AIRE-1 (autoimmune regulator type 1) as a regulator of the thymic induction of negative selection

Annals of the New York Academy of Sciences

Volumn 1005, Issue , 2003, Pages 431-435

  Park, Yongsoo ^a   Moon, Yoomi ^a   Chung, Hee Yong ^a  

^a Hanyang University College of Medicine   (South Korea)

Author keywords

AIRE; Negative selection; Regulator

Indexed keywords

ALBUMIN; AUTOIMMUNE REGULATOR TYPE 1 PROTEIN; BETA GALACTOSIDASE; COMPLEMENTARY DNA; EPITOPE; PEPTIDE; REGULATOR PROTEIN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; CONFERENCE PAPER; CONTROLLED STUDY; DNA MICROARRAY; EMBRYO; GENE OVEREXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; IMMUNE RESPONSE GENE; IMMUNOGENICITY; IMMUNOLOGICAL TOLERANCE; IN VITRO STUDY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; THYMOCYTE; THYMUS; THYMUS FUNCTION; TRANSCRIPTION REGULATION; TRANSGENICS;

ANIMALIA;

EID: 1942506727     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1288.073     Document Type: Conference Paper

References (6)

1. BJORSES, P. et al. 1996. Genetic homogeneity of autoimmune polyglandular disease type I. Am. J. Hum. Genet. 59: 879-886.
2. PUGLIESE, A. et al. 1997. The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes. Nat. Genet. 15: 293-297.
3. PARK, Y. et al. 2000. Humoral autoreactivity to an alternatively spliced variant of ICA512/IA-2 in type 1 diabetes. Diabetologia 43: 1293-1301.
4. RAMSEY, C. et al. 2002. AIRE deficient mice develop multiple features of APECED phenotype and show altered immune response. Hum. Mol. Genet. 11: 397-409.
5. FERRERO, I. et al. 1998. Viral superantigen-induced negative selection of TCR transgenic CD4+ CD8+ thymocytes depends on activation, but not proliferation. Blood 91: 4248-4254.
6. ANDERSON, M.S. et al. 2002. Projection of an immunological self-shadow within the thymus by the AIRE protein. Science 298: 1395-1401.