A randomised trial of povidone-iodine to reduce visual impairment from corneal ulcers in rural Nepal

British Journal of Ophthalmology

Volumn 88, Issue 12, 2004, Pages 1487-1492

  Katz, Joanne ^a,c   Khatry, S K ^b   Thapa, M D ^b   Schein, O D ^c   Pradhan, E Kimbrough ^d   LeClerq, S C ^a   West Jr , K P ^a  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^b Nepal Natl Society for Eye Hlth   (Nepal)

^c JOHNS HOPKINS UNIVERSITY   (United States)

^d UNIVERSITY OF MARYLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CHLORAMPHENICOL; GENTAMICIN; HOMATROPINE; POVIDONE IODINE; TETRACYCLINE;

ADOLESCENT; ADULT; AGED; ANTIBIOTIC THERAPY; ARTICLE; CHILD; CLINICAL TRIAL; CONJUNCTIVAL HYPEREMIA; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORNEA ULCER; DRUG EFFICACY; EDEMA; EYE PAIN; FEMALE; FOLLOW UP; HUMAN; LACRIMATION; MAJOR CLINICAL STUDY; MALE; NEPAL; OCULAR PRURITUS; PRIORITY JOURNAL; PUS; RANDOMIZED CONTROLLED TRIAL; RURAL AREA; SCAR; TEAR; VISUAL ACUITY; VISUAL IMPAIRMENT;

ADOLESCENT; ADULT; ANTI-INFECTIVE AGENTS, LOCAL; CHILD; CORNEAL ULCER; FEMALE; HUMANS; IODOPHORS; MALE; MIDDLE AGED; NEPAL; POVIDONE-IODINE; TREATMENT OUTCOME; VISION DISORDERS; VISUAL ACUITY;

EID: 9644289222     PISSN: 00071161     EISSN: None     Source Type: Journal    
DOI: 10.1136/bjo.2004.044412     Document Type: Article

References (44)

1. Thylefors B. Epidemiological patterns of ocular trauma. Aust N Z J Ophthalmol 1992;20:95-8.
2. Seva Foundation. Epidemiology of blindness in Nepal, Chapter 9, Trauma. MI: Chelsea, 1988.
3. Negrel AD, Thylefors B. The global impact of eye injuries. Ophthalmic Epidemiol 1998;5:143-69.
4. Smith GT, Taylor HR. Epidemiology of corneal blindness in developing countries. Retract Corneal Surg 1991;7:211-4.
5. Upadhyay MP, Karmacharya PCD, Koirala S, et al. Epidemiologic characteristics, predisposing factors, and etiologic diagnosis of corneal ulceration in Nepal. Am J Ophthalmol 1991;111:92-9.
6. Whitcher JP, Srinivasan M. Corneal ulceration in the developing world: a silent epidemic. Br J Ophthalmol 1997;81:622-3.
7. Gonzales CA, Srinivasan M, Witcher JP, et al. Incidence of corneal ulceration in Madurai District, South India. Ophthalmic Epidemiol 1996;3:159-66.
8. Srinivasan M, Gonzales CA, George C, et al. Epidemiology and aetiological diagnosis of corneal ulceration in Madurai, south India. Br J Ophthalmol 1997;81:965-71.
9. Upadhyay MP, Karmacharya PC, Koirala S, et al. The Bhaktapur Eye Study: ocular trauma and antibiotic prophylaxis for the prevention of corneal ulceration in Nepal. Br J Ophthalmol 2001;85:388-92.
10. Srinivasan M, Gonzales CA, George C, et al. Epidemiology and aetiological diagnosis of corneal ulceration in Madurai, south India. Br J Ophthalmol 1997;81:965-71.
11. Chander J, Sharma A. Prevalence of fungal corneal ulcers in northern India. Infection 1994;22:207-9.
12. Leck AK, Thomas PA, Hagan M, et al. Aetiology of suppurative corneal ulcers in Ghana and south India, and epidemiology of fungal keratitis. Br J Ophthalmol 2002;86:1211-15.
13. Apt L, Isenberg S, Yoshimori R, et al. Chemical preparation of the eye in ophthalmic surgery. III. The effects of povidone-iodine on the conjunctiva. Arch Ophthalmol 1984;102:728-9.
14. Apt L, Isenberg S, Yoshimori R, et al. Outpatient topical use of povidone-iodine in preparing the eye for surgery. Ophthalmology 1989;96:289-92.
15. Apt L, Isenberg S. Chemical preparation of skin and eye in ophthalmic surgery: An international survey. Ophthalmic Surg 1982;13:1026-9.
16. Grimes SR, Mein CE, Trevino S. Preoperative antibiotic and povidone-iodine preparation of the eye. Ann Ophthalmol 1991;23:263-6.
17. Lagoutte F, Fosse T, Jasinski M, et al. Povidone iodine (Betadine) for the prophylaxis of postoperative infection. A multicentre study. J Fr Ophtalmol 1992;15:14-18.
18. Boes DA, Lindquist TD, Fritsche TR, et al. Effects of povidone-iodine chemical preparation and saline irrigation on the perilimbal flora. Ophthalmology 1992;99:1569-74.
19. Caldwell DR, Kastl PR, Cook J, et al. Povidone-iodine: its efficacy as a perioperative conjunctival and periocular preparation. Ann Ophthalmol 1984;16:577-8.
20. Klie F, Boge-Rasmussen I, Jensen OL. The effect of polyvinyl-pyrrolidone- iodine as a disinfectant in eye surgery. Acta Ophthalmol 1986;64:67-71.
21. Speaker MG, Menikoff JA. Prophylaxis of endophthalmitis with topical povidone-iodine. Ophthalmology 1991;98:1769-75.
22. Ariyasu RG, Nakamura T, Trousdale MD, et al. Intraoperative bacterial contamination of the aqueous humor. Ophthalmic Surg 1993;24:367-74.
23. Hale ML. Povidone-iodine in ophthalmic surgery. Ophthalmic Surg 1970;1:9-13.
24. Isenberg S, Apt L, Yoshimori R, et al. Chemical preparation of the eye in ophthalmic surgery. IV. Comparison of povidone-iodine on the conjunctiva with a prophylactic antibiotic. Arch Ophthalmol 1985;103:1340-2.
25. Saggers BA, Stewart GT. Polyvinyl-pyrrolidone-iodine: an assessment of anti-bacterial activity. J Hygiene 1964;62:509-18.
26. Gershenfeld L. Povidone-iodine as a topical antiseptic. Am J Surg 1957;94:938-9.
27. White JH, Stephens GM, Cinotti AA. The use of povidone-iodine for treatment of fungi in rabbit eyes. Ann Ophthalmol 1972:855-6.
28. Panda A, Ahuja R, Biswas NR, et al. Role of 0.02% polyhexamethylene biguanide and 1% povidone iodine in experimental apergillus keratitis. Cornea 2003;22:138-41.
29. Benevento WJ, Murray P, Reed CA, et al. The sensitivity of Neisseria gonorrhoeae, Chlamydia trachomatis, and herpes simplex type II to disinfection with povidone iodine. Am J Ophthalmol 1990;109:329-33.
30. Isenberg SJ, Apt L, Yoshimori R, et al. Povidone-iodine for ophthalmia neonatorum prophylaxis. Am J Ophalmol 1994;118:701-6.
31. Hale LM. The treatment of corneal ulcer with povidone-iodine (Betadine). N C Med J 1969;30:54-6.
32. Kuwahara Y, Ohta Y, Yamada M. Experience with PVP-iodine. J Clin Ophthalmol 1962;16:93.
33. Sloan JB. Povidone-iodine to treat pseudomonas corneal ulcers. Abstract, 7th Annual staff meeting of the University of North Carolina Department of Ophthalmalogy, 1969.
34. Hale LM. Treatment of experimental herpes simplex keratitis with povidone-iodine. Abstract, 7th Annual staff meeting of the University of North Carolina Department of Ophthalmology, 1969.
35. Taylor J. Appropriate drugs for developing countries. Int Ophthalmol 1990;14:173-9.
36. West KP, Katz J, Khatry SK, et al. Double blind, cluster randomized trial of low dose supplementation with vitamin A or beta-carotene on mortality related to pregnancy in Nepal. BMJ 1999;318:570-5.
37. Khatry SK, Lewis AE, Schein OD, et al. The epidemiology of ocular trauma in rural Nepal. Br J Ophthalmol 2004;88:456-60.
38. Katz J, West KP, Khatry SK, et al. Prevalence and risk factors for trachoma in Sarlahi district, Nepal. Br J Ophthalmol 1996;80:1037-41.
39. Katz J, West KP, Khatry SK, et al. The impact of vitamin A supplementation on prevalence and incidence of xerophthalmia in Nepal. Inv Ophthalmol Vis Sci 1995;36:2577-83.
40. Khatry SK, West KP, Katz J, et al. Epidemiology of xerophthalmia in Nepal: a pattern of household poverty, childhood illness and mortality. Arch Ophthalmol 1995;113:425-9.
41. Chrai SS, Makoid MC, Eriksen SP, et al. Drop size and initial dosing frequency problems of topically applied ophthalmic drugs. J Pharm Sci 1974;63:333-8.
42. Martin MJ, Rahman MR, Johnson GJ, et al. Mycotic keratitis: susceptibility to antiseptic agents. Int Ophthalmol 1996;19:299-302.
43. Rahman MR, Minassian DC, Srinivasan M, et al. Trial of chorhexidine gluconate for fungal corneal unlcers. Ophthalmic Epidemiol 1997;4:141-9.
44. Rahman MR, Johnson GJ, Husain R, et al. Randomized trial of 0.2% chlorhexidine gluconate and 2.5% natamycin for fungal keratitis in Bangladesh. Br J Ophthalmol 1998;82:919-25.