Spray-coating of rhDNase on lactose: Effect of system design, operational parameters and protein formulation

International Journal of Pharmaceutics

Volumn 144, Issue 1, 1996, Pages 47-59

  Maa, Yuh Fun ^a   Nguyen, Phuong Anh ^a   Hsu, Chung C ^a  

^a GENENTECH INC   (United States)

Author keywords

Agglomeration; Aggregation; Fluid bed; rhDNase; Spray coating; STREA 1; Wurster process

Indexed keywords

DEOXYRIBONUCLEASE; LACTOSE; PROTEIN;

AEROSOL; ARTICLE; DRUG COATING; DRUG FORMULATION; FLUIDIZED BED; METHODOLOGY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DENATURATION;

EID: 0030598291     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(96)04721-7     Document Type: Article

References (13)

1. Fukumori, Y., Fukuda, T., Hanyu, Y., Taheuchi, Y. and Osako, Y., Coating of pharmaceutical powders by fluidized bed process. I. Aqueous enteric coating with methacrylic acid-ethylacrylate copolymer and the dissolution behavior of products. Chem. Pharm. Bull., 35 (1987) 2949-2957.
2. Fukumori, Y., Yamaoka, Y., Ichikawa, H., Fukuda, T., Taheuchi, Y. and Osako, Y., Coating of pharmaceutical powders by fluidized bed process. II. Microcapsules produced by layering of fine powders on coarse particles and subsequent aqueous enteric coating. Chem. Pharm. Bull., 36 (1988) 1491-1501.
3. Fukumori, Y., Ichikawa, H., Yamaoka, Y., Akaho, E., Taheuchi, Y., Fukuda, T., Kanamori, R. and Osako, Y., Effect of additives on physical properties of fine ethyl cellulose microcapsules prepared by the Würster process. Chem. Pharm. Bull., 39 (1991a) 164-169.
4. Fukumori, Y., Ichikawa, H., Yamaoka, Y., Akaho, E., Taheuchi, Y., Fukuda, T., Kanamori, R. and Osako Y., Microgranulation and encapsulation of pulverized pharmaceutical powders with ethyl cellulose by the Würster process. Chem. Pharm. Bull., 39 (1991b) 1806-1812.
5. Fukumori, Y., Ichikawa, H., Jono, K., Taheuchi, Y. and Fukuda, T., Computer simulation of agglomeration in the Würster process. Chem. Pharm. Bull., 40 (1992) 2159-2163.
6. Katta, S. and Gauvin, W.H., Some fundamental aspects of spray drying. AICHE J., 21 (1975) 143-152.
7. Maa, Y.F. and Hsu, C., Feasibility of protein spray using a fluid-bed Würster processor. Biotechnol. Bioeng., (1996a) in press.
8. Maa, Y.F. and Hsu, C., Effect of high shear on proteins. Biotechnol. Bioeng., 51 (1996b) 458-465.
9. Maa, Y.F. and Hsu, C., Protein aggregation by combined effect of shear and air-liquid interface on proteins. Biotechnol. Bioeng., (1996c) in press.
10. Maa, Y.F. and Hsu, C., Liquid/liquid emulsification by rotor/ stator homogenization. J. Controlled Release, 38 (1996d) 219-228.
11. Masters, K. Spray Drying Handbook, 5th Edn., Wiley, New York, 1991, pp. 256-257.
12. Olsen, K.W., Batch fluid-bed processing equipment: a design overview. Part I. Pharm. Technol., 13(1) (1989a) 34-46.
13. Olsen, K.W., Batch fluid-bed processing equipment: a design overview. Part II. Pharm. Technol., 13(6) (1989b) 39-50.