Effects of drugs on olfaction and taste

Otolaryngologic Clinics of North America

Volumn 37, Issue 6 SPEC.ISS., 2004, Pages 1229-1254

  Doty, Richard L ^a   Bromley, Steven M ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UMDNJ Robert Wood Johnson Medical School at Camden   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACEBUTOLOL; ACETAZOLAMIDE; ADENOSINE; ADRENERGIC RECEPTOR STIMULATING AGENT; ALDACTAZINE; ALDOCLOR; ALPRAZOLAM; AMILORIDE; AMILORIDE PLUS HYDROCHLOROTHIAZIDE; AMIODARONE; AMITRIPTYLINE; AMLODIPINE BESYLATE; AMLODIPINE PLUS BENAZEPRIL; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; ANTIARRHYTHMIC AGENT; ANTIBIOTIC AGENT; ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; ANTIHISTAMINIC AGENT; ANTIHYPERTENSIVE AGENT; ANTIINFLAMMATORY AGENT; ANTILIPEMIC AGENT; ANTIMIGRAINE AGENT; ANTINEOPLASTIC AGENT; ANTIPARKINSON AGENT; ANTITHYROID AGENT; ANTIVIRUS AGENT; ANXIOLYTIC AGENT; ATENOLOL; ATENOLOL PLUS CHLORTALIDONE; ATORVASTATIN; ATROMID; AURANOFIN; AUROTHIOMALATE; AVALIDE; AZITHROMYCIN; BACLOFEN; BECLOMETASONE DIPROPIONATE; BENDROFLUMETHIAZIDE PLUS NADOLOL; BEPRIDIL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETAXOLOL; BISOPROLOL FUMARATE; BISOPROLOL FUMARATE PLUS HYDROCHLOROTHIAZIDE; BITOLTEROL MESILATE; BRONCHODILATING AGENT; BUDESONIDE; BUSPIRONE; CALCIUM CHANNEL BLOCKING AGENT; CANDESARTAN HEXETIL; CAPTOPRIL; CARBAMAZEPINE; CARBIDOPA PLUS LEVODOPA; CARBONATE DEHYDRATASE INHIBITOR; CARTEOLOL; CARVEDILOL; CERIVASTATIN; CHLOROTHIAZIDE; CHLORTALIDONE; CIPROFLOXACIN; CISPLATIN; CLARITHROMYCIN; CLOMIPRAMINE; CLONIDINE; CLORPRES; CLOZAPINE; COLESTIPOL; CORONARY VASODILATING AGENT; COVERA; DANTROLENE; DECONGESTIVE AGENT; DESIPRAMINE; DEXAMETHASONE; DICLOFENAMIDE; DIGOXIN; DIHYDROERGOTAMINE MESILATE; DILTIAZEM; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DISOPYRAMIDE PHOSPHATE; DIURETIC AGENT; DOXAZOSIN; DOXEPIN; DOXORUBICIN; ENALAPRIL MALEATE; ENALAPRIL MALEATE PLUS FELODIPINE; ENALAPRIL PLUS HYDROCHLOROTHIAZIDE; ESIDIX; ESMOLOL; ETACRYNIC ACID; FELODIPINE; FENOFIBRATE; FLECAINIDE ACETATE; FLUINDOSTATIN; FLUNISOLIDE; FLUTICASONE PROPIONATE; FOSINOPRIL; GANCICLOVIR; GEMFIBROZIL; GLYCERYL TRINITRATE; GRISEOFULVIN; GUANADREL SULFATE; GUANFACINE; HYDROCHLOROTHIAZIDE; HYDROCHLOROTHIAZIDE PLUS LISINOPRIL; HYDROCHLOROTHIAZIDE PLUS LOSARTAN; HYDROCHLOROTHIAZIDE PLUS METHYLDOPA; HYDROCHLOROTHIAZIDE PLUS PROPRANOLOL; HYDROCHLOROTHIAZIDE PLUS TRIAMTERENE; HYDROFLUMETHIAZIDE; IMIPRAMINE; IRBESARTAN; ISOPTIM; ISOSORBIDE 5 NITRATE; ISOSORBIDE DINITRATE; LABETALOL; LEVAMISOLE; LEVODOPA; LISINOPRIL; LORATADINE; LOSARTAN POTASSIUM; METHOTREXATE; METHYCLOTHIAZIDE; METHYLDOPA; METOLAZONE; METOPROLOL SUCCINATE; METRONIDAZOLE; MEVINOLIN; MEXILETINE; MOEXIPRIL; MORACIZINE; MUSCLE RELAXANT AGENT; NARATRIPTAN; NEUROLEPTIC AGENT; NICARDIPINE; NICOTINE; NIFEDIPINE; NIMODIPINE; NISOLDIPINE; NORTRIPTYLINE; OFLOXACIN; PANCRELIPASE; PENBUTOLOL; PENICILLAMINE; PERINDOPRIL; PHENOXYBENZAMINE; PHENYTOIN; PIRBUTEROL ACETATE; PIRODAVIR; POLYTHIAZIDE; PRAVASTATIN; PRAZOSIN; PROCAINAMIDE; PROPAFENONE; PROPRANOLOL; QUINAGULATE; QUINAPRIL; QUINIDINE POLYGALACTURONATE; QUINIDINE SULFATE; RAMIPRIL; RIZATRIPTAN; RUFERON A; SIMVASTATIN; SOTALOL; SPIRONOLACTONE; SUMATRIPTAN SUCCINATE; TELMISARTAN; TERAZOSIN; TERBINAFINE; THIAMAZOLE; THIAZIDE DIURETIC AGENT; TIMENTIN; TIMOLIDE; TIMOLOL MALEATE; TOCAINIDE; TORASEMIDE; TRANDOLAPRIL; TRANDOLAPRIL PLUS VERAPAMIL; TRANQUILIZER; TRIAMTERENE; TRIFLUOPERAZINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; UNIRETIC; VALSARTAN; VERAPAMIL; VINCRISTINE SULFATE; ZALCITABINE;

AGEUSIA; ALCOHOL CONSUMPTION; AMBULATORY CARE; ANOSMIA; BITTER TASTE; CANDIDIASIS; CLINICAL TRIAL; DRUG EFFECT; DRUG EFFICACY; DYSGEUSIA; GASTROESOPHAGEAL REFLUX; GINGIVA HYPERPLASIA; GLOSSITIS; HUMAN; IMMUNOPATHOLOGY; MOUTH HYGIENE; NAUSEA; NUTRITIONAL HEALTH; OLFACTORY SYSTEM; ORAL BLEEDING; PAROSMIA; PRESCRIPTION; REVIEW; SIDE EFFECT; SMELLING; SMELLING DISORDER; SMOKING; STOMATITIS; TASTE; TASTE ACUITY; TASTE DISORDER; TOOTH DISEASE; VITAMIN SUPPLEMENTATION; XEROSTOMIA;

EID: 9644277045     PISSN: 00306665     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.otc.2004.05.002     Document Type: Review

References (72)

1. Guggenheimer J. Oral manifestations of drug therapy. Dent Clin North Am. 46:2002;857-868
2. Marks H.M. Revisiting the origins of compulsory drug prescriptions. [comment] Am J Pub Health. 85:1995;109-115
3. Lewis I.K., Hanlon J.T., Hobbins M.J., et al. Use of medications with potential oral adverse drug reactions in community-dwelling elderly. Spec Care Dentist. 13:1993;171-176
4. Schiffman S.S. Taste and smell losses in normal aging and disease. JAMA. 278:1997;1357-1362
5. Physician's Desk Reference. 2003;Medical Economics Company, Inc., Montvale (NJ)
6. Doty R.L., Philip S., Reddy K., et al. Influences of antihypertensive and antihyperlipidemic drugs on the senses of taste and smell: a review. J Hypertens. 21:2003;1805-1813
7. Fallis N., Lasagna L., Tetreault L. Gustatory thresholds in patients with hypertension. Nature. 196:1962;74-75
8. Viskoper R.J., Lugassy G. Elevated taste threshold for salt in hypertensive subjects. Kidney Int. 15:1979;582
9. Zervakis J., Graham B.G., Schiffman S.S. Taste effects of lingual application of cardiovascular medications. Physiol Behav. 68:2000;405-413
10. Doty R.L., Hastings L. Neurotoxic exposure and olfactory impairment. Clin Occup Environ Med. 1:2001;547-575
11. Hastings L., Miller M.L. Influence of environmental toxicants on olfactory function. Doty R.L. Handbook of olfaction and gestation. 2nd edition:2003;575-591 Marcel Dekker, New York
12. Ackerman B.H., Kasbekar N. Disturbances of taste and smell induced by drugs. Pharmacotherapy. 17:1997;482-496
13. Schiffman S.S., Zervakis J., Westall H.L., et al. Effect of antimicrobial and anti-inflammatory medications on the sense of taste. Physiol Behav. 69:2000;413-424
14. Hyman B.T., Reiter J., Moss M., et al. Extracellular signal-regulated kinase (MAP kinase) immunoreactivity in the rhesus monkey brain. Neurosci Lett. 166:1994;113-116
15. Juhlin L. Loss of taste and terbinafine. Lancet. 339:1992;1483
16. Beutler M., Hartmann K., Kuhn M., et al. Taste disorders and terbinafine. BMJ. 307:1993;26
17. Duxbury A.J., Oliver R.J., Pemberton M.N. Persistent impairment of taste associated with terbinafine. Br Dent J. 188:2000;295-296
18. Lemont H., Sabo M. Terbinafine-associated taste disturbance with normal taste threshold scores. J Am Podiatr Med Assoc. 91:2001;540-541
19. Bong J.L., Lucke T.W., Evans C.D. Persistent impairment of taste resulting from terbinafine. Br J Dermatol. 139:1998;747-748
20. Stricker B.H., Van R.M., Sturkenboom M.C., et al. Taste loss to terbinafine: a case-control study of potential risk factors. Br J Clin Pharmacol. 42:1996;313-318
21. Schiffman S.S., Zervakis J., Heffron S., et al. Effect of protease inhibitors on the sense of taste. Nutrition. 15:1999;767-772
22. Hayden F.G., Andries K., Janssen P.A. Safety and efficacy of intranasal pirodavir (R77975) in experimental rhinovirus infection. Antimicrob Agents Chemother. 36:1992;727-732
23. Eksborg S., Pal N., Kalin M., et al. Pharmacokinetics of acyclovir in immunocompromized children with leukopenia and mucositis after chemotherapy: can intravenous acyclovir be substituted by oral valacyclovir? Med Pediatr Oncol. 38:2002;240-246
24. Boyd I. Captopril-induced taste disturbance. Lancet. 342:1993;304
25. Griffen J.P. Drug-induced disorders of taste. Adverse Drug React Toxicol Rev. 11:1992;229-239
26. Barria M.S., Plubins L., Rodriguez M.S., et al. Enalapril in essential arterial hypertension (in Spanish). Rev Med Chil. 117:1989;667-670
27. Schiffman S.S. Taste and smell in disease. N Engl J Med. 308:1983;1275-1279
28. Grosskopf I., Rabinovitz M., Garty M., et al. Persistent captopril-associated taste alteration. Clin Pharm. 3:1984;235
29. McNeill J.J., Anderson A., Christophidis N., et al. Taste loss associated with oral captopril treatment. BMJ. 2:1979;1555-1556
30. Heeringa M., Van P.E. Reversible dysgeusia associated with losartan. Ann Intern Med. 129:1998;72
31. Levenson J.L., Kennedy K. Dysosmia, dysgeusia, and nifedipine. Ann Intern Med. 102:1985;135-136
32. Tennissen A.M. Amiloride reduces intensity responses of human fungiform papillae. Physol Behav. 51:1992;1061-1068
33. Ossebaard C.A., Smith D.V. Effect of amiloride on the taste of NaCl, Na-gluconate and KCl in humans: implications for Na+ receptor mechanisms. Chem Senses. 20:1995;37-46
34. Epstein J.B., Phillips N., Parry J., et al. Quality of life, taste, olfactory and oral function following high-dose chemotherapy and allogeneic hematopoietic cell transplantation. Bone Marrow Transplant. 30:2002;785-792
35. Hinds J.W., Hinds P.L., McNelly N.A. An autoradiographic study of the mouse olfactory epithelium: evidence for long-lived receptors. Anat Rec. 210:1984;375-383
36. Mackay-Sim A. Neurogenesis in the adult olfactory neuroepithelium. Doty R.L. Handbook of olfaction and gestation. 2nd edition:2003;93-113 Marcel Dekker, New York
37. Wickham R.S., Rehwaldt M., Kefer C., et al. Taste changes experienced by patients receiving chemotherapy. Oncol Nurs Forum. 26:1999;697-706
38. Bartoshuk L.M. Chemosensory alterations and cancer therapies. NCI Monogr. 9:1990;179-184
39. Murray C., Solish N. Metallic taste: an unusual reaction to botulinum toxin A. Dermatol Surg. 29:2003;562-563
40. Rossie K., Guggenheimer J. Oral candidiasis: clinical manifestations, diagnosis, and treatment. Pract Periodontics Aesthet Dent. 9:1997;635-641
41. Mitchell J.C., Counselman F.L. A taste comparison of three different liquid steroid preparations: prednisone, prednisolone, and dexamethasone. Acad Emerg Med. 10:2003;400-403
42. Samulak K.M., El Chaar G.M., Rubin L.G. Randomized, double blind comparison of brand and generic antibiotic suspensions: I. A study of taste in adults. Pediatr Infect Dis. 15:1996;14-17
43. Bachert C., El Akkad T. Patient preferences and sensory comparisons of three intranasal corticosteroids for the treatment of allergic rhinitis. [comment] Ann Allergy Asthma Immunol. 89:2002;292-297
44. Rebeck G.W., Maynard K.I., Hyman B.T., et al. Selective 5-HT1D alpha serotonin receptor gene expression in trigeminal ganglia: implications for antimigraine drug development. Proc Natl Acad Sci USA. 91:1994;3666-3669
45. Halone P., Lang H.A., Nyrke T., et al. Quantitative vibration perception thresholds in patients under prolonged antiepileptic treatment. Acta Neurol Scand. 72:1985;307-311
46. Schiffman S.S., Graham B.G., Suggs M.S., et al. Effect of psychotropic drugs on taste responses in young and elderly persons. Ann N Y Acad Sci. 855:1998;732-737
47. Schiffman S.S., Zervakis J., Suggs M.S., et al. Effect of medications on taste: example of amitriptyline HCl. Physiol Behav. 66:1999;183-191
48. Deems D.A., Doty R.L., Settle R.G., et al. Smell and taste disorders, a study of 750 patients from the University of Pennsylvania Smell and Taste Center. Arch Otolaryngol Head Neck Surg. 117:1991;519-528
49. Mattes R.D. Nutritional implications of taste and smell. Doty R.L. Handbook of olfaction and gestation. 2nd edition:2003;881-903 Marcel Dekker, New York
50. Henkin R.I. Impairment of olfaction and of the tastes of sour and bitter in pseudohypoparathyroidism. J Clin Endocrinol Metab. 28:1968;624-628
51. McConnell R.J., Menendez C.E., Smith F.R., et al. Defects of taste and smell in patients with hypothyroidism. Am J Med. 59:1975;354-364
52. Brosvic G.M., Doty R.L., Rowe M.M., et al. Influences of hypothyroidism on the taste detection performance of rats: a signal detection analysis. Behav Neurosci. 106:1992;992-998
53. Brosvic G.M., Risser J.M., Mackay-Sim A., et al. Odor detection performance in hypothyroid and euthyroid rats. Physiol Behav. 59:1996;117-121
54. Lewitt M.S., Laing D.G., Panhuber H., et al. Sensory perception and hypothyroidism. Chem Senses. 14:1989;537-546
55. Mattes R.D., Heller A.D., Rivlin R.S. Abnormalities in suprathreshold taste function in early hypothyroidism in humans. Meiselman H.L., Rivlin R.S. Clinical measurement of taste and smell. 1986;467-486 Macmillan Publishing Company, New York
56. Pittman J.A., Beschi R.J. Taste thresholds in hyper- and hypothyroidism. J Clin Endocrinol Metab. 27:1967;895-896
57. Frye R.E., Schwartz B.S., Doty R.L. Dose-related effects of cigarette smoking on olfactory function. JAMA. 263:1990;1233-1236
58. Matulionis D.H. Ultrastructure of olfactory epithelia in mice after smoke exposure. Ann Otol Rhinol Laryngol. 83:1974;192-201
59. Patel S.J., Bollhoefer A.D., Doty R.L. Influences of ethanol ingestion on olfactory function in humans. Psychopharmacology (Berl). 171:2004;429-434
60. Kesslak J.P., Profitt B.F., Criswell P. Olfactory function in chronic alcoholics. Percept Mot Skills. 73:1991;551-554
61. Mair R., Capra C., McEntee W.J., et al. Odor discrimination and memory in Korsakoff's psychosis. J Exp Psychol Hum Percept Perform. 6:1980;445-458
62. Shear P.K., Butters N., Jernigan T.L., et al. Olfactory loss in alcoholics: correlations with cortical and subcortical MRI indices. Alcohol. 9:1992;247-255
63. DiTraglia G.M., Press D.S., Butters N., et al. Assessment of olfactory deficits in detoxified alcoholics. Alcohol. 8:1991;109-115
64. Dahlof C. Clinical applications of new therapeutic deliveries in migraine. Neurology. 61:2003;S31-S34
65. Bromley S.M., Doty R.L. Clinical disorders affecting taste: evaluation and management. Doty R.L. Handbook of olfaction and gestation. 2nd edition:2003;935-957 Marcel Dekker, New York
66. Zazgornik J., Kaiser W., Biesenbach G. Captopril-induced dysgeusia. Lancet. 341:1993;1542
67. Doty R.L., Bromley S.M. Anosmia, ageusia, and other disorders of chemosensation. Brandt T., Caplan L.R., Dichgans J.,, et al. Neurological diseases: course and treatment. 2nd edition:2002;171-183 Academic Press, San Diego (CA)
68. Chambers K.C., Bernstein I.L. Conditioned taste aversions. Doty R.L. Handbook of olfaction and gustation. 2003;905-933 Marcel Dekker, New York
69. Diaz-Arnold A.M., Marek C.A. The impact of saliva on patient care: a literature review. J Prosthet Dent. 88:2002;337-343
70. Helms J.A., Della-Fera M.A., Mott A.E., et al. Effects of chlorhexidine on human taste perception. Arch Oral Biol. 40:1995;913-920
71. Deems D.A., Yen D.M., Kreshak A., et al. Spontaneous resolution of dysgeusia. Arch Otolaryngol Head Neck Surg. 122:1996;961-963
72. West S.E., Doty R.L. Influence of epilepsy and temporal lobe resection on olfactory function. Epilepsia. 36:1995;531-542