9744245007     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-04-0871     Document Type: Article

References (32)

1. Haugen H, Johansson K-A, Mercke C. Hyperfractionated-accelerated or conventionally fractionated radiotherapy for early glottic cancer. Int J Radiat Oncol Biol Phys 2002;52:109-19.
2. Haugen H, Johansson K-A, Ejnell H, Edström S, Mercke C. Accelerated radiotherapy for advanced laryngeal cancer. Acta Oncologica 2004.
3. 2 predicts survival in advanced cancer of the uterine cervix. Radiother Oncol 1993;26:45-50.
4. Brizel DM, Dodge RK, Clough RW, Dewhirst MW. Oxygenation of head and neck cancer: changes during radiotherapy and impact on treatment outcome. Radiother Oncol 1999;53:113-7.
5. Caro JJ, Salas M, Ward A, Gloss G. Anemia as an independent prognostic factor for survival in patients with cancer. Cancer (Phila) 2001;91:2214-21.
6. Warde P, O'Sullivan MB, Bristow RG, et al. T1/T2 glottic cancer managed by external beam radiotherapy: the influence of pretreatment hemoglobin on local control. Int J Radiat Oncol Biol Phys 1998;41:347-53.
7. Tamawski R, Skladowski K, Maciejewski B. Prognostic value of hemoglobin concentration in radiotherapy for cancer of supraglottic larynx. Int J Radiat Oncol Biol Phys 1997;38:1007-11.
8. Fein DA, Lee WR, Hanlon AL, et al. Pretreatment hemoglobin level influences local control and survival of T1-T2 squamous cell carcinomas of the glottic larynx. J Clin Oncol 1995;13:2077-83.
9. van Acht MJJ, Hermans J, Boks DES, Leer JWH. The prognostic value of hemoglobin and a decrease in hemoglobin during radiotherapy in laryngeal cancer. Radiother Oncol 1992;23:229-35.
10. Skladowski K, Tamawski R, Maciejewski B, Wygoda A, Slosarek K. Clinical radiobiology of glottic T1 squamous cell carcinoma. Int J Radiother Oncol Biol Phys 1999;43:101-6.
11. Weidner N, Semple JP, Welch WR, Folkman J. Tumor angiogenesis and metastasis-correlation in invasive breast cancer. N Engl J Med 1991;324:1-8.
12. Weidner N, Caroll PR, Flax J, Blumenfield W, Folkman J. Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma. Am J Pathol 1993;143:401-9.
13. Brun E, Zätterström U, Kjellén E, et al. Prognostic value of histopathological response to radiotherapy and microvessel density in oral squamous cell carcinomas. Acta Oncol 2001;40:491-6.
14. Zätterström UK, Brun E, Willén R, Kjellén E, Wennerberg J. Tumor angiogenesis and prognosis in squamous cell carcinoma of the head and neck. Head and Neck 1995;17:312-8.
15. Kamijo T, Yokose T, Hasebe T, et al. Potential role of microvessel density in predicting radiosensitivity of T1 and T2 stage laryngeal squamous cell carcinoma treated with radiotherapy. Clin Cancer Res 2000;6:3159-65.
16. Kamijo T, Yokose T, Hasebe T, et al. Image analysis of microvessel surface area predicts radiosensitivity in early-stage laryngeal cancer treated with radiotherapy. Clin Cancer Res 2001;7:2809-14.
17. Union Internationale Contre le Cancer. UICC TNM atlas, illustrated guide to the TNM/pTNM classification of malignant tumors, 3rd edition. Berlin, Heidelberg, New York, London, Paris, Tokyo, Hong Kong, Barcelona, Budapest: Springer Verlag, 1990. p. 32-43.
18. Bland JM, Altman DG. Measurement error. British Med J 1996;313:744-53.
19. Overgaard J, Sand Hansen H, Overgaard M, et al. Randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) protocol 5-85. Radiother Oncol 1998;46:135-46.
20. Kaanders JH, Pop LA, Marres HA, et al. ARCON: experience in 215 patients with advanced head and neck cancer. Int J Radiat Oncol Biol Phys 2002;52:769-78.
21. Becker A, Stadler P, Lavey RS, et al. Severe anemia is associated with poor tumor oxygenation in head and neck carcinomas. Int J Radiat Oncol Biol Phys 2000;46:459-66.
22. 2 on tumor oxygenation in advanced head and neck tumours. Radiat Oncol 2003;66:71-4.
23. Overgaard J, Horsman MR. Modification of hypoxia-induced radioresistance in tumors by the use of oxygen and sensitizers. Semin Radiat Oncol 1996;6:10-21.
24. Lee WR, Berkey B, Marcial V, et al. Anemia is associated with decreased survival and increased locoregional failure in patients with locally advanced head and neck carcinoma: a secondary analysis of RTOG 85-87. Int J Radiat Oncol Biol Phys 1999;42:1069-75.
25. Overgaard J, Horsman MR, Andersen AP, et al. Misonidazole combined with split-course radiotherapy in the treatment of invasive carcinoma of the larynx and pharynx: report from the DAHANC 2 study. Int J Radiat Oncol Biol Phys 1989;16:1065-8.
26. Cho EI, Sasaki CT, Haffty BC. Prognostic significance of pretreatment hemoglobin for local control and survival in T1-T2N0 larynx cancer treated with external beam radiotherapy. Int J Radiat Oncol Biol Phys 2004;58:1135-40.
27. Nguyen-Tan PF, Le QT, Quivey JM, et al. Treatment results and prognostic factors of advanced T3-4 laryngeal carcinoma: the University of California, San Francisco (UCSF) and Stanford University Hospital (SUH) experience. Int J Radiat Oncol Biol Phys 2001;50:1172-80.
28. Murray JD, Carlson GW, McLaughlin K, et al. Tumor angiogenesis as a prognostic factor in laryngeal cancer Am J Surg 1997;174:523-6.
29. Kupisz K, Chibowski D, Klatka J, Klonowski S. Tumor angiogenesis in patients with laryngeal cancer. Eur Arch Otorhinolaryngol 1999;256:303-5.
30. Pignataro L, Carboni N, Midolo V, et al. Clinical relevance of microvessel density in laryngeal squamous cell carcinomas. Int J Cancer 2001;92:666-70.
31. Glaser C, Millesi W, Komek GV, et al. Impact of hemoglobin level and the use of recombinant erythropoetin on efficacy of preoperative chemoradiation therapy for squamous cell carcinoma of the oral cavity and oropharynx. Int J Radiat Oncol Biol Phys 2001;50:705-15.
32. Henke M, Laszig R, Rube C, et al. Erythropoietin to treat head and neck cancer patients with anemia undergoing radiotherapy: randomized, double-blind, placebo-controlled trial. Lancet 2003;362:1255-60.