Prediction of the risk of type 1 diabetes from polymorphisms in candidate genes

Diabetes Research and Clinical Practice

Volumn 66, Issue SUPPL., 2004, Pages

  Park, Y ^a  

^a Hanyang University College of Medicine   (South Korea)

Author keywords

Genetic susceptibility; Prediction; T1D

Indexed keywords

AUTOANTIBODY; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GLUTAMATE DECARBOXYLASE ANTIBODY; HLA ANTIGEN; HLA ANTIGEN CLASS 1; HLA ANTIGEN CLASS 2; HLA ANTIGEN CLASS III; HLA DQ ANTIGEN; HLA DQB1 ANTIGEN; HLA DR ANTIGEN; IA ANTIBODY; IMMUNOGLOBULIN RECEPTOR; INSULIN ANTIBODY; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR; TOLL LIKE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ACCURACY; ALLELE; ANTIBODY DETECTION; ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; AUTOIMMUNE DISEASE; AUTOIMMUNE REGULATOR; CELL DESTRUCTION; CHROMOSOME 19Q; CHROMOSOME 2Q; CONFERENCE PAPER; DIABETOGENESIS; DISEASE COURSE; DISEASE MARKER; DISEASE PREDISPOSITION; ETHNIC DIFFERENCE; GENE; GENE FUNCTION; GENE LOCUS; GENE MUTATION; GENE OVEREXPRESSION; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HAPLOTYPE; HEREDITY; HIGH RISK POPULATION; HLA SYSTEM; HUMAN; IMMUNE RESPONSE; INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL; PHENOTYPE; PREDICTION; RELIABILITY; RISK ASSESSMENT; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

DIABETES MELLITUS, TYPE 1; GENETIC PREDISPOSITION TO DISEASE; HISTOCOMPATIBILITY ANTIGENS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA ANTIGENS; HUMANS; IMMUNITY, NATURAL; MUTATION; POLYMORPHISM, GENETIC;

EID: 9644281707     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.diabres.2003.10.026     Document Type: Conference Paper

References (20)

1. Y. Park, G.S. Eisenbarth, Natural History of type 1 diabetes, in: S. Taylor, D. LeRoith, J. Olefsky (Eds.), Diabetes Mellitus: A Fundamantal and Clinical Text, second ed., Lippincott Williams & Wilkins, Philadelphia, PA, 2000, pp. 347-362.
2. Beyan H., Buckley L.R., Yousaf N., Londei M., Leslie R.D.G. A role for innate immunity in type 1 diabetes? Diab. Metab. Res. Rev. 19:2003;89-100
3. Park Y., Ko K., Yang S., et al. Evaluation of the efficacy of multiple autoantibody screening in Korean patients with IDDM. Acta Diabetol. 37:2001;213-217
4. S. Choi, Y. Park, H. Park, et al., Development of a new type 1 diabetes-related autoantibody detection method using GAD65/IA-2 fusion protein, in: Perspectives of Diabetes in The New Millennium, Proceedings of the 11th Korea-Japan Symposium on Diabetes Mellitus, Elsevier, Singapore, 2003, pp. 64-66.
5. Park Y., Park H., Yoo E., Kim D., Yang S. HLA DR3 haplotypes confer susceptibility to T1DM without association with particular immune marker, while HLA DR4 haplotypes confer susceptibility through GAD antibody production. Diabetes. 51:2002;A210
6. Park Y., Eisenbarth G.S. Genetic susceptibility factors of type 1 diabetes in Asians and their functional evaluation. Diab. Metab. Res. Rev. 17:2001;2-11
7. Park Y., Wang C., Ko K., et al. Combinations of HLA DR and DQ molecules determine the susceptibility to insulin-dependent diabetes mellitus in Koreans. Hum. Immunol. 59:1998;794-801
8. Park Y., She J., Wang C., et al. Common susceptibility and transmission pattern of HLA DRB1-DQB1 haplotypes to Korean and Caucasian patients with type 1 diabetes. J. Clin. Endocrinol. Metab. 85:2000;4538-4542
9. Park Y., She J., Noble J.A., Erlich H.A., Eisenbarth G.S. Transracial evidence for the influence of the homologous HLA DR-DQ haplotype on transmission of HLA DR4 haplotypes to diabetic children. Tissue Antigens. 57:2001;185-191
10. Park Y., Lee H., Sanjeevi C., Eisenbarth G.S. MIC-A polymorphism is associated with type 1 diabetes in the Korean population. Diab. Care. 24:2001;33-38
11. Zake L.N., Ghaderi M., Park Y., Babu S., Eisenbarth G., Sanjeevi C. MHC class I chain related gene (MIC-A) alleles 5 and 5.1 are transmitted more frequently to type 1 diabetes offsprings in HBDI families. Ann. NY Acad. Sci. 958:2002;309-311
12. Park Y., Sanjeevi C., Robles D., et al. HLA genotypes (class II, MIC-A, D6S273): additional association of intra-MHC genes, MICA and D6S273 with Addison's disease. Tissue Antigens. 60:2002;155-163
13. Park Y., Jospe E., Babu S., Eisenbarth G.S. D6S2223 alleles associated with risk of IDDM in DR3-DQ2/DR4-DQ8 heterozygotes. Diabetes. 48:1999;A183
14. *0401) transgenic mice. Proc. Natl. Acad. Sci. U.S.A. 94:1997;8082-8087
15. Wen L., Wong F.S., Tang J., et al. In vivo evidence for the contribution of human histocompatibility leukocyte antigen (HLA)-DQ molecules to the development of diabetes. J. Exp. Med. 191:2000;97-104
16. Marron M., Zeidler A., Raffel L., et al. Genetic and physical fine-mapping of a type 1 diabetes susceptibility gene (IDDM12) to a 100-kb phagemid artificial chromosome clone containing D2S72-CTLA4-D2S105 on chromosome 2q33. Diabetes. 49:2000;492-499
17. Ueda H., Howson J., Esposito L., et al. Association of T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature. 29:2003;506-511
18. Park Y., Kim T., Kim D., Sanjeevi C. Natural killer cell immunoglobulin-like receptor (KIR) genes in Korean patients with type 1 diabetes mellitus. Diabetologia. 46:2003;A16
19. Y. Park, Y. Moon, H. Chung, AIRE-1 (autoimmune regulator type 1) as a regulator of the thymic induction of negative selection, Ann. NY Acad. Sci. 1005 (2003) 431-435.
20. Anderson M., Venanzi E., Klein L., et al. Projection of an immunological self shadow within the thymus by the aire protein. Science. 298:2002;1348-1349