MgSO 4 and lazaroid (U-83836E) partially protects glioma cells against glutamate toxidty in vitro

Acta Neurobiologiae Experimentalis

Volumn 64, Issue 4, 2004, Pages 461-466

  Kabadere, Selda ^a   Öztopçu, Pinar ^b   Korkmaz, Seval ^c   Erol, Kevser ^a   Uyar, Ruhi ^a  

^a ESKISEHIR OSMANGAZI UNIVERSITY   (Turkey)

^b Faculty of Art and Sciences   (Turkey)

^c ANADOLU UNIVERSITY   (Turkey)

Author keywords

Glioma; Glutamate toxicity; Lazaroid; MgSO 4

Indexed keywords

2 [[4 [2,6 BIS(1 PYRROLIDINYL) 4 PYRIMIDINYL] 1 PIPERAZINYL]METHYL] 3,4 DIHYDRO 2,5,7,8 TETRAMETHYL 2H 1 BENZOPYRAN 6 OL; GLUTAMIC ACID; LAZAROID; MAGNESIUM SULFATE; METABOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; ANTIOXIDANT; CALCIUM CHANNEL BLOCKING AGENT; CHROMAN DERIVATIVE; DIAGNOSTIC AGENT; PIPERAZINE DERIVATIVE; TETRAZOLIUM; THIAZOLE DERIVATIVE; THIAZOLYL BLUE;

ARTICLE; ASTROCYTE; CELL DEATH; CELL PROTECTION; CELL SURVIVAL; DRUG CYTOTOXICITY; DRUG EFFECT; GLIOBLASTOMA; GLIOMA; HUMAN; HUMAN CELL; IC 50; NEUROPROTECTION; NEUROTRANSMITTER RELEASE; TUMOR GROWTH; ANIMAL; CELL PROLIFERATION; COMPARATIVE STUDY; CYTOLOGY; DOSE RESPONSE; DRUG INTERACTION; GLIA; MOUSE; TUMOR CELL LINE;

ANIMALS; ANTIOXIDANTS; CALCIUM CHANNEL BLOCKERS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CHROMANS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; GLIOMA; GLUTAMIC ACID; HUMANS; INHIBITORY CONCENTRATION 50; MAGNESIUM SULFATE; MICE; NEUROGLIA; PIPERAZINES; TETRAZOLIUM SALTS; THIAZOLES;

EID: 9644302678     PISSN: 00651400     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Alley MC, Scudiero DA, Monks A, Hursey ML, Czerwinski MJ, Fine DL, Abbott BJ, Mayo JG, Shoemaker RH, Boyd MR (1988) Feasibility of drug screening with panels of human tumor cell lines using a micro-culture tetrazolium assay. Cancer Res 48: 589-601.
2. Araque A, Parpura V, Sanzgiri RP, Haydon PG (1999) Tripartite synapses: glia, the unacknowledged partner. Trends Neurosci 22: 208-215.
3. Arora P, Lee YS, Origitano TC, Wurster RD (1996) Lazaroids inhibit proliferation of cultured human astrocytoma cells. J Neurooncol 29: 143-148.
4. Chen CJ, Liao SL, Kuo JS (2000) Gliotoxic action of glutamate on cultured astrocytes. J Neurochem 75: 1557-1565.
5. Chen TT, Mealey J (1970) Microculture of human brain tumors. Cancer Chemother Rep 54: 9-14.
6. Coyle JT, Puttfarcken P (1993) Oxidative stress, glutamate and neurodegenerative disorders. Science 262: 689-695.
7. Durmaz R, Deliorman S, Uyar R, Işiksoy S, Erol K, Tel E (1999a) The effects of anticancer drugs in combination with nimodipine and verapamil on cultured cells of glioblastoma multiforme. Clin Neurol Neurosurg 101: 238-244.
8. Durmaz R, Deliorman S, Işiksoy S, Uyar R, Erol K, Tel E (1999b) Antiproliferative properties of Lazaroids U-83836E and U-74389G on glioma cells in vitro. Pathol Oncol Res 5: 223-228.
9. Durmaz R, Inal M, Angýn K, Atasoy MA, Altimşik M, Tel E (1999c) The effects of MK-801 and U-83836E on post-ischemic reperfusion injury in rat brain. Acta Neurobiol Exp (Wars) 59: 99-104.
10. Grasbon-Frodl EM, Andersson A, Brundin P (1996) Lazaroid treatment prevents death of cultured rat embryonic mesencephalic neurons following glutathione depletion. J Neurochem 67: 1653-1660.
11. Hall ED, Pazara KE, Braughler JM, Linseman KL, Jacobsen EJ (1990) Nonsteroidal lazaroid U78517F in models of focal and global ischemia. Stroke 21 (Supl.): 11183-87.
12. Hall ED, Braughler JM, Yonkers PA, Smith SL, Linseman KL, Means ED, Scherch HM, Voigtlander FV, Lahti RA, Jacobsen EJ (1991) U-78517F: a potent inhibitor of lipid peroxidation with activity in experimental brain injury and ischemia. J Pharmacol Exp Ther 258: 688-694.
13. Han D, Sen CK, Roy S, Kobayashi MS, Tritschler HJ, Packer L (1997) Protection against glutamate-induced cytotoxicity in C6 glial cells by thiol antioxidants. Am Physiol Soc 273: R1771-R1778.
14. Hansson E, Muyderman H, Leonova J, Allansson L, Sinclair J, Blomstrand F, Thorlin T, Nilsson M, Rönnback L (2000) Astroglia and glutamate in physiology and pathology: aspects on glutamate transport, glutamate-induced cell swelling and gap-junction communication. Neurochem Int 37: 317-329.
15. Harris KM, Rosenberg PA (1993) Localization of synapses in rat cortical cultures. Neuroscience 53: 495-508.
16. 2 in closed head injury: a comparative phosphorus NMR study. J Neurotrauma 15: 183-189.
17. Izumi Y, Roussel S, Pinard E, Seylaz J (1991) Reduction of infarct volume by magnesium after middle cerebral artery occlusion in rats. J Cerebral Blood Flow Metab 11: 1025-1030.
18. Kass IS, Cottrell JE, Chambers G (1988) Magnesium and cobalt, not nimodipine, protect neurons against anoxic damage in the rat hyppocampal slice. Anesthesiology 69: 710-715.
19. Kato S, Higashida H, Higuchi Y, Hatakenaka S, Negishi K (1984) Sensitive and insensitive states of cultured glioma cells to glutamate damage. Brain Res 303: 365-73.
20. Kornblith P (1978) Role of tissue culture in prediction of malignancy. Clin Neurosurg 25: 346-375.
21. Marshall LF, Mass AI, Marshall SB, Bricolo A, Fearnside M, Iannotti F, Klauber MR, Lagarrigue J, Lobato R, Persson L, Pickard JD, Pick J, Servadei F, Wellis GN, Morris GF, Means ED, Musch B (1998) A multicenter trial on the efficacy of using tirilazad mesylate in cases of head injury. J Neurosurg 89: 519-525.
22. McLean RM (1994) Magnesium and its therapeutical uses: a review. Am J Med 96: 63-76.
23. Mossmann T (1983) Rapid colorimetric assay of cellular growth and survival: application to proliferation and cytotoxicity assay. J Immun Method 65: 55-63.
24. Nakao N, Frodl EM, Duan WM, Widner H, Brundin P (1994) Lazaroids improve the survival of grafted rat embryonic dopamine neurons. Neurobiol 91: 12408-12412.
25. Ohnishi ST, Ohnishi T (1995) Central Nervous System Trauma Research Techniques. CRC Press, USA
26. Rosenberg PA, Aizenman E (1989) Hundred-fold increase in neuronal vulnerability to glutamate toxicity in astrocyte-poor cultures of rat cerebral cortex. Neurosci Lett 103: 162-168.
27. Steinhauser C, Gallo V (1996) News on glutamate receptors in glial cells. Trends Neurosci 19: 339-345.
28. Sureda FX, Gabriel C, Pubill D, Palas M, Ascubedo E, Camarasa J, Camins J (1999) Effects of U-83836E on glutamate induced neurotoxicity in dissociated rat cerebellar granule cells. Toxicol Appl Pharmacol 156: 1-5.
29. Unterman TG, Glick RP, Waites GT, Bell SC (1991) Production of insulin-like growth factor-binding proteins by human central nervous system tumors. Cancer Res 51: 3030-3036.
30. Zhou Q, Olinescu RM, Kummerow FA (1999) Influence of low magnesium concentrations in the medium on the antioxidant system in cultured human arterial endothelial cells. Magnes Res 12: 19-29.