In vitro and in vivo analysis of human herpesvirus-6 U90 protein expression

Journal of Medical Virology

Volumn 75, Issue 1, 2005, Pages 86-92

  Nishimura, N ^a   Yoshikawa, Tetsushi ^b   Ozaki, T ^a   Sun, H ^c   Goshima, F ^c   Nishiyama, Y ^c   Asano, Y ^b   Kurata, T ^d   Iwasaki, T ^e  

^a SHOWA UNIVERSITY HOSPITAL   (Japan)

^b FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^e NAGASAKI UNIVERSITY   (Japan)

Author keywords

Antigenemia; Exanthem subitum; HHV 6; IEA ex3

Indexed keywords

POLYCLONAL ANTIBODY; VIRUS ANTIGEN; VIRUS PROTEIN;

ARTICLE; CHILD; CONTROLLED STUDY; EXANTHEMA SUBITUM; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 6; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; INFANT; LASER MICROSCOPY; MAJOR CLINICAL STUDY; NUCLEOTIDE SEQUENCE; PERIPHERAL BLOOD MONONUCLEAR CELL; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; VIRUS LOAD; WESTERN BLOTTING;

ANTIBODIES, VIRAL; ANTIGENS, VIRAL; BLOTTING, WESTERN; CELLS, CULTURED; GENE EXPRESSION REGULATION, VIRAL; HERPESVIRUS 6, HUMAN; HUMANS; INFANT; LEUKOCYTES, MONONUCLEAR; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; ROSEOLOVIRUS INFECTIONS; SENSITIVITY AND SPECIFICITY; VIRAL LOAD; VIRAL PROTEINS;

HERPESVIRIDAE; HUMAN HERPESVIRUS 6;

EID: 9644291587     PISSN: 01466615     EISSN: None     Source Type: Journal    
DOI: 10.1002/jmv.20241     Document Type: Article

References (22)

1. Asano Y, Yoshikawa T, Suga S, Yazaki T, Hata T, Nagai T, Kajita Y, Ozaki T, Yoshida S. 1989. Viremia and neutralizing antibody response in infants with exanthem subitum. J Pediatr 114:535-539.
2. Asano Y, Nakashima T, Yoshikawa T, Suga S, Yazaki T. 1991. Severity of human herpesvirus-6 viremia and clinical findings in infants with exanthem subitum. J Pediatr 118:891-895.
3. Asano Y, Yoshikawa T, Suga S, Kobayashi I, Nakashima T, Yazaki T, Kajita Y, Ozaki T. 1994. Clinical features of infants with primary human herpesvirus-6 infection (exanthem subitum, roseola infantum). Pediatrics 93:104-108.
4. Chiu SS, Cheung CY, Tse CYC, Peiris M. 1998. Early diagnosis of primary human herpesvirus-6 infection in childhood: Serology, polymerase chain reaction, and virus load. J Infect Dis 178:1250-1256.
5. Clark DA, Kidd IM, Collingham KE, Tarlow M, Ayeni T, Riordan A, Griffiths PD, Emery VC, Pillay D. 1997. Diagnosis of primary human herpesvirus-6 and -7 infections in febrile infants by polymerase chain reaction. Arch Dis Child 77:42-45.
6. Frenkel N, Katsafanas GC, Wyatt LS, Yoshikawa T, Asano Y. 1994. Bone marrow transplant recipients harbor the B variant of human herpesvirus 6. Bone Marrow Transplant 14:839-843.
7. Gravel A, Dion V, Cloutier N, Gosselin J, Flamand L. 2004. Characterization of human herpesvirus 6 variant B immediate-early 1 protein modifications by small ubiquitin-related modifiers. J Gen Virol 85:1319-1328.
8. Hall CB, Long CE, Schnabel KC, Caserta MT, McIntyre KM, Costanzo MA, Knott A, Dewhurst S, Insel RA, Epstein LG. 1994. Human herpesvirus-6 infection in children: A prospective study of complications and reactivation. N Engl J Med 331:432-438.
9. Lautenschlager I, Hockerstedt K, Linnavuori K, Taskinen E. 1998. Human herpesvirus-6 infection after liver transplantation. Clin Infect Dis 26:702-707.
10. Lautenschlager I, Linnavuori K, Hockerstedt K. 2000. Human herpesvirus-6 antigenemia after liver transplantation. Transplantation 69:2561-2566.
11. Mirandola P, Menegazzi P, Merighi S, Ravaioli T, Cassai E, Di Luca D. 1998. Temporal mapping of transcripts in herpesvirus 6 variants. J Virol 72:3837-3844.
12. Nikolaou K, Varinou L, Inoue N, Arsenakis M. 2003. Identification and characterization of gene products of ORF U90/89 of human herpesvirus 6. Acta Virol 47:17-26.
13. Sashihara J, Tanaka-Taya K, Tanaka S, Amo K, Miyagawa H, Hosoi G, Taniguchi T, Fukui T, Kasuga N, Aono T, Sako M, Hara J, Yamanishi K, Okada S. 2002. High incidence of human herpesvirus 6 infection with a high viral load in cord blood stem cell transplant recipients. Blood 100:2005-2011.
14. Secchiero P, Carrigan DR, Asano Y, Benedetti L, Crowley RW, Komaroff AL, Gallo RC, Lusso P. 1995. Detection of human herpesvirus-6 in plasma of children with primary infection and immunosuppressed patients by polymerase chain reaction. J Infect Dis 171:273-280.
15. Stanton R, Fox JD, Caswell R, Sherratt E, Wilkinson GW. 2002. Analysis of the human herpesvirus-6 immediate-early 1 protein. J Gen Virol 83:2811-2820.
16. Suga S, Yoshikawa T, Asano Y, Yazaki T, Yoshida S. 1990. Simultaneous infection with human herpesvirus 6 and measles virus in infants. J Med Virol 31:306-311.
17. Suga S, Yoshikawa T, Kajita Y, Ozaki T, Asano Y. 1998. Prospective study of persistence and excretion of human herpesvirus-6 in patients with exanthem subitum and their parents. Pediatrics 102:900-904.
18. Yamanishi K, Okuno T, Shiraki K, Takahashi M, Kondo T, Asano Y, Kurata T. 1988. Identification of human herpesvirus-6 as a causal agent for exanthem subitum. Lancet 1:1065-1067.
19. Yoshikawa T. 2004. Human herpesvirus 6 infection in hematopoietic stem cell transplant patients. Br J Haematol 124:421-432.
20. Yoshikawa T, Asano Y. 2000. Central nervous system complications in human herpesvirus-6 infection. Brain Dev 22:307-314.
21. Yoshikawa T, Ihira M, Suzuki K, Suga S, Iida K, Saito Y, Asonuma K, Tanaka K, Asano Y. 2000. Human herpesvirus 6 infection after living related liver transplantation. J Med Virol 62:52-59.
22. Yoshikawa T, Akimoto S, Nishimura N, Ozaki T, Ihira M, Ohashi M, Morooka M, Suga S, Asano Y, Takemoto M, Nishiyama Y. 2003. Evaluation of active human herpesvirus 6 infection by reverse transcription-PCR. J Med Virol 70:267-272.