Identification and characterization of gene products of ORF U90/89 of human herpesvirus 6

Acta Virologica

Volumn 47, Issue 1, 2003, Pages 17-26

  Nikolaou, K ^a   Varinou, L ^a   Inoue, N ^b   Arsenakis, M ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^b CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

Author keywords

Human herpesvirus 6; IE A region; Immediate early gene; U90; U90 89

Indexed keywords

AMINO ACID; COMPLEMENTARY DNA; GENE PRODUCT; HYBRID PROTEIN; POLYCLONAL ANTIBODY;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DNA BINDING; DNA FLANKING REGION; ESCHERICHIA COLI; GENE LOCUS; GENE SEQUENCE; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 6; IMMEDIATE EARLY GENE; NONHUMAN; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SEQUENCE HOMOLOGY; SOUTHERN BLOTTING; VIROGENESIS; VIRUS ISOLATION;

ANIMALS; ANTIBODIES, VIRAL; CELLS, CULTURED; CLONING, MOLECULAR; DNA-BINDING PROTEINS; FEMALE; FETAL BLOOD; GENE EXPRESSION REGULATION, VIRAL; HELA CELLS; HERPESVIRUS 6, HUMAN; HUMANS; IMMEDIATE-EARLY PROTEINS; IMMUNIZATION; LYMPHOCYTES; MODELS, GENETIC; OPEN READING FRAMES; PHOSPHOPROTEINS; PROMOTER REGIONS (GENETICS); RABBITS; RECOMBINANT FUSION PROTEINS; VIRAL PROTEINS;

ANIMALIA; ESCHERICHIA COLI; HERPESVIRIDAE; HUMAN HERPESVIRUS 5; HUMAN HERPESVIRUS 6;

EID: 0038586227     PISSN: 0001723X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Ablashi D, Agut H, Berneman Z, Campadelli-Fiume G, Carrigan D, Ceccerini-Nelli L, Chandran B, Chou S, Collandre H, Cone R, Dambaugh T, Dewhurst S, Diluca D, Foa-Tomasi L, Fleckenstein B, Frenkel N, Gallo R, Gompels U, Hall C, Jones M, Lawrence G, Martin M, Montangier L, Neipel F, Nicholas J, Pellet P, Razzaque A, Torrelli G, Thomson B, Salahuddin S, Wyatt L, Yamanishi K (1993): Human herpesvirus-6 strain groups-A nomenclature. Arch. Virol. 129, 1-4.
2. Arsenakis M, Hubenthal-Voss J, Campadelli-Fiume G, Pereira E, Roizman B (1986): Construction and properties of a cell line constitutively expressing the Herpes simplex virus glycoprotein B dependent on functional a4 protein synthesis. J. Virol. 60, 674-682.
3. Blaho JA, Mitchell C, Roizman B (1993): Guanylylation and adenylylation of the a regulatory proteins of the herpesvirus simplex virus require a viral b and g function. J. Virol. 67, 3891-3900.
4. Cherrington JM, Mocarski ES (1989): Human cytomegalovirus iel transactivates the á-promoter-enhancer via a 18-base-pair repeat element. J. Virol. 63, 1435-1440.
5. Dominguez G, Dambaugh TR, Stamey FR, Dewhurst S, Inoue N, Pellett F (1999): Human herpesvirus 6B genome sequence: coding content and comparison with Human herpesvirus 6A. J. Virol. 73, 8040-8052.
6. Downing RG, Sewankambo N, Serwadda D, Honess RW, Crawford D, Jarrett R, Griffen BE (1987): Isolation of human lymphotropic herpesviruses from Uganda. Lancet 2, 390.
7. Frenkel N, Schirmer EC, Wyatt LS, Katsafanas G, Roffman E, Danovich RM, June CH (1990): Isolation of a new herpesvirus from human CD4+ T cells. Proc. Natl. Acad. Sci. USA 87, 748-752.
8. Gelman IH, Silverstein SJ (1987): Herpes simplex virus immediate-early promoters are responsive to virus and cell transacting factors. J. Virol. 61, 2286-2296.
9. Gompels UA, Nicholas J, Lawrence G, Jones M, Thomson BJ, Martin MED, Efstathiou S, Craxton M, Macaulay HA (1995): The DNA sequence of human herpesvirus-6: Structure, coding content, and genome evolution. Virology 209, 29-51.
10. Hall CB, Long CE, Schnabel KC, Caserta MT, McIntyre KM, Costanzo MA, Knott A, Dewhurst S, Insel RA, Epstein LG (1994): Human herpesvirus-6 infection in children-A prospective study of complications and reactivation. N. Engl. J. Med. 331, 432-438.
11. Hofmann H, Floss S, Stamminger T (2000): Covalent modification of the transactivator protein IE2-p86 of human cytomegalovirus by conjugation to the ubiquitin-homologous proteins SUMO-1 and hSMT3b. J. Virol. 74, 2510-2524.
12. Honess RW, Gompels UA, Barrell BG, Craxton MA, Staden R, Chang Y-C, Hayward G (1989): Deviations from expected frequencies of CpG dinucleotides in herpesviruses DNAs may be diagnostic of differences in the state of their latent genomes. J. Gen. Virol. 70, 837-855.
13. Honess RW (1984): Herpes simplex and the "herpes comlex": diverse observations and a unifying hypothesis. J. Gen. Virol. 65, 2077-2107.
14. Inoue N, Dambaugh TR, Rapp JC, Pellet PE (1994): Alphaherpes-viruses origin-binding protein homologue by human herpesvirus-6B, a betaherpesvirus, binds to nucleotide sequences that are similar to ori regions of alphaherpes-viruses. J. Virol. 68, 4126-4136.
15. Isegawa Y, Mukai T, Nakano K, Kagawa M, Chen J, Mori Y, Sunagawa T, Kawanishi K, Sashihara J, Hata A, Zou P, Kosuge H, Yamanishi K (1999): Comparison of the complete DNA sequences of human herpesvirus 6 variants A and B. J. Virol. 73, 8053-8063.
16. Johnson G, Nelson S, Petric M, Tellier R (2000): Comprehensive PCR-based assay for detection and species identification of human herpesviruses. J. Clin. Microbiol. 38, 3274-3279.
17. Karlin S, Doerfler W, Cardon LR (1994a): Why is CpG suppressed in the genomes of virtually all small eukaryoric viruses but not in those of large eukaryotic viruses? J. Virol. 68, 2889-2897.
18. Karlin S, Mocarski ES, Schachtel GA (1994b): Molecular evolution of herpesviruses: genomic and protein sequence comparisons. J. Virol. 68, 1886-1902.
19. Kondo K, Kondo T, Okuno T, Takahashi M, Yamanishi K (1991): Latent Human herpesvirus 6 infection of human monocytes/macrophages. J. Gen. Virol. 72, 1401-1408.
20. Kosuge H, Isegawa Y, Yamanishi K (1997): Nucleotide sequence analysis of a 30-kilobase-pair region of human herpesvirus-6B (HHV-6) genome and strain specific variations in major immediate-early genes. Virus Res. 52, 1-14.
21. Larcher C, Huemer HP, Margreiter R, Dierich MP (1988): Serological crossreaction of human herpesvirus-6 with cytomegalovirus. Lancet ii, 963-964.
22. Lawrence GL, Chee M, Craxton MA, Gompels UA, Honess RW, Barrell BG (1990): Human herpesvirus 6 is closely related to human cytomegalovirus. J Virol. 64, 287-299.
23. Lopez C, Pellett P, Stewart J, Goldsmith C, Sandelin K, Black J, Warfield D, Feorino P (1988): Characteristics of human herpesvirus 6. J. Infect. Dis. 157, 1271-1273.
24. Lusso P, Markham PD, Tschachler E, Veronese FDM, Salahuddin SZ, Ablashi DV, Pahwa S, Krohn K, Gallo RC (1988): In vitro cellular tropism of human B-lymphotropic virus (human herpesvirus-6). J. Exp. Med. 167, 1659-1670.
25. Maina CV, Riggs PD, Grandea AG, Slatko BE, Moran LS, Tagliamont JA, McReynolds LA, Guan C (1988): A vector to express and purify foreign proteins in Escherichia coli by fusion to, and separation from, maltose binding protein. Gene 74, 365-373.
26. Martin MED, Nicholas J, Thomson BJ, Newman C, Honess RW (1991): Identification of a transactivating function mapping to the putative immediate early locus of human herpesvirus 6. J. Virol. 65, 5381-5390.
27. Mocarski ES, Courcelle CT (2001): Cytomegalovirus and their replication. In Knipe DM, Howley PM (Eds): Fields Virology. Fourth ed., Lippincott, Williams & Wilkins, Philadelphia, pp. 2629-2674.
28. Neipel F, Ellinger K, Fleckenstein B (1991): The unique region of the human herpesvirus 6 genome is essentially collinear with the U(L) segment of human cytomegalovirus. J. Gen. Virol. 72, 2293-2297.
29. Papanikolaou E, Kouvatsis V, Dimitriadis G, Inoue N, Arsenakis M (2002): Identification and characterization of the gene products of open reading frame U86/87 of human herpesvirus 6. Virus Res. 89, 89-101.
30. Purves FC, Roizman B (1992): The UL13 gene of herpes simplex virus 1 encodes the functions for posttranslational processing associated with phosphorylation of the regulatory protein α22. Proc. Natl. Acad. Sci. USA 89, 7310-7314.
31. Rapp CJ, Krug LT, Inoue N, Dambaugh TR, Pellett PE (2000): U94, the human herpesvirus 6 homolog of the parvovirus nonstructual gene, is highly conserved among isolates and is expressed at low mRNA level as a spliced transcript. Virology 268, 504-516.
32. Salahuddin SZ, Ablashi CV, Markham PD, Josephs SF, Sturzenegger S, Kaplan M, Halligan G, Biberfield P, Wong-Staal F, Kramarsky B, Gallo R (1986): Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. Science 234, 596-601.
33. Sambrook J, Fritsch EF, Maniatis T (1989): Molecular Cloning. A Laboratory Manual. Laboratory Press, Cold Spring Harbor.
34. Schiewe U, Neipel F, Schreiner D, Fleckenstein B (1994): Structure and transcription of an immediate-early region in the human herpesvirus 6 genome. J. Virol. 68, 2978-2985.
35. Spengler ML, Kurapatwinski K, Black AR, Azizkhan-Clifford J (2002): SUMO-1 modification of human cytomegalovirus IE1/IE72. J. Virol. 76, 2990-2996.
36. Sunwen C, Marousek GI (1994): Analysis of interstrain variation in a putative immediate-early region of human herpesvirus 6 DNA and definition of variant-specific sequences. Virology 198, 370-376.
37. Takeda K, Nakagawa N, Yamamoto T, Inagi R, Kawanishi K, Isegawa Y, Yamanishi K (1996): Prokaryotic expression of an immediate-early gene of human herpesvirus 6 and analysis of its viral antigen expression in human cells. Virus Res. 41, 193-200.
38. Tsutsui Y, Yamazaki Y (1991): Subcellular distribution of the major immediate early proteins of human cytomegalovirus changes during infection. J. Gen. Virol. 72, 1415-1419.
39. Wathen MW, Tomsen DR, Stinski MF (1981): Temporal regulation of human cytomegalovirus transcription at immediate early times after infection. J. Virol. 38, 446-459.
40. Yamanishi K, Okuno T, Shiraki K, Takahashi M, Kondo T, Asano Y, Kurata T (1988): Identification of human herpesvirus-6 as a causal agent for exanthem subitum. Lancet 1, 1065-1067.
41. Yasukawa M, Yakushijin Y, Furukawa M, Fujita S (1993): Specificity analysis of human CD4+ T-cell clones directed against human herpesvirus 6 (HHV-6), HHV-7, and human cytomegalovirus. J. Virol. 67, 6259-6264.