The gender-specific risk to liver toxicity and cancer of flounder (Platichthys flesus (L.)) at the German Wadden Sea coast

Aquatic Toxicology

Volumn 70, Issue 4, 2004, Pages 257-276

  Koehler, Angela ^a  

^a ALFRED WEGENER INSTITUTE FOR POLAR AND MARINE RESEARCH   (Germany)

Author keywords

Carcinogenesis; Diagnostic guideline; Flatfish liver; Histopathology; Non genotoxic chemicals; North Sea; Pollution

Indexed keywords

ESTRADIOL; FRESH WATER; ORGANOCHLORINE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

CARCINOGEN; CHEMICAL POLLUTANT; ECOTOXICOLOGY; FLATFISH; SEX-RELATED DIFFERENCE;

AGE DISTRIBUTION; ANGIOSARCOMA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATLANTIC OCEAN; BALTIC SEA; BASOPHIL; BILE DUCT CARCINOMA; CANCER GROWTH; CELL VACUOLE; CHEMICAL ANALYSIS; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; CORRELATION ANALYSIS; ENDOTHELIUM CELL; EOSINOPHIL; EPIGENETICS; ESTUARY; FEMALE; FLATFISH; FLOUNDER; HEALTH SURVEY; HISTOPATHOLOGY; LIVER CANCER; LIVER CELL; LIVER CELL CARCINOMA; LIVER TOXICITY; MALE; MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; RISK; SALINITY; SEASHORE; SEX ROLE; SEXUAL MATURATION; UPREGULATION; WATER CONTAMINATION;

ADENOMA, LIVER CELL; ANIMALS; CARCINOMA, HEPATOCELLULAR; ENVIRONMENTAL EXPOSURE; FEMALE; FISH DISEASES; FLOUNDER; HISTOLOGICAL TECHNIQUES; LIVER; LIVER NEOPLASMS; MALE; NORTH SEA; SEX FACTORS; WATER POLLUTANTS, CHEMICAL;

ATLANTIC OCEAN; NORTH SEA; OCEANIC REGIONS; WADDEN SEA; WORLD;

MAMMALIA; PLATICHTHYS FLESUS; PLEURONECTIFORMES; PLEURONECTOIDEI;

EID: 9644290830     PISSN: 0166445X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.aquatox.2004.07.002     Document Type: Article

References (69)

1. P. Bannasch, H. Enzmann, F. Klimek, E. Weber, and H. Zerban Significance of sequential cellular changes inside and outside foci of altered hepatocytes during hepatocarcinogenesis Toxicol. Pathol. 17 1989 617 629
2. P. Bannasch Pathobiology of chemical hepatocarcinogenesis: recent progress and perspectives. Part I. Cytomorphological changes and cell proliferation J. Gastroenterol. Hepatol. 5 1990 149 159
3. J.C. Barrett Mechanisms of action of known human carcinogens IARC Sci. Publ. 116 1992 115 134
4. P.C. Baumann, W.D. Smith, and W.K. Parland Tumor frequencies and contaminant concentrations in brown bullheads from an industrialized river and a recreational lake Trans. Am. Fish. Soc. 116 1987 79 86
5. O.B. Bayliss Lipids. J.D. Bancroft A. Stevens Theory and Practice of Histological Techniques 1982 Churchill-Livingstone Edinburgh, UK 217 241
6. BEQUALM, 1999. External fish diseases and liver histopathology. Biological Effects Quality Assurance in Monitoring Programmes (BEQUALM), Work package 6. Report of the first workshop, 21-23 October, 1999. CEFAS Weymouth Laboratory, UK.
7. G.A. Boorman, S. Botts, T.E. Bunton, J.W. Fournie, J.C. Harshbarger, W.E. Hawkins, D.E. Hinton, M.P. Jokinen, M.S. Okihiro, and M.J. Wolfe Diagnostic criteria for degenerative, inflammatory, proliferative nonneoplastic and neoplastic liver lesions in medaka (Oryzias latipes): consensus of a National Toxicology Program Pathology Working Group. Toxicol. Pathol. 25 1997 202 210
8. N.J. Brown-Peterson, R.M. Krol, Y. Zhu, and W.E. Hawkins N-Nitrosodiethylamine initiation of carcinogenesis in Japanese medaka (Oryzias latipes): hepatocellular proliferation, toxicity, and neoplastic lesions resulting from short term, low level exposure Toxicol. Sci. 50 2 1999 186 194
9. J.A. Couch, and J.C. Harshberger Effects of carcinogenic agents on aquatic animals: an environmental and experimental overview Environ. Carcinog. Rev. 3 1985 63 105
10. H. Elias, and F. Bengelsdorf The structure of liver of vertebrates Acta Anat. 14 1952 279
11. J. Emmersen, and J.M. Petersen Natural occurrence and experimental induction by estradiol-17-β, of a lipophosphoprotein (vitellogenin) in flounder (Platichthys flesus L.) Comp. Biochem. Physiol. B 54 1976 443 446
12. J. Emmersen, B. Korsgaard, and J.M. Petersen Dose-response kinetics of serum vitellogenin, liver DNA, RNA, protein and lipid after induction by estradiol-17-β in male flounder (Platichthys flesus) Comp. Biochem. Physiol. B 63 1979 1 6
13. E. Farber Clonal adaption during carcinogenesis Biochem. Pharamacol. 39 1990 1837 1846
14. E. Farber, and D.S.R. Sarma Biology of disease: hepatocarcinogenesis: a dynamic cellular perspective Lab. Invest. 56 1987 4 22
15. Feist, S.W., Lang, T., Stentiford, G.D., Koehler, A. The use of liver pathology of flatfish for monitoring biological effects of contaminants. ICES Techniques in Marine Environmental Sciences (TIMES), pp35 (in press).
16. S. Franke, S. Hildebrandt, W. Francke, and H. Reincke The occurrence of chlorinated bis-(propyl)ethers in the Elbe River and tributaries Naturwissenschaften 82 1995 80 83
17. T.M. Franklin, J.S. Lee, A. Koehler, and J.K. Chipman Analysis of mutations in the p53 tumor suppressor gene and Ki- and Ha-ras proto-oncogenes in hepatic tumors of European flounder (Platichthys flesus) Mar. Environ. Res. 50 1-5 2000 251 255
18. G.R. Gardner, P.P. Yevich, J.C. Harshberger, and M.A. Russell Carcinogenecity of black rock harbour sediments to the eastern oyster and trophic transfer of black rock harbour carcinogens from the blue mussel to the winter flounder Environ. Health Perspect. 90 1991 53 66
19. T. Harada, R.R. Maronpot, R.W. Morris, K.A. Stitzel, and G.A. Boorman Morphological and stereological characterization of hepatic foci of cellular alteration in control fischer 344 rats Toxicol. Pathol. 17 1989 579 593
20. D.E. Hinton, J.A. Couch, S.J. Teh, and L.A. Courtney Cytological changes during progression of neoplasia in selected fish species Aquat. Toxicol. 11 1988 77 112
21. D.E. Hinton, S.J. Teh, M.S. Okihiro, J.B. Cooke, and L.M. Parker Phenotypically altered hepatocyte populations in diethylnitrosamine-induced medeka liver carcinogenesis: resistence, growth, and fate Mar. Environ. Res. 34 1992 1 5
22. D.E. Hinton Cells, cellular responses, and their markers in chronic toxicity of fishes Aquat. Toxicol. 24 1994 207 239
23. ICES (1997). Report of the Special Meeting on the Use of Liver Pathology of Flatfish for Monitoring Biological Effects of Contaminants. ICES CM, 1997/F:2., 75 pp.
24. L.L. Johnson, C.M. Stehr, O.P. Olson, M.S. Myers, S.M. Pierce, C.A. Wigren, B.B. McCain, and U. Varanasi Chemical contamintants and hepatic lesions in winter flounder (Pleuronectes americanus) from the northeast coast of the United States Environ. Sci. Technol. 27 1993 2759
25. J.E. Klaunig, and L.M. Kamendulus The role of oxidative stress in carcinogenesis Annu. Rev. Pharmacol. Toxicol. 44 2004 239 267
26. A. Koehler, U. Harms, and B. Luckas Accumulation of organochlorines and mercury in flounder - an approach to pollution assessments Helgoländer Meeresunters 40 1986 431 440
27. A. Koehler Experimental studies on the regeneration of contaminant-induced liver lesions in flounder from the Elbe estuary: steps towards the identification of cause-effect relationships Aquat. Toxicol. 14 1989 203 232
28. A. Koehler Identification of contaminant-induced cellular and subcellular lesions in the liver of flounder (Platichthys flesus L.) caught at differently polluted estuaries Aquat. Toxicol. 16 1990 271 294
29. A. Koehler, H. Deisemann, and B. Lauritzen Histological and cytochemical indices of toxic injury in the liver of dab Limanda limanda L. Mar. Ecol. Prog. Ser. 92 1992 141 153
30. A. Koehler, and H.J. Pluta Lysosomal injury and MFO activity in the liver of flounder (Platichthys flesus L.) in relation to histopathology of hepatic degeneration and carcinogenesis Mar. Environ. Res. 39 1995 255 260
31. A. Koehler, and C.J.F. Van Noorden Initial velocities of G6PDH and PGDH in situ and the expression of proliferating cell nuclear antigen (PCNA) are sensitive diagnostic markers during environmental hepatocellular carcinogenesis in marine flatfish Aquat. Toxicol. 40 1998 233 252
32. A. Koehler, K. Soeffker, and E. Wahl Functional and morphological changes of lysosomes as prognostic biomarker of toxic injury in a marine flatfish Platichthys flesus (L.) Environ. Toxicol. Chem. 21 2002 2434 2444
33. A. Koehler, and C.J.F. Van Noorden Reduced nictotinamide adenine dinucleotide and the higher incidence of pollution-induced liver cancer in female flounder Environ. Toxicol. Chem. 22 2003 2703 2710
34. A. Koehler, T. Alpermann, B. Lauritzen, and C.J.F. Van Noorden Clonal xenobiotic resistance during pollution-induced toxic injury and hepatocellular carcinogenesis in liver of female flounder Acta Histochemica. 106 2004 155 170
35. B. Korsgaard, J. Emmersen, and I. Petersen Estradiol-induced hepatic protein synthesis and transaminase activity in the male flounder Platichthys flesus(L.) Gen. Comp. Endocrinol. 50 1983 11 17
36. R. Lüllmann-Rauch Drug-induced lysosomal storage disorders. J.T. Dingle P.J. Jacques I.H. Shaw Lysosomes in applied biology and therapeutics 1979 North-Holland Publ. Co Amsterdam 49 130
37. D.C. Malins, M.M. Krahn, M.S. Myers, L.D. Rhodes, D.W. Brown, C.A. Krone, B.B. McCain, and S.-L. Chan Toxic chemicals in sediments and biota from creosote-polluted harbor: relationships with hepatic neoplasms and other hepatic lesions in English sole (Parophrys vetulus) Carcinogenesis 6 1985 1463 1469
38. D.C. Malins, M.M. Krahn, D.W. Brown, L.D. Rhodes, M.S. Myers, B.B. McCain, and S.-L. Chan Toxic chemicals in marine sediment and biota from Mukilteo Washington: relationships with hepatic neoplasms and other hepatic lesions in English sole (Parophrys vetulus) J. Natl. Cancer Inst. 74 1985 487 494
39. D.C. Malins, B.B. McCain, M.S. Myers, D.W. Brown, M.M. Krahn, W.T. Roubal, M.H. Schiewe, J.T. Landahl, and S.-L. Chan Field and laboratory studies of the etiology of liver neoplasms in marine fish from Puget Sound Environ. Health Perspect. 71 1987 5 16
40. R.R. Maronpot, H.C. Pitot, and C. Peraino Use of rat liver altered focus models for testing chemicals that have completed two-year carcinogenicity studies Toxicol. Pathol. 17 1989 651 662
41. P. Masahito, K. Aoki, N. Egami, T. Ishikawa, and H. Sugano Life-span studies on spontaneous tumor development in the medaka (Oryzias latipes) Jpn. J. Cancer Res. 80 1989 1058 1065
42. M.S. Myers, L.D. Rhodes, and B.B. McCain Pathologic anatomy and patterns of occurence of hepatic neoplasms, putative preneoplastic lesions, and other idiopathic hepatic conditions in English sole (Parophrys vetulus) from Puget Sound Washington. J. Natl. Cancer Inst. 78 1987 333 363
43. M.S. Myers, O.P. Olson, L.L. Johnson, C.S. Stehr, T. Hom, and U. Varanasi Hepatic lesions other than neoplasms in subadult flatfish from Puget Sound Washington: relationships with indices of contaminant exposure Mar. Environ. Res. 34 1992 45 51
44. O. Nunez, J.D. Hendricks, and G.S. Bailey Enhancement of aflatoxin B1 and N-methyl-N′-nitro-N-nitrosoguanide hepatocarcinogenesis in rainbow trout Salma gairdneri by 17-β-estradiol and other organic chemicals Dis. Aquat. Organ. 5 1988 185 196
45. O. Nunez, J.D. Hendricks, D.N. Arbogast, A.T. Fong, B.C. Lee, and G.S. Bailey Promotion of aflatoxin B1 hepatocarcinogenesis in rainbow trout by 17-β-estradiol Aquat. Toxicol. 15 1989 289 302
46. T. Nagazawa, S. Hamaguchi, and Y. Kuono-Hamaguchi Histochemistry of liver tumors induced by diethylnitrosamine and differential sex susceptibility to carcinogenesis in Oryzia latipes J. Natl. Cancer Inst. 75 1985 567 573
47. P.M. Newborne Assessment of the hepatocarcinogenic potential of chemicals: resonses of the liver G. Plaa W.R. Hewitt Toxicology of the liver 1982 Raven Press New York 243 309
48. H. Popper, L.B. Thomas, N.C. Telles, H. Falk, and I.J. Selikoff Development of hepatic angiosarcoma in man induced by vinyl chloride, thorotrast, and arsenic: comparison with cases of unknown etiology Am. J. Pathol. 92 1978 349 370
49. C. Porte, and J. Albaigés Bioaccumulation patterns of hydrocarbons and polychlorinated biphenyls in bivalves, crustaceans, and fishes Arch. Environ. Contam. Toxicol. 26 1993 273 281
50. L.D. Rhodes, M.S. Myers, W.D. Gronlund, and B.B. McCain Epizootic characteristics of hepatic and renal lesions in English sole, Parophris vetulus, from Puget Sound J. Fish. Biol. 38 1987 395 407
51. S.H. Safe Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs) CRC Crit. Rev. Toxicol. 24 1994 51 88
52. S. Sell The role of determined stem cells in the cellular lineage of hepatocellular carcinoma Int. J. Dev. Biol. 37 1993 189 201
53. Soeffker, K. 2000. Saisonalität der Kontamination von Klieschen (Limanda limanda (Linnaeus, 1758), Osteichthyes) mit Organochlorverbindungen. Bedeutung der Lipide für die Kinetik der Umlagerung von Kontaminanten zwischen verschiedenen Organen. Shaker, Aachen, Germany.
54. J.E. Stein, W.L. Reichert, M. Nishimoto, and U. Varanasi Overview of studies on liver carcinogenesis in English sole from Puget Sound; evidence for a xenobiotic chemical etiology 2 biochemical studies Sci. Total Environ. 94 1990 51 69
55. G.D. Stentiford, M. Longshaw, B.P. Lyons, G. Jones, M. Green, and S.W. Feist Histopathological biomarkers in estuarine fish species for the assessment of biological effects of contaminants Mar Eviron. Res. 55 2003 137 159
56. S.Y. Teh, S.M. Adams, and D.E. Hinton Histopathologic biomarkers in feral freshwater fish populations exposed to different types of contaminant stress Aquat. Toxicol. 37 1997 51 70
57. S.Y. Teh, and D.E. Hinton Gender-specific growth and hepatic neoplasia in medaka (Oryzias latipes) Aquat. Toxicol. 41 1998 141 159
58. F. Takashima Hepatoma and cutaneous fibrosarcoma in hatchery-reared trout and salmon related to gonadal maturation Prog. Exp. Tumor Res. 20 1976 351 366
59. U. Varanasi, J.E. Stein, M. Nishimoto, W.L. Reichert, and T.K. Collier Chemical carcinogenesis in feral fish: uptake, activation, and detoxication of organic xenobiotics Environ. Health Perspect. 71 1987 155 170
60. A.D. Vethaak, and J.G. Jol Diseases of flounder (Platichthys flesus) in Dutch coastal and estuarine waters, with particular reference to environmental stress factors liver histopathology Dis. Aquat. Organ. 26 1996 81 97
61. A.D. Vethaak, and P.W. Wester Diseases of flounder (Platichthys flesus) in Dutch coastal and estuarine waters, with particular reference to environmental stress factors. 2. Liver histopathology Dis. Aquat. Organ. 26 1996 99 116
62. A.D. Vethaak, J.G. Jol, A. Meijboom, M.L. Eggens, T. apRheinalt, P.W. Wester, T. van de Zande, A. Bergman, N. Dankers, F. Ariese, R.A. Baan, J.M. Everts, A. Opperhuizen, and J.M. Marquenie Skin and liver diseases induced in flounder (Platichthys flesus) after long-term exposure to contaminated sediments in large-scale mesocosms Environ. Health Perspect. 104 11 1996 1218 1229
63. L. Vigano, A. Arillo, C. Falugi, F. Melodia, and S. Pollesello Biomarkers of exposure and effects in flounder (Plathichthys flesus) exposed to sediments of the Adriatic Sea Mar. Pollut. Bull. 42 2001 887 894
64. Von Landwüst, C., Holst, S., Möller, H., Anders, K., Momme, M., Von Neuhoff, N., Scharenberg, W., Weis, N., Lee, K., Koehler, A., Cameron, P., Brauer, F., Pluta, H.J., Kruse, R., Ballin, U., Söffker, K., Dethlefsen, V., 1996. Fischkrankheiten in der Nordsee. Umweltbundesamt Nr. 106 03 900, UBA Texte 57/96, 0722-186X Umweltbundesamt Berlin, Germany, 557 pp.
65. U. Welsch, and V. Storch Enzyme histochemical and ultrastructural observations on the liver of teleosts Arch. Histol. Jpn. 36 1973 21 27
66. K. Winzer, W. Becker, C.J.F. Van Noorden, and A. Koehler Short-time induction of oxidative stress in living hepatocytes of flounder (Platichthys flesus L.) Mar. Environ. Res. 50 2000 495 501
67. K. Winzer, C.J.F. Van Noorden, and A. Koehler Glucose-6-phosphate dehydrogenase: the key to sex-related xenobiotic toxicity in hepatocytes of European flounder (Platichthys flesus L.) Aquat. Toxicol. 56 2002 275 288
68. K. Winzer, C.J.F. Van Noorden, and A. Koehler Sex-specific biotransformation and detoxification after xenobiotic exposure of primary cultures hepatocytes of European flounder (Platichthys flesus L.) Aquat. Toxicol. 59 2002 17 33
69. J.D. Yager Endogenous estrogens as carcinogens through metabolic activation J. Natl. Cancer Inst. Monogr. 27 2000 67 73