The Ppz protein phosphatases regulate Trk-independent potassium influx in yeast

FEBS Letters

Volumn 578, Issue 1-2, 2004, Pages 58-62

  Ruiz, Amparo ^a   Del Carmen Ruiz, María ^b   Sánchez Garrido, Miguel Angel ^b   Ariño, Joaquín ^a   Ramos, José ^b  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b UNIVERSITY OF CÓRDOBA   (Spain)

Author keywords

Potassium uptake; Protein phosphatases; Trk1 Trk2 transporters; Yeast

Indexed keywords

EGTAZIC ACID; HYGROMYCIN B; LITHIUM; MEMBRANE PROTEIN; MUTANT PROTEIN; PHOSPHATASE; PPZ PROTEIN PHOSPHATASE; RUBIDIUM; SODIUM; SPERMINE; TRK PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; FUNGAL STRAIN; FUNGUS GROWTH; NONHUMAN; POTASSIUM TRANSPORT; PRIORITY JOURNAL; PROTEIN FUNCTION; YEAST; YEAST CELL;

CALCIUM; CATION TRANSPORT PROTEINS; CATIONS; MUTATION; PHOSPHOPROTEIN PHOSPHATASE; POTASSIUM; RUBIDIUM; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

MAMMALIA; SACCHAROMYCES CEREVISIAE;

EID: 9644296127     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2004.10.069     Document Type: Article

References (28)

1. Arino J. Novel protein phosphatases in yeast. Eur. J. Biochem. 269:2002;1072-1077
2. Yenush L., Mulet J.M., Arino J., Serrano R. The Ppz protein phosphatases are key regulators of K+ and pH homeostasis: implications for salt tolerance, cell wall integrity and cell cycle progression. EMBO J. 21:2002;920-929
3. Merchan S., Bernal D., Serrano R., Yenush L. Response of the Saccharomyces cerevisiae Mpk1 mitogen-activated protein kinase pathway to increases in internal turgor pressure caused by loss of Ppz protein phosphatases. Eukaryot. Cell. 3:2004;100-107
4. Ramos, J., Contreras, P. and Rodriguez-Navarro, A. (1985) A potassium transport mutant of Saccharomyces cerevisiae. 143, 88-93
5. Ko C.H., Gaber R.F. TRK1 and TRK2 encode structurally related K+ transporters in Saccharomyces cerevisiae. Mol. Cell. Biol. 11:1991;4266-4273
6. Gaber R.F., Styles C.A., Fink G.R. TRK1 encodes a plasma membrane protein required for high-affinity potassium transport in Saccharomyces cerevisiae. Mol. Cell. Biol. 8:1988;2848-2859
7. Gomez M.J., Luyten K., Onuhoa C.N., Ramos J. Sodium tolerance depends on the capacity to transport potassium in Saccharomyces cerevisiae. Folia Microbiol. (Praha). 39:1994;519-520
8. Mendoza I., Rubio F., Rodriguez-Navarro A., Pardo J.M. The protein phosphatase calcineurin is essential for NaCl tolerance of Saccharomyces cerevisiae. J. Biol. Chem. 269:1994;8792-8796
9. Haro R., Bañuelos M.A., Quintero F.J., Rubio F., Rodríguez-Navarro A. Genetic basis of sodium exclusion and sodium tolerance in yeast. A model for plants. Physiol. Plantarum. 89:1993;868-874
10. Bertl A., Ramos J., Ludwig J., Lichtenberg-Frate H., Reid J., Bihler H., Calero F., Martinez P., Ljungdahl P.O. Characterization of potassium transport in wild-type and isogenic yeast strains carrying all combinations of trk1, trk2 and tok1 null mutations. Mol. Microbiol. 47:2003;767-780
11. Madrid R., Gomez M.J., Ramos J., Rodriguez-Navarro A. Ectopic potassium uptake in trk1 trk2 mutants of Saccharomyces cerevisiae correlates with a highly hyperpolarized membrane potential. J. Biol. Chem. 273:1998;14838-14844
12. Roberts S.K., Fischer M., Dixon G.K., Sanders D. Divalent cation block of inward currents and low-affinity K+ uptake in Saccharomyces cerevisiae. J. Bacteriol. 181:1999;291-297
13. Bihler H., Slayman C.L., Bertl A. NSC1: a novel high-current inward rectifier for cations in the plasma membrane of Saccharomyces cerevisiae. FEBS Lett. 432:1998;59-64
14. Bihler H., Slayman C.L., Bertl A. Low-affinity potassium uptake by Saccharomyces cerevisiae is mediated by NSC1, a calcium-blocked non-specific cation channel. Biochim. Biophys. Acta. 1558:2002;109-118
15. Wright M.B., Ramos J., Gomez M.J., Moulder K., Scherrer M., Munson G., Gaber R.F. Potassium transport by amino acid permeases in Saccharomyces cerevisiae. J. Biol. Chem. 272:1997;13647-13652
16. Asensio J., Ruiz-Argueso T., Rodriguez-Navarro A. Sensitivity of yeasts to lithium. Antonie Van Leeuwenhoek. 42:1976;1-8
17. Ramos J., Rodriguez-Navarro A. Regulation and interconversion of the potassium transport systems of Saccharomyces cerevisiae as revealed by rubidium transport. Eur. J. Biochem. 154:1986;307-311
18. Posas F., Casamayor A., Morral N., Arino J. Molecular cloning and analysis of a yeast protein phosphatase with an unusual amino-terminal region. J. Biol. Chem. 267:1992;11734-11740
19. Clotet J., Posas F., de Nadal E., Arino J. The NH2-terminal extension of protein phosphatase PPZ1 has an essential functional role. J. Biol. Chem. 271:1996;26349-26355
20. Gomez M.J., Luyten K., Ramos J. The capacity to transport potassium influences sodium tolerance in Saccharomyces cerevisiae. FEMS Microbiol. Lett. 135:1996;157-160
21. Rodriguez-Navarro A., Ramos J. Dual system for potassium transport in Saccharomyces cerevisiae. J. Bacteriol. 159:1984;940-945
22. Ruiz A., Yenush L., Arino J. Regulation of ENA1 Na(+)-ATPase gene expression by the Ppz1 protein phosphatase is mediated by the calcineurin pathway. Eukaryot. Cell. 2:2003;937-948
23. Forment J., Mulet J.M., Vicente O., Serrano R. The yeast SR protein kinase Sky1p modulates salt tolerance, membrane potential and the Trk1,2 potassium transporter. Biochim. Biophys. Acta. 1565:2002;36-40
24. Mulet J.M., Leube M.P., Kron S.J., Rios G., Fink G.R., Serrano R. A novel mechanism of ion homeostasis and salt tolerance in yeast: the Hal4 and Hal5 protein kinases modulate the Trk1-Trk2 potassium transporter. Mol. Cell. Biol. 19:1999;3328-3337
25. de Nadal E., Clotet J., Posas F., Serrano R., Gomez N., Arino J. The yeast halotolerance determinant Hal3p is an inhibitory subunit of the Ppz1p Ser/Thr protein phosphatase. Proc. Natl. Acad. Sci. USA. 95:1998;7357-7362
26. Ruiz A., Munoz I., Serrano R., Gonzalez A., Simon E., Arino J. Functional characterization of the Saccharomyces cerevisiae VHS3 gene: a regulatory subunit of the Ppz1 protein phosphatase with novel, phosphatase-unrelated functions. J. Biol. Chem. 279:2004;34421-34430
27. Erez O., Kahana C. Deletions of SKY1 or PTK2 in the Saccharomyces cerevisiae trk1Deltatrk2Delta mutant cells exert dual effect on ion homeostasis. Biochem. Biophys. Res. Commun. 295:2002;1142-1149
28. Posas F., Camps M., Arino J. The PPZ protein phosphatases are important determinants of salt tolerance in yeast cells. J. Biol. Chem. 270:1995;13036-13041