Role of 0.02% polyhexamethylene biguanide and 1% povidone iodine in experimental Aspergillus keratitis

Cornea

Volumn 22, Issue 2, 2003, Pages 138-141

  Panda, Anita ^a   Ahuja, Rakesh ^a   Biswas, Nihar Ranjan ^a   Satpathy, Gita ^a   Khokhar, Sudershan ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Epithelial defect; Experimental Aspergillus keratitis; Hydroxypropylmethyl cellulose; Hypopyon; Natamycin; Polyhexamethylene biguanide; Povidone iodine

Indexed keywords

COSMOCIL CQ; HYDROXYPROPYLMETHYLCELLULOSE; NATAMYCIN; OCUDONE; POLY(HEXAMETHYLENEBIGUANIDE); POVIDONE IODINE; BIGUANIDE DERIVATIVE; DISINFECTANT AGENT; EYE DROPS; TOPICAL ANTIINFECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLOSIS; ASPERGILLUS FUMIGATUS; CONTROLLED STUDY; CORNEA PERFORATION; CORNEA ULCER; HYPOPYON; NONHUMAN; PRIORITY JOURNAL; RABBIT; ULCER HEALING; ANIMAL; COMPARATIVE STUDY; CORNEA STROMA; DRUG SCREENING; FUNGAL EYE INFECTION; KERATITIS; MICROBIOLOGY; PHYSIOLOGY; PROSPECTIVE STUDY; RANDOMIZATION;

ANIMALS; ANTI-INFECTIVE AGENTS, LOCAL; ASPERGILLOSIS; ASPERGILLUS FUMIGATUS; BIGUANIDES; CORNEAL STROMA; DISINFECTANTS; DRUG EVALUATION; EYE INFECTIONS, FUNGAL; KERATITIS; NATAMYCIN; OPHTHALMIC SOLUTIONS; POVIDONE-IODINE; PROSPECTIVE STUDIES; RABBITS; RANDOM ALLOCATION;

EID: 0037363682     PISSN: 02773740     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003226-200303000-00012     Document Type: Article

References (21)

1. Srinivasan R, Kanungo R, Goyal JL. Spectrum of oculomycosis in South India. Acta Ophthalmol (Copenh) 1991;69:744-9.
2. Chander J, Sharma A. Prevalence of fungal corneal ulcers in Northern India. Infection 1994;22:207-9.
3. Panda A, Sharma N, Das G, et al. Mycotic keratitis in children: epidemiologic and microbiologic evaluation. Cornea 1997;16:295-9.
4. Dunlop AA, Wright ED, Howlader SA, et al. Suppurative corneal ulceration in Bangladesh. A study of 142 cases examining the microbiological diagnosis, clinical and epidemiological features of bacterial and fungal keratitis. Aust N Z J Ophthalmol 1994;22:105-10.
5. McDonnell PJ, McDonnel JM, Brown RH, et al. Ocular involvement in patients with fungal infections. Ophthalmology 1985;92:706-9.
6. Rosa RH Jr, Miller D, Alfonso EC. The changing spectrum of fungal keratitis in South Florida. Ophthalmology 1994;101:1005-13.
7. Keeven J, Wrobel S, Portoles M, et al. Evaluating the preservative effectiveness of RGP lens care solutions. CLAO J 1995;21:238-41.
8. Messick CR, Pendland SL, Moshirfar M, et al. In-vitro activity of polyhexamethylene biguanide (PHMB) against fungal isolates associated with infective keratitis. J Antimicrob Chemother 1999;44:297-8.
9. Liu NH, Khong, Chung SK. In vitro susceptibility of ocular bacterial and fungal pathogens to polyhexamethylene biguanide. Invest Ophthalmol Vis Sci 1996;37(suppl):4058.
10. Fiscella RG, Moshifar M, Messick CR, et al. Polyhexamethylene biguanide (PHMB) in the treatment of experimental Fusarium keratomycosis. Cornea 1997;16:447-9.
11. Larkin DF, Kilvington S, Dark JK. Treatment of Acanthamoeba keratitis with polyhexamethylene biguanide. Ophthalmology 1992;99:185-91.
12. Panda A, Das GK, Biswas NR, et al. Therapy of Acanthamoeba keratitis - an experimental study. Indian J Physiol Pharmacol 2000;44:363-7.
13. Apt L, Isenberg S, Yoshimori R, et al. Chemical preparation of the eye in ophthalmic surgery. III. Effect of povidone-iodine on the conjunctiva. Arch Ophthalmol 1984;102:728-9.
14. Martin MJ, Rahman MR, Johnson GJ, et al. Mycotic keratitis: susceptibility to antiseptic agents. Int Ophthalmol 1995-96;19:299-302.
15. White JH, Stephens GM, Cinotti AA. The use of povidone-iodine for treatment of fungi in rabbit eyes. Ann Ophthalmol 1972;4:855-6.
16. McLeod LJ. Pharmacological experiments on intact preparations. Edinburgh: Livingstone, 1970:2-5.
17. O'Day DM. Fungal keratitis. In: Leibowitz HM, ed. Corneal disorders: clinical diagnosis and management. Philadelphia: Saunders, 1998:711-8.
18. Forster RK. Fungal keratitis and conjunctivitis: clinical disease. In: Smolin G, Thoft RA, eds. The cornea. Boston: Little, Brown, 1994:239-52.
19. Mohan M, Sangawe JL, Mahajan VM. Pathogenesis of experimentally produced corneal ulcers in rabbits. Ann Ophthalmol 1984;16:246-8, 250-2.
20. Biswas NR, Das H, Satpathy G, et al. Role of aprotinin in the management of experimental fungal keratitis. Ophthalmic Res 2001;33:147-50.
21. Rahman MR, Johnson GJ, Husain R, et al. Randomized trial of 0.2% chlorhexidine gluconate and 2.5% natamycin for fungal keratitis in Bangladesh. Br J Ophthalmol 1998;82:919-25.