Evaluation of extrusion/spheronisation, layering and compaction for the preparation of an oral, multi-particulate formulation of viable, hIL-10 producing Lactococcus lactis

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 59, Issue 1, 2005, Pages 9-15

  Huyghebaert, Nathalie ^a   Vermeire, An ^a   Neirynck, Sabine ^b,c   Steidler, Lothar ^b,c   Remaut, Eric ^b   Remon, Jean Paul ^a  

^a GHENT UNIVERSITY   (Belgium)

^b DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^c UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

Compaction; Extrusion spheronisation; L. lactis; Layering; Recombinant; Viability

Indexed keywords

INTERLEUKIN 10; MG 1363; RECOMBINANT INTERLEUKIN 10; RECOMBINANT VACCINE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIUM CULTURE; CELL DENSITY; CELL VIABILITY; CYTOKINE PRODUCTION; DRUG FORMULATION; DRUG STORAGE; FREEZE DRYING; LACTOCOCCUS LACTIS; PELLET EXTRUSION; SPHERONIZATION; SUSPENSION; TABLET; TEMPERATURE; VACCINE PRODUCTION;

ADMINISTRATION, ORAL; CHEMISTRY, PHARMACEUTICAL; HUMANS; INTERLEUKIN-10; LACTOCOCCUS LACTIS; TECHNOLOGY, PHARMACEUTICAL;

EID: 9644272346     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2004.09.003     Document Type: Article

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