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Volumn 64, Issue 22, 2004, Pages 2493-2501

Durability and rapidity of response to anakinra in patients with rheumatoid arthritis

Author keywords

[No Author keywords available]

Indexed keywords

ADALIMUMAB; C REACTIVE PROTEIN; ETANERCEPT; INTERLEUKIN 1; METHOTREXATE; PLACEBO; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; TUMOR NECROSIS FACTOR ALPHA;

EID: 9744222833     PISSN: 00126667     EISSN: None     Source Type: Journal    
DOI: 10.2165/00003495-200464220-00001     Document Type: Review
Times cited : (7)

References (64)
  • 1
    • 0010907273 scopus 로고    scopus 로고
    • Rheumatoid arthritis
    • Braunwald E, Fauci AS, Kasper DL, et al., editors. New York: McGraw-Hill
    • Lipsky PE. Rheumatoid arthritis. In: Braunwald E, Fauci AS, Kasper DL, et al., editors. Harrison's principles of internal medicine. 15th ed. New York: McGraw-Hill, 2001: 1928-37
    • (2001) Harrison's Principles of Internal Medicine. 15th Ed. , pp. 1928-1937
    • Lipsky, P.E.1
  • 2
    • 0024368707 scopus 로고
    • Evidence of significant radiographic damage in rheumatoid arthritis within the first 2 years of disease
    • Fuchs HA, Kaye JJ, Callahan LF, et al. Evidence of significant radiographic damage in rheumatoid arthritis within the first 2 years of disease. J Rheumatol 1989; 16: 585-91
    • (1989) J Rheumatol , vol.16 , pp. 585-591
    • Fuchs, H.A.1    Kaye, J.J.2    Callahan, L.F.3
  • 3
    • 0033509237 scopus 로고    scopus 로고
    • The relationship between synovitis and bone changes in early untreated rheumatoid arthritis: A controlled magnetic resonance imaging study
    • McGonagle D, Conaghan PG, O'Connor P, et al. The relationship between synovitis and bone changes in early untreated rheumatoid arthritis: a controlled magnetic resonance imaging study. Arthritis Rheum 1999; 42: 1706-11
    • (1999) Arthritis Rheum , vol.42 , pp. 1706-1711
    • McGonagle, D.1    Conaghan, P.G.2    O'Connor, P.3
  • 4
    • 0033945108 scopus 로고    scopus 로고
    • Magnetic resonance imaging, radiography, and scintigraphy of the finger joints: One year follow up of patients with early arthritis
    • Klarlund M, Ostergaard M, Jensen KE, et al. Magnetic resonance imaging, radiography, and scintigraphy of the finger joints: one year follow up of patients with early arthritis. Ann Rheum Dis 2000; 59: 521-8
    • (2000) Ann Rheum Dis , vol.59 , pp. 521-528
    • Klarlund, M.1    Ostergaard, M.2    Jensen, K.E.3
  • 5
    • 0025868134 scopus 로고
    • The progression of erosion and joint space narrowing scores in rheumatoid arthritis during the first twenty-five years of disease
    • Sharp JT, Wolfe F, Mitchell DM, et al. The progression of erosion and joint space narrowing scores in rheumatoid arthritis during the first twenty-five years of disease. Arthritis Rheum 1991; 34: 660-8
    • (1991) Arthritis Rheum , vol.34 , pp. 660-668
    • Sharp, J.T.1    Wolfe, F.2    Mitchell, D.M.3
  • 6
    • 0021212076 scopus 로고
    • Severe functional declines, work disability, and increased mortality in seventy-five rheumatoid arthritis patients studied over nine years
    • Pincus T, Callahan LF, Sale WG, et al. Severe functional declines, work disability, and increased mortality in seventy-five rheumatoid arthritis patients studied over nine years. Arthritis Rheum 1984; 27: 864-72
    • (1984) Arthritis Rheum , vol.27 , pp. 864-872
    • Pincus, T.1    Callahan, L.F.2    Sale, W.G.3
  • 7
    • 0022616430 scopus 로고
    • The development of disability in rheumatoid arthritis
    • Sherrer YS, Bloch DA, Mitchell DM, et al. The development of disability in rheumatoid arthritis. Arthritis Rheum 1986; 29: 494-500
    • (1986) Arthritis Rheum , vol.29 , pp. 494-500
    • Sherrer, Y.S.1    Bloch, D.A.2    Mitchell, D.M.3
  • 8
    • 0028105830 scopus 로고
    • Prediction of long-term mortality in patients with rheumatoid arthritis according to a simple questionnaire and joint count measures
    • Pincus T, Brooks RH, Callahan LF. Prediction of long-term mortality in patients with rheumatoid arthritis according to a simple questionnaire and joint count measures. Ann Intern Med 1994; 120: 26-34
    • (1994) Ann Intern Med , vol.120 , pp. 26-34
    • Pincus, T.1    Brooks, R.H.2    Callahan, L.F.3
  • 9
    • 0022996769 scopus 로고
    • Taking mortality in rheumatoid arthritis seriously: Predictive markers, socioeconomic status and comorbidity
    • Pincus T, Callahan LF. Taking mortality in rheumatoid arthritis seriously: predictive markers, socioeconomic status and comorbidity. J Rheumatol 1986; 13: 841-5
    • (1986) J Rheumatol , vol.13 , pp. 841-845
    • Pincus, T.1    Callahan, L.F.2
  • 10
    • 0026766850 scopus 로고
    • Life table analysis of 879 treatment episodes with slow-acting antirheumatic drugs in community rheumatology practice
    • Morand EF, McCloud PI, Littlejohn GO. Life table analysis of 879 treatment episodes with slow-acting antirheumatic drugs in community rheumatology practice. J Rheumatol 1992; 19: 704-8
    • (1992) J Rheumatol , vol.19 , pp. 704-708
    • Morand, E.F.1    McCloud, P.I.2    Littlejohn, G.O.3
  • 11
    • 0033830527 scopus 로고    scopus 로고
    • Meta-analysis of treatment termination rates among rheumatoid arthritis patients receiving disease-modifying anti-rheumatic drugs
    • Maetzel A, Wong A, Strand V, et al. Meta-analysis of treatment termination rates among rheumatoid arthritis patients receiving disease-modifying anti-rheumatic drugs. Rheumatology (Oxford) 2000; 39: 975-81
    • (2000) Rheumatology (Oxford) , vol.39 , pp. 975-981
    • Maetzel, A.1    Wong, A.2    Strand, V.3
  • 12
    • 0023853643 scopus 로고
    • Long-term prospective trial of low-dose methotrexate in rheumatoid arthritis
    • Weinblatt ME, Trentham DE, Fraser PA, et al. Long-term prospective trial of low-dose methotrexate in rheumatoid arthritis. Arthritis Rheum 1988; 31: 167-75
    • (1988) Arthritis Rheum , vol.31 , pp. 167-175
    • Weinblatt, M.E.1    Trentham, D.E.2    Fraser, P.A.3
  • 13
    • 0032901316 scopus 로고    scopus 로고
    • Paucity of radiographic progression in rheumatoid arthritis treated with methotrexate as the first disease modifying antirheumatic drug
    • Rich E, Moreland LW, Alarcon GS. Paucity of radiographic progression in rheumatoid arthritis treated with methotrexate as the first disease modifying antirheumatic drug. J Rheumatol 1999; 26: 259-61
    • (1999) J Rheumatol , vol.26 , pp. 259-261
    • Rich, E.1    Moreland, L.W.2    Alarcon, G.S.3
  • 14
    • 0032804664 scopus 로고    scopus 로고
    • Mechanism of action for leflunomide in rheumatoid arthritis
    • Fox RI, Herrmann ML, Frangou CG, et al. Mechanism of action for leflunomide in rheumatoid arthritis. Clin Immunol 1999; 93: 198-208
    • (1999) Clin Immunol , vol.93 , pp. 198-208
    • Fox, R.I.1    Herrmann, M.L.2    Frangou, C.G.3
  • 15
    • 0033596065 scopus 로고    scopus 로고
    • Treatment of active rheumatoid arthritis with leflunomide compared with placebo and methotrexate
    • Strand V, Cohen S, Schiff M, et al. Treatment of active rheumatoid arthritis with leflunomide compared with placebo and methotrexate. Arch Intern Med 1999; 159: 2542-50
    • (1999) Arch Intern Med , vol.159 , pp. 2542-2550
    • Strand, V.1    Cohen, S.2    Schiff, M.3
  • 16
    • 0034123087 scopus 로고    scopus 로고
    • Treatment with leflunomide slows radiographic progression of rheumatoid arthritis: Results from three randomized, controlled trials of leflunomide in patients with active rheumatoid arthritis
    • Sharp JT, Strand V, Leung H, et al. Treatment with leflunomide slows radiographic progression of rheumatoid arthritis: results from three randomized, controlled trials of leflunomide in patients with active rheumatoid arthritis. Arthritis Rheum 2000; 43: 495-505
    • (2000) Arthritis Rheum , vol.43 , pp. 495-505
    • Sharp, J.T.1    Strand, V.2    Leung, H.3
  • 17
    • 0033524159 scopus 로고    scopus 로고
    • Infliximab (chimeric anti-tumor necrosis factor α monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: A randomised phase III trial
    • Maini R, St Clair EW, Breedveld F, et al. Infliximab (chimeric anti-tumor necrosis factor α monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised phase III trial. Lancet 1999; 354: 1932-9
    • (1999) Lancet , vol.354 , pp. 1932-1939
    • Maini, R.1    St. Clair, E.W.2    Breedveld, F.3
  • 18
    • 0034735842 scopus 로고    scopus 로고
    • Infliximab and methotrexate in the treatment of rheumatoid arthritis
    • Lipsky PE, van der Heijde DMFM, St Clair EW, et al. Infliximab and methotrexate in the treatment of rheumatoid arthritis. N Engl J Med 2000; 343: 1594-602
    • (2000) N Engl J Med , vol.343 , pp. 1594-1602
    • Lipsky, P.E.1    Van Der Heijde, D.M.F.M.2    St. Clair, E.W.3
  • 19
    • 0033611472 scopus 로고    scopus 로고
    • A trial of etanercept, a recombinant tumor necrosis factor receptor: Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate
    • Weinblatt ME, Kremer JM, Bankhurst AD, et al. A trial of etanercept, a recombinant tumor necrosis factor receptor: Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate. N Engl J Med 1999; 340: 253-9
    • (1999) N Engl J Med , vol.340 , pp. 253-259
    • Weinblatt, M.E.1    Kremer, J.M.2    Bankhurst, A.D.3
  • 20
    • 33746253436 scopus 로고    scopus 로고
    • Center for Biologics Evaluation and Research, Office of Therapeutics Research and Review, Division of Clinical Trial Design and Analysis, Immunology and Infectious Diseases Branch [online]. Available from URL
    • Kress S. Adalimumab: for use in the treatment of rheumatoid arthritis. Clinical review, Abbott, biologic licensing application STN 125057. Center for Biologics Evaluation and Research, Office of Therapeutics Research and Review, Division of Clinical Trial Design and Analysis, Immunology and Infectious Diseases Branch [online]. Available from URL: http://www.fda.gov/cder/biologics/ products/adalabb123102.htm [Accessed 2004 Jul 9]
    • Adalimumab: For Use in the Treatment of Rheumatoid Arthritis. Clinical Review, Abbott, Biologic Licensing Application STN 125057
    • Kress, S.1
  • 21
    • 0034735827 scopus 로고    scopus 로고
    • A comparison of etanercept and methotrexate in patients with early rheumatoid arthritis
    • Bathon JM, Martin RW, Fleischmann RM, et al. A comparison of etanercept and methotrexate in patients with early rheumatoid arthritis. N Engl J Med 2000; 343: 1586-93
    • (2000) N Engl J Med , vol.343 , pp. 1586-1593
    • Bathon, J.M.1    Martin, R.W.2    Fleischmann, R.M.3
  • 22
    • 0035100991 scopus 로고    scopus 로고
    • Anti-cytokine therapy in chronic destructive arthritis
    • van den Berg WB. Anti-cytokine therapy in chronic destructive arthritis. Arthritis Res 2001; 3: 18-26
    • (2001) Arthritis Res , vol.3 , pp. 18-26
    • Van Den Berg, W.B.1
  • 23
    • 0029979369 scopus 로고    scopus 로고
    • Biological basis for interleukin-1 in disease
    • Dinarello CA. Biological basis for interleukin-1 in disease. Blood 1996; 87: 2095-147
    • (1996) Blood , vol.87 , pp. 2095-2147
    • Dinarello, C.A.1
  • 24
    • 0027434995 scopus 로고
    • Proinflammatory cytokines enhance human synoviocyte expression of intercellular adhesion molecule-1 (ICAM-1)
    • Lindsley HB, Smith DD, Cohick CB, et al. Proinflammatory cytokines enhance human synoviocyte expression of intercellular adhesion molecule-1 (ICAM-1). Clin Immunol Immunopathol 1993; 68: 311-20
    • (1993) Clin Immunol Immunopathol , vol.68 , pp. 311-320
    • Lindsley, H.B.1    Smith, D.D.2    Cohick, C.B.3
  • 25
    • 0033429413 scopus 로고    scopus 로고
    • Effects of tumor necrosis factor-α, interleukin 1β, and activated peripheral blood mononuclear cells on the expression of adhesion molecules and recruitment of leukocytes in rheumatoid synovial xenografts in SCID mice
    • Proudman SM, Cleland LG, Mayrhofer G. Effects of tumor necrosis factor-α, interleukin 1β, and activated peripheral blood mononuclear cells on the expression of adhesion molecules and recruitment of leukocytes in rheumatoid synovial xenografts in SCID mice. J Rheumatol 1999; 26: 1877-89
    • (1999) J Rheumatol , vol.26 , pp. 1877-1889
    • Proudman, S.M.1    Cleland, L.G.2    Mayrhofer, G.3
  • 27
    • 0028213334 scopus 로고
    • Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissue: Effects of interleukin-1 beta, phorbol ester, and corticosteroids
    • Crofford LJ, Wilder RL, Ristimaki AP, et al. Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissue: effects of interleukin-1 beta, phorbol ester, and corticosteroids. J Clin Invest 1994; 93: 1095-101
    • (1994) J Clin Invest , vol.93 , pp. 1095-1101
    • Crofford, L.J.1    Wilder, R.L.2    Ristimaki, A.P.3
  • 28
    • 0029985232 scopus 로고    scopus 로고
    • Nitric oxide production in cells derived from the human joint
    • Grabowski PS, Macpherson H, Ralston SH. Nitric oxide production in cells derived from the human joint. Br J Rheumatol 1996; 35: 207-12
    • (1996) Br J Rheumatol , vol.35 , pp. 207-212
    • Grabowski, P.S.1    Macpherson, H.2    Ralston, S.H.3
  • 29
    • 0025149103 scopus 로고
    • Discoordinate expression of stromelysin, collagenase, and tissue inhibitor of metalloproteinases-1 in rheumatoid human synovial fibroblasts: Synergistic effects of interleukin-1 and tumor necrosis factor-alpha on stromelysin expression
    • MacNaul KL, Chartrain N, Lark M, et al. Discoordinate expression of stromelysin, collagenase, and tissue inhibitor of metalloproteinases-1 in rheumatoid human synovial fibroblasts: synergistic effects of interleukin-1 and tumor necrosis factor-alpha on stromelysin expression. J Biol Chem 1990; 265: 17238-45
    • (1990) J Biol Chem , vol.265 , pp. 17238-17245
    • MacNaul, K.L.1    Chartrain, N.2    Lark, M.3
  • 30
    • 0026650427 scopus 로고
    • Recombinant human interleukin-1β-induced increase in levels of proteoglycans, stromelysin, and leukocytes in rabbit synovial fluid
    • McDonnell J, Hoerrner LA, Lark MW, et al. Recombinant human interleukin-1β-induced increase in levels of proteoglycans, stromelysin, and leukocytes in rabbit synovial fluid. Arthritis Rheum 1992; 35: 799-805
    • (1992) Arthritis Rheum , vol.35 , pp. 799-805
    • McDonnell, J.1    Hoerrner, L.A.2    Lark, M.W.3
  • 31
    • 0033602023 scopus 로고    scopus 로고
    • Interleukin 1 induces multinucleation and bone-resorbing activity of osteoclasts in the absence of osteoblasts/stromal cells
    • Jimi E, Nakamura I, Duong LT, et al. Interleukin 1 induces multinucleation and bone-resorbing activity of osteoclasts in the absence of osteoblasts/stromal cells. Exp Cell Res 1999; 247: 84-93
    • (1999) Exp Cell Res , vol.247 , pp. 84-93
    • Jimi, E.1    Nakamura, I.2    Duong, L.T.3
  • 32
    • 0031943254 scopus 로고    scopus 로고
    • Interleukin-1 receptor antagonist: Role in biology
    • Arend WP, Malyak M, Guthridge CJ, et al. Interleukin-1 receptor antagonist: role in biology. Annu Rev Immunol 1998; 16: 27-55
    • (1998) Annu Rev Immunol , vol.16 , pp. 27-55
    • Arend, W.P.1    Malyak, M.2    Guthridge, C.J.3
  • 33
    • 0023617050 scopus 로고
    • A urine inhibitor of interleukin 1 activity that blocks ligand binding
    • Seckinger P, Lowenthal JW, Williamson K, et al. A urine inhibitor of interleukin 1 activity that blocks ligand binding. J Immunol 1987; 139: 1546-9
    • (1987) J Immunol , vol.139 , pp. 1546-1549
    • Seckinger, P.1    Lowenthal, J.W.2    Williamson, K.3
  • 34
    • 0025614619 scopus 로고
    • Natural and recombinant human IL-1 receptor antagonists block the effects of IL-1 on bone resorption and prostaglandin production
    • Seckinger P, Klein-Nulend J, Alander C, et al. Natural and recombinant human IL-1 receptor antagonists block the effects of IL-1 on bone resorption and prostaglandin production. J Immunol 1990; 145: 4181-4
    • (1990) J Immunol , vol.145 , pp. 4181-4184
    • Seckinger, P.1    Klein-Nulend, J.2    Alander, C.3
  • 35
    • 0025288396 scopus 로고
    • Biological properties of recombinant human monocyte-derived interleukin 1 receptor antagonist
    • Arend WP, Welgus HG, Thompson RC, et al. Biological properties of recombinant human monocyte-derived interleukin 1 receptor antagonist. J Clin Invest 1990; 85: 1694-7
    • (1990) J Clin Invest , vol.85 , pp. 1694-1697
    • Arend, W.P.1    Welgus, H.G.2    Thompson, R.C.3
  • 36
    • 0026025748 scopus 로고
    • Biologic effects of an interleukin-1 receptor antagonist protein on interleukin-1-stimulated cartilage erosion and chondrocyte responsiveness
    • Smith RJ, Chin JE, Sam LM, et al. Biologic effects of an interleukin-1 receptor antagonist protein on interleukin-1-stimulated cartilage erosion and chondrocyte responsiveness. Arthritis Rheum 1991; 34: 78-83
    • (1991) Arthritis Rheum , vol.34 , pp. 78-83
    • Smith, R.J.1    Chin, J.E.2    Sam, L.M.3
  • 37
    • 0028295883 scopus 로고
    • Synovial interleukin-1 receptor antagonist and interleukin-1 balance in rheumatoid arthritis
    • Firestein GS, Boyle DL, Yu C, et al. Synovial interleukin-1 receptor antagonist and interleukin-1 balance in rheumatoid arthritis. Arthritis Rheum 1994; 37: 644-52
    • (1994) Arthritis Rheum , vol.37 , pp. 644-652
    • Firestein, G.S.1    Boyle, D.L.2    Yu, C.3
  • 38
    • 0028926102 scopus 로고
    • Interleukin-1 receptor antagonist production in cultured synovial cells from patients with rheumatoid arthritis and osteoarthritis
    • Fujikawa Y, Shingu M, Torisu T, et al. Interleukin-1 receptor antagonist production in cultured synovial cells from patients with rheumatoid arthritis and osteoarthritis. Ann Rheum Dis 1995; 54: 318-20
    • (1995) Ann Rheum Dis , vol.54 , pp. 318-320
    • Fujikawa, Y.1    Shingu, M.2    Torisu, T.3
  • 39
    • 0034677123 scopus 로고    scopus 로고
    • Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice
    • Horai R, Saijo S, Tanioka H, et al. Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice. J Exp Med 2000; 191: 313-20
    • (2000) J Exp Med , vol.191 , pp. 313-320
    • Horai, R.1    Saijo, S.2    Tanioka, H.3
  • 40
    • 0030071084 scopus 로고    scopus 로고
    • Suppression of experimental arthritis by gene transfer of interleukin 1 receptor antagonist cDNA
    • Makarov SS, Olsen JC, Johnston WN, et al. Suppression of experimental arthritis by gene transfer of interleukin 1 receptor antagonist cDNA. Proc Natl Acad Sci U S A 1996; 93: 402-6
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 402-406
    • Makarov, S.S.1    Olsen, J.C.2    Johnston, W.N.3
  • 41
    • 0029967052 scopus 로고    scopus 로고
    • Suppression of antigen-induced arthritis in rabbits by ex vivo gene therapy
    • Otani K, Nita I, Macaulay W, et al. Suppression of antigen-induced arthritis in rabbits by ex vivo gene therapy. J Immunol 1996; 156: 3558-62
    • (1996) J Immunol , vol.156 , pp. 3558-3562
    • Otani, K.1    Nita, I.2    Macaulay, W.3
  • 42
    • 0031112232 scopus 로고    scopus 로고
    • Human IL-IRa gene transfer into human synovial fibroblasts is chondroprotective
    • Muller-Ladner U, Roberts CR, Franklin BN, et al. Human IL-IRa gene transfer into human synovial fibroblasts is chondroprotective. J Immunol 1997; 158: 3492-8
    • (1997) J Immunol , vol.158 , pp. 3492-3498
    • Muller-Ladner, U.1    Roberts, C.R.2    Franklin, B.N.3
  • 43
    • 0033016267 scopus 로고    scopus 로고
    • Efficacy of sustained blood levels of interelukin-1 receptor antagonist in animal models: Comparison of efficacy in animal models with human clinical data
    • Bendele A, McAbee T, Sennello G, et al. Efficacy of sustained blood levels of interelukin-1 receptor antagonist in animal models: comparison of efficacy in animal models with human clinical data. Arthritis Rheum 1999; 42: 498-506
    • (1999) Arthritis Rheum , vol.42 , pp. 498-506
    • Bendele, A.1    McAbee, T.2    Sennello, G.3
  • 44
    • 9744280716 scopus 로고    scopus 로고
    • Thousand Oaks (CA): Amgen Inc., Apr
    • Kineret® [package insert]. Thousand Oaks (CA): Amgen Inc., 2004 Apr
    • (2004) Kineret® [Package Insert]
  • 45
    • 17444394445 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist
    • Bresnihan B, Alvaro-Gracia JM, Cobby M, et al. Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist. Arthritis Rheum 1998; 41 (12): 2196-204
    • (1998) Arthritis Rheum , vol.41 , Issue.12 , pp. 2196-2204
    • Bresnihan, B.1    Alvaro-Gracia, J.M.2    Cobby, M.3
  • 46
    • 0036190776 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with anakinra, a recombinant human interleukin-1 receptor antagonist (IL-1ra), in combination with methotrexate: Results of a twenty-four-week, multicenter, randomized, double-blind, placebo-controlled trial
    • Cohen S, Hurd E, Cush J, et al. Treatment of rheumatoid arthritis with anakinra, a recombinant human interleukin-1 receptor antagonist (IL-1ra), in combination with methotrexate: results of a twenty-four-week, multicenter, randomized, double-blind, placebo-controlled trial. Arthritis Rheum 2002; 46: 614-24
    • (2002) Arthritis Rheum , vol.46 , pp. 614-624
    • Cohen, S.1    Hurd, E.2    Cush, J.3
  • 47
    • 0034083128 scopus 로고    scopus 로고
    • A multicenter, double-blind, dose-ranging, randomized, placebo-controlled study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis: Radiologic progression and correlation of Genant and Larsen scores
    • Jiang Y, Genant HK, Watt I, et al. A multicenter, double-blind, dose-ranging, randomized, placebo-controlled study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis: radiologic progression and correlation of Genant and Larsen scores. Arthritis Rheum 2000; 43: 1001-9
    • (2000) Arthritis Rheum , vol.43 , pp. 1001-1009
    • Jiang, Y.1    Genant, H.K.2    Watt, I.3
  • 48
    • 9744227457 scopus 로고    scopus 로고
    • Anakinra (Kineret®) inhibits the progression of radiographically measured joint destruction in rheumatoid arthritis
    • Oct 25-29; New Orleans
    • Shergy WJ, Cohen S, Greenwald S, et al. Anakinra (Kineret®) inhibits the progression of radiographically measured joint destruction in rheumatoid arthritis [abstract]. American College of Rheumatology 2002 Annual Meeting; 2002 Oct 25-29; New Orleans
    • (2002) American College of Rheumatology 2002 Annual Meeting
    • Shergy, W.J.1    Cohen, S.2    Greenwald, S.3
  • 49
    • 0029044362 scopus 로고
    • American College of Rheumatology preliminary definition of improvement in rheumatoid arthritis
    • Felson DT, Anderson JJ, Boers M, et al. American College of Rheumatology preliminary definition of improvement in rheumatoid arthritis. Arthritis Rheum 1995; 38: 727-35
    • (1995) Arthritis Rheum , vol.38 , pp. 727-735
    • Felson, D.T.1    Anderson, J.J.2    Boers, M.3
  • 50
    • 0141435751 scopus 로고    scopus 로고
    • Durability and rapidity of response for rheumatoid arthritis patients receiving therapy with anakinra (IL-IRa)
    • Miller DM, Schiff MH, Cohen SB, et al. Durability and rapidity of response for rheumatoid arthritis patients receiving therapy with anakinra (IL-IRa) [abstract]. Ann Rheum Dis 2001; 60 Suppl. 1: S171
    • (2001) Ann Rheum Dis , vol.60 , Issue.SUPPL. 1
    • Miller, D.M.1    Schiff, M.H.2    Cohen, S.B.3
  • 51
    • 0037389680 scopus 로고    scopus 로고
    • Anakinra, a recombinant human interleukin-1 receptor antagonist (r-metHuIL-1ra), in patients with rheumatoid arthritis: A large, international, multicenter, placebo-controlled trial
    • Fleischmann RM, Schechtman J, Bennett R, et al. Anakinra, a recombinant human interleukin-1 receptor antagonist (r-metHuIL-1ra), in patients with rheumatoid arthritis: a large, international, multicenter, placebo-controlled trial. Arthritis Rheum 2003; 48: 927-34
    • (2003) Arthritis Rheum , vol.48 , pp. 927-934
    • Fleischmann, R.M.1    Schechtman, J.2    Bennett, R.3
  • 52
    • 9744243758 scopus 로고    scopus 로고
    • Long-term safety of anakinra (interleukin-1 receptor antagonist) in patients receiving standard treatments for rheumatoid arthritis: A 36-month update from a large phase 3 study
    • Oct 25-29; New Orleans
    • Fleischmann RM, Tesser JRP, Pirow B, et al. Long-term safety of anakinra (interleukin-1 receptor antagonist) in patients receiving standard treatments for rheumatoid arthritis: a 36-month update from a large phase 3 study [abstract]. American College of Rheumatology 2002 Annual Meeting; 2002 Oct 25-29; New Orleans
    • (2002) American College of Rheumatology 2002 Annual Meeting
    • Fleischmann, R.M.1    Tesser, J.R.P.2    Pirow, B.3
  • 53
    • 0036845130 scopus 로고    scopus 로고
    • Long-term safety and maintenance of clinical improvement following treatment with anakinra (recombinant human interleukin-1 receptor antagonist) in patients with rheumatoid arthritis
    • Nuki G, Bresnihan B, Bear MB, et al. Long-term safety and maintenance of clinical improvement following treatment with anakinra (recombinant human interleukin-1 receptor antagonist) in patients with rheumatoid arthritis. Arthritis Rheum 2002; 46: 2838-46
    • (2002) Arthritis Rheum , vol.46 , pp. 2838-2846
    • Nuki, G.1    Bresnihan, B.2    Bear, M.B.3
  • 54
    • 9744237531 scopus 로고    scopus 로고
    • Safety of anakinra (Kineret) added to traditional disease-modifying antirheumatic drug therapy in patients with active rheumatoid arthritis: Results of the OMEGA trial
    • Oct 23-28; Orlando
    • Le Loet X, Nordstrom D, Rodriguez M, et al. Safety of anakinra (Kineret) added to traditional disease-modifying antirheumatic drug therapy in patients with active rheumatoid arthritis: results of the OMEGA trial [poster no. 174]. American College of Rheumatology 2003 Annual Meeting; 2003 Oct 23-28; Orlando
    • (2003) American College of Rheumatology 2003 Annual Meeting
    • Le Loet, X.1    Nordstrom, D.2    Rodriguez, M.3
  • 55
    • 3142597475 scopus 로고    scopus 로고
    • Thousand Oaks (CA): Immunex Corp., Apr [online]. Available from URL
    • Enbrel® [package insert]. Thousand Oaks (CA): Immunex Corp., 2004 Apr [online]. Available from URL: http://www.wyeth.com/content/ShowLabeling.asp?.id = 101 [Accessed 2004 Jul 9]
    • (2004) Enbrel® [Package Insert]
  • 56
    • 9744235374 scopus 로고    scopus 로고
    • North Chicago (IL): Abbott Laboratories, Jan [online]. Available from URL
    • Humira™ [package insert]. North Chicago (IL): Abbott Laboratories, 2003 Jan [online]. Available from URL: http://www.rx-abbott.com/pdf/humira.pdf [Accessed 2004 Jul 9]
    • (2003) Humira™ [Package Insert]
  • 57
    • 0003547850 scopus 로고    scopus 로고
    • Malvern (PA): Centocor Inc., Mar
    • Remicade® [package insert]. Malvern (PA): Centocor Inc., 2004 Mar
    • (2004) Remicade® [Package Insert]
  • 58
    • 0033765449 scopus 로고    scopus 로고
    • Role of interleukin 1 and interleukin 1 receptor antagonist in the mediation of rheumatoid arthritis
    • Schiff MH. Role of interleukin 1 and interleukin 1 receptor antagonist in the mediation of rheumatoid arthritis. Ann Rheum Dis 2000; 59 Suppl. 1: i103-8
    • (2000) Ann Rheum Dis , vol.59 , Issue.SUPPL. 1
    • Schiff, M.H.1
  • 59
    • 9744221403 scopus 로고    scopus 로고
    • RADIUS 1: Comparison of disease characteristics of patients with rheumatoid arthritis initiating biologic therapy for the first time versus other DMARD therapy
    • Jun 18-21; Lisbon
    • Gibofsky A, Cush J, Schiff MH, et al. RADIUS 1: comparison of disease characteristics of patients with rheumatoid arthritis initiating biologic therapy for the first time versus other DMARD therapy [abstract]. European League Against Rheumatism (EULAR) Meeting; 2003 Jun 18-21; Lisbon
    • (2003) European League Against Rheumatism (EULAR) Meeting
    • Gibofsky, A.1    Cush, J.2    Schiff, M.H.3
  • 60
    • 9744265972 scopus 로고    scopus 로고
    • An evaluation of the use of anakinra by rheumatoid arthritis patients previously treated with a TNF inhibitor
    • Jun 18-21; Lisbon
    • Schiff MH, Keystone EC, Gibofsky A, et al. An evaluation of the use of anakinra by rheumatoid arthritis patients previously treated with a TNF inhibitor [abstract]. European League Against Rheumatism (EULAR) Meeting; 2003 Jun 18-21; Lisbon
    • (2003) European League Against Rheumatism (EULAR) Meeting
    • Schiff, M.H.1    Keystone, E.C.2    Gibofsky, A.3
  • 61
    • 9744266279 scopus 로고    scopus 로고
    • Data on file. Thousand Oaks (CA): Amgen Inc., 2004
    • Data on file. Thousand Oaks (CA): Amgen Inc., 2004
  • 62
    • 9744264443 scopus 로고    scopus 로고
    • Thousand Oaks (CA): Amgen Inc., Oct
    • Kineret® [package insert]. Thousand Oaks (CA): Amgen Inc., 2002 Oct
    • (2002) Kineret® [Package Insert]
  • 63
    • 2342551979 scopus 로고    scopus 로고
    • Combination therapy with etanercept and anakinra in the treatment of patients with rheumatoid arthritis who have been treated unsuccessfully with methotrexate
    • Genovese MC, Cohen SB, Moreland LW, et al. Combination therapy with etanercept and anakinra in the treatment of patients with rheumatoid arthritis who have been treated unsuccessfully with methotrexate. Arthritis Rheum 2004; 50: 1412-9
    • (2004) Arthritis Rheum , vol.50 , pp. 1412-1419
    • Genovese, M.C.1    Cohen, S.B.2    Moreland, L.W.3
  • 64
    • 9744261220 scopus 로고    scopus 로고
    • Combination therapy with anakinra and PEGylated soluble tumor necrosis factor receptor type I (pegsunercept) in rheumatoid arthritis (RA): Preliminary analysis of clinical, functional, synovial tissue, and radiographic outcomes from a phase II, open-label, mode of action study
    • Oct 23-28; Orlando
    • Rooney T, Madigan A, Greenan L, et al. Combination therapy with anakinra and PEGylated soluble tumor necrosis factor receptor type I (pegsunercept) in rheumatoid arthritis (RA): preliminary analysis of clinical, functional, synovial tissue, and radiographic outcomes from a phase II, open-label, mode of action study [abstract]. American College of Rheumatology (ACR) 2003 Annual Meeting; 2003 Oct 23-28; Orlando
    • (2003) American College of Rheumatology (ACR) 2003 Annual Meeting
    • Rooney, T.1    Madigan, A.2    Greenan, L.3


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