Preparation of arsenic trioxide-loaded microemulsion and its enhanced cytotoxicity on MCF-7 breast carcinoma cell line

Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents

Volumn 11, Issue 6, 2004, Pages 345-350

  Karasulu, H Yeşim ^a   Karabulut, Bülent ^a   Kantarci, Gülten ^a   Özgüney, Işik ^a   Sezgin, Canfeza ^a   Sanli, Ulus Ali ^a   Göker, Erdem ^a  

^a EGE UNIVERSITY   (Turkey)

Author keywords

Arsenic Trioxide; Breast Cancer; Cytotoxic Effect; Local Injections; Microemulsion; Stability

Indexed keywords

ALCOHOL; ARSENIC TRIOXIDE; CETOMACROGOL; COSURFACTANT; DRUG CARRIER; SORBITAN OLEATE; SOYBEAN OIL; SURFACTANT;

AMPOULE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; AQUEOUS SOLUTION; ARTICLE; AUTOCLAVE; CANCER INHIBITION; CELL STRAIN MCF 7; CONTROLLED STUDY; CYTOTOXICITY; DRUG FORMULATION; DRUG MANUFACTURE; DRUG STABILITY; HUMAN; HUMAN CELL; IN VITRO STUDY; INJECTION; INTRATUMORAL DRUG ADMINISTRATION; MICROEMULSION; PARTICLE SIZE; PH; PRIORITY JOURNAL; ROOM TEMPERATURE; THERMOSTABILITY; TUMOR GROWTH;

ARSENICALS; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; EMULSIONS; HUMANS; INJECTIONS, INTRALESIONAL; OXIDES; PARTICLE SIZE;

EID: 9644281175     PISSN: 10717544     EISSN: None     Source Type: Journal    
DOI: 10.1080/10717540490494096     Document Type: Article

References (23)

1. Boman, L., Lindgren, A., and Sandelin, K. 2002. Women's perceptions of seroma and their drainage following mastectomy and axillary lymh node dissectin. Eur. J. Onc. Nurs. 6:213-219.
2. Chairman, S. A., Chairman, W. N., Rogge, M. C., Wilson, T. D., Dutko, F. J., and Pouton, C. W. 1992. Self-emulsifying drug delivery systems: formulation and biophanmaceutical evaluation of an investigational lipophilic compound. Pharm. Res. 9:87-93.
3. Constantinides, P. P., and Yiv, S. H. 1995. Particle size determination of phase-inverted water-in-oil microemulsions under different dilution and storage conditions. Int. J. Pharm. 115:225-234.
4. Constantinides, P. P., Scalart, J.-P., Lancaster, C., Marcello, J., Marks, G., Ellens, H., and Smith, P. L. 1994. Formulation and intestinal absorption enhancement evaluation of water-in-oil microemulsions incorporating medum-chain glycerides. Phar. Res. 11:1358-1390.
5. Corswant, C. V., Thorén, P., and Engström, S. 1998. Triglyceride-based microemulsion for intravenous administration of sparingly soluble substances. J. Pharm. Sci. 87:200-208.
6. Dagar, S., Sekosan, M., Lee, B. S., Rubinstein, I., and Onyüksel, H. 2001. VIP receptors as molecular targets of breast cancer: implications for targeted imaging and drug delivery. J. Cont. Rel. 74:129-134.
7. Fanun, M., Wachtel, E., Antalek, B., Aserin, A., and Garti, N. 2001. A study of the mictostructure of four-component sucrose ester microemulsions by SAXS and NMR. Colloids and Surfaces A: Physicochem. Eng. Aspects 180:173-186.
8. Kawakami, S., Yamashita, F., and Hashida, M. 2000. Disposition characteristics of emulsions and incorporated drugs after systemic or local injection. Adv. Drug Deliv. Rev. 45:77-88.
9. Kim, C.-K., Ryuu, S. A., Park, K.-M, Lim, S.-L., and Hwang, S. J. 1997. Preparation and physicochemical characterization of phase inverted water-in-oil microemulsions containing cyclosporin A. Int. J. Pharm. 147:131-134.
10. Kim, C.-K., Cho, Y.-J., and Gao, Z.-G. 2001. Preparation and evaluation of biphenyl dimethyl dicarboxylate microemulsions for oral delivery. J. Cont. Rel. 70:149-155.
11. Knepp, W. A., Jayakrishman, A., Quigg, J. M., Stren, H. S., Bagnall, J. J., and Goldberg, E. P. 1993. Synthesis, properties and intratumoral evaluation of mitoxantrone-loaded casein microspheres in lewis lung carsinoma. J. Pharm. Pharmacol 58:887-891.
12. Lawrance, M. J., and Rees, G. D. 2000. Microemulsion-based media as novel drug delivery systems. Adv. Drug Deliv. Rev. 45:89-121.
13. Lee, T. C., and Ho, I. C. 1994. Different cytotoxic effects of arsenic on human and animal cells. Environ. Health Perspect. 102:101-105.
14. Lu, M., Levin, J., Sulpice, E., Grand, A. S.-L., Alemany, M., Caen, J. P., and Han, Z. C. 1999. Effect of arsenic trioxide on viability, proliferation, and apoptosis in human megakaryocytic leukemia cell lines. Exp. Hemat. 27:845-852.
15. Nishioka, Y., and Yoshino, H. 2001. Lymphatic targeting with nanoparticulate system. Adv. Drug Delv. Rev. 47:55-64.
16. Nomura, T., Koreeda, N., Yamashita, F., Takakura, Y., and Hashida, M. 1998. Effect of particle size and charge on the disposition of lipid carriers after intratumoral injection into tissue-isolated tumors. Pharm. Res. 15:128-132.
17. Park, K. M., and Kim, C. K. 1999. Preparation and evaluation of flurbiprofen-loaded microemulsion for parenteral delivery. Int. J. Pharm. 181:173-179.
18. Sezgin, C., Şanli, U. A., Uslu, R., and Göker, E. 2002. Arsenic trioxide has additive cytotoxic effects on MCF-7 breast cancer cell line with taxanes. Turk J. Med. Sci. 32:439-444.
19. Tarr, B. D., and Yalkowsky, S. H. 1989. Enhanced intestinal absorption of cyclosporine in rats through the reduction of emulsion droplet size. Pharm. Res. 6:40-43.
20. Uslu, R., Borsellino, N., Frost, P., Garban, H., Ng, C. P., Mizutani, Y., Belldegrum, A., and Bonovida, B. 1997. Chemosensitization of human prostate carcinoma cell lines to anti-Fas-mediated cytotoxicity and apoptosis. Clin. Cancer Res. 3:963-972..
21. Uslu, R., Sanli, U. A., Sezgin, C., Karabulut, B., Terziolu, E., Omay, S. B., and Göker, E. 2000. Arsenic trioxide-mediated cytotoxicity and apoptosis in prostate and ovarian carcinoma cell lines. Clin. Ca. Res. 6:4957-4964.
22. Washington, C., and Evans, K. 1995. Release rate measurements of model hydrophobic solutes from submicron triglyceride emulsions. J. Cont. Rel. 33:383-390.
23. Zhan, Q., Zhao, S. C., and Xu, Z. 2001. Antitumor activity of cytotropic heterogeneous molecular lipids (CHNL) on human breast cancer xenograft in nude mice. Anticancer Res. 21:2477-2482.